Jacob Strahilevitz

Summary

Affiliation: Hadassah University Hospital
Country: Israel

Publications

  1. pmc Changes in qnr prevalence and fluoroquinolone resistance in clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 to 2005
    Jacob Strahilevitz
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Ein Kerem, Jerusalem, Israel
    Antimicrob Agents Chemother 51:3001-3. 2007
  2. pmc Plasmid-mediated quinolone resistance: a multifaceted threat
    Jacob Strahilevitz
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Ein Kerem, Jerusalem 91120, Israel
    Clin Microbiol Rev 22:664-89. 2009
  3. pmc KPC-9, a novel carbapenemase from clinical specimens in Israel
    Carlos Hidalgo-Grass
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Antimicrob Agents Chemother 56:6057-9. 2012
  4. doi request reprint Comparison of two carbapenem-resistant Klebsiella pneumoniae clones: from a contained outbreak in a paediatric population and from a national epidemic
    Shmuel Benenson
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University, Jerusalem, 91120, Israel
    J Antimicrob Chemother 67:1651-4. 2012
  5. doi request reprint A carbapenem-resistant Klebsiella pneumoniae epidemic clone in Jerusalem: sequence type 512 carrying a plasmid encoding aac(6')-Ib
    Gabriela Warburg
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University, Jerusalem, 91120, Israel
    J Antimicrob Chemother 67:898-901. 2012
  6. pmc Changes in aac(6')-Ib-cr prevalence and fluoroquinolone resistance in nosocomial isolates of Escherichia coli collected from 1991 through 2005
    Gabriela Warburg
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University, Jerusalem 91120, Israel
    Antimicrob Agents Chemother 53:1268-70. 2009
  7. doi request reprint Carbapenem-resistant Klebsiella pneumoniae endocarditis in a young adult. Successful treatment with gentamicin and colistin
    Shmuel Benenson
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, Kiryat Hadassah, POB 12000, IL 91120, Jerusalem, Israel
    Int J Infect Dis 13:e295-8. 2009
  8. pmc High-resolution melt curve analysis for identification of single nucleotide mutations in the quinolone resistance gene aac(6')-Ib-cr
    Carlos Hidalgo-Grass
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Ein Kerem, Jerusalem 91120, Israel
    Antimicrob Agents Chemother 54:3509-11. 2010
  9. pmc Clinical and epidemiological aspects of infections caused by fusarium species: a collaborative study from Israel
    Ran Nir-Paz
    Department of Clinical Microbiology and Infectious Diseases, The Hebrew University Hadassah Medical Center, P O Box 12000, Ein Kerem, Jerusalem 91120, Israel
    J Clin Microbiol 42:3456-61. 2004
  10. pmc NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus
    Que Chi Truong-Bolduc
    Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston Massachusetts 02114 2696, USA
    Antimicrob Agents Chemother 50:1104-7. 2006

