Itai Berger

Summary

Affiliation: Hadassah University Hospital
Country: Israel

Publications

  1. ncbi Diagnosis of attention deficit hyperactivity disorder: much ado about something
    Itai Berger
    Neuro Pediatric Unit, Hadassah Hebrew University Medical Center Mount Scopus Campus, Jerusalem, Israel
    Isr Med Assoc J 13:571-4. 2011
  2. doi The effect of environmental distractors incorporation into a CPT on sustained attention and ADHD diagnosis among adolescents
    Itai Berger
    The Neuro Cognitive Center, Pediatric Division, Hadassah Hebrew University Medical Center, Jerusalem, Israel Electronic address
    J Neurosci Methods 222:62-8. 2014
  3. doi Early developmental cues for diagnosis of attention deficit/hyperactivity disorder in young children
    Itai Berger
    Neuro Cognitive Center, Pediatric Division, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Dev Disabil Res Rev 17:170-9. 2011
  4. doi Intractable epilepsy of infancy due to homozygous mutation in the EFHC1 gene
    Itai Berger
    Monique and Jacques Roboh Department of Genetic Research, Hadassah, Hebrew University Medical Center, Jerusalem, Israel
    Epilepsia 53:1436-40. 2012
  5. doi Early prenatal ventriculomegaly due to an AIFM1 mutation identified by linkage analysis and whole exome sequencing
    Itai Berger
    Monique and Jacques Roboh Department of Genetic Research, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Mol Genet Metab 104:517-20. 2011
  6. doi Prenatal microcephaly: can we be more accurate?
    Itai Berger
    Neuro Fetal Clinic, Neuro Pediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Child Neurol 24:97-100. 2009
  7. doi Attention-deficit hyperactivity disorder (ADHD) and birth order
    Itai Berger
    Neuro Pediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Child Neurol 24:692-6. 2009
  8. doi The effect of antiepileptic drugs on mitochondrial activity: a pilot study
    Itai Berger
    The Neuro Pediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Child Neurol 25:541-5. 2010
  9. doi Paediatric Hashimoto encephalopathy, refractory epilepsy and immunoglobulin treatment - unusual case report and review of the literature
    I Berger
    The Neuro Pediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Acta Paediatr 99:1903-5. 2010
  10. ncbi Objective measures of attention-deficit/hyperactivity disorder: a pilot study
    Itai Berger
    Neuro Pediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Isr Med Assoc J 12:531-5. 2010

