Tamir Ben-Hur

Summary

Affiliation: Hadassah University Hospital
Country: Israel

Publications

  1. ncbi request reprint Involvement of brain cytokines in the neurobehavioral disturbances induced by HIV-1 glycoprotein120
    Ohr Barak
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, 91905, Israel
    Brain Res 933:98-108. 2002
  2. ncbi request reprint Stem cell therapy for myelin diseases
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Curr Drug Targets 6:3-19. 2005
  3. doi request reprint Cell-based reparative therapies for multiple sclerosis
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Curr Neurol Neurosci Rep 13:397. 2013
  4. ncbi request reprint Acute effects of purified and UV-inactivated Herpes simplex virus type 1 on the hypothalamo-pituitary-adrenocortical axis
    T Ben-Hur
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University, Jerusalem, Israel
    Neuroendocrinology 74:160-6. 2001
  5. doi request reprint Prospects of cell therapy for disorders of myelin
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Ann N Y Acad Sci 1142:218-49. 2008
  6. ncbi request reprint Role of the central amygdala in modulating the pituitary-adrenocortical and clinical responses in experimental herpes simplex virus-1 encephalitis
    Joseph Weidenfeld
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Neuroendocrinology 81:267-72. 2005
  7. pmc Reconstructing neural circuits using transplanted neural stem cells in the injured spinal cord
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical School, Jerusalem, Israel
    J Clin Invest 120:3096-8. 2010
  8. ncbi request reprint Immunization with a nonpathogenic HSV-1 strain prevents clinical and neuroendocrine changes of experimental HSV-1 encephalitis
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, P O Box 12, 000, Jerusalem 91120, Israel
    J Neuroimmunol 152:5-10. 2004
  9. ncbi request reprint Human embryonic stem cells for neuronal repair
    Tamir Ben-Hur
    Department of Neurology, Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Isr Med Assoc J 8:122-6. 2006
  10. ncbi request reprint Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Mol Cell Neurosci 24:623-31. 2003

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Involvement of brain cytokines in the neurobehavioral disturbances induced by HIV-1 glycoprotein120
    Ohr Barak
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, 91905, Israel
    Brain Res 933:98-108. 2002
    ....
  2. ncbi request reprint Stem cell therapy for myelin diseases
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Curr Drug Targets 6:3-19. 2005
    ....
  3. doi request reprint Cell-based reparative therapies for multiple sclerosis
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Curr Neurol Neurosci Rep 13:397. 2013
    ..Major challenges in clinical translation include the determination of the optimal cellular platform, the route of cell delivery, and candidate patients for treatment. ..
  4. ncbi request reprint Acute effects of purified and UV-inactivated Herpes simplex virus type 1 on the hypothalamo-pituitary-adrenocortical axis
    T Ben-Hur
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University, Jerusalem, Israel
    Neuroendocrinology 74:160-6. 2001
    ..Adrenalectomized rats failed to respond to ICV inoculation of purified HSV-1 by increase in ACTH. In contrast, these rats responded to ICV injection of LPS...
  5. doi request reprint Prospects of cell therapy for disorders of myelin
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Ann N Y Acad Sci 1142:218-49. 2008
    ..In this review we consider the potential application of cell-based therapeutic strategies to disorders of myelin, highlighting the promises as well as the problems and potential perils of this treatment approach...
  6. ncbi request reprint Role of the central amygdala in modulating the pituitary-adrenocortical and clinical responses in experimental herpes simplex virus-1 encephalitis
    Joseph Weidenfeld
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Neuroendocrinology 81:267-72. 2005
    ..These responses were also attenuated in rats with cAMG lesions. The cAMG plays an important role in mediating the neuroendocrine, febrile and behavioral responses to HSV-1 infection...
  7. pmc Reconstructing neural circuits using transplanted neural stem cells in the injured spinal cord
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical School, Jerusalem, Israel
    J Clin Invest 120:3096-8. 2010
    ....
  8. ncbi request reprint Immunization with a nonpathogenic HSV-1 strain prevents clinical and neuroendocrine changes of experimental HSV-1 encephalitis
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, P O Box 12, 000, Jerusalem 91120, Israel
    J Neuroimmunol 152:5-10. 2004
    ..Mortality was completely prevented. These results indicate that immunization with HSV-1 strain R-15 protects rats from lethal HSV-1 encephalitis and prevents its clinical and neurochemical manifestations...
