Oren Shibolet

Summary

Affiliation: Hadassah University Hospital
Country: Israel

Publications

  1. pmc Infliximab in ulcerative colitis
    Avi Levin
    Gastroenterology and Liver Units, Division of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Biologics 2:379-88. 2008
  2. ncbi request reprint Late cytomegalovirus disease following liver transplantation
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah University Hospital, P O Box 12000, 91120, Jerusalem, Israel
    Transpl Int 16:861-5. 2003
  3. ncbi request reprint Suppression of hepatocellular carcinoma growth via oral immune regulation towards tumor-associated antigens is associated with increased NKT and CD8+ lymphocytes
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Oncology 66:323-30. 2004
  4. ncbi request reprint Reduced incidence of hyperuricemia, gout, and renal failure following liver transplantation in comparison to heart transplantation: a long-term follow-up study
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel
    Transplantation 77:1576-80. 2004
  5. ncbi request reprint Air transportation of patients with end-stage liver disease to distant liver transplantation centers
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Liver Transpl 11:650-5. 2005
  6. ncbi request reprint NKT and CD8 lymphocytes mediate suppression of hepatocellular carcinoma growth via tumor antigen-pulsed dendritic cells
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Int J Cancer 106:236-43. 2003
  7. ncbi request reprint Immunomodulation of experimental colitis via caloric restriction: role of Nk1.1+ T cells
    Oren Shibolet
    Liver Unit, Department of Medicine, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Clin Immunol 105:48-56. 2002
  8. ncbi request reprint Variable response to probiotics in two models of experimental colitis in rats
    Oren Shibolet
    Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem
    Inflamm Bowel Dis 8:399-406. 2002
  9. ncbi request reprint Exacerbation of pulmonary sarcoidosis after liver transplantation
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah Hebrew University Hospital, Jerusalen, Israel
    J Clin Gastroenterol 35:356-8. 2002
  10. ncbi request reprint Lamivudine therapy for prevention of immunosuppressive-induced hepatitis B virus reactivation in hepatitis B surface antigen carriers
    Oren Shibolet
    Liver Unit, Division of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Blood 100:391-6. 2002

