Eli Pikarsky

Summary

Affiliation: Hadassah University Hospital
Country: Israel

Publications

  1. ncbi request reprint Contradictory functions of NF-kappaB in liver physiology and cancer
    Gilad W Vainer
    Department of Pathology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cancer Lett 267:182-8. 2008
  2. pmc beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor
    Udi Gluschnaider
    Department of Pathology and the Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 5:e9060. 2010
  3. pmc Genome-wide analysis of androgen receptor targets reveals COUP-TF1 as a novel player in human prostate cancer
    Ruth Perets
    Department of Pathology and Lautenberg center for immunology, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 7:e46467. 2012
  4. pmc The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice
    Keren Bitton-Worms
    Department of Molecular Genetics, The Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel
    Mol Cancer 9:54. 2010
  5. ncbi request reprint NF-kappaB functions as a tumour promoter in inflammation-associated cancer
    Eli Pikarsky
    Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Nature 431:461-6. 2004
  6. ncbi request reprint NF-kappaB inhibition: a double-edged sword in cancer?
    Eli Pikarsky
    Department of Pathology, Hebrew University Hadassah Medical School, Ein Kerem Campus, Kiryat Hadassah, Jerusalem 91120, Israel
    Eur J Cancer 42:779-84. 2006
  7. doi request reprint Function of heparanase in prostate tumorigenesis: potential for therapy
    Immanuel Lerner
    Sharett Institute of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Clin Cancer Res 14:668-76. 2008
  8. pmc Interaction between CXCR4 and CCL20 pathways regulates tumor growth
    Katia Beider
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel
    PLoS ONE 4:e5125. 2009
  9. doi request reprint A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism
    Ariel Pribluda
    The Lautenberg Center for Immunology, Institute of Medical Research, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cancer Cell 24:242-56. 2013
  10. doi request reprint CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth
    Katia Beider
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Exp Hematol 39:282-92. 2011

