Amnon Peled

Summary

Affiliation: Hadassah University Hospital
Country: Israel

Publications

  1. ncbi request reprint Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1
    Amnon Peled
    Hadassah University Hospital, Gene Therapy Institutem, Jerusalem, Israel
    Stem Cells 20:259-66. 2002
  2. pmc Interaction between CXCR4 and CCL20 pathways regulates tumor growth
    Katia Beider
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel
    PLoS ONE 4:e5125. 2009
  3. doi request reprint Ccr5 deficiency regulates the proliferation and trafficking of natural killer cells under physiological conditions
    Ido D Weiss
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, P O Box 12000, Jerusalem 91120, Israel
    Cytokine 54:249-57. 2011
  4. doi request reprint Development of novel CXCR4-based therapeutics
    Amnon Peled
    Hadassah Hebrew University Hospital, Goldyne Savad Institute of Gene Therapy, Jerusalem, Israel
    Expert Opin Investig Drugs 21:341-53. 2012
  5. pmc Role of CXCR4 in the pathogenesis of acute myeloid leukemia
    Amnon Peled
    Goldyne Savad Institute of Gene Therapy, Hebrew University Hospital, P O B 12000, Jerusalem 91120, Israel
    Theranostics 3:34-9. 2013
  6. doi request reprint Focal liver necrosis appears early after partial hepatectomy and is dependent on T cells and antigen delivery from the gut
    Noam Rudich
    Laboratory for Surgical Research, Hadassah University Hospital, Jerusalem, Israel
    Liver Int 29:1273-84. 2009
  7. ncbi request reprint Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interaction with endothelial cells
    Suzanna Franitza
    Hadassah University Hospital, Goldyne Savad Gene Therapy Institute, Jerusalem, Israel
    Eur J Immunol 34:1333-41. 2004
  8. ncbi request reprint CD4+CXCR4highCD69+ T cells accumulate in lung adenocarcinoma
    Ori Wald
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Isreal
    J Immunol 177:6983-90. 2006
  9. doi request reprint IFN-gamma treatment at early stages of influenza virus infection protects mice from death in a NK cell-dependent manner
    Ido D Weiss
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    J Interferon Cytokine Res 30:439-49. 2010
  10. doi request reprint In vitro and in vivo therapeutic efficacy of CXCR4 antagonist BKT140 against human non-small cell lung cancer
    Duha Fahham
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    J Thorac Cardiovasc Surg 144:1167-1175.e1. 2012

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1
    Amnon Peled
    Hadassah University Hospital, Gene Therapy Institutem, Jerusalem, Israel
    Stem Cells 20:259-66. 2002
    ..These findings suggest a major role for SDF-1-mediated, integrin-dependent BM retention of Ph+CD34+ cells...
  2. pmc Interaction between CXCR4 and CCL20 pathways regulates tumor growth
    Katia Beider
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel
    PLoS ONE 4:e5125. 2009
    ..These results reveal a role for CCL20 in CXCR4-dependent and -independent tumor growth and suggest a therapeutic potential for CCL20 and CCR6 antagonists in the treatment of CXCR4- and CCL20-dependent malignancies...
  3. doi request reprint Ccr5 deficiency regulates the proliferation and trafficking of natural killer cells under physiological conditions
    Ido D Weiss
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, P O Box 12000, Jerusalem 91120, Israel
    Cytokine 54:249-57. 2011
    ..These results suggest a role for Ccr5 in NK cell proliferation and circulation under physiological conditions and a complex role for Ccr5 in determining the fate of NK cells under pathological conditions...
  4. doi request reprint Development of novel CXCR4-based therapeutics
    Amnon Peled
    Hadassah Hebrew University Hospital, Goldyne Savad Institute of Gene Therapy, Jerusalem, Israel
    Expert Opin Investig Drugs 21:341-53. 2012
    ..Targeting the CXCR4-CXCL12 axis, therefore, is an attractive therapeutic approach in various diseases...
  5. pmc Role of CXCR4 in the pathogenesis of acute myeloid leukemia
    Amnon Peled
    Goldyne Savad Institute of Gene Therapy, Hebrew University Hospital, P O B 12000, Jerusalem 91120, Israel
    Theranostics 3:34-9. 2013
    ..The hypothesis that CXCL12/CXCR4 interactions contribute to the resistance of AML cells to signal transduction inhibitor- and chemotherapy-induced apoptosis is currently being tested in a series of Phase I/II studies in humans...
