Jacob Rachmilewitz

Summary

Affiliation: Hadassah University Hospital
Country: Israel

Publications

  1. ncbi request reprint Serial triggering model
    Jacob Rachmilewitz
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, P O B 12000, Jerusalem, 91120, Israel
    Adv Exp Med Biol 640:95-102. 2008
  2. ncbi request reprint A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding
    Jacob Rachmilewitz
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, PO Box 12000, Jerusalem, 91120, Israel
    Trends Immunol 23:592-5. 2002
  3. ncbi request reprint Negative regulation of T cell activation by placental protein 14 is mediated by the tyrosine phosphatase receptor CD45
    Jacob Rachmilewitz
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem 91120, Israel
    J Biol Chem 278:14059-65. 2003
  4. ncbi request reprint alpha2,6-Sialylation promotes binding of placental protein 14 via its Ca2+-dependent lectin activity: insights into differential effects on CD45RO and CD45RA T cells
    Eliran Ish-Shalom
    Goldyne Savad Institute of Gene Therayp, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Glycobiology 16:173-83. 2006
  5. ncbi request reprint Differential regulation of Th1/Th2 cytokine responses by placental protein 14
    Galit Mishan-Eisenberg
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    J Immunol 173:5524-30. 2004
  6. ncbi request reprint Focal localization of placental protein 14 toward sites of TCR engagement
    Jacob Rachmilewitz
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    J Immunol 168:2745-50. 2002
  7. ncbi request reprint Placental protein 14 regulates selective B cell responses
    Einat Yaniv
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    Cell Immunol 222:156-63. 2003
  8. pmc Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14
    Zohar Ochanuna
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 5:e12868. 2010
  9. pmc The induction of APC with a distinct tolerogenic phenotype via contact-dependent STAT3 activation
    Devorah Gur-Wahnon
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 4:e6846. 2009
  10. ncbi request reprint Contact-dependent induction of regulatory antigen-presenting cells by human mesenchymal stem cells is mediated via STAT3 signaling
    Devorah Gur-Wahnon
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Exp Hematol 35:426-33. 2007

Collaborators

  • Gregory J Riely
  • Tatyana B Prigozhina
  • Gabriel Nussbaum
  • Hans Joachim Gabius
  • Michal Dranitzki-Elhalel
  • Rinat Abramovitch
  • Dror Mevorach
  • Sabine Andre
  • MARK TYKOCINSKI
  • A Lanzavecchia
  • Zipora Borovsky
  • Devorah Gur-Wahnon
  • Ariel Orbach
  • Anat Geiger-Maor
  • Zohar Ochanuna
  • Galit Mishan-Eisenberg
  • Eithan Galun
  • Meir Liebergall
  • Jui Han Huang
  • Michal Dranitzki Elhalel
  • Shaul Beyth
  • Alexandra Aronin
  • Natan Toledano
  • Noam Shani
  • Sharona Even-Ram
  • Nurit Yachimovich-Cohen
  • Einat Yaniv
  • Elina Zorde-Khvalevsky
  • Hagai Amsalem
  • Ludmila Rivkin
  • Hilla Giladi
  • Elina Khvalevsky
  • Eliran Ish-Shalom
  • Kobi Tzdaka
  • Adi Ben-Yehuda
  • Shira Amsili
  • Dawn M Bowdish
  • Yoav Smith
  • Inbar Levi
  • Dimitrios Karussis
  • Miriam Parnas
  • Yoel Shufaro
  • Adi Dembinsky-Vaknin
  • Benjamin Reubinoff
  • Yonatan Isenberg
  • Hila Barash
  • Irit Spivak-Pohis
  • Anat Gaiger
  • Sa ar Mizrahi
  • Simcha Yagel
  • Miram Parnas
  • Ari Gargir
  • Hadi Aslan
  • Zulma Gazit
  • Roi Gazit
  • Matthew C Weber
  • William Schmidt