Collaborators

Detail Information

Publications40

  1. pmc Infliximab in ulcerative colitis
    Avi Levin
    Gastroenterology and Liver Units, Division of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Biologics 2:379-88. 2008
    ..We review the role of TNF-alpha in the pathogenesis of UC and describe the randomized, double-blind, placebo-controlled trials and systematic reviews that assess the efficacy of infliximab in the treatment of moderate to severe UC...
  2. ncbi request reprint Late cytomegalovirus disease following liver transplantation
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah University Hospital, P O Box 12000, 91120, Jerusalem, Israel
    Transpl Int 16:861-5. 2003
    ..Late-onset CMV disease can occur several years after OLT. Although it manifests classic clinical features of early disease, it is not associated with traditional risk factors and its pathogenesis may differ from that of early disease...
  3. ncbi request reprint Suppression of hepatocellular carcinoma growth via oral immune regulation towards tumor-associated antigens is associated with increased NKT and CD8+ lymphocytes
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Oncology 66:323-30. 2004
    ..Adoptive transfer of orally immunomodulated lymphocytes suppressed the growth of hepatocellular carcinoma (HCC) expressing HBsAg in athymic mice. NKT lymphocytes play a role in the defense against tumor growth...
  4. ncbi request reprint Reduced incidence of hyperuricemia, gout, and renal failure following liver transplantation in comparison to heart transplantation: a long-term follow-up study
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel
    Transplantation 77:1576-80. 2004
    ..In contrast, they are seldom reported following orthotopic liver transplantation (OLT)...
  5. ncbi request reprint Air transportation of patients with end-stage liver disease to distant liver transplantation centers
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Liver Transpl 11:650-5. 2005
    ..Therefore, allocation regions may be broadened to include larger and more distant populations...
  6. ncbi request reprint NKT and CD8 lymphocytes mediate suppression of hepatocellular carcinoma growth via tumor antigen-pulsed dendritic cells
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Int J Cancer 106:236-43. 2003
    ..This effect was associated with enhanced NKT and CD8(+) lymphocyte function and augmentation of the antitumor/antiviral-specific IFNgamma production...
  7. ncbi request reprint Immunomodulation of experimental colitis via caloric restriction: role of Nk1.1+ T cells
    Oren Shibolet
    Liver Unit, Department of Medicine, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Clin Immunol 105:48-56. 2002
    ..This effect was mediated via an increase in NK1.1+ T lymphocytes, which may play a critical role in keeping the T-cell balance in immunoregulation...
  8. ncbi request reprint Variable response to probiotics in two models of experimental colitis in rats
    Oren Shibolet
    Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem
    Inflamm Bowel Dis 8:399-406. 2002
    ..We evaluated the effect of different preparations of probiotic bacteria on experimental colitis in rats...
  9. ncbi request reprint Exacerbation of pulmonary sarcoidosis after liver transplantation
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah Hebrew University Hospital, Jerusalen, Israel
    J Clin Gastroenterol 35:356-8. 2002
    ..To the best of our knowledge, this is a first description of severe exacerbation of pulmonary sarcoidosis in an immunosuppressed patient who underwent liver transplantation for sarcoidosis-associated liver disease...
  10. ncbi request reprint Lamivudine therapy for prevention of immunosuppressive-induced hepatitis B virus reactivation in hepatitis B surface antigen carriers
    Oren Shibolet
    Liver Unit, Division of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Blood 100:391-6. 2002
    ..In contrast, 2 of 5 control patients had HBV reactivation. Lamivudine prophylaxis in HBsAg carriers receiving immunosuppressive therapy may prevent HBV reactivation and hepatic failure...
  11. ncbi request reprint Schnitzler syndrome: chronic urticaria, fever and immunoglobulin M monoclonal gammopathy
    Oren Shibolet
    Division of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Isr Med Assoc J 4:466-7. 2002
  12. ncbi request reprint Suppression of hepatocellular carcinoma by transplantation of ex-vivo immune-modulated NKT lymphocytes
    Maya Margalit
    Liver Unit, Department of Medicine, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Int J Cancer 115:443-9. 2005
    ..Ex-vivo modulation of NKT lymphocytes holds promise as a novel mode of immune therapy for HCC...
  13. ncbi request reprint The role of intrahepatic CD8+ T cell trapping and NK1.1+ cells in liver-mediated immune regulation
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah Hebrew University Medical Center, Il 91120 Jerusalem, Israel
    Clin Immunol 111:82-92. 2004
    ..In the presence of antigen, these lymphocytes may be accountable for keeping an anti-inflammatory lymphocyte balance. However, in the absence of antigen, they may induce a pro-inflammatory shift...
  14. ncbi request reprint A double-blind clinical trial for treatment of Crohn's disease by oral administration of Alequel, a mixture of autologous colon-extracted proteins: a patient-tailored approach
    Maya Margalit