  6. doi request reprint Focal liver necrosis appears early after partial hepatectomy and is dependent on T cells and antigen delivery from the gut
    Noam Rudich
    Laboratory for Surgical Research, Hadassah University Hospital, Jerusalem, Israel
    Liver Int 29:1273-84. 2009
    ..Progressive liver failure may develop following removal of a large part of the liver or transplantation of a small for size liver graft. The pathophysiology of this clinical syndrome is only partially understood...
  7. ncbi request reprint Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interaction with endothelial cells
    Suzanna Franitza
    Hadassah University Hospital, Goldyne Savad Gene Therapy Institute, Jerusalem, Israel
    Eur J Immunol 34:1333-41. 2004
    ..This study therefore suggests an important role for CXCR4 levels of expression and for VLA-4 in regulating the accumulation of NKT cells in the BM...
  8. ncbi request reprint CD4+CXCR4highCD69+ T cells accumulate in lung adenocarcinoma
    Ori Wald
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Isreal
    J Immunol 177:6983-90. 2006
    ..Overall, these observations suggest that CXCL12 expression may influence tumor progression by shaping the immune cell population infiltrating lung adenocarcinoma tumors...
  9. doi request reprint IFN-gamma treatment at early stages of influenza virus infection protects mice from death in a NK cell-dependent manner
    Ido D Weiss
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    J Interferon Cytokine Res 30:439-49. 2010
    ..Thus, rapidly clearing the virus and reducing inflammation by shaping the cellular and cytokine profiles in the early stages of infection may favorably change the fate of influenza pathogenesis...
  10. doi request reprint In vitro and in vivo therapeutic efficacy of CXCR4 antagonist BKT140 against human non-small cell lung cancer
    Duha Fahham
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    J Thorac Cardiovasc Surg 144:1167-1175.e1. 2012
    ..Therefore, the CXCR4/CXCL12 axis constitutes an attractive therapeutic target for the treatment of NSCLC. We aimed to characterize the therapeutic efficacy of the novel CXCR4 antagonist BKT140 against human NSCLC...
  11. pmc Involvement of CCR6/CCL20/IL-17 axis in NSCLC disease progression
    Sophie Kirshberg
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    PLoS ONE 6:e24856. 2011
    ..The expression and function of CCL20/CCR6 and its related Th-17 type immune response in NSCLC is not yet defined. We sought to characterize the role of the CCL20/CCR6/IL-17 axis in NSCLC tumor growth...
  12. ncbi request reprint Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
    Merav Darash-Yahana
    Goldyne Savad Institute of Gene Therapy, HBRC, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    FASEB J 18:1240-2. 2004
    ..Thus high levels of the chemokine receptor CXCR4 induce a more aggressive phenotype in prostate cancer cells and identify CXCR4 as a potential therapeutic target in advanced cases of metastatic prostate cancer...
  13. ncbi request reprint Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11
    Michal Dagan-Berger
    Gene Therapy Institute, Hadassah University Hospital, PO Box 12000, Jerusalem, Israel
    Blood 107:3821-31. 2006
    ..Thus, distinct conformational changes induced by a given CXCR3 ligand trigger different downstream effectors of adhesion, motility, and CXCR3 desensitization...
  14. doi request reprint CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth
    Katia Beider
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Exp Hematol 39:282-92. 2011
    ..Binding CXCL12 to CXCR4 activates a variety of intracellular signal transduction pathways that regulate cell chemotaxis, adhesion, survival, proliferation, and apoptosis...
  15. doi request reprint Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12/CXCR4 axis: role in non-small cell lung cancer tumor proliferation
    Ori Wald
    Department of Cardiothoracic Surgery, Hadassah University Hospital, Jerusalem, Israel
    J Thorac Cardiovasc Surg 141:1503-12. 2011
    ..We sought to characterize roles of CXCL12/CXCR4 in crosstalk between non-small cell lung cancer epithelial cell and carcinoma-associated fibroblasts and in tumor growth...
