Research Topics
Genomes and Genes | Amnon PeledSummaryAffiliation: Hadassah University Hospital Country: Israel Publications
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Detail Information
Publications
Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1Amnon Peled
Hadassah University Hospital, Gene Therapy Institutem, Jerusalem, Israel
Stem Cells 20:259-66. 2002..These findings suggest a major role for SDF-1-mediated, integrin-dependent BM retention of Ph+CD34+ cells...
Interaction between CXCR4 and CCL20 pathways regulates tumor growthKatia Beider
Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel
PLoS ONE 4:e5125. 2009..These results reveal a role for CCL20 in CXCR4-dependent and -independent tumor growth and suggest a therapeutic potential for CCL20 and CCR6 antagonists in the treatment of CXCR4- and CCL20-dependent malignancies...
Development of novel CXCR4-based therapeuticsAmnon Peled
Hadassah Hebrew University Hospital, Goldyne Savad Institute of Gene Therapy, Jerusalem, Israel
Expert Opin Investig Drugs 21:341-53. 2012....- Role of CXCR4 in the pathogenesis of acute myeloid leukemiaAmnon Peled
Goldyne Savad Institute of Gene Therapy, Hebrew University Hospital, P O B 12000, Jerusalem 91120, Israel
Theranostics 3:34-9. 2013..The hypothesis that CXCL12/CXCR4 interactions contribute to the resistance of AML cells to signal transduction inhibitor- and chemotherapy-induced apoptosis is currently being tested in a series of Phase I/II studies in humans... - Focal liver necrosis appears early after partial hepatectomy and is dependent on T cells and antigen delivery from the gutNoam Rudich
Laboratory for Surgical Research, Hadassah University Hospital, Jerusalem, Israel
Liver Int 29:1273-84. 2009..Progressive liver failure may develop following removal of a large part of the liver or transplantation of a small for size liver graft. The pathophysiology of this clinical syndrome is only partially understood... - Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interaction with endothelial cellsSuzanna Franitza
Hadassah University Hospital, Goldyne Savad Gene Therapy Institute, Jerusalem, Israel
Eur J Immunol 34:1333-41. 2004..This study therefore suggests an important role for CXCR4 levels of expression and for VLA-4 in regulating the accumulation of NKT cells in the BM... - Ccr5 deficiency regulates the proliferation and trafficking of natural killer cells under physiological conditionsIdo D Weiss
Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, P O Box 12000, Jerusalem 91120, Israel
Cytokine 54:249-57. 2011..These results suggest a role for Ccr5 in NK cell proliferation and circulation under physiological conditions and a complex role for Ccr5 in determining the fate of NK cells under pathological conditions... - CD4+CXCR4highCD69+ T cells accumulate in lung adenocarcinomaOri Wald
Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Isreal
J Immunol 177:6983-90. 2006..Overall, these observations suggest that CXCL12 expression may influence tumor progression by shaping the immune cell population infiltrating lung adenocarcinoma tumors... - IFN-gamma treatment at early stages of influenza virus infection protects mice from death in a NK cell-dependent mannerIdo D Weiss
Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
J Interferon Cytokine Res 30:439-49. 2010..Thus, rapidly clearing the virus and reducing inflammation by shaping the cellular and cytokine profiles in the early stages of infection may favorably change the fate of influenza pathogenesis... - In vitro and in vivo therapeutic efficacy of CXCR4 antagonist BKT140 against human non-small cell lung cancerDuha Fahham
Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
J Thorac Cardiovasc Surg 144:1167-1175.e1. 2012..Therefore, the CXCR4/CXCL12 axis constitutes an attractive therapeutic target for the treatment of NSCLC. We aimed to characterize the therapeutic efficacy of the novel CXCR4 antagonist BKT140 against human NSCLC... - Involvement of CCR6/CCL20/IL-17 axis in NSCLC disease progressionSophie Kirshberg
Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
PLoS ONE 6:e24856. 2011..The expression and function of CCL20/CCR6 and its related Th-17 type immune response in NSCLC is not yet defined. We sought to characterize the role of the CCL20/CCR6/IL-17 axis in NSCLC tumor growth... - Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11Michal Dagan-Berger
Gene Therapy Institute, Hadassah University Hospital, PO Box 12000, Jerusalem, Israel