Research Grants

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Contradictory functions of NF-kappaB in liver physiology and cancer
    Gilad W Vainer
    Department of Pathology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cancer Lett 267:182-8. 2008
    ..In this review, we will focus on the seemingly contradictory role of NF-kappaB in liver homeostasis, as well as in liver cancer...
  2. pmc beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor
    Udi Gluschnaider
    Department of Pathology and the Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 5:e9060. 2010
    ..Thus, alternative strategies targeting novel molecular mechanisms are required. beta-TrCP is an E3 ligase that targets various substrates essential for many aspects of tumorigenesis...
  3. pmc Genome-wide analysis of androgen receptor targets reveals COUP-TF1 as a novel player in human prostate cancer
    Ruth Perets
    Department of Pathology and Lautenberg center for immunology, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 7:e46467. 2012
    ..This study extends the pool of recognized putative AR targets and identifies a negatively regulated target of AR - COUP-TF1 - which could possibly play a role in human prostate cancer...
  4. pmc The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice
    Keren Bitton-Worms
    Department of Molecular Genetics, The Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel
    Mol Cancer 9:54. 2010
    ..We used diethylnitrosamine (DEN) injection to initiate liver cancer in mice and assessed the extent of liver cancer in JDP2-transgenic and wild type control mice by biochemical and molecular biology techniques...
  5. ncbi request reprint NF-kappaB functions as a tumour promoter in inflammation-associated cancer
    Eli Pikarsky
    Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Nature 431:461-6. 2004
    ..Our studies thus indicate that NF-kappaB is essential for promoting inflammation-associated cancer, and is therefore a potential target for cancer prevention in chronic inflammatory diseases...
  6. ncbi request reprint NF-kappaB inhibition: a double-edged sword in cancer?
    Eli Pikarsky
    Department of Pathology, Hebrew University Hadassah Medical School, Ein Kerem Campus, Kiryat Hadassah, Jerusalem 91120, Israel
    Eur J Cancer 42:779-84. 2006
    ..Further cancer model studies should help to clarify this issue, complementing the intensive drug development effort of the pharmaceutical industry around NF-kappaB...
  7. doi request reprint Function of heparanase in prostate tumorigenesis: potential for therapy
    Immanuel Lerner
    Sharett Institute of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Clin Cancer Res 14:668-76. 2008
    ..Our research was undertaken to elucidate the significance of heparanase in prostate tumorigenesis and bone metastasis...
  8. pmc Interaction between CXCR4 and CCL20 pathways regulates tumor growth
    Katia Beider
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel
    PLoS ONE 4:e5125. 2009
    ..These results reveal a role for CCL20 in CXCR4-dependent and -independent tumor growth and suggest a therapeutic potential for CCL20 and CCR6 antagonists in the treatment of CXCR4- and CCL20-dependent malignancies...
  9. doi request reprint A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism
    Ariel Pribluda
    The Lautenberg Center for Immunology, Institute of Medical Research, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cancer Cell 24:242-56. 2013
    ..SIR/para-inflammation suppression may therefore constitute a key mechanism in the anticarcinogenic effects of nonsteroidal anti-inflammatory drugs...
  10. doi request reprint CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth
    Katia Beider
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Exp Hematol 39:282-92. 2011
    ..Binding CXCL12 to CXCR4 activates a variety of intracellular signal transduction pathways that regulate cell chemotaxis, adhesion, survival, proliferation, and apoptosis...
  11. pmc Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks
    Hila Barash
    The Goldyne Savad Institute of Gene Therapy, Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Laboratory, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Proc Natl Acad Sci U S A 107:2207-12. 2010
    ..Thus, we clarify the immediate and long-term contributions of the DNA damage response to HCC development and recurrence...
  12. ncbi request reprint A common pathway mediated through Toll-like receptors leads to T- and natural killer-cell immunosuppression
    Ilan Vaknin
    Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Blood 111:1437-47. 2008
    ..Thus, although acute TLR-mediated activation could be beneficial in clearing pathogens or may serve as an immune adjuvant, such activation could be detrimental under sustained conditions...
  13. ncbi request reprint Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice
    Neta Barashi
    Goldyne Savad Institute of Gene Therapy, Human Biology Research Center, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Hepatology 58:1021-30. 2013
    ..DKO mice for Mdr2 and CCR5 exhibited a significant decrease in tumor incidence and size...
  14. doi request reprint A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells
    Ronit Meyuhas
    Department of Virology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Mol Cancer Res 6:1397-409. 2008
    ....
  15. pmc Pregnancy restores the regenerative capacity of the aged liver via activation of an mTORC1-controlled hyperplasia/hypertrophy switch
    Yuval Gielchinsky
    Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Hebrew University Hadassah Medical School, Ein Kerem, Jerusalem, Israel
    Genes Dev 24:543-8. 2010
    ....
  16. doi request reprint The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesis
    Galit Lazer
    Hubert H Humphrey Centre for Experimental Medicine and Cancer Research, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Pathol 219:25-34. 2009
    ..These data suggest that Vav1 plays a role in the neoplastic process in lung cancer, identifying it as a potential therapeutic target for lung cancer therapy...
  17. pmc Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF{beta}-TrCP by single substrate depletion
    Naama Kanarek
    The Lautenberg Center for Immunology, Jerusalem, Israel
    Genes Dev 24:470-7. 2010
    ..Our studies highlight an unexpected functional reserve of this central E3, as well as a bottleneck in a specific tissue: a single substrate whose stabilization is incompatible with testicular differentiation...
  18. doi request reprint CKIα ablation highlights a critical role for p53 in invasiveness control
    Ela Elyada
    The Lautenberg Center for Immunology, IMRIC, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nature 470:409-13. 2011
    ..PSIS transcription and tumour invasion were suppressed by p21, independently of cell cycle control. Restraining tissue invasion through suppressing PSIS expression is thus a novel tumour-suppressor function of wild-type p53...
  19. ncbi request reprint Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenografts
    Mirela Goldenberg-Furmanov
    Department of Experimental Medicine and Cancer Research, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Cancer Res 64:1058-66. 2004
    ..Histological analyses of the treated tumors indicated extensive apoptosis. Thus, we suggest that Lyn inhibition may serve as a prime target for the treatment of hormone-refractory PC...
  20. ncbi request reprint Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
    Merav Darash-Yahana