  16. ncbi request reprint IFN-gamma acts on T cells to induce NK cell mobilization and accumulation in target organs
    Ori Wald
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    J Immunol 176:4716-29. 2006
    ..Mechanistic insights regarding the role of IFN-gamma in the regulation of NK cell mobilization and their accumulation at sites of tumor metastasis may lead to the development of novel immunotherapy for cancer...
  17. ncbi request reprint Chemokines and chemokine receptors in stem cell circulation
    Katia Beider
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, 91120 P O B 12000, Israel
    Front Biosci 13:6820-33. 2008
    ..It is therefore evident that understanding the role of chemokines and their receptors in stem cell circulation is critical for the successful use of these cells in therapy for a wide variety of pathological conditions...
  18. ncbi request reprint Enhanced unique pattern of hematopoietic cell mobilization induced by the CXCR4 antagonist 4F-benzoyl-TN14003
    Michal Abraham
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, P O Box 12000, Jerusalem, 91120 Israel
    Stem Cells 25:2158-66. 2007
    ..These results demonstrate that different CXCR4 antagonists may have different therapeutic potentials...
  19. ncbi request reprint Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns
    Shani Avniel
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    J Invest Dermatol 126:468-76. 2006
    ..Blocking the CXCR4/CXCL12 axis resulted in the significant reduction in eosinophil accumulation in the dermis and improved epithelialization. Thus, blocking CXCR4/CXCL12 interaction may significantly improve skin recovery after burns...
  20. doi request reprint Targeting the CD20 and CXCR4 pathways in non-hodgkin lymphoma with rituximab and high-affinity CXCR4 antagonist BKT140
    Katia Beider
    Division of Hematology, Bone Marrow Transplantation and Cord Blood Bank, Sheba Medical Center, Tel Hashomer, Israel
    Clin Cancer Res 19:3495-507. 2013
    ..Here, we investigated the effect of high-affinity CXCR4 antagonist BKT140 on lymphoma cell growth and rituximab-induced cytotoxicity in vitro and in vivo...
  21. doi request reprint Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment
    Tony Peled
    Gamida Cell Ltd, Jerusalem, Israel
    Exp Hematol 40:342-55.e1. 2012
    ..Our findings suggest a critical function of SIRT1 in the regulation of hematopoietic stem cell activity and imply the clinical utility of NAM for ex vivo expansion of functional CD34(+) cells...
  22. ncbi request reprint CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells
    Jacob Hanna
    The Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel
    Blood 102:1569-77. 2003
    ....
  23. ncbi request reprint Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus
    Ori Wald
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    Eur J Immunol 34:1164-74. 2004
    ..These observations suggest an important role for the CXCL12/CXCR4 pathway in recruitment and retention of immune cells in the liver during chronic HCV and HBV infection...
  24. doi request reprint Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice
    Neta Barashi
    Goldyne Savad Institute of Gene Therapy, Human Biology Research Center, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Hepatology 58:1021-30. 2013
    ..Therefore, we propose that a CCR5 antagonist can serve for HCC cancer prevention and treatment. (Hepatology 2013;53:1021-1030). ..
  25. doi request reprint Recruited macrophages control dissemination of group A Streptococcus from infected soft tissues
    Inbal Mishalian
    Department of Microbiology and Molecular Genetics, Faculty of Medicine, The Institute for Medical Research Israel Canada, The Hebrew University, Jerusalem 91120, Israel
    J Immunol 187:6022-31. 2011
    ..c. administration of peritoneal macrophages. These experiments demonstrated that recruited macrophages play a key role in defense against the extracellular pathogen GAS by limiting its spread from soft tissues...
  26. ncbi request reprint Chemokines in hepatitis C virus infection: pathogenesis, prognosis and therapeutics
    Ori Wald
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, P O Box 12000, Jerusalem 91120, Israel
    Cytokine 39:50-62. 2007
    ..Furthermore, the clinical implications of these novel findings, which mark chemokines as prognostic markers and therapeutic targets for immune-modulation during chronic liver viral infection, are documented...
  27. doi request reprint Interstrain differences in chronic hepatitis and tumor development in a murine model of inflammation-mediated hepatocarcinogenesis
    Tamara Potikha
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Hepatology 58:192-204. 2013
    ....
  28. pmc The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers
    Merav Darash-Yahana
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    PLoS ONE 4:e6695. 2009
    ....
