Nir Giladi

Summary

Country: Israel

Publications

  1. ncbi request reprint Rater-blinded, prospective comparison: quetiapine versus clozapine for Parkinson's disease psychosis
    Doron Merims
    Movement Disorders Unit, National Parkinson Foundation Parkinson s Center, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    Clin Neuropharmacol 29:331-7. 2006
  2. ncbi request reprint New onset heightened interest or drive for gambling, shopping, eating or sexual activity in patients with Parkinson's disease: the role of dopamine agonist treatment and age at motor symptoms onset
    Nir Giladi
    Movement Disorders Unit and Parkinson Centre, Department of Neurology, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel
    J Psychopharmacol 21:501-6. 2007
  3. doi request reprint A training program to improve gait while dual tasking in patients with Parkinson's disease: a pilot study
    Galit Yogev-Seligmann
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Arch Phys Med Rehabil 93:176-81. 2012
  4. doi request reprint Virtual reality for gait training: can it induce motor learning to enhance complex walking and reduce fall risk in patients with Parkinson's disease?
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
    J Gerontol A Biol Sci Med Sci 66:234-40. 2011
  5. ncbi request reprint Interference to consolidation phase gains in learning a novel movement sequence by handwriting: dependence on laterality and the level of experience with the written sequence
    Meirav Balas
    The Brain Behavior Research Center, University of Haifa, Haifa, Israel
    Exp Brain Res 180:237-46. 2007
  6. pmc Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease
    Merav Kedmi
    Genetic Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
    Mol Neurodegener 6:66. 2011
  7. pmc Automated detection of near falls: algorithm development and preliminary results
    Aner Weiss
    Laboratory for Gait and Neurodynamics and Movement Disorders Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    BMC Res Notes 3:62. 2010
  8. doi request reprint Rotigotine transdermal system for control of early morning motor impairment and sleep disturbances in patients with Parkinson's disease
    Nir Giladi
    Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, 6 Weizman Street, 64239 Tel Aviv, Israel
    J Neural Transm 117:1395-9. 2010
  9. doi request reprint Validation of the freezing of gait questionnaire in patients with Parkinson's disease
    Nir Giladi
    Movement Disorders Unit, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 24:655-61. 2009
  10. ncbi request reprint Freezing of gait in older adults with high level gait disorders: association with impaired executive function
    N Giladi
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Neural Transm 114:1349-53. 2007