Blood 107:3821-31. 2006..Thus, distinct conformational changes induced by a given CXCR3 ligand trigger different downstream effectors of adhesion, motility, and CXCR3 desensitization... - Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasisMerav Darash-Yahana
Goldyne Savad Institute of Gene Therapy, HBRC, Hadassah Hebrew University Medical Center, Jerusalem, Israel
FASEB J 18:1240-2. 2004..Thus high levels of the chemokine receptor CXCR4 induce a more aggressive phenotype in prostate cancer cells and identify CXCR4 as a potential therapeutic target in advanced cases of metastatic prostate cancer... - Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12/CXCR4 axis: role in non-small cell lung cancer tumor proliferationOri Wald
Department of Cardiothoracic Surgery, Hadassah University Hospital, Jerusalem, Israel
J Thorac Cardiovasc Surg 141:1503-12. 2011..We sought to characterize roles of CXCL12/CXCR4 in crosstalk between non-small cell lung cancer epithelial cell and carcinoma-associated fibroblasts and in tumor growth... - CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growthKatia Beider
Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel
Exp Hematol 39:282-92. 2011..Binding CXCL12 to CXCR4 activates a variety of intracellular signal transduction pathways that regulate cell chemotaxis, adhesion, survival, proliferation, and apoptosis... - IFN-gamma acts on T cells to induce NK cell mobilization and accumulation in target organsOri Wald
Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
J Immunol 176:4716-29. 2006..Mechanistic insights regarding the role of IFN-gamma in the regulation of NK cell mobilization and their accumulation at sites of tumor metastasis may lead to the development of novel immunotherapy for cancer... - Chemokines and chemokine receptors in stem cell circulationKatia Beider
Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, 91120 P O B 12000, Israel
Front Biosci 13:6820-33. 2008..It is therefore evident that understanding the role of chemokines and their receptors in stem cell circulation is critical for the successful use of these cells in therapy for a wide variety of pathological conditions... - Enhanced unique pattern of hematopoietic cell mobilization induced by the CXCR4 antagonist 4F-benzoyl-TN14003Michal Abraham
Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, P O Box 12000, Jerusalem, 91120 Israel
Stem Cells 25:2158-66. 2007..These results demonstrate that different CXCR4 antagonists may have different therapeutic potentials... - Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burnsShani Avniel
Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
J Invest Dermatol 126:468-76. 2006..Blocking the CXCR4/CXCL12 axis resulted in the significant reduction in eosinophil accumulation in the dermis and improved epithelialization. Thus, blocking CXCR4/CXCL12 interaction may significantly improve skin recovery after burns... - Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftmentTony Peled
Gamida Cell Ltd, Jerusalem, Israel
Exp Hematol 40:342-55.e1. 2012..Our findings suggest a critical function of SIRT1 in the regulation of hematopoietic stem cell activity and imply the clinical utility of NAM for ex vivo expansion of functional CD34(+) cells... - Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virusOri Wald
Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
Eur J Immunol 34:1164-74. 2004..These observations suggest an important role for the CXCL12/CXCR4 pathway in recruitment and retention of immune cells in the liver during chronic HCV and HBV infection... - CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cellsJacob Hanna
The Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel
Blood 102:1569-77. 2003.... - Recruited macrophages control dissemination of group A Streptococcus from infected soft tissuesInbal Mishalian
Department of Microbiology and Molecular Genetics, Faculty of Medicine, The Institute for Medical Research Israel Canada, The Hebrew University, Jerusalem 91120, Israel
J Immunol 187:6022-31. 2011..c. administration of peritoneal macrophages. These experiments demonstrated that recruited macrophages play a key role in defense against the extracellular pathogen GAS by limiting its spread from soft tissues... - Chemokines in hepatitis C virus infection: pathogenesis, prognosis and therapeuticsOri Wald
Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, P O Box 12000, Jerusalem 91120, Israel