  29. doi request reprint Chemokine receptor expression in peripheral blood monocytes from patients with neovascular age-related macular degeneration
    Michelle Grunin
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 53:5292-300. 2012
    ..Chemokine signaling and monocytes/macrophages were implicated in the pathogenesis of AMD. We tested the association between chemokines involved in monocyte recruitment and AMD...
  30. ncbi request reprint Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice
    Katia Beider
    Hadassah University Hospital, Gene Therapy Institute, PO Box 12000, Jerusalem, Israel
    Blood 102:1951-8. 2003
    ..Thus, down-regulation of CXCR4 and up-regulation of CXCR3 may direct the trafficking of cells to the site of inflammation, rather than to hematopoietic organs, and therefore may limit their alloreactive potential...
  31. pmc A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues
    Carlos Hidalgo-Grass
    Institute of Microbiology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    EMBO J 25:4628-37. 2006
    ..ScpC degrades KC and MIP-2 locally in the infected skin tissues, inhibiting PMN recruitment. In conclusion, ScpC represents a novel GAS virulence factor functioning to directly inactivate a key element of the host innate immune response...
  32. pmc Inhibition of nuclear factor-κB activation in pancreatic β-cells has a protective effect on allogeneic pancreatic islet graft survival
    Roy Eldor
    Department of Endocrinology, Hadassah University Hospital, Jerusalem, Israel
    PLoS ONE 8:e56924. 2013
    ..Furthermore, we suggest a potential, readily available therapeutic agent that may temper this process...
  33. ncbi request reprint G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Immunol 3:687-94. 2002
    ..We suggest that manipulation of SDF-1 CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation...
  34. ncbi request reprint Human CD34(+)CXCR4(-) sorted cells harbor intracellular CXCR4, which can be functionally expressed and provide NOD/SCID repopulation
    Orit Kollet
    Immunology Department, Weizmann Institute of Science, Rehovot, Israel
    Blood 100:2778-86. 2002
    ..Our results suggest dynamic CXCR4 expression on CD34(+) stem and progenitor cells, regulating their motility and repopulation capacities...
  35. ncbi request reprint CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow
    Abraham Avigdor
    Immunology Department, The Weizmann Institute of Science, Rehovot, Israel
    Blood 103:2981-9. 2004
    ..Taken together, our data suggest a key role for CD44 and HA in SDF-1-dependent transendothelial migration of HSCs/HPCs and their final anchorage within specific niches of the BM...
  36. ncbi request reprint Cycling G1 CD34+/CD38+ cells potentiate the motility and engraftment of quiescent G0 CD34+/CD38-/low severe combined immunodeficiency repopulating cells
    Tamara Byk
    The Weizmann Institute of Science, Department of Immunology, P O Box 26, Rehovot 76100, Israel
    Stem Cells 23:561-74. 2005
    ....
  37. pmc Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 115:168-76. 2005
    ..Our results demonstrate a central role for PKC-zeta in SDF-1-dependent regulation of hematopoietic stem and progenitor cell motility and development...
  38. ncbi request reprint Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling
    Asaf Spiegel
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Blood 103:2900-7. 2004
    ..Altogether, our data provide new insights into different SDF-1-induced signaling, activation, and consequent motility between normal CD34+ and precursor-B ALL progenitors, which may lead to improved clinical protocols...
  39. ncbi request reprint Tumor necrosis factor promotes human T-cell development in nonobese diabetic/severe combined immunodeficient mice
    Sarit Samira
    Immunology Department, Weizmann Institute of Science, Rehovot, Israel
    Stem Cells 22:1085-100. 2004
    ..This study demonstrates the potential of TNF to rapidly augment human T lymphopoiesis in vivo and also provides clinically relevant evidence for this process with adult MPBL progenitors...
  40. doi request reprint NeoR6 inhibits HIV-1-CXCR4 interaction without affecting CXCL12 chemotaxis activity
    Aviva Lapidot
    Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biochim Biophys Acta 1780:914-20. 2008
    ..g. T140 and AMD3100. This complementary utilization of chemical, biology, and computation analysis provides a powerful approach for designing anti-HIV-1 drugs without interfering with the natural function of CXCL12/CXCR4 binding...