  9. ncbi request reprint Human embryonic stem cells for neuronal repair
    Tamir Ben-Hur
    Department of Neurology, Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Isr Med Assoc J 8:122-6. 2006
    ....
  10. ncbi request reprint Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Mol Cell Neurosci 24:623-31. 2003
    ..TNFalpha and IFNgamma increased outward migration of cells from spheres in vitro. Thus, TNFalpha and IFNgamma, key players in MS and EAE, inhibit NPC proliferation and induce their migration...
  11. pmc Cell therapy for multiple sclerosis
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
    Neurotherapeutics 8:625-42. 2011
    ..An initial clinical trial has established the probable safety of their intravenous and intrathecal delivery. Short-term follow-up observed immunomodulatory effects and clinical benefit justifying further clinical trials...
  12. ncbi request reprint Cytokine-mediated modulation of MMPs and TIMPs in multipotential neural precursor cells
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Neuroimmunol 175:12-8. 2006
    ..IFN-beta, on the other hand, appears to have an anti-proteolytic influence that may attenuate such NPC-mediated repair processes...
  13. ncbi request reprint Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Glia 41:73-80. 2003
    ..Thus, the inflammatory process may attract targeted migration of transplanted precursor cells into the brain parenchyma...
  14. ncbi request reprint Immunomodulation by neural stem cells
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
    J Neurol Sci 265:102-4. 2008
    ..In conclusion, neural precursor cells exert an immunomodulatory effect that inhibits CNS inflammation. Cell therapy in MS should be optimized to utilize both regenerative and immunologic properties of the cells...
  15. ncbi request reprint A novel permissive role for glucocorticoids in induction of febrile and behavioral signs of experimental herpes simplex virus encephalitis
    T Ben-Hur
    Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Neuroscience 108:119-27. 2001
    ..Circulating glucocorticoids play an essential permissive role in the induction of these host brain responses...
  16. doi request reprint Time limited immunomodulatory functions of transplanted neural precursor cells
    Nina Fainstein
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center Jerusalem, Israel
    Glia 61:140-9. 2013
    ..Thus, the immunomodulatory effects of neural precursor cell transplantation are limited in time...
  17. ncbi request reprint Transplanted neural precursor cells reduce brain inflammation to attenuate chronic experimental autoimmune encephalomyelitis
    Ofira Einstein
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Exp Neurol 198:275-84. 2006
    ..We suggest that the beneficial effect of transplanted NPCs in chronic EAE is mediated, in part, by decreasing brain inflammation and reducing tissue injury...
  18. pmc Conserved fate and function of ferumoxides-labeled neural precursor cells in vitro and in vivo
    Mikhal E Cohen
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Medical Center, Jerusalem, Israel
    J Neurosci Res 88:936-44. 2010
    ..These results demonstrate that ferumoxides-based MRI cell tracking is well suited for non-invasive monitoring of NPC transplantation...
  19. ncbi request reprint Neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression
    Ofira Einstein
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Ann Neurol 61:209-18. 2007
    ..Although stem cell therapy was introduced initially for cell replacement, we examine here whether NPCs possess immunomodulatory effects...
  20. pmc Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis
    Dimitrios Karussis
    Department of Neurology, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem IL 91120, Israel
    Arch Neurol 67:1187-94. 2010
    ....
  21. ncbi request reprint Survival of neural precursor cells in growth factor-poor environment: implications for transplantation in chronic disease
    Ofira Einstein
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Glia 53:449-55. 2006
    ....
  22. ncbi request reprint Intraventricular transplantation of neural precursor cell spheres attenuates acute experimental allergic encephalomyelitis
    Ofira Einstein
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Mol Cell Neurosci 24:1074-82. 2003
    ..Thus, transplanted NPCs attenuate acute EAE via an anti-inflammatory mechanism which depends on cell ability to migrate into inflamed brain tissue...
  23. ncbi request reprint Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats
    Tamir Ben-Hur
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Jerusalem, Israel
    Stem Cells 22:1246-55. 2004
    ..Our observations encourage further developments for the potential use of hESCs in the treatment of Parkinson's disease...
  24. ncbi request reprint Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis
    Ibrahim Kassis
    Department of Neurology and Agnes Ginges Center for Neurogenetics, Jerusalem, Israel
    Arch Neurol 65:753-61. 2008
    ..To investigate the therapeutic potential of mesenchymal stromal cells (MSCs) in the chronic model of experimental autoimmune encephalomyelitis (EAE)...
