Affiliation: Hadassah University Hospital
- The spectrum of MEFV clinical presentations--is it familial Mediterranean fever only?Eldad Ben-Chetrit
Department of Medicine, Hadassah Hebrew University Hospital, Ein Kerem, Israel
Rheumatology (Oxford) 48:1455-9. 2009..This gene is considered to be responsible only for FMF. In the present study, we tried to find out whether the MEFV gene is associated with or responsible for clinical conditions other than FMF...
- Familial mediterranean Fever and hypercoagulabilityOshrat E Tayer-Shifman
Rheumatology Unit, Division of Medicine, Hadassah Hebrew University Medical Center Jerusalem, Israel
Mediterr J Hematol Infect Dis 3:e2011017. 2011..Colchicine which is the treatment of choice in FMF may also play a role in reducing inflammation thereby decreasing hypercoagulability...
- Kimura's disease and Behcet's syndrome in the same family--are they associated?Eldad Ben-Chetrit
Department of Medicine, Rheumatology Unit, Hadassah Hebrew University Medical Center Head, POB 12000, Jerusalem, Israel
Joint Bone Spine 80:44-7. 2013..Recently, we encountered a family whose three siblings suffer from BD and an additional brother suffers from KD. This observation raised the question as to whether both diseases have a common underlying genetic basis...
- Relapsing macrophage activating syndrome in a 15-year-old girl with Still's disease: a case reportMeir Mizrahi
Department of Internal Medicine A, Hadassah Hebrew University Medical Center, POB 12000, Ein Kerem, Jerusalem, Israel
J Med Case Reports 3:138. 2009..Cases of relapse of macrophage activating syndrome are relatively rare...
- The E148Q mutation in the MEFV gene: is it a disease-causing mutation or a sequence variant?E Ben-Chetrit
Department of Medicine A, Hadassah Hebrew University, Jerusalem, Israel
Hum Mutat 15:385-6. 2000..Two healthy sibs of one of the E148Q homozygous were also homozygous E148Q. These observations are not in accordance to the notion that E148Q is a mutation causing disease...
- The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2Eldad Ben-Chetrit
FMF Clinic, Department of Medicine, Hadassah University Hospital, POB 12000, Jerusalem, Israel
Rheumatol Int 25:332-5. 2005..The aim of this study was to test whether colchicine and hydroxychloroquine have an inhibitory effect on cyclo-oxygenases (COX)...
- The outcome of pregnancy in the wives of men with familial mediterranean fever treated with colchicineEldad Ben-Chetrit
Department of Medicine, Hadassah University Hospital, POB 12000, Jerusalem, Israel
Semin Arthritis Rheum 34:549-52. 2004..To evaluate the outcome of pregnancies of normal women married to men with familial Mediterranean fever (FMF), some of whom took colchicine during the conception with their wives...
- Cetirizine: An effective agent in Kimura's diseaseEldad Ben-Chetrit
Hadassah and Hebrew University Medical Center, Jerusalem, Israel
Arthritis Rheum 53:117-8. 2005
- Mechanism of the anti-inflammatory effect of colchicine in rheumatic diseases: a possible new outlook through microarray analysisE Ben-Chetrit
Department of Biochemistry, School of Medicine, Stanford University, CA, USA
Rheumatology (Oxford) 45:274-82. 2006..We aim to study the molecular basis of colchicine action by analysing the effect of this drug on global gene expression of HUVEC (human umbilical vein endothelial cell line) cells...
- Pregnancy outcomes in women with familial Mediterranean fever receiving colchicine: is amniocentesis justified?Eli Ben-Chetrit
Shaare Zedek Medical Center, Jerusalem, Israel
Arthritis Care Res (Hoboken) 62:143-8. 2010..To evaluate the outcome of pregnancies in women with familial Mediterranean fever (FMF) who are taking colchicine, and to reconsider the justification for amniocentesis in these women...
- Colchicine-induced leukopenia in a patient with familial Mediterranean fever: the cause and a possible approachE Ben-Chetrit
Department of Medicine, Hadassah University Hospital, Jerusalem, POB12000, Israel
Clin Exp Rheumatol 21:S38-40. 2003..In the case of bone marrow suppression, colchicine should be continued with injections of G-CSF, whereas if the bone marrow is hypercellular it is suggested to use steroids and colchicine concomitantly...
- Molecular diagnosis of FMF: lessons from a study of 446 unrelated individualsE Ben-Chetrit
Department of Medicine, Hadassah University Hospital in Ein Kerem, Jerusalem, Israel
Clin Exp Rheumatol 20:S25-9. 2002..Following the cloning of the gene associated with this disease (MEFV), genetic analysis of its mutations has become available, providing a new tool for the establishment or confirmation of the diagnosis of FMF...
- Reproductive system in familial Mediterranean fever: an overviewE Ben-Chetrit
FMF Unit, Department of Medicine, Hadassah University Hospital, Jerusalem, Israel
Ann Rheum Dis 62:916-9. 2003..However, colchicine may induce oligospermia/azoospermia, but this effect is rare. Overall, colchicine treatment improves the prognosis of patients with FMF and increases their reproductive ability...