Collaborators

Detail Information

Publications34

  1. ncbi Diagnosis of attention deficit hyperactivity disorder: much ado about something
    Itai Berger
    Neuro Pediatric Unit, Hadassah Hebrew University Medical Center Mount Scopus Campus, Jerusalem, Israel
    Isr Med Assoc J 13:571-4. 2011
    ..This review addresses the diagnostic difficulties of ADHD and considers some steps that would make ADHD a more easily identifiable disorder...
  2. doi The effect of environmental distractors incorporation into a CPT on sustained attention and ADHD diagnosis among adolescents
    Itai Berger
    The Neuro Cognitive Center, Pediatric Division, Hadassah Hebrew University Medical Center, Jerusalem, Israel Electronic address
    J Neurosci Methods 222:62-8. 2014
    ..The aim of this study was to explore whether the incorporation of environmental distractors into a CPT would increase its ability to distinguish ADHD from non-ADHD adolescents...
  3. doi Early developmental cues for diagnosis of attention deficit/hyperactivity disorder in young children
    Itai Berger
    Neuro Cognitive Center, Pediatric Division, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Dev Disabil Res Rev 17:170-9. 2011
    ..In this review, we describe the complex factors that predict and mediate the developmental course of ADHD, providing early cues for ADHD diagnosis and intervention in young children that will optimize outcome...
  4. doi Intractable epilepsy of infancy due to homozygous mutation in the EFHC1 gene
    Itai Berger
    Monique and Jacques Roboh Department of Genetic Research, Hadassah, Hebrew University Medical Center, Jerusalem, Israel
    Epilepsia 53:1436-40. 2012
    ..The molecular etiology of primary intractable epilepsy in infancy is largely unknown. We studied a nonconsanguineous Moroccan-Jewish family, where three of their seven children presented with intractable seizures and died at 18-36 months...
  5. doi Early prenatal ventriculomegaly due to an AIFM1 mutation identified by linkage analysis and whole exome sequencing
    Itai Berger
    Monique and Jacques Roboh Department of Genetic Research, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Mol Genet Metab 104:517-20. 2011
    ..In summary, linkage analysis followed by exome sequencing of a single patient is a cost-effective approach for the identification of disease causing mutations in small non-consanguineous families...
  6. doi Prenatal microcephaly: can we be more accurate?
    Itai Berger
    Neuro Fetal Clinic, Neuro Pediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Child Neurol 24:97-100. 2009
    ..The charts should be customized between different professionals assessing prenatal and postnatal head circumference...
  7. doi Attention-deficit hyperactivity disorder (ADHD) and birth order
    Itai Berger
    Neuro Pediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Child Neurol 24:692-6. 2009
    ..This study provides evidence that birth order has no effect in relation to attention-deficit hyperactivity disorder...
  8. doi The effect of antiepileptic drugs on mitochondrial activity: a pilot study
    Itai Berger
    The Neuro Pediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Child Neurol 25:541-5. 2010
    ....
  9. doi Paediatric Hashimoto encephalopathy, refractory epilepsy and immunoglobulin treatment - unusual case report and review of the literature
    I Berger
    The Neuro Pediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Acta Paediatr 99:1903-5. 2010
    ..Hashimoto encephalopathy (HE) is a rare autoimmune disorder. It is defined as a 'corticosteroid-responsive encephalopathy associated with thyroiditis'...
  10. ncbi Objective measures of attention-deficit/hyperactivity disorder: a pilot study
    Itai Berger
    Neuro Pediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Isr Med Assoc J 12:531-5. 2010
    ..Computerized continuous performance tests are designed to improve the validity of the process but are controversial due to low odds ratios. There is a need to find more definitive measures of assessment...
  11. doi Attitudes toward attention-deficit hyperactivity disorder (ADHD) treatment: parents' and children's perspectives
    Itai Berger
    Neuro Pediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem 91240, Israel
    J Child Neurol 23:1036-42. 2008
    ..It is concluded that the pediatric neurologist has a crucial role in affecting attitudes of children and parents toward methylphenidate treatment...
  12. pmc Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia
    Simon Edvardson
    Metabolic Disease Unit, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Am J Hum Genet 83:643-8. 2008
    ..In patients with autosomal-recessive unclassified leukodystrophy or complex spastic paraparesis, sequence analysis of the FA2H gene is warranted...
  13. doi Mitochondrial complex I deficiency caused by a deleterious NDUFA11 mutation
    Itai Berger
    Pediatric Neurology Unit, Hadassah Hebrew University Medical Center, Jerusalem
    Ann Neurol 63:405-8. 2008
    ..Mutation analysis of the NDUFA11 is warranted in isolated complex I deficiency presenting with infantile lactic acidemia or encephalocardiomyopathy...
  14. ncbi Lamotrigine overdose in a child
    Muhannad Daana
    Department of Pediatrics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Child Neurol 22:642-4. 2007
    ..In this patient, toxic manifestation occurred after the initial 250 mg. This case report demonstrates the low safety margin in children treated with lamotrigine...
  15. ncbi The impact of sex and subtypes on cognitive and psychosocial aspects of ADHD
    Varda Gross-Tsur
    Neuropaediatric Unit, Shaare Zedek Medical Centre, Jerusalem, Israel
    Dev Med Child Neurol 48:901-5. 2006
    ..The results support the supposition that ADHD in females is the same disorder as in males. ADHD subtyping was the important determinant of ADHD core symptoms; females with ADHD were found to have significant risk of psychopathology...
  16. ncbi Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency
    Ann Saada
    Metabolic Disease Unit, Shaare Zedek Medical Center, Jerusalem, Israel
    Biochem Biophys Res Commun 310:963-6. 2003
    ..These findings underline the importance of balanced mitochondrial dNTP pools for mtDNA synthesis and may serve as the basis for future therapeutic interventions...
  17. doi Mitochondrial deoxyribonucleotide pools in deoxyguanosine kinase deficiency
    Ann Saada
    Metabolic Disease Unit, Hadassah Medical Center, Jerusalem 91120, Israel
    Mol Genet Metab 95:169-73. 2008
    ..It is suggested that the cytoplasmic deoxycytine kinase supplemented with external substrates may compensate for the deficient dGK...
  18. pmc 2-Hydroxylated sphingomyelin profiles in cells from patients with mutated fatty acid 2-hydroxylase