    Goldyne Savad Institute of Gene Therapy, HBRC, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    FASEB J 18:1240-2. 2004
    ..Thus high levels of the chemokine receptor CXCR4 induce a more aggressive phenotype in prostate cancer cells and identify CXCR4 as a potential therapeutic target in advanced cases of metastatic prostate cancer...
  21. pmc Critical role for IL-1β in DNA damage-induced mucositis
    Naama Kanarek
    Lautenberg Centre for Immunology and Cancer Research, Institute for Medical Research Israel Canada, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 111:E702-11. 2014
    ..IL-1β antagonists should thus be considered for prevention and treatment of severe morbidity associated with mucositis. ..
  22. ncbi request reprint Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells
    Eyal Banin
    Department of Ophthalmology, The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, P O Box 12, 000, Ein Kerem, Jerusalem 91120, Israel
    Stem Cells 24:246-57. 2006
    ..This may be the first step toward further developments that eventually may allow the use of hESCs for transplantation in retinal degenerations...
  23. pmc Effects of the single nucleotide polymorphism at MDM2 309 on breast cancer patients with/without BRCA1/2 mutations
    Hovav Nechushtan
    Department of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    BMC Cancer 9:60. 2009
    ..The differential effects of this SNP were also linked to estrogen receptor activation. Here we report on our study of 453 Ashkenazi breast cancer patients of whom 180 were positive for the known Ashkenazi BRCA1/2 mutations..
  24. pmc Vav1 fine tunes p53 control of apoptosis versus proliferation in breast cancer
    Shulamit Sebban
    Departement of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Hadassah Medical School Hebrew University, Jerusalem, Israel
    PLoS ONE 8:e54321. 2013
    ..These results highlight for the first time the potential role of Vav1 as an oncogenic stress activator in cancer and the p53 dependence of its pro-apoptotic effect in breast cells...
  25. ncbi request reprint Tamoxifen induces heparanase expression in estrogen receptor-positive breast cancer
    Irit Cohen
    Sharett Institute of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Clin Cancer Res 13:4069-77. 2007
    ..The present study was undertaken to elucidate molecular mechanisms responsible for heparanase overexpression in breast cancer...
  26. pmc The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers
    Merav Darash-Yahana
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    PLoS ONE 4:e6695. 2009
    ....
  27. ncbi request reprint TCR zeta down-regulation under chronic inflammation is mediated by myeloid suppressor cells differentially distributed between various lymphatic organs
    Analía V Ezernitchi
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Immunol 177:4763-72. 2006
    ..Such an environment is anticipated to limit the success of immunotherapeutic strategies based on vaccination and T cell transfer, which are currently under investigation for immunotherapy of cancer...
  28. ncbi request reprint Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment
    Elad Horwitz
    Authors Affiliations The Lautenberg Center for Immunology Department of Developmental Biology and Cancer Research, IMRIC, Hadassah Medical School, Hebrew University Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem Liver Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Institute of Pathology, University Hospital Basel, Basel, Switzerland Division of Signal Transduction and Growth Control A100, Division of Molecular Genetics B060, and Junior Group Molecular Mechanisms of Head and Neck Tumors A102, German Cancer Research Center DKFZ, DKFZ ZMBH Alliance Institute of Pathology, University Hospital Heidelberg Departments of Otolaryngology, Head and Neck Surgery and Internal Medicine, University Hospital Heidelberg, Heidelberg and Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Cancer Discov 4:730-43. 2014
    ....
  29. pmc Transcription factor MITF regulates cardiac growth and hypertrophy
    Sagi Tshori
    Department of Biochemistry, Hebrew University Medical School, Jerusalem, Israel
    J Clin Invest 116:2673-81. 2006
    ..Thus, for what we believe is the first time, we have demonstrated that MITF plays an essential role in beta-adrenergic-induced cardiac hypertrophy...
  30. ncbi request reprint Nuclear factor-kappaB protects the liver against genotoxic stress and functions independently of p53
    Iris Lavon
    The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cancer Res 63:25-30. 2003
    ..These findings may have important implications with respect to the potential use of NF-kappaB modulators in cancer therapy...
  31. doi request reprint Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk
    Moshe Biton
    Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Nat Immunol 12:239-46. 2011
    ..Our findings indicate that epithelial microRNAs are key regulators of gut homeostasis and mucosal immunity...
  32. ncbi request reprint An Ashkenazi founder mutation in the MSH6 gene leading to HNPCC
    Yael Goldberg
    Sharret Institute of Oncology, Hadassah Hebrew University Medical Center, Kyriat Hadassah, POB 12000, 91120, Jerusalem, Israel
    Fam Cancer 9:141-50. 2010
    ..3984_3987dup and c.1906G>C account for 61% of HNPCC Ashkenazi families in this cohort. These findings are of great importance for counseling, diagnosis, management and surveillance for Ashkenazi families with Lynch syndrome...
  33. ncbi request reprint Oct-3/4 is a dose-dependent oncogenic fate determinant
    Sharon Gidekel
    Department of Experimental Medicine and Cancer Research, The Hebrew University Hadassah Medical School, Jerusalem, Israel 91120
    Cancer Cell 4:361-70. 2003
    ..Our findings suggest that Oct-3/4 is not only a distinctive immunohistochemical marker for GCTs, but also plays a critical role in the genesis of these tumors...
  34. ncbi request reprint The expression level of ligands for natural killer cell receptors predicts response to bacillus Calmette-Guerin therapy: a pilot study
    Vladimir Yutkin
    Department of Urology, Hadassah Hebrew University Medical School, Jerusalem, Israel
    J Urol 178:2660-4. 2007
    ....
  35. pmc α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease
    Eitan Israeli
    Department of Biochemistry and Molecular Biology, IMRIC, Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 6:e19622. 2011
    ..Based on these results, we suggest that certain forms of α-Syn may selectively accelerate cellular mechanisms leading to cancer...
  36. doi request reprint NF-κB in liver cancer: the plot thickens
    Shlomi Finkin
    Department of Immunology and Cancer Research and Department of Pathology, IMRIC, Hebrew University Hadassah Medical School, Ein Kerem, 91120, Jerusalem, Israel
    Curr Top Microbiol Immunol 349:185-96. 2011
    ..Moreover, it is possible that specific interventions could boost the tumor suppressor functions of NF-κB in tumors that harbor mutations that render this pathway constitutively active...
  37. ncbi request reprint Inflammation and cancer: is the link as simple as we think?
    Brian J Nickoloff
    Oncology Institute, Cardinal Bernadin Cancer Center, Loyola University Chicago Medical Center, Chicago, Illinois, USA
    J Invest Dermatol 124:x-xiv. 2005

Research Grants1

  1. TNFalpha as a potential target for liver cancer prophyl*
    Eli Pikarsky; Fiscal Year: 2006
    ..Understanding the mechanisms underlying the response to this treatment and the mechanisms of escape may help to plan effective treatment regimens for clinical studies. ..