Collaborators

Detail Information

Publications19

  1. pmc Changes in qnr prevalence and fluoroquinolone resistance in clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 to 2005
    Jacob Strahilevitz
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Ein Kerem, Jerusalem, Israel
    Antimicrob Agents Chemother 51:3001-3. 2007
    ..Isolates bearing these genes emerged in the mid-1990s, coinciding with the time of a rapid increase in fluoroquinolone resistance. Sixty percent of these isolates were ciprofloxacin susceptible by CLSI breakpoints...
  2. pmc Plasmid-mediated quinolone resistance: a multifaceted threat
    Jacob Strahilevitz
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Ein Kerem, Jerusalem 91120, Israel
    Clin Microbiol Rev 22:664-89. 2009
    ..Of concern, these genes are not yet being taken into account in resistance screening by clinical microbiology laboratories...
  3. pmc KPC-9, a novel carbapenemase from clinical specimens in Israel
    Carlos Hidalgo-Grass
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Antimicrob Agents Chemother 56:6057-9. 2012
    ..bla(KPC-9) was found on a plasmid indistinguishable from pKpQIL that carries bla(KPC-3) in the epidemic clone. Compared to KPC-3, KPC-9 conferred less resistance to carbapenems and higher resistance to ceftazidime...
  4. doi request reprint Comparison of two carbapenem-resistant Klebsiella pneumoniae clones: from a contained outbreak in a paediatric population and from a national epidemic
    Shmuel Benenson
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University, Jerusalem, 91120, Israel
    J Antimicrob Chemother 67:1651-4. 2012
    ..We therefore sought bacterial factors associated with these different epidemiological behaviours...
  5. doi request reprint A carbapenem-resistant Klebsiella pneumoniae epidemic clone in Jerusalem: sequence type 512 carrying a plasmid encoding aac(6')-Ib
    Gabriela Warburg
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University, Jerusalem, 91120, Israel
    J Antimicrob Chemother 67:898-901. 2012
    ..We characterized distinctive features of a hypertransmissible carbapenem-resistant Klebsiella pneumoniae (CRKP) clone that emerged at Hadassah Hospital, Ein-Kerem, Jerusalem, Israel, in 2006...
  6. pmc Changes in aac(6')-Ib-cr prevalence and fluoroquinolone resistance in nosocomial isolates of Escherichia coli collected from 1991 through 2005
    Gabriela Warburg
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University, Jerusalem 91120, Israel
    Antimicrob Agents Chemother 53:1268-70. 2009
    ..Isolates bearing aac(6')-Ib-cr emerged in 1998, coinciding with an increase in ciprofloxacin resistance. The presence of aac(6')-Ib-cr was multiclonal and was associated with the presence of extended-spectrum beta-lactamases...
  7. doi request reprint Carbapenem-resistant Klebsiella pneumoniae endocarditis in a young adult. Successful treatment with gentamicin and colistin
    Shmuel Benenson
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, Kiryat Hadassah, POB 12000, IL 91120, Jerusalem, Israel
    Int J Infect Dis 13:e295-8. 2009
    ..We present a case of hospital-acquired endocarditis caused by carbapenem-resistant K. pneumoniae in a young adult...
  8. pmc High-resolution melt curve analysis for identification of single nucleotide mutations in the quinolone resistance gene aac(6')-Ib-cr
    Carlos Hidalgo-Grass
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Ein Kerem, Jerusalem 91120, Israel
    Antimicrob Agents Chemother 54:3509-11. 2010
    ..Dissociation curves showed 100% concordance with DNA sequencing, including the identification of a strain where aac(6')-Ib and aac(6')-Ib-cr coexist...
  9. pmc Clinical and epidemiological aspects of infections caused by fusarium species: a collaborative study from Israel
    Ran Nir-Paz
    Department of Clinical Microbiology and Infectious Diseases, The Hebrew University Hadassah Medical Center, P O Box 12000, Ein Kerem, Jerusalem 91120, Israel
    J Clin Microbiol 42:3456-61. 2004
    ..At one of the hospitals (in a mountainous area), there was an increase in the isolation rate over time...
  10. pmc NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus
    Que Chi Truong-Bolduc
    Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston Massachusetts 02114 2696, USA
    Antimicrob Agents Chemother 50:1104-7. 2006
    ..norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phenotype of an mgrA mutant...
  11. pmc DX-619, a novel des-fluoro(6) quinolone manifesting low frequency of selection of resistant Staphylococcus aureus mutants: quinolone resistance beyond modification of type II topoisomerases
    Jacob Strahilevitz
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St, Boston, Massachusetts 02114 2696, USA
    Antimicrob Agents Chemother 49:5051-7. 2005
    ..aureus and thus are likely novel...
  12. pmc Dual targeting of topoisomerase IV and gyrase to reduce mutant selection: direct testing of the paradigm by using WCK-1734, a new fluoroquinolone, and ciprofloxacin
    Jacob Strahilevitz
    Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
    Antimicrob Agents Chemother 49:1949-56. 2005
    ..By use of a combination of differentially targeting quinolones, this study provides novel data in direct support of the paradigm for dual targeting of quinolone action and reduced development of resistance...
  13. pmc Serogroup A Neisseria meningitidis with reduced susceptibility to ciprofloxacin
    Jacob Strahilevitz
    Emerg Infect Dis 14:1667-9. 2008
  14. pmc Role of the extended alpha4 domain of Staphylococcus aureus gyrase A protein in determining low sensitivity to quinolones
    Jacob Strahilevitz
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2696, USA
    Antimicrob Agents Chemother 50:600-6. 2006
    ..Our findings suggest that the extended alpha4 domain of S. aureus GyrA is responsible, at least in part, for the increased resistance of S. aureus gyrase to quinolones and that this effect is modulated by K+-glutamate...
  15. ncbi request reprint Plasmid-mediated quinolone resistance in non-Typhi serotypes of Salmonella enterica
    Kathryn Gay
    Atlanta Research and Education Foundation, Atlanta, GA, USA
    Clin Infect Dis 43:297-304. 2006
    ....
  16. ncbi request reprint Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
    Ari Robicsek
    Harvard Medical School, Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St, GRJ 512, Boston, Massachusetts 02114, USA
    Nat Med 12:83-8. 2006
    ....
  17. ncbi request reprint A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus
    Noel J De Souza
    Wockhardt Limited, Wockhardt Research Centre, D 4, MIDC, Chikalthana, Aurangabad 431 210, India
    J Med Chem 48:5232-42. 2005
    ....
  18. ncbi request reprint An outbreak of Phialemonium infective endocarditis linked to intracavernous penile injections for the treatment of impotence
    Jacob Strahilevitz
    Infectious Diseases Unit, Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Infect Dis 40:781-6. 2005
    ..As part of his therapy for erectile dysfunction, the patient had been trained to self-inject a compound of vasoactive drugs provided by an impotence clinic into his penile corpus cavernosous...
  19. ncbi request reprint Experimental pneumococcal pleural empyema model: the effect of moxifloxacin
    Jacob Strahilevitz
    Infectious Diseases Unit, Sheba Medical Center, Sackler School of Medicine, Tel Hashomer 52621, Israel
    J Antimicrob Chemother 51:665-9. 2003
    ..Pleural empyema is a serious complication of pneumonia, the optimal therapy of which is still unknown. The objective of this study was to evaluate the use of moxifloxacin in this condition...