    Phyllis Dan
    Department of Genetics and Metabolic Diseases and the Monique and Jacques Roboh Department of Genetic Research, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Lipids Health Dis 10:84. 2011
    ....
  19. doi l-arginine:glycine amidinotransferase (AGAT) deficiency: clinical presentation and response to treatment in two patients with a novel mutation
    Simon Edvardson
    Pediatric Neurology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Mol Genet Metab 101:228-32. 2010
    ..Similarly, there was an apparent improvement in cognitive function, with significantly increased IQ-scores in the sister and marginal improvement in the brother...
  20. doi Down syndrome and attention-deficit/hyperactivity disorder (ADHD)
    Sivan Ekstein
    Pediatric Neurology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Child Neurol 26:1290-5. 2011
    ..When evaluating children with Down syndrome for attention deficits, psychiatric comorbidity as well as medical problems should be carefully taken into consideration...
  21. doi A virtual reality system combined with biofeedback for treating pediatric chronic headache--a pilot study
    Shimon Shiri
    Department of Physical Medicine and Rehabilitation, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Pain Med 14:621-7. 2013
    ..Here we present the rationale, feasibility, and preliminary results of a pilot study applying a novel system, combining virtual reality and biofeedback, aimed as an abortive treatment of pediatric chronic headache...
  22. ncbi Transverse myelitis: unusual sequelae of neonatal group B streptococcus disease
    Michael S Schimmel
    Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel
    J Perinatol 22:580-1. 2002
    ..We wish to report a case of transverse myelitis following early onset form of GBS meningitis. The diagnosis and the clinical approach will be discussed...
  23. ncbi Third ventricle enlargement among newborn infants with trisomy 21
    Michael S Schimmel
    Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel
    Pediatrics 117:e928-31. 2006
    ..These structures participate in cognitive development, and hypoplasia in this area may be responsible for some of the unique cognitive abnormalities observed among children with trisomy 21...
  24. pmc Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion
    Orly Elpeleg
    Metabolic Disease Unit, Shaare Zedek Medical Center, Jerusalem, Israel
    Am J Hum Genet 76:1081-6. 2005
    ..Succinyl-CoA synthetase is invariably in a complex with mitochondrial nucleotide diphosphate kinase; hence, we propose that a defect in the last step of mitochondrial dNTP salvage is a novel cause of the mtDNA depletion syndrome...
  25. pmc Acute infantile liver failure due to mutations in the TRMU gene
    Avraham Zeharia
    Department of Human Genetics and Metabolic Diseases, Hadassah, The Hebrew University Medical Center, Jerusalem, Israel
    Am J Hum Genet 85:401-7. 2009
    ..Given that sulfur is a TRMU substrate and its availability is limited during the neonatal period, we propose that there is a window of time whereby patients with TRMU mutations are at increased risk of developing liver failure...
  26. ncbi [Periventricular leukomalacia in premature infants: from pathogenesis to treatment]
    Talia Dor
    The Neuro Fetal Clinic, Pediatric Neurology Unit, Hadassah Hebrew University Medical Center, Mount Scopus, Jerusalem
    Harefuah 147:159-62, 181. 2008
    ..Advances in understanding the biology of PVL may result in clinical interventions that reduce the burden of CP...
  27. ncbi Neonatal mydriasis: intravenous lidocaine adverse reaction
    Itai Berger
    Neuro Pediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel
    J Child Neurol 17:400-1. 2002
    ..We suggest adding this side effect to the list of untoward effects of lidocaine and to the differential diagnosis of fixed dilated pupils in neonates treated with lidocaine...
  28. pmc Deleterious mutation in the mitochondrial arginyl-transfer RNA synthetase gene is associated with pontocerebellar hypoplasia
    Simon Edvardson
    Pediatric Neurology Unit, Hadassah Hebrew University Medical Center, Jerusalem, 91120, Israel
    Am J Hum Genet 81:857-62. 2007
    ..We speculate that missplicing mutations in mitochondrial aminoacyl-tRNA synthethase genes preferentially affect the brain because of a tissue-specific vulnerability of the splicing machinery...
  29. ncbi Defective mitochondrial translation caused by a ribosomal protein (MRPS16) mutation
    Chaya Miller
    Metabolic Disease Unit, Shaare Zedek Medical Center, Jerusalem, Israel
    Ann Neurol 56:734-8. 2004
    ..A new group of mitochondrial respiratory chain disorders is proposed, resulting from mutations in nuclear encoded components of the mitochondrial translation apparatus...
  30. pmc Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit
    Igor Ruvinsky
    Department of Biochemistry and Molecular Biology, IMRIC, Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 4:e5618. 2009
    ..A relatively passive behavior of these mice has raised the possibility that they suffer from muscle weakness, which has, indeed, been confirmed by a variety of physical performance tests...
  31. ncbi Deoxyribonucleotides and disorders of mitochondrial DNA integrity
    Ann Saada
    Metabolic Disease Unit, Shaare Zedek Medical Center, Jerusalem, Israel
    DNA Cell Biol 23:797-806. 2004
    ..This article reviews the current knowledge of deoxyribonucleotide metabolism in relation to disorders affecting mtDNA integrity...
  32. pmc alpha-Synuclein abnormalities in mouse models of peroxisome biogenesis disorders
    Eugenia Yakunin
    Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel Canada, Hebrew University, Jerusalem, Israel
    J Neurosci Res 88:866-76. 2010
    ..Furthermore, we show that alphaS abnormalities correlate with the altered lipid metabolism and, specifically, with accumulation of long chain, n-6 polyunsaturated fatty acids that occurs in the PBD models...
  33. doi TAT-mediated delivery of LAD restores pyruvate dehydrogenase complex activity in the mitochondria of patients with LAD deficiency
    Matan Rapoport
    Department of Cellular Biochemistry and Human Genetics, Faculty of Medicine, Hebrew University, Jerusalem, Israel
    Mol Ther 16:691-7. 2008
    ..We believe that this approach involving TAT-mediated enzyme replacement therapy (ERT) can be applied to the treatment of LAD deficiency as well as to other mitochondrial and metabolic disorders...
  34. ncbi Depletion of the other genome-mitochondrial DNA depletion syndromes in humans
    Orly Elpeleg
    Hebrew University, Faculty of Medicine, Jerusalem, Israel
    J Mol Med (Berl) 80:389-96. 2002
    ..We also speculate on future genes to be discovered in other phenotypes of mtDNA depletion...