Alexander Lossos

Summary

Affiliation: Hadassah University Hospital
Country: Israel

Publications

  1. ncbi request reprint Frontotemporal dementia and parkinsonism with the P301S tau gene mutation in a Jewish family
    Alexander Lossos
    The Agnes Ginges Center for Human Neurogenetics, Dept of Neurology, Hadassah University Hospital, POB 12000, Jerusalem 91120, Israel
    J Neurol 250:733-40. 2003
  2. ncbi request reprint Refinement of the SPG15 candidate interval and phenotypic heterogeneity in three large Arab families
    Nizar Elleuch
    INSERM, U679, Groupe Hospitalier Pitie Salpetriere, 47 bd de l Hopital, 75013 Paris, France
    Neurogenetics 8:307-15. 2007
  3. ncbi request reprint Late-delayed cerebral involvement in systemic non-Hodgkin lymphoma: a second primary tumor or a tardy recurrence?
    Alexander Lossos
    Leslie and Michael Gaffin Center for Neuro Oncology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Cancer 101:1843-9. 2004
  4. ncbi request reprint A novel autosomal recessive myopathy with external ophthalmoplegia linked to chromosome 17p13.1-p12
    Alexander Lossos
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, POB 12000, Jerusalem 91120, Israel
    Brain 128:42-51. 2005
  5. ncbi request reprint Extended phenotype in the transthyretin Tyr77 familial amyloid polyneuropathy
    Alexander Lossos
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel
    Eur Neurol 53:55-9. 2005
  6. ncbi request reprint Early clinical heterogeneity in choreoacanthocytosis
    Alexander Lossos
    Department of Neurology, Hadassah Hebrew Unviersity Hospital, Jerusalem, Israel
    Arch Neurol 62:611-4. 2005
  7. pmc Phenotypic variability among adult siblings with Sjögren-Larsson syndrome
    Alexander Lossos
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Arch Neurol 63:278-80. 2006
  8. ncbi request reprint Hereditary spastic paraplegia with thin corpus callosum: reduction of the SPG11 interval and evidence for further genetic heterogeneity
    Alexander Lossos
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Arch Neurol 63:756-60. 2006
  9. ncbi request reprint Leukoencephalopathy with neuroaxonal spheroids presenting as frontotemporal dementia
    Netta Levin
    Department of Neurology, Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center Ein Kerem Campus, Jerusalem, Israel
    Isr Med Assoc J 10:386-7. 2008
  10. ncbi request reprint CSF analysis of IgH gene rearrangement in CNS lymphoma: relationship to the disease course
    Dana Ekstein
    Department of Neurology, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, Israel
    J Neurol Sci 247:39-46. 2006