  25. ncbi request reprint Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells
    Eyal Banin
    Department of Ophthalmology, The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, P O Box 12, 000, Ein Kerem, Jerusalem 91120, Israel
    Stem Cells 24:246-57. 2006
    ..This may be the first step toward further developments that eventually may allow the use of hESCs for transplantation in retinal degenerations...
  26. doi request reprint Transplanted neural precursors enhance host brain-derived myelin regeneration
    Ofira Einstein
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    J Neurosci 29:15694-702. 2009
    ..In conclusion, NPC transplantation enhances host-derived myelin regeneration following chronic demyelination. This trophic effect may stimulate resident OPCs to overcome the remyelination failure in multiple sclerosis...
  27. doi request reprint The changing face of neural stem cell therapy in neurologic diseases
    Ofira Einstein
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel
    Arch Neurol 65:452-6. 2008
    ..Herein, we review recent developments and future prospects of NSC therapy in neurologic diseases...
  28. ncbi request reprint Intraarterial multi-modal reperfusion therapy for acute ischemic stroke: a10 year single-center experience
    Roni Eichel
    Department of Neurology, Center for Neurogenetics and Cerebrovascular Research Laboratory, Hadassah University Hospital and Hebrew University Hadassah Medical School, Jerusalem, Israel
    Isr Med Assoc J 14:479-83. 2012
    ..Only 0.5% of stroke patients in Israel are treated with endovascular multi-modal reperfusion therapy (MMRT) each year...
  29. ncbi request reprint Glucocorticoid resistance following herpes simplex-1 infection: role of hippocampal glucocorticoid receptors
    Dafna Bener
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Neuroendocrinology 85:207-15. 2007
    ..The results suggest that HSV-1 induced GC resistance may be mediated by downregulation of GC receptors in hippocampal tissue. These results may clarify a mechanism responsible for GC resistance following immune challenges...
  30. pmc Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclerosis
    Michal Aharonowiz
    The Hadassah Human Embryonic Stem Cells Research Center, The Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 3:e3145. 2008
    ..A potential new therapeutic approach for MS is cell transplantation which may promote remyelination and suppress the inflammatory process...
  31. ncbi request reprint Neural precursor cells inhibit multiple inflammatory signals
    Nina Fainstein
    Department of Neurology, The Agnes Ginges Center of Human Neurogenetics, Hadassah Hebrew University Medical Center, EinKerem, Jerusalem, Israel
    Mol Cell Neurosci 39:335-41. 2008
    ..In conclusion, NPCs ameliorate TCR-mediated T cell activation and inhibit inflammatory cytokines' signaling in immune cells. These findings may underlie the broad anti-inflammatory effects of NPCs in vivo...
  32. doi request reprint Recanalization of symptomatic carotid artery dissections causing occlusion with multiple stents: the use of delayed double-contrast road map
    Jose E Cohen
    Department of Neurosurgery, Hadassah University Medical Center, Jerusalem, Israel
    Neurol Res 32:293-6. 2010
    ..Spontaneous ICAD causing occlusion successfully recanalized with multiple telescoped stents extending intracranially has only been reported exceptionally...
  33. ncbi request reprint Manganese-enhanced MRI in a rat model of Parkinson's disease
    Galit Pelled
    MRI MRS Laboratory, Human Biology Research Center, Department of Medical Biophysics and Nuclear Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Magn Reson Imaging 26:863-70. 2007
    ..To measure intra- and inter-hemispheric connectivity within the basal ganglia (BG) nuclei in healthy and in unilateral 6-hydroxydopamine (6-OHDA) Parkinson disease rat model in order to test the BG interhemispheric connectivity hypothesis...
  34. ncbi request reprint Intrahippocampal transplantation of transgenic neural precursor cells overexpressing interleukin-1 receptor antagonist blocks chronic isolation-induced impairment in memory and neurogenesis
    Ofra Ben Menachem-Zidon
    Department of Psychology, The Hebrew University of Jerusalem, Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Neuropsychopharmacology 33:2251-62. 2008
    ....
  35. doi request reprint Temporal reorganization to overcome monocular demyelination
    Noa Raz
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Neurology 81:702-9. 2013
    ....
