Genomes and Genes
Affiliation: Hadassah University Hospital
- Contradictory functions of NF-kappaB in liver physiology and cancerGilad W Vainer
Department of Pathology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Cancer Lett 267:182-8. 2008..In this review, we will focus on the seemingly contradictory role of NF-kappaB in liver homeostasis, as well as in liver cancer...
- The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in miceKeren Bitton-Worms
Department of Molecular Genetics, The Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel
Mol Cancer 9:54. 2010..We used diethylnitrosamine (DEN) injection to initiate liver cancer in mice and assessed the extent of liver cancer in JDP2-transgenic and wild type control mice by biochemical and molecular biology techniques...
- NF-kappaB inhibition: a double-edged sword in cancer?Eli Pikarsky
Department of Pathology, Hebrew University Hadassah Medical School, Ein Kerem Campus, Kiryat Hadassah, Jerusalem 91120, Israel
Eur J Cancer 42:779-84. 2006..Further cancer model studies should help to clarify this issue, complementing the intensive drug development effort of the pharmaceutical industry around NF-kappaB...
- NF-kappaB functions as a tumour promoter in inflammation-associated cancerEli Pikarsky
Department of Pathology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
Nature 431:461-6. 2004..Our studies thus indicate that NF-kappaB is essential for promoting inflammation-associated cancer, and is therefore a potential target for cancer prevention in chronic inflammatory diseases...
- Function of heparanase in prostate tumorigenesis: potential for therapyImmanuel Lerner
Sharett Institute of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Clin Cancer Res 14:668-76. 2008..Our research was undertaken to elucidate the significance of heparanase in prostate tumorigenesis and bone metastasis...
- beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptorUdi Gluschnaider
Department of Pathology and the Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
PLoS ONE 5:e9060. 2010..Thus, alternative strategies targeting novel molecular mechanisms are required. beta-TrCP is an E3 ligase that targets various substrates essential for many aspects of tumorigenesis...
- Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaksHila Barash
The Goldyne Savad Institute of Gene Therapy, Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Laboratory, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Proc Natl Acad Sci U S A 107:2207-12. 2010..Thus, we clarify the immediate and long-term contributions of the DNA damage response to HCC development and recurrence...
- A common pathway mediated through Toll-like receptors leads to T- and natural killer-cell immunosuppressionIlan Vaknin
Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
Blood 111:1437-47. 2008..Thus, although acute TLR-mediated activation could be beneficial in clearing pathogens or may serve as an immune adjuvant, such activation could be detrimental under sustained conditions...
- A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanismAriel Pribluda
The Lautenberg Center for Immunology, Institute of Medical Research, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Cancer Cell 24:242-56. 2013..SIR/para-inflammation suppression may therefore constitute a key mechanism in the anticarcinogenic effects of nonsteroidal anti-inflammatory drugs. ..
- CKIα ablation highlights a critical role for p53 in invasiveness controlEla Elyada
The Lautenberg Center for Immunology, IMRIC, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Nature 470:409-13. 2011..PSIS transcription and tumour invasion were suppressed by p21, independently of cell cycle control. Restraining tissue invasion through suppressing PSIS expression is thus a novel tumour-suppressor function of wild-type p53...
- Pregnancy restores the regenerative capacity of the aged liver via activation of an mTORC1-controlled hyperplasia/hypertrophy switchYuval Gielchinsky
Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Hebrew University Hadassah Medical School, Ein Kerem, Jerusalem, Israel
Genes Dev 24:543-8. 2010....
- The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesisGalit Lazer
Hubert H Humphrey Centre for Experimental Medicine and Cancer Research, Hebrew University Hadassah Medical School, Jerusalem, Israel
J Pathol 219:25-34. 2009..These data suggest that Vav1 plays a role in the neoplastic process in lung cancer, identifying it as a potential therapeutic target for lung cancer therapy...
- The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancersMerav Darash-Yahana
Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
PLoS ONE 4:e6695. 2009....
- Nuclear factor-kappaB protects the liver against genotoxic stress and functions independently of p53Iris Lavon
The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Cancer Res 63:25-30. 2003..These findings may have important implications with respect to the potential use of NF-kappaB modulators in cancer therapy...
- Tamoxifen induces heparanase expression in estrogen receptor-positive breast cancerIrit Cohen
Sharett Institute of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Clin Cancer Res 13:4069-77. 2007..The present study was undertaken to elucidate molecular mechanisms responsible for heparanase overexpression in breast cancer...
- Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasisMerav Darash-Yahana
Goldyne Savad Institute of Gene Therapy, HBRC, Hadassah Hebrew University Medical Center, Jerusalem, Israel
FASEB J 18:1240-2. 2004..Thus high levels of the chemokine receptor CXCR4 induce a more aggressive phenotype in prostate cancer cells and identify CXCR4 as a potential therapeutic target in advanced cases of metastatic prostate cancer...
- Effects of the single nucleotide polymorphism at MDM2 309 on breast cancer patients with/without BRCA1/2 mutationsHovav Nechushtan
Department of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
BMC Cancer 9:60. 2009..The differential effects of this SNP were also linked to estrogen receptor activation. Here we report on our study of 453 Ashkenazi breast cancer patients of whom 180 were positive for the known Ashkenazi BRCA1/2 mutations..
- TCR zeta down-regulation under chronic inflammation is mediated by myeloid suppressor cells differentially distributed between various lymphatic organsAnalía V Ezernitchi
The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
J Immunol 177:4763-72. 2006..Such an environment is anticipated to limit the success of immunotherapeutic strategies based on vaccination and T cell transfer, which are currently under investigation for immunotherapy of cancer...
- An Ashkenazi founder mutation in the MSH6 gene leading to HNPCCYael Goldberg
Sharret Institute of Oncology, Hadassah Hebrew University Medical Center, Kyriat Hadassah, POB 12000, 91120, Jerusalem, Israel
Fam Cancer 9:141-50. 2010..3984_3987dup and c.1906G>C account for 61% of HNPCC Ashkenazi families in this cohort. These findings are of great importance for counseling, diagnosis, management and surveillance for Ashkenazi families with Lynch syndrome...
- Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cellsEyal Banin
Department of Ophthalmology, The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, P O Box 12, 000, Ein Kerem, Jerusalem 91120, Israel
Stem Cells 24:246-57. 2006..This may be the first step toward further developments that eventually may allow the use of hESCs for transplantation in retinal degenerations...
- α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's diseaseEitan Israeli
Department of Biochemistry and Molecular Biology, IMRIC, Hebrew University Hadassah Medical School, Jerusalem, Israel
PLoS ONE 6:e19622. 2011..Based on these results, we suggest that certain forms of α-Syn may selectively accelerate cellular mechanisms leading to cancer...
- NF-κB in liver cancer: the plot thickensShlomi Finkin
Department of Immunology and Cancer Research and Department of Pathology, IMRIC, Hebrew University Hadassah Medical School, Ein Kerem, 91120, Jerusalem, Israel
Curr Top Microbiol Immunol 349:185-96. 2011..Moreover, it is possible that specific interventions could boost the tumor suppressor functions of NF-κB in tumors that harbor mutations that render this pathway constitutively active...
- Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalkMoshe Biton
Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
Nat Immunol 12:239-46. 2011..Our findings indicate that epithelial microRNAs are key regulators of gut homeostasis and mucosal immunity...
- Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenograftsMirela Goldenberg-Furmanov
Department of Experimental Medicine and Cancer Research, The Hebrew University Hadassah Medical School, Jerusalem, Israel
Cancer Res 64:1058-66. 2004..Histological analyses of the treated tumors indicated extensive apoptosis. Thus, we suggest that Lyn inhibition may serve as a prime target for the treatment of hormone-refractory PC...
- Inflammation and cancer: is the link as simple as we think?Brian J Nickoloff
Oncology Institute, Cardinal Bernadin Cancer Center, Loyola University Chicago Medical Center, Chicago, Illinois, USA
J Invest Dermatol 124:x-xiv. 2005
- Transcription factor MITF regulates cardiac growth and hypertrophySagi Tshori
Department of Biochemistry, Hebrew University Medical School, Jerusalem, Israel
J Clin Invest 116:2673-81. 2006..Thus, for what we believe is the first time, we have demonstrated that MITF plays an essential role in beta-adrenergic-induced cardiac hypertrophy...
- A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cellsRonit Meyuhas
Department of Virology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
Mol Cancer Res 6:1397-409. 2008....
- TNFalpha as a potential target for liver cancer prophyl*Eli Pikarsky; Fiscal Year: 2006..Understanding the mechanisms underlying the response to this treatment and the mechanisms of escape may help to plan effective treatment regimens for clinical studies. ..