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Frontotemporal dementia and parkinsonism with the P301S tau gene mutation in a Jewish family
    Alexander Lossos
    The Agnes Ginges Center for Human Neurogenetics, Dept of Neurology, Hadassah University Hospital, POB 12000, Jerusalem 91120, Israel
    J Neurol 250:733-40. 2003
    ..Among others, the P301S mutation has been previously reported in three families of European and one of Japanese origin presenting with different clinical phenotypes...
  2. ncbi request reprint Refinement of the SPG15 candidate interval and phenotypic heterogeneity in three large Arab families
    Nizar Elleuch
    INSERM, U679, Groupe Hospitalier Pitie Salpetriere, 47 bd de l Hopital, 75013 Paris, France
    Neurogenetics 8:307-15. 2007
    ..Our study highlights the phenotypic heterogeneity of SPG15 in which mental retardation or cognitive deterioration, but not all other signs of Kjellin syndrome, are associated with HSP and significantly reduces the SPG15 locus...
  3. ncbi request reprint Late-delayed cerebral involvement in systemic non-Hodgkin lymphoma: a second primary tumor or a tardy recurrence?
    Alexander Lossos
    Leslie and Michael Gaffin Center for Neuro Oncology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Cancer 101:1843-9. 2004
    ..The authors attempted to investigate the clonal relation between the late-delayed central nervous system involvement and the original systemic tumor...
  4. ncbi request reprint A novel autosomal recessive myopathy with external ophthalmoplegia linked to chromosome 17p13.1-p12
    Alexander Lossos
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, POB 12000, Jerusalem 91120, Israel
    Brain 128:42-51. 2005
    ..One of these genes, MYH2, is involved in inclusion body myopathy 3, but no exonic mutations were found by direct sequencing. The molecular basis for this new myopathy remains to be identified...
  5. ncbi request reprint Extended phenotype in the transthyretin Tyr77 familial amyloid polyneuropathy
    Alexander Lossos
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel
    Eur Neurol 53:55-9. 2005
    ..Brain MRI in the proband showed multifocal white matter lesions. These features extend the reported Tyr77 phenotype and support the modifying effect of additional factors on the disease expression...
  6. ncbi request reprint Early clinical heterogeneity in choreoacanthocytosis
    Alexander Lossos
    Department of Neurology, Hadassah Hebrew Unviersity Hospital, Jerusalem, Israel
    Arch Neurol 62:611-4. 2005
    ..Choreoacanthocytosis (CHAC) is a slowly progressive multisystem disorder with involuntary movements, cognitive decline, behavioral changes, seizures, and polyneuropathy caused by mutations in the VPS13A gene...
  7. pmc Phenotypic variability among adult siblings with Sjögren-Larsson syndrome
    Alexander Lossos
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Arch Neurol 63:278-80. 2006
    ..Cerebral proton magnetic resonance spectroscopy in those with SLS demonstrates an abnormal white matter peak at 1.3 ppm, consistent with long-chain fatty alcohol accumulation...
  8. ncbi request reprint Hereditary spastic paraplegia with thin corpus callosum: reduction of the SPG11 interval and evidence for further genetic heterogeneity
    Alexander Lossos
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Arch Neurol 63:756-60. 2006
    ..The locus for HSP-TCC, designated SPG11, was mapped to chromosome 15q13-15 in some of the affected families from Japan, Europe, and North America, spanning an interval of 17.5 megabases (Mb)...
  9. ncbi request reprint Leukoencephalopathy with neuroaxonal spheroids presenting as frontotemporal dementia
    Netta Levin
    Department of Neurology, Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center Ein Kerem Campus, Jerusalem, Israel
    Isr Med Assoc J 10:386-7. 2008
  10. ncbi request reprint CSF analysis of IgH gene rearrangement in CNS lymphoma: relationship to the disease course
    Dana Ekstein
    Department of Neurology, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, Israel
    J Neurol Sci 247:39-46. 2006
    ..To assess whether clonal IgH genes in CSF of patients with CNS lymphoma correlates with the disease course...
  11. ncbi request reprint Extrathymic malignancies in patients with myasthenia gravis
    Netta Levin
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
    J Neurol Sci 237:39-43. 2005
    ..Data on clinical characteristics of MG patients with extrathymic malignancies and the role of concomitant diseases and their treatment are lacking...
  12. doi request reprint Cerebellar T2 hyperintensities in a patient with tremor
    Menachem Sadeh
    Department of Neurology, Wolfson Medical Center, Holon, Israel
    Neurology 70:578. 2008
  13. doi request reprint Intradural lumbar varix resembling a tumor: case report of a magnetic resonance imaging-based diagnosis
    Iddo Paldor
    Department of Neurosurgery, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Spine (Phila Pa 1976) 35:E864-6. 2010
    ..Review the presentation and diagnosis of a lumbar intradural varix...
  14. ncbi request reprint Brain metastases: a rare initial presentation of prostate cancer
    Tal Grenader
    Department of Oncology, Hadassah University Hospital, Jerusalem, Israel
    Int Urol Nephrol 39:537-9. 2007
    ..The pathological diagnosis of the tumor was consistent with metastatic prostate carcinoma. Further evaluation revealed widespread bony metastases by technetium 99 bone scan and high level of prostate-specific antigen...
  15. ncbi request reprint Short-chain acyl-CoA dehydrogenase gene mutation (c.319C>T) presents with clinical heterogeneity and is candidate founder mutation in individuals of Ashkenazi Jewish origin
    Ingrid Tein
    Division of Neurology, Department of Pediatrics, Laboratory Medicine and Pathobiology, Hospital for Sick Children, University of Toronto, Toronto, Canada M5G 1X8
    Mol Genet Metab 93:179-89. 2008
    ..This should be screened for in individuals with multicore myopathy, particularly among the Ashkenazim...
  16. ncbi request reprint Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration
    Giovanni Stevanin
    1INSERM, U679, Universite Pierre et Marie Curie Paris 6, UMR S679, Paris, France
    Brain 131:772-84. 2008
    ..In conclusion, our study reveals the high frequency of SPG11 mutations in patients with HSP, a TCC and cognitive impairment, including in isolated patients, and extends the associated phenotype...
  17. ncbi request reprint Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum
    Giovanni Stevanin
    INSERM, UMR679, Federal Institute for Neuroscience Research, Pitie Salpetriere Hospital, Paris, France
    Nat Genet 39:366-72. 2007
    ..The identification of the function of the gene will provide insight into the mechanisms leading to the degeneration of the corticospinal tract and other brain structures in this frequent form of ARHSP...
  18. pmc Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome
    Sylvain Hanein
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité Mixte de Recherche UMR S679, Neurologie et Thérapeutique Expérimentale, Paris, F 75013 France
    Am J Hum Genet 82:992-1002. 2008
    ..In cultured cells, spastizin colocalized partially with markers of endoplasmic reticulum and endosomes, suggesting a role in intracellular trafficking...