  36. ncbi request reprint The use of telescoped flow diverters as an endovascular bypass in the management of symptomatic chronic carotid occlusion
    Jose E Cohen
    Department of Neurosurgery, Hadassah Hebrew University Medical Center, P O Box 12000, Jerusalem 91120, Israel
    J Clin Neurosci 19:1026-8. 2012
    ..The optimal application of these devices will continue to be defined as clinical experience evolves...
  37. doi request reprint Myasthenia gravis-associated neuromyelitis optica-like disease: an immunological link between the central nervous system and muscle?
    Adi Vaknin-Dembinsky
    Department of Neurology, Multiple Sclerosis Center and Immunobiology Research Laboratory, Hadassah University Hospital, Ein Kerem, PO Box 12000, Jerusalem 91120, Israel
    Arch Neurol 68:1557-61. 2011
    ..Aquaporin 4 (AQP4), the target autoantigen in neuromyelitis optica, is expressed both in the CNS and in the neuromuscular junction...
  38. pmc Gliomas display a microRNA expression profile reminiscent of neural precursor cells
    Iris Lavon
    Department of Neurology, Hadassah Hebrew University Medical Centre, Leslie and Michael Gaffin Centre for Neuro Oncology, Jerusalem, Israel
    Neuro Oncol 12:422-33. 2010
    ..Furthermore, careful study of the 15 miRNAs that differ in expression between SCs and gliomas, particularly those 5 that are not SC-specific, may enhance our understanding of gliomagenesis...
  39. ncbi request reprint A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics
    Hanna Rosenmann
    The Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Medical Center, Jerusalem, Israel
    Exp Neurol 212:71-84. 2008
    ....
  40. doi request reprint The effect of herpes simplex virus-1 on nitric oxide synthase in the rat brain: the role of glucocorticoids
    Joseph Hasson
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
    Neuroimmunomodulation 18:111-6. 2011
    ..The effect of glucocorticoids (GCs) on NOS responses to HSV-1 was also determined...
  41. ncbi request reprint Implementing novel imaging methods for improved diagnosis of disorder of consciousness patients
    Atira S Bick
    fMRI unit, Department of Neurology, Hadassah Hebrew University Medical Center, Jerusalem, Israel Electronic address
    J Neurol Sci 334:130-8. 2013
    ..Translating novel imaging methods into the clinical evaluation of DOC patients is essential for better diagnosis and may encourage treatment development. ..
  42. pmc Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies
    Haya Kisos
    Biochemistry and Molecular Biology, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 7:e46817. 2012
    ..Hence, pathogenic mechanisms leading to elevated levels of α-Syn in neurons underlie neuronal secretion and subsequent uptake of α-Syn by oligodendrocytes in MSA...
  43. doi request reprint Rehabilitation outcomes of stroke patients treated with tissue plasminogen activator
    Zeev Meiner
    Department of Physical Medicine, POB 24035, Hadassah Hebrew University Medical Center, Jerusalem, 91240 Israel
    PM R 2:698-702; quiz 792. 2010
    ..To investigate the influence of thrombolysis on functional outcomes after rehabilitation...
  44. doi request reprint Decompressive hemicraniectomy improves outcome in patients with failed arterial recanalization after acute carotid artery occlusion
    David Arkadir
    Department of Neurology, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Neurol Res 32:1077-82. 2010
    ..Decompressive hemicraniectomy reduces morbidity and mortality in patients with large hemispheric stroke. However, its role in patients that underwent failed endovascular reperfusion remains unknown...
  45. ncbi request reprint Reversal of heroin neurobehavioral teratogenicity by grafting of neural progenitors
    Sophia Katz
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neurochem 104:38-49. 2008
    ..Neural progenitor grafting thus offers an animal model for reversing neurobehavioral deficits originating in septohippocampal cholinergic defects elicited by pre-natal exposure to insults...
  46. ncbi request reprint Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production
    Yehuda Pollak
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel
    Ann Neurol 57:741-5. 2005
    ..These findings demonstrate that cholinergic enhancement produces central and peripheral antiinflammatory effects and suggest a novel therapeutic mechanism for acetylcholinesterase inhibitors...
  47. ncbi request reprint Pomegranate seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: the case of genetic CJD
    Michal Mizrahi
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
    Nanomedicine 10:1353-63. 2014
    ..We propose that Nano-PSO and alike formulations may be both beneficial and safe enough to be administered for long years to subjects at risk or to those already affected by neurodegenerative conditions...