    Gastroenterology and Liver Units, Department of Medicine, Hebrew University Hadassah Medical Center, Jerusalem, Israel IL 91120
    Am J Gastroenterol 101:561-8. 2006
    ..In this study, we evaluated the safety and efficacy of a personalized mode of treatment for Crohn's disease (CD) by oral administration of Alequel an extract of autologous colonic proteins...
  15. ncbi request reprint Adoptive transfer of ex vivo immune-programmed NKT lymphocytes alleviates immune-mediated colitis
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah University Hospital, Jerusalem, Israel IL 91120
    J Leukoc Biol 75:76-86. 2004
    ..Adoptive transfer of a relatively small number of immune-programmed NKT cells induced a systemic Th1 to Th2-immune shift and alleviated immune-mediated colitis...
  16. ncbi request reprint Induction of oral immune regulation towards liver-extracted proteins for treatment of chronic HBV and HCV hepatitis: results of a phase I clinical trial
    Eran Israeli
    Liver Unit, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Liver Int 24:295-307. 2004
    ..Anti-viral immunity can be modulated via oral feeding of viral proteins. Hepatitis B and C viral (HBV, HCV)-associated hepatocellular injury is mediated by a defective host anti-viral immune response...
  17. ncbi request reprint Adoptive transfer of NK 1.1+ lymphocytes in immune-mediated colitis: a pro-inflammatory or a tolerizing subgroup of cells?
    Yoram Menachem
    Liver Unit, Department of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Microbes Infect 7:825-35. 2005
    ..T lymphocytes expressing NK1.1 marker (NKT) have been suggested to play crucial roles in immune modulation...
  18. ncbi request reprint Amelioration of non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice by oral immune regulation towards liver-extracted proteins is associated with elevated intrahepatic NKT lymphocytes and serum IL-10 levels
    Eran Elinav
    Liver Unit, Department of Medicine, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    J Pathol 208:74-81. 2006
    ..Immune regulation towards disease-associated antigens holds promise as a new mode of therapy for NASH...
  19. ncbi request reprint Oral immune regulation using colitis extracted proteins for treatment of Crohn's disease: results of a phase I clinical trial
    Eran Israeli
    Gastroenterology Unit, Department of Medicine, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    World J Gastroenterol 11:3105-11. 2005
    ..To evaluate safety and possible efficacy of induction of oral immune regulation using colitis extracted proteins (CEP) in Crohn's disease (CD) subjects...
  20. ncbi request reprint Regulatory role of the pituitary-adrenal axis in experimental colitis: effect of adrenalectomy on the clinical course and the TH1/TH2 immune profile
    Oren Shibolet
    Liver Unit, Division of Medicine, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Inflamm Bowel Dis 11:1053-9. 2005
    ..The hypothalamic-pituitary-adrenal (HPA) axis plays an important role in modulating immune reactions in inflammatory bowel disease. Our aim was to assess the role of the HPA axis in the pathogenesis of immunomediated colitis in mice...
  21. ncbi request reprint Treatment of chronic hepatitis B virus infection via oral immune regulation toward hepatitis B virus proteins
    Rifaat Safadi
    Liver Unit, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Gastroenterol 98:2505-15. 2003
    ..The aims of this study were to determine the safety and efficacy of treatment of patients with chronic HBV by means of p.o. administration of HBV envelope proteins...
  22. ncbi request reprint Early expression of interferon gamma following oral antigen administration is associated with peripheral tolerance induction
    Olga Kolker
    Department of Medicine, Liver Unit, Hadassah University Hospital, Hadassah Medical Center, Hebrew University, PO Box 12000, 91120 Jerusalem, Israel
    Microbes Infect 5:807-13. 2003
    ..In contrast, late expression of IFNgamma is associated with a pro-inflammatory response in non-tolerized controls...
  23. ncbi request reprint Treatment of chronic hepatitis C virus infection via antioxidants: results of a phase I clinical trial
    Alla Melhem
    Liver Unit, Department of Medicine, Hebrew University, Hadassah Medical Center, Jerusalem, Israel
    J Clin Gastroenterol 39:737-42. 2005
    ..Previous trials suggested that antioxidative therapy may have a beneficial effect on patients with chronic HCV infection...
  24. doi request reprint Immunosuppression and HBV reactivation
    Daniel Shouval
    Liver Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Semin Liver Dis 33:167-77. 2013
    ..Prompt administration of a potent antiviral agent upon diagnosis of reactivation may be lifesaving in such patients...
  25. ncbi request reprint Large solitary splenic diffuse large B cell lymphoma in a hepatitis C virus-infected patient
    Meirav Kedmi
    Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Isr Med Assoc J 7:346-7. 2005
  26. ncbi request reprint [Neurologic complications following liver transplantation]
    Oren Shibolet
    Liver Unit, Division of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Harefuah 141:30-3, 127. 2002
    ..We review the current literature on the subject...
  27. doi request reprint Endotipsitis-persistent infection of transjugular intrahepatic portosystemic shunt: pathogenesis, clinical features and management
    Meir Mizrahi
    Liver Unit, Division of Medicine, Jerusalem, Israel
    Liver Int 30:175-83. 2010
