Hanna Rosenmann

Summary

Affiliation: Hadassah University Hospital
Country: Israel

Publications

  1. ncbi request reprint Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein
    Hanna Rosenmann
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel, AHEPA University Hospital, Thessaloniki, Greece
    Arch Neurol 63:1459-67. 2006
  2. ncbi request reprint Immunotherapy for targeting tau pathology in Alzheimer's disease and tauopathies
    Hanna Rosenmann
    Department of Neurology, Hadassah University Hospital, Ein Karem, Jerusalem 91120, Israel
    Curr Alzheimer Res 10:217-28. 2013
  3. doi request reprint CSF biomarkers for amyloid and tau pathology in Alzheimer's disease
    Hanna Rosenmann
    The Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem 91120, Israel
    J Mol Neurosci 47:1-14. 2012
  4. ncbi request reprint A polymorphism in the complement component C1r is not associated with sporadic Alzheimer's disease
    Hanna Rosenmann
    The Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah University Hospital, Ein Karem, Jerusalem 91120, Israel
    Neurosci Lett 336:101-4. 2003
  5. doi request reprint A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics
    Hanna Rosenmann
    The Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Medical Center, Jerusalem, Israel
    Exp Neurol 212:71-84. 2008
  6. ncbi request reprint Detection of circulating antibodies against tau protein in its unphosphorylated and in its neurofibrillary tangles-related phosphorylated state in Alzheimer's disease and healthy subjects
    Hanna Rosenmann
    The Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah University Hospital, Ein Karem, Jerusalem 91120, Israel
    Neurosci Lett 410:90-3. 2006
  7. ncbi request reprint An association study of a polymorphism in the heparan sulfate proteoglycan gene (perlecan, HSPG2) and Alzheimer's disease
    Hanna Rosenmann
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem 91120, Israel
    Am J Med Genet B Neuropsychiatr Genet 128:123-5. 2004
  8. ncbi request reprint Lack of association of interleukin-1beta polymorphism with Alzheimer's disease in the Jewish population
    Hanna Rosenmann
    The Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah University Hospital, Jerusalem, Israel
    Neurosci Lett 363:131-3. 2004
  9. ncbi request reprint The Fas promoter polymorphism at position -670 is not associated with late-onset sporadic Alzheimer's disease
    Hanna Rosenmann
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
    Dement Geriatr Cogn Disord 17:143-6. 2004
  10. ncbi request reprint An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's disease
    Hanna Rosenmann
    Department of Neurology, Hadassah University Hospital, Ein Karem, Jerusalem 91120, Israel
    Neurosci Lett 340:29-32. 2003