  48. ncbi request reprint Demyelination affects temporal aspects of perception: an optic neuritis study
    Noa Raz
    The Agnes Ginges Center for Human Neurogenetics, Laboratory for Neuroimmunology, The Department of Neurology, Jerusalem, Israel
    Ann Neurol 71:531-8. 2012
    ..We hypothesized that dynamic visual processes, such as motion perception, may be more vulnerable to slowed conduction in the optic nerve, and consequently be better associated with projection rates...
  49. doi request reprint Natural course and pathogenesis of transient focal neurologic symptoms during pregnancy
    Anatoly Liberman
    Department of Neurology, Hebrew University Hadassah Medical Center, Hadassah Ein Kerem, Jerusalem, Israel
    Arch Neurol 65:218-20. 2008
    ..To determine the pathogenesis and course of transient focal neurologic symptoms in pregnant women and to identify prognostic variables that will enable targeted workup...
  50. ncbi request reprint Stable genetic modification of human embryonic stem cells by lentiviral vectors
    Michal Gropp
    The Goldyne Savad Institute of Gene Therapy, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, 91120 Jerusalem, Israel
    Mol Ther 7:281-7. 2003
    ..Genetic modification of hES cells by lentiviral vectors provides a powerful tool for basic and applied research in the area of human ES cells...
  51. doi request reprint Prior use of angiotensin-converting enzyme inhibitors does not affect outcome in patients with intracerebral hemorrhage
    Roni Eichel
    Cerebrovascular Service and the Periz and Chantel Sheinberg Cerebrovascular Research Laboratory, Department of Neurology, Hadassah Hebrew University Medical Center, Israel
    Neurol Res 32:905-9. 2010
    ..Angiotensin-converting enzyme inhibitors (ACEI) exert protective effects in patients with stroke but their effects remain unknown in patients with intracerebral hemorrhage (ICH)...
  52. ncbi request reprint Misleading one detail: a preventable mode of diagnostic error?
    Shahar Arzy
    Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    J Eval Clin Pract 15:804-6. 2009
    ..The presence of a single misleading detail may lead clinicians down a cognitive and actual path toward an incorrect diagnosis...
  53. ncbi request reprint Novel therapies for acute ischemic stroke
    Ronen R Leker
    Department of Neurology, Ginges Center for Neurogenetics, Scheinberg Cerebrovascular Research Laboratory, Hadassah University Hospital, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Isr Med Assoc J 8:788-92. 2006
    ..The current situation calls for novel therapeutic strategies to be used in acute ischemic stroke. This review surveys some of these novel and promising cutting edge therapies...
  54. ncbi request reprint Susac syndrome
    Menachem Gross
    Department of Otolaryngology Head and Neck Surgery, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Otol Neurotol 25:470-3. 2004
    ..The objective of this study was to describe the clinical manifestations; radiographic, audiometric, and retinal fluorescein angiography findings; pathogenesis and treatment of Susac syndrome with review of the literature...
  55. ncbi request reprint Reduced basal activity and increased functional homogeneity in sensorimotor and striatum of a Parkinson's disease rat model: a functional MRI study
    Galit Pelled
    MRI MRS Lab, the Human Biology Research Center, Department of Medical Biophysics, Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Eur J Neurosci 21:2227-32. 2005
    ....
  56. ncbi request reprint Category specific dysnomia after thalamic infarction: a case-control study
    Netta Levin
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Neuropsychologia 43:1385-90. 2005
    ..This might reflect the role of the thalamus not only as a relay station but further as a central integrator of different stages of perceptual and semantic processing...
  57. ncbi request reprint The thyroid hormone, triiodothyronine, enhances fluoxetine-induced neurogenesis in rats: possible role in antidepressant-augmenting properties
    Renana Eitan
    Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Int J Neuropsychopharmacol 13:553-61. 2010
    ....
  58. ncbi request reprint Reversible functional connectivity disturbances during transient global amnesia
    Michael Peer
    Department of Neurology, Hadassah Hebrew University Medical School, Jerusalem, Israel Faculty of Medicine, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Ann Neurol 75:634-43. 2014
    ..Despite extensive research, there is no clear evidence for the underlying pathophysiological basis of TGA. Moreover, there is no neuroimaging method to evaluate TGA in real time...
  59. doi request reprint Hypnotic relaxation vs amitriptyline for tension-type headache: let the patient choose
    Yacov Ezra
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Medical Center, Jerusalem, Israel
    Headache 52:785-91. 2012
    ....