Cytokine 39:50-62. 2007..Furthermore, the clinical implications of these novel findings, which mark chemokines as prognostic markers and therapeutic targets for immune-modulation during chronic liver viral infection, are documented... - The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancersMerav Darash-Yahana
Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
PLoS ONE 4:e6695. 2009.... - Chemokine receptor expression in peripheral blood monocytes from patients with neovascular age-related macular degenerationMichelle Grunin
Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Invest Ophthalmol Vis Sci 53:5292-300. 2012..Chemokine signaling and monocytes/macrophages were implicated in the pathogenesis of AMD. We tested the association between chemokines involved in monocyte recruitment and AMD... - Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID miceKatia Beider
Hadassah University Hospital, Gene Therapy Institute, PO Box 12000, Jerusalem, Israel
Blood 102:1951-8. 2003..Thus, down-regulation of CXCR4 and up-regulation of CXCR3 may direct the trafficking of cells to the site of inflammation, rather than to hematopoietic organs, and therefore may limit their alloreactive potential... - A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissuesCarlos Hidalgo-Grass
Institute of Microbiology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
EMBO J 25:4628-37. 2006..ScpC degrades KC and MIP-2 locally in the infected skin tissues, inhibiting PMN recruitment. In conclusion, ScpC represents a novel GAS virulence factor functioning to directly inactivate a key element of the host innate immune response... - Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signalingAsaf Spiegel
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Blood 103:2900-7. 2004..Altogether, our data provide new insights into different SDF-1-induced signaling, activation, and consequent motility between normal CD34+ and precursor-B ALL progenitors, which may lead to improved clinical protocols... - G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4Isabelle Petit
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Nat Immunol 3:687-94. 2002..We suggest that manipulation of SDF-1 CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation... - CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrowAbraham Avigdor
Immunology Department, The Weizmann Institute of Science, Rehovot, Israel
Blood 103:2981-9. 2004..Taken together, our data suggest a key role for CD44 and HA in SDF-1-dependent transendothelial migration of HSCs/HPCs and their final anchorage within specific niches of the BM... - Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cellsIsabelle Petit
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
J Clin Invest 115:168-76. 2005..Our results demonstrate a central role for PKC-zeta in SDF-1-dependent regulation of hematopoietic stem and progenitor cell motility and development... - Cycling G1 CD34+/CD38+ cells potentiate the motility and engraftment of quiescent G0 CD34+/CD38-/low severe combined immunodeficiency repopulating cellsTamara Byk
The Weizmann Institute of Science, Department of Immunology, P.O. Box 26, Rehovot 76100, Israel
Stem Cells 23:561-74. 2005.... - Human CD34(+)CXCR4(-) sorted cells harbor intracellular CXCR4, which can be functionally expressed and provide NOD/SCID repopulationOrit Kollet
Immunology Department, Weizmann Institute of Science, Rehovot, Israel
Blood 100:2778-86. 2002..Our results suggest dynamic CXCR4 expression on CD34(+) stem and progenitor cells, regulating their motility and repopulation capacities... - Tumor necrosis factor promotes human T-cell development in nonobese diabetic/severe combined immunodeficient miceSarit Samira
Immunology Department, Weizmann Institute of Science, Rehovot, Israel
Stem Cells 22:1085-100. 2004..This study demonstrates the potential of TNF to rapidly augment human T lymphopoiesis in vivo and also provides clinically relevant evidence for this process with adult MPBL progenitors... - NeoR6 inhibits HIV-1-CXCR4 interaction without affecting CXCL12 chemotaxis activityAviva Lapidot
Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
Biochim Biophys Acta 1780:914-20. 2008..g. T140 and AMD3100. This complementary utilization of chemical, biology, and computation analysis provides a powerful approach for designing anti-HIV-1 drugs without interfering with the natural function of CXCL12/CXCR4 binding...