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein
    Hanna Rosenmann
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel, AHEPA University Hospital, Thessaloniki, Greece
    Arch Neurol 63:1459-67. 2006
    ..Vaccination with amyloid-beta peptide was reported to cause marked reduction in amyloid deposition, but it also induced encephalitis. Not much is known regarding neurofibrillary tangle-related autoimmune effects...
  2. ncbi request reprint Immunotherapy for targeting tau pathology in Alzheimer's disease and tauopathies
    Hanna Rosenmann
    Department of Neurology, Hadassah University Hospital, Ein Karem, Jerusalem 91120, Israel
    Curr Alzheimer Res 10:217-28. 2013
    ....
  3. doi request reprint CSF biomarkers for amyloid and tau pathology in Alzheimer's disease
    Hanna Rosenmann
    The Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem 91120, Israel
    J Mol Neurosci 47:1-14. 2012
    ....
  4. ncbi request reprint A polymorphism in the complement component C1r is not associated with sporadic Alzheimer's disease
    Hanna Rosenmann
    The Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah University Hospital, Ein Karem, Jerusalem 91120, Israel
    Neurosci Lett 336:101-4. 2003
    ..No interactive effect was found with apolipoprotein E e4. These findings show no evidence for association between C1r codon 135 polymorphism and AD in our population...
  5. doi request reprint A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics
    Hanna Rosenmann
    The Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Medical Center, Jerusalem, Israel
    Exp Neurol 212:71-84. 2008
    ....
  6. ncbi request reprint Detection of circulating antibodies against tau protein in its unphosphorylated and in its neurofibrillary tangles-related phosphorylated state in Alzheimer's disease and healthy subjects
    Hanna Rosenmann
    The Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah University Hospital, Ein Karem, Jerusalem 91120, Israel
    Neurosci Lett 410:90-3. 2006
    ..Whether these Abs are neuroprotective or neurotoxic - is unknown, as it is with anti-amyloid-beta Abs...
  7. ncbi request reprint An association study of a polymorphism in the heparan sulfate proteoglycan gene (perlecan, HSPG2) and Alzheimer's disease
    Hanna Rosenmann
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem 91120, Israel
    Am J Med Genet B Neuropsychiatr Genet 128:123-5. 2004
    ..In addition, no interactive effect was found with the known risk factor for AD, the apolipoprotein E (APOE) epsilon4. These findings show no evidence for association between HSPG2 intron 6 BamHI polymorphism and AD in our population...
  8. ncbi request reprint Lack of association of interleukin-1beta polymorphism with Alzheimer's disease in the Jewish population
    Hanna Rosenmann
    The Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah University Hospital, Jerusalem, Israel
    Neurosci Lett 363:131-3. 2004
    ..These findings show no evidence for an association between the IL-1B +3953 polymorphism and AD in the Jewish population...
  9. ncbi request reprint The Fas promoter polymorphism at position -670 is not associated with late-onset sporadic Alzheimer's disease
    Hanna Rosenmann
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
    Dement Geriatr Cogn Disord 17:143-6. 2004
    ..These findings show no evidence for an association between the Fas promoter polymorphism at position -670 and AD in our population...
  10. ncbi request reprint An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's disease
    Hanna Rosenmann
    Department of Neurology, Hadassah University Hospital, Ein Karem, Jerusalem 91120, Israel
    Neurosci Lett 340:29-32. 2003
    ..These findings show no evidence for an association between p53 codon 72 polymorphism and AD in our population...
  11. doi request reprint Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation
    Lea Rozenstein-Tsalkovich
    The Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Exp Neurol 248:451-6. 2013
    ....
  12. doi request reprint Moderate environmental enrichment mitigates tauopathy in a neurofibrillary tangle mouse model
    Inbal Lahiani-Cohen
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Neuropathol Exp Neurol 70:610-21. 2011
    ..These results suggest that NFTs may be directly responsive to environmental stimulating activities and that even nonstrained activities may mitigate tauopathies independent of the involvement of amyloid...
  13. doi request reprint Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice
    Moran Boimel
    The Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Exp Neurol 224:472-85. 2010
    ..The robust anti-NFT effect and the lack of encephalitogenicity in NFT mice immunized with phos-tau peptides, even though CFA with PT was included in vaccine, point to their anti-NFT therapeutic potential...
  14. doi request reprint Statins reduce the neurofibrillary tangle burden in a mouse model of tauopathy
    Moran Boimel
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Neuropathol Exp Neurol 68:314-25. 2009
    ..Statins may provide therapy against NFTs in tauopathies, particularly when NFTs are the major neuropathologic component...
  15. doi request reprint Tau and 14-3-3 of genetic and sporadic Creutzfeldt-Jakob disease patients in Israel
    Zeev Meiner
    Departments of Neurology, Hadassah University Hospital, Jerusalem, Israel
    J Neurol 258:255-62. 2011
    ..We conclude that CSF biomarkers, Tau and 14-3-3, may be used in the diagnosis in both patients' populations, presenting a similar sensitivity yet Tau assay having higher specificity...
  16. doi request reprint Estrogen receptor beta gene variant is associated with vascular dementia in elderly women
    Rivka Dresner-Pollak
    Endocrinology and Metabolism Service, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Genet Test Mol Biomarkers 13:339-42. 2009
    ..Sequence variants in the estrogen receptor alpha gene (ESR1) and beta gene (ESR2) may alter the effects of estrogen...
  17. pmc Phenotypic variability among adult siblings with Sjögren-Larsson syndrome
    Alexander Lossos
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Arch Neurol 63:278-80. 2006
    ..Cerebral proton magnetic resonance spectroscopy in those with SLS demonstrates an abnormal white matter peak at 1.3 ppm, consistent with long-chain fatty alcohol accumulation...
  18. ncbi request reprint [Biological markers in the diagnosis of dementia and Alzheimer's disease]
    Zeev Meiner
    Neurogeriatric and Memory Clinic, Department of Physical Medicine and Rehabilitation, Hadassah Hebrew University Medical Center, Jerusalem
    Harefuah 151:289-93, 318. 2012
    ..These biomarkers may be used to diagnose the disease in the early pre-symptomatic phase, to differentiate Alzheimer's disease from other causes of dementia and may be helpful in the follow-up of newly developed specific treatments...
  19. ncbi request reprint Frontotemporal dementia and parkinsonism with the P301S tau gene mutation in a Jewish family
    Alexander Lossos
    The Agnes Ginges Center for Human Neurogenetics, Dept of Neurology, Hadassah University Hospital, POB 12000, Jerusalem 91120, Israel
    J Neurol 250:733-40. 2003
    ..Among others, the P301S mutation has been previously reported in three families of European and one of Japanese origin presenting with different clinical phenotypes...
  20. ncbi request reprint [Frontotemporal dementia: clinical features, genetics, pathogenesis and treatment]
    Hanna Rosenmann
    The Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah Hebrew University Medical Center, Jerusalem
    Harefuah 152:661-6, 687. 2013
    ..Unfortunately, there is no effective treatment for FTD but we hope that recent developments will make advances towards finding effective therapy...
  21. ncbi request reprint Extended phenotype in the transthyretin Tyr77 familial amyloid polyneuropathy
    Alexander Lossos
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel
    Eur Neurol 53:55-9. 2005
    ..Brain MRI in the proband showed multifocal white matter lesions. These features extend the reported Tyr77 phenotype and support the modifying effect of additional factors on the disease expression...
  22. doi request reprint The herbal preparation Padma® 28 protects against neurotoxicity in PC12 cells
    Isaac Ginsburg
    Dental Research, Faculty of Dental Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Phytother Res 25:740-3. 2011
    ..Padma 28, which is available in Europe and USA, seems to be a promising candidate for the treatment of CNS diseases...
  23. doi request reprint Pruritus in familial Creutzfeldt-Jakob disease: a common symptom associated with central nervous system pathology
    Oren S Cohen
    Department of Neurology, The Sagol Center for Neuroscience, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel
    J Neurol 258:89-95. 2011
    ..Pruritus is relatively common in patients with familial CJD carrying the E200K mutation. Our findings point to a central origin that involves damage to the inhibitory gating mechanism for itch in the periaqueductal grey matter...