  60. ncbi request reprint Patterns of misdiagnosis of multiple sclerosis
    Netta Levin
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
    Isr Med Assoc J 5:489-90. 2003
    ..This variability in the clinical presentation may result in misdiagnosis, unnecessary referrals and misleading information to the patients...
  61. ncbi request reprint Induced neuroprotection independently from PrPSc accumulation in a mouse model for prion disease treated with simvastatin
    Yaron Haviv
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
    Arch Neurol 65:762-75. 2008
    ..Previous in vitro studies suggest that cholesterol-lowering drugs inhibit the conversion of PrP(C) to PrP(Sc) and the accumulation of the latter, possibly through the disturbance of cholesterol-rich membrane domains (lipid rafts)...
  62. ncbi request reprint Limbic encephalitis presenting as a post-partum psychiatric condition
    Marc Gotkine
    Department of Neurology, Hadassah University Hospital, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neurol Sci 308:152-4. 2011
    ..These antibodies are found in many non-paraneoplastic patients with LE. Although antibody-mediated conditions tend to present or relapse post-partum, VGKC-LE in the post-partum period has not been described...
  63. ncbi request reprint Endovascular stent-assisted angioplasty in the management of traumatic internal carotid artery dissections
    Jose E Cohen
    Department of Neurosurgery, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Stroke 36:e45-7. 2005
    ..The prognosis of traumatic dissection of the internal carotid artery is worse than for spontaneous dissections. Rapid stenting followed by antiplatelet therapy may prevent complications when anticoagulation therapy is not applicable...
  64. ncbi request reprint Extrathymic malignancies in patients with myasthenia gravis
    Netta Levin
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
    J Neurol Sci 237:39-43. 2005
    ..Data on clinical characteristics of MG patients with extrathymic malignancies and the role of concomitant diseases and their treatment are lacking...
  65. ncbi request reprint Intracerebral HIV-1 glycoprotein 120 produces sickness behavior and pituitary-adrenal activation in rats: role of prostaglandins
    Ohr Barak
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    Brain Behav Immun 16:720-35. 2002
    ..Prostaglandins are important mediators of the physiological, but not the behavioral effects of brain gp120...
  66. ncbi request reprint Serial in vivo MR tracking of magnetically labeled neural spheres transplanted in chronic EAE mice
    Tamir Ben-Hur
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 57:164-71. 2007
    ..The results are directly relevant for designing and optimizing cell therapies for MS, and achieving a better understanding of in vivo cell dynamics and cell-tissue interactions...
  67. ncbi request reprint A dual role for interleukin-1 in hippocampal-dependent memory processes
    Inbal Goshen
    Department of Psychology, The Hebrew University, Jerusalem 91905, Israel
    Psychoneuroendocrinology 32:1106-15. 2007
    ..e., a slight increase in brain IL-1 levels can improve memory, whereas any deviation from the physiological range, either by excess elevation in IL-1 levels or by blockade of IL-1 signaling, results in impaired memory...
  68. ncbi request reprint MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain
    Jeff W M Bulte
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    Magn Reson Med 50:201-5. 2003
    ..The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols...
  69. ncbi request reprint PKCepsilon induces astrocytic differentiation of multipotential neural precursor cells
    Rivka Steinhart
    Gonda Goldschmied Medical Diagnosis Research Center, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Glia 55:224-32. 2007
    ..Our data suggest an important role of PKCepsilon in astrocytic differentiation and implicate Notch1 as a possible mediator of this effect...
  70. ncbi request reprint Nutritional status, cognition, and survival: a new role for leptin and AMP kinase
    Yossi Dagon
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem 91120
    J Biol Chem 280:42142-8. 2005
    ..Should these findings extend to Man, then controlled activation of AMPK may improve neurodegenerative diseases, and leptin may have a new role in treating stress-associated malnutrition...
  71. ncbi request reprint Axonal damage in multiple sclerosis: a complex issue in a complex disease
    Nikolaos Grigoriadis
    Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 Stilp Kyriakidi Str, 54636 Thessaloniki, Greece
    Clin Neurol Neurosurg 106:211-7. 2004
    ..Experimental data suggest that therapeutic interventions such as the induction of rapid remyelination may lead to the protection of axons. In addition to immunomodulation, future strategies for neuroprotection may be of great importance...