    ..The aim of this review was to describe the definition, clinical course, diagnosis, pathogenesis, microbiology, treatment and outcome of endotipsitis...
  28. ncbi request reprint Idiopathic liver involvement in Turner syndrome
    Hila Elinav
    Isr Med Assoc J 6:56-7. 2004
  29. pmc Trans-arterial chemo-embolization is safe and effective for very elderly patients with hepatocellular carcinoma
    Matan J Cohen
    Division of Internal Medicine, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    World J Gastroenterol 19:2521-8. 2013
    ..To assess the safety and efficacy of trans-arterial chemo-embolization (TACE) in very elderly patients...
  30. pmc CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model
    Viviana Scaiewicz
    Institute for Drug Research, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 8:e81065. 2013
    ..To explore the role of CHOP in hepatocarcinogenesis, we induced hepatocellular carcinoma (HCC) in wild type (wt) and CHOP knockout (KO) mice using the carcinogen N-diethylnitrosamine (DEN)...
  31. pmc Toll-like receptors in inflammatory bowel disease-stepping into uncharted territory
    Avi Levin
    Liver Unit, Division of Medicine, POB 12000, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    World J Gastroenterol 14:5149-53. 2008
    ..The role of TLRs in the pathogenesis of inflammatory bowel disease (IBD) has not been fully elucidated. In this review, we aim to analyze the available data connecting individual TLRs to intestinal inflammation and IBD...
  32. ncbi request reprint [Refractory ascites following liver transplantation caused by an anastomotic stricture of the portal vein]
    Liane Rabinowich
    Liver Unit, Department of Gastroenterology and Liver Disease Tel Aviv Sourasky Medical Center and the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Harefuah 151:667-70, 722. 2012
    ..The patient underwent percutaneous angioplasty with balloon dilatation and stent placement, with resolution of the ascites. We review the literature and discuss the etiology of posttransplant refractory ascites and its treatment...
  33. pmc HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response
    Emmanuelle Merquiol
    Liver Unit, Division of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 6:e24660. 2011
    ..We wanted to characterize the kinetics of HCV-induced ER stress during infection and assess adaptation mechanisms and their significance...
  34. doi request reprint Adalimumab-induced autoimmune hepatitis
    Tomer Adar
    Liver Unit, Division of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Gastroenterol 44:e20-2. 2010
    ..The patient made a full recovery after discontinuation of adalimumab and treatment with steroids. This is the first reported case of adalimumab-induced autoimmune hepatitis...
  35. doi request reprint CHOP is a critical regulator of acetaminophen-induced hepatotoxicity
    Dotan Uzi
    Institute for Drug Research, School of Pharmacy, Faculty of Medicine, Hebrew University, Jerusalem, Israel
    J Hepatol 59:495-503. 2013
    ..UPR regulation of the transcription repressor CHOP promotes cell death. We analyzed the role of UPR and CHOP in mediating APAP hepatotoxicity...
  36. ncbi request reprint A prospective study assessing the efficacy of abdominal computed tomography scan without bowel preparation in diagnosing intestinal wall and luminal lesions in patients presenting to the emergency room with abdominal complaints
    Michal Mizrahi
    Gastroenterology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    World J Gastroenterol 11:1981-6. 2005
    ..To evaluate the positive predictive value of abdominal non-prepared computed tomography (CT) for diagnosing intestinal lumen or wall lesions in patients presenting to the emergency room (ER) with abdominal complaints...
  37. ncbi request reprint Hepatic hydrothorax--pathophysiology, diagnosis and treatment--review of the literature
    Chamutal Gur
    Liver Unit, Division of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Liver Int 24:281-4. 2004
    ..These modalities may be of help as a bridge to transplantation. The aim of this review is to describe recent developments in the pathogenesis, diagnosis and treatment of hepatic hydrothorax...
  38. ncbi request reprint Th2 cytokines down-regulate TLR expression and function in human intestinal epithelial cells
    Tobias Mueller
    Gastrointestinal Unit, Department of Medicine, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    J Immunol 176:5805-14. 2006
    ..Taken together, our data underscore the important role of Th2 cytokines in balancing TLR signaling in human IECs...
  39. ncbi request reprint AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling
    Oren Shibolet
    Gastroenterology Unit, Center for Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 282:35308-17. 2007
    ..Together, our results suggest that AKAP13 plays a role in TLR2-mediated NF-kappaB activation and suggest that GEF-containing scaffold proteins may confer specificity to innate immune responses downstream of TLRs...
  40. ncbi request reprint TLRs in the Gut. IV. Negative regulation of Toll-like receptors and intestinal homeostasis: addition by subtraction
    Oren Shibolet
    Gastroenterology Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1469-73. 2007
    ..However, it remains to be determined whether they comprise the entire spectrum of negative control mechanisms and how they are bypassed to trigger activation during challenge by pathogens...