- Amyloidosis induced, end stage renal disease in patients with familial Mediterranean fever is highly associated with point mutations in the MEFV geneE Ben-Chetrit
Rheumatology Unit, Department of Medicine, Hadassah University Hospital, Jerusalem, Israel
Ann Rheum Dis 60:146-9. 2001..Recently the gene (MEFV) causing this disease was cloned and more than 18 mutations have been identified. The hypothesis that the development of amyloidosis is associated with one of these mutations was tested...
- Familial mediterranean fever and Behçet's disease--are they associated?Eldad Ben-Chetrit
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel
J Rheumatol 29:530-4. 2002..To test whether the coexistence of familial Mediterranean fever (FMF) and Behçet's disease (BD) is more frequent than expected and whether each disease affects the severity of the other...
- Familial Mediterranean fever (FMF) and renal AA amyloidosis--phenotype-genotype correlation, treatment and prognosisEldad Ben-Chetrit
Department of Medicine, FMF Clinic, Hadassah University Hospital, Jerusalem, Israel
J Nephrol 16:431-4. 2003..The risk of amyloidosis is increased in male FMF patients and in patients bearing polymorphism a/a in the SAA1 gene. Colchicine is the chosen drug for the treatment of FMF and can prevent amyloidosis...
- Major vessel thrombosis in Behçet's disease: the dilemma of anticoagulant therapy - the approach of rheumatologists from different countriesOshrat E Tayer-Shifman
Hadassah Hebrew University Medical Center, Jerusalem, Israel
Clin Exp Rheumatol 30:735-40. 2012..Our objective was to raise this therapeutic dilemma and to call for controlled studies to help establish guidelines to address this problem...
- Familial Mediterranean fever: a critical digest of the 2012-2013 literatureEli M Eisenstein
Department of Pediatrics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Clin Exp Rheumatol 31:103-7. 2013..In this review, we summarise these and other salient findings from the recent FMF literature, and discuss their significance for the clinician. ..
- Laryngeal involvement in Behcet's disease--a challenge for treatmentMenachem Gross
Department of Otolaryngology Head and Neck Surgery, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Clin Rheumatol 32:S75-7. 2013..Although some cases may still require surgical intervention, the therapeutic option of anti-TNF agents, specifically anti-TNF antibodies such as infliximab, may decrease the need for the surgical option...
- Pulmonary hemorrhage in antiphospholipid antibody syndromeAnat Scheiman Elazary
Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
J Rheumatol 39:1628-31. 2012..To characterize the clinical manifestations of patients with antiphospholipid antibody syndrome (APS) and pulmonary hemorrhage (PH)...
- Serum levels of anti-streptolysin O antibodies: their role in evaluating rheumatic diseasesEli Ben-Chetrit
Department of Medicine, Shaare Zedek Medical Center, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Int J Rheum Dis 15:78-85. 2012..Family physicians measure serum levels of anti-streptolysin O antibodies (ASO) in the routine evaluation of patients with rheumatic conditions...
- Fatal nephrotic syndrome complicating allogeneic stem cell transplantation: a case reportIddo Z Ben-Dov
Hadassah Hebrew University Medical Center, Jerusalem, Israel
Nephrol Dial Transplant 24:2946-9. 2009..Physicians should be aware of the possibility that infections and inflammation accompanying the post-transplantation period may rarely promote the development of systemic amyloidosis or exacerbate silent pre-existing disease...
- Major bleeding caused by warfarin in a genetically susceptible patientAharon Bloch
Division of Medicine, Hadassah University Hospital, Jerusalem, Israel
Pharmacotherapy 22:97-101. 2002..The patient's enhanced sensitivity to warfarin 5 mg/day can be ascribed to decreased clearance of S-warfarin secondary to genetic alteration of the gene encoding CYP2C9, resulting in a life-threatening complication...
- The distribution of MEFV common mutations among Israeli patients with familial Mediterranean feverEldad Ben-Chetrit
Isr Med Assoc J 5:592-4. 2003
- Country as the primary risk factor for renal amyloidosis in familial Mediterranean feverIsabelle Touitou
Hopital Arnaud de Villeneuve, Montpellier, France
Arthritis Rheum 56:1706-12. 2007..The aim of this study was to examine the controversial issue of amyloidosis susceptibility in FMF by determining the relative contributions of MEFV and numerous epidemiologic factors to the risk of renal amyloidosis...
- Effect of colchicine and cytokines on MEFV expression and C5a inhibitor activity in human primary fibroblast culturesSuzan Abedat
Hematology Unit, Hadassah Hospitals, Mount Scopus, Israel
Isr Med Assoc J 4:7-12. 2002..A C5a inhibitor, previously detected in normal serosal fluids, was recently identified in serosal cultures as well, and was found to be deficient in serosal fluids and cultures obtained from FMF patients...
- Allogenic bone marrow transplantation: not a treatment yet for familial Mediterranean feverIsabelle Touitou
Blood 102:409. 2003
- The rise and fall of FMF research--fifty years of publicationsEli Ben-Chetrit
Clin Exp Rheumatol 23:S3-7. 2005
- Peritoneal adhesions and intestinal obstructions in patients with familial Mediterranean fever--are they more frequent?Yackov Berkun
Department of Pediatrics, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
Semin Arthritis Rheum 36:316-21. 2007..The aim of the study was to estimate the rate of spontaneous or postsurgical small-bowel obstruction (SBO) in FMF patients...
- Periodic fever in infants: familial Mediterranean fever only?Eldad Ben-Chetrit
Isr Med Assoc J 5:739-40. 2003