Detail Information

Publications22

  1. ncbi request reprint Serial triggering model
    Jacob Rachmilewitz
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, P O B 12000, Jerusalem, 91120, Israel
    Adv Exp Med Biol 640:95-102. 2008
    ....
  2. ncbi request reprint A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding
    Jacob Rachmilewitz
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, PO Box 12000, Jerusalem, 91120, Israel
    Trends Immunol 23:592-5. 2002
    ..Several phenomena related to T-cell behavior and self-nonself discrimination are discussed...
  3. ncbi request reprint Negative regulation of T cell activation by placental protein 14 is mediated by the tyrosine phosphatase receptor CD45
    Jacob Rachmilewitz
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem 91120, Israel
    J Biol Chem 278:14059-65. 2003
    ....
  4. ncbi request reprint alpha2,6-Sialylation promotes binding of placental protein 14 via its Ca2+-dependent lectin activity: insights into differential effects on CD45RO and CD45RA T cells
    Eliran Ish-Shalom
    Goldyne Savad Institute of Gene Therayp, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Glycobiology 16:173-83. 2006
    ..Finally, we demonstrate that PP14 promotes CD45 dimerization and clustering, a phenomenon that may regulate CD45 activity...
  5. ncbi request reprint Differential regulation of Th1/Th2 cytokine responses by placental protein 14
    Galit Mishan-Eisenberg
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    J Immunol 173:5524-30. 2004
    ..Taken together, these data document for the first time the ability of PP14 to skew Th responses...
  6. ncbi request reprint Focal localization of placental protein 14 toward sites of TCR engagement
    Jacob Rachmilewitz
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    J Immunol 168:2745-50. 2002
    ..Thus, PP14 provides an example of a soluble negative T cell regulator whose inhibitory activity is linked to modulation of the APC-T cell contact site, thereby hindering early events triggered by the TCR...
  7. ncbi request reprint Placental protein 14 regulates selective B cell responses
    Einat Yaniv
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    Cell Immunol 222:156-63. 2003
    ....
  8. pmc Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14
    Zohar Ochanuna
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 5:e12868. 2010
    ..Placental Protein 14 (PP14) is a 28 kDa glycoprotein highly secreted in early pregnancy that is able to desensitize T cell receptor (TCR) signaling and modulate T cell activation...
  9. pmc The induction of APC with a distinct tolerogenic phenotype via contact-dependent STAT3 activation
    Devorah Gur-Wahnon
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 4:e6846. 2009
    ..We now tested whether tumor cells can activate STAT3 within APC using the contact-dependent mechanism, in addition to soluble factors, and compared these two STAT3 activating pathways...
  10. ncbi request reprint Contact-dependent induction of regulatory antigen-presenting cells by human mesenchymal stem cells is mediated via STAT3 signaling
    Devorah Gur-Wahnon
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Exp Hematol 35:426-33. 2007
    ..However, the molecular mechanisms that block initiation of immune responses by MSCs remains to be investigated...
  11. pmc CD40·FasL and CTLA-4·FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling
    Ariel Orbach
    Nephrology and Hypertension Services, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Am J Pathol 177:3159-68. 2010
    ..Therefore, these proteins emerge as promising agents to be used for targeted and specific tumor cell killing...
  12. ncbi request reprint Serial triggering of T cell receptors results in incremental accumulation of signaling intermediates
    Zipora Borovsky
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem 91120, Israel
    J Biol Chem 277:21529-36. 2002
    ..Thus, the data suggest that signaling events originating from serially triggered TCR are not simply sustained but are gradually accumulated and are integrated in a corresponding response...
  13. pmc Fn14•TRAIL effectively inhibits hepatocellular carcinoma growth
    Alexandra Aronin
    Nephrology and Hypertension Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 8:e77050. 2013
    ..Consequently, Fn14•TRAIL's capacity to inhibit HCC growth was tested...
  14. pmc Novel CD47: SIRPα dependent mechanism for the activation of STAT3 in antigen-presenting cell
    Natan Toledano
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 8:e75595. 2013
    ....
  15. ncbi request reprint Characterization of a lymphocyte subset displaying a unique regulatory activity in human decidua
    Hagai Amsalem
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    Int Immunol 20:1147-54. 2008
    ..These findings suggest the existence of a dynamic regulatory system in human decidua that is highly responsive to environmental factors...
  16. ncbi request reprint Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness
    Shaul Beyth
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel
    Blood 105:2214-9. 2005
    ..Our data may reveal a physiologic phenomenon whereby the development of a distinct APC population is regulated by the tissue's cellular microenvironment...
  17. doi request reprint Cells exposed to sublethal oxidative stress selectively attract monocytes/macrophages via scavenger receptors and MyD88-mediated signaling
    Anat Geiger-Maor
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, 91120 Jerusalem, Israel
    J Immunol 188:1234-44. 2012
    ..Furthermore, the data indicate that MyD88 independently regulates monocyte activation and motility...
  18. doi request reprint Human embryonic stem cells suppress T cell responses via arginase I-dependent mechanism
    Nurit Yachimovich-Cohen
    Hadassah Human Embryonic Stem Cell Research Center, Goldyne Savad Institute of Gene Therapy, Hadassah University Medical Center, Jerusalem, Israel
    J Immunol 184:1300-8. 2010
    ..Finally, T cells infiltrating ESC-derived teratomas have significantly lower levels of CD3-zeta chain. Collectively, the data indicate a role for ESC-arginase I activity in the attenuation of T cell activation...
  19. ncbi request reprint Toll-like receptor 3 signaling attenuates liver regeneration
    Elina Zorde-Khvalevsky
    Goldyne Savad Institute for Gene Therapy, Human Biology Research Center Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Hepatology 50:198-206. 2009
    ..Conclusion: TLR3 plays an inhibitory role in the priming of liver regeneration, thus reinforcing the role of the innate immune system in balancing tissue regeneration...
  20. ncbi request reprint CTLA-4 . FasL induces early apoptosis of activated T cells by interfering with anti-apoptotic signals
    Ariel Orbach
    Nephrology and Hypertension Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Immunol 179:7287-94. 2007
    ..Furthermore, activation of caspases 8 and 3 were not affected by CTLA-4 . FasL. These findings suggest a model for CTLA-4 . FasL action wherein there is coordinate triggering of a death receptor and suppression of a proapoptotic protein...
  21. ncbi request reprint TLR3 signaling in a hepatoma cell line is skewed towards apoptosis
    Elina Khvalevsky
    The Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    J Cell Biochem 100:1301-12. 2007
    ..These results indicate preferential induction of the apoptotic pathway over the cytokine induction pathway by TLR3 signaling in hepatocellular carcinoma cells with potential implications for therapeutic strategies...
  22. ncbi request reprint CTLA-4. FasL induces alloantigen-specific hyporesponsiveness
    Michal Dranitzki Elhalel
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 170:5842-50. 2003
    ..Thus, CTLA-4. FasL, a paradigmatic trans signal converter protein, manifests unique functional properties and emerges as a potentially useful immunotherapeutic for modulating alloresponsiveness...