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint Rater-blinded, prospective comparison: quetiapine versus clozapine for Parkinson's disease psychosis
    Doron Merims
    Movement Disorders Unit, National Parkinson Foundation Parkinson s Center, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    Clin Neuropharmacol 29:331-7. 2006
    ..To compare the safety and efficacy of quetiapine versus clozapine for the treatment of psychosis in patients with Parkinson's disease (PD)...
  2. ncbi request reprint New onset heightened interest or drive for gambling, shopping, eating or sexual activity in patients with Parkinson's disease: the role of dopamine agonist treatment and age at motor symptoms onset
    Nir Giladi
    Movement Disorders Unit and Parkinson Centre, Department of Neurology, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel
    J Psychopharmacol 21:501-6. 2007
    ..Age, gender and duration of treatment with DAs have an independent and additive effect on the risk to develop such behavioural changes. Patients should be informed about potential treatment-associated behavioural changes...
  3. doi request reprint A training program to improve gait while dual tasking in patients with Parkinson's disease: a pilot study
    Galit Yogev-Seligmann
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Arch Phys Med Rehabil 93:176-81. 2012
    ..The present results are also consistent with the possibility that DT gait training enhances divided attention abilities during walking...
  4. doi request reprint Virtual reality for gait training: can it induce motor learning to enhance complex walking and reduce fall risk in patients with Parkinson's disease?
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
    J Gerontol A Biol Sci Med Sci 66:234-40. 2011
    ..We hypothesized that VR may be applied to address the multifaceted deficits associated with fall risk in PD...
  5. ncbi request reprint Interference to consolidation phase gains in learning a novel movement sequence by handwriting: dependence on laterality and the level of experience with the written sequence
    Meirav Balas
    The Brain Behavior Research Center, University of Haifa, Haifa, Israel
    Exp Brain Res 180:237-46. 2007
    ....
  6. pmc Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease
    Merav Kedmi
    Genetic Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
    Mol Neurodegener 6:66. 2011
    ..abstract:..
  7. pmc Automated detection of near falls: algorithm development and preliminary results
    Aner Weiss
    Laboratory for Gait and Neurodynamics and Movement Disorders Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    BMC Res Notes 3:62. 2010
    ..The purpose of the present study was to develop a method for automatic detection of near falls, potentially a sensitive, objectivemarker of fall risk and to demonstrate the ability to detect near falls using this approach...
  8. doi request reprint Rotigotine transdermal system for control of early morning motor impairment and sleep disturbances in patients with Parkinson's disease
    Nir Giladi
    Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, 6 Weizman Street, 64239 Tel Aviv, Israel
    J Neural Transm 117:1395-9. 2010
    ..Rotigotine also improved sleep quality. These results suggest a role for rotigotine in treatment of nocturnal and early morning motor disabilities in PD patients...
  9. doi request reprint Validation of the freezing of gait questionnaire in patients with Parkinson's disease
    Nir Giladi
    Movement Disorders Unit, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 24:655-61. 2009
    ..1% using UPDRS item 14 (> or =1) (P < 0.001). FOG-Q was a reliable tool for the assessment of treatment intervention. FOG-Q item 3 was effective as a screening question for the presence of FOG...
  10. ncbi request reprint Freezing of gait in older adults with high level gait disorders: association with impaired executive function
    N Giladi
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Neural Transm 114:1349-53. 2007
    ..These results indicate that FOG is common in HLGD, and that it is associated with significant functional disability and a specific frontal cognitive disturbance of initiation...
  11. ncbi request reprint Rotigotine transdermal patch in early Parkinson's disease: a randomized, double-blind, controlled study versus placebo and ropinirole
    Nir Giladi
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 22:2398-404. 2007
    ..Application-site reactions were predominantly mild or moderate in intensity. In conclusion, the rotigotine transdermal patch represents an effective and safe option for the treatment of patients with early Parkinson's disease...
  12. ncbi request reprint The role of mental function in the pathogenesis of freezing of gait in Parkinson's disease
    Nir Giladi
    Movement Disorders Unit, NPF Center for Parkinson s Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Neurol Sci 248:173-6. 2006
    ..A conceptual model that explains how mental conditions may modulate FOG is developed...
  13. doi request reprint Effects of explicit prioritization on dual task walking in patients with Parkinson's disease
    Galit Yogev-Seligmann
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Gait Posture 35:641-6. 2012
    ..Both groups, however, use some form of the posture second strategy and naturally focus on the cognitive task...
  14. ncbi request reprint Dual-tasking effects on gait variability: the role of aging, falls, and executive function
    Shmuel Springer
    Movement Disorders Unit, Neurology Department, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Mov Disord 21:950-7. 2006
    ..In contrast, dual tasking destabilizes the gait of idiopathic elderly fallers, an effect that appears to be mediated in part by a decline in EF...
  15. ncbi request reprint Fall risk and gait in Parkinson's disease: the role of the LRRK2 G2019S mutation
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel School of Health Related Professions, Ben Gurion University, Beer Sheba, Israel
    Mov Disord 28:1683-90. 2013
    ..Therapeutic approach specifically designed to delay gait disturbances and falls may be justified in patients who carry the G2019S mutation...
  16. ncbi request reprint Dual tasking, gait rhythmicity, and Parkinson's disease: which aspects of gait are attention demanding?
    Galit Yogev
    Movement Disorders Unit, Neurology Department, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
    Eur J Neurosci 22:1248-56. 2005
    ..Moreover, the associations between executive function and gait variability suggest that a decline in executive function in PD may exacerbate the effects of dual tasking on gait, potentially increasing fall risk...
  17. pmc Gray matter atrophy distinguishes between Parkinson disease motor subtypes
    Keren Rosenberg-Katz
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Neurology 80:1476-84. 2013
    ..To assess differences in gray matter (GM) atrophy between 2 Parkinson disease (PD) subtypes: the tremor dominant (TD) subtype and the postural instability gait difficulty (PIGD) subtype...
  18. doi request reprint The age at motor symptoms onset in LRRK2-associated Parkinson's disease is affected by a variation in the MAPT locus: a possible interaction
    Ziv Gan-Or
    The Genetic Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel
    J Mol Neurosci 46:541-4. 2012
    ..7 ± 11.6) among carriers of the C/C genotype (p = 0.025). Our results further support a possible interaction between genetic factors in the MAPT region and the LRRK2 gene, which influence the clinical course of PD patients...
  19. ncbi request reprint Gait in attention deficit hyperactivity disorder : effects of methylphenidate and dual tasking
    Yael Leitner
    Paediatric Neurology Unit and Child Development Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Neurol 254:1330-8. 2007
    ..Cognitive function and the loading of attention presumably play an important role in gait as well as in fall risk, but previous work has not demonstrated this in any cause-and-effect way...
  20. pmc Executive control deficits as a prodrome to falls in healthy older adults: a prospective study linking thinking, walking, and falling
    Talia Herman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Gerontol A Biol Sci Med Sci 65:1086-92. 2010
    ..Indeed, the effects of dual tasking (DT) on gait, a challenge to executive control, are more exaggerated in persons with a history of falls. Prospective evidence is, however, lacking...
  21. doi request reprint Cognition in multiple system atrophy: neuropsychological profile and interaction with mood
    Meirav Balas
    Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Neural Transm 117:369-75. 2010
    ..The neuropsychological assessments of MSA patients should test for and then take into account their level of anxiety and depression, insofar as it might have an adverse effect on their cognitive performance...
  22. pmc Can methylphenidate reduce fall risk in community-living older adults? A double-blind, single-dose cross-over study
    Ron Ben-Itzhak
    Movement Disorders Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Am Geriatr Soc 56:695-700. 2008
    ..To test the hypothesis that methylphenidate modifies markers of fall risk in older adults...
  23. pmc Lower cognitive performance in healthy G2019S LRRK2 mutation carriers
    Avner Thaler
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
    Neurology 79:1027-32. 2012
    ..To assess cognitive abilities of healthy first-degree relatives of Ashkenazi patients with Parkinson disease (PD), carriers of the G2019S mutation in the LRRK2 gene...
  24. ncbi request reprint Effect of rivastigmine on tremor in patients with Parkinson's disease and dementia
    Tanya Y Gurevich
    Tel Aviv Medical Center, Department of Neurology, Movement Disorders Unit, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 21:1663-6. 2006
    ..08 +/- 0.03 xg at baseline; 0.12 +/- 0.02 xg at Week 12 of treatment, P = 0.02). Left-hand tremor amplitude did not change. Rivastigmine caused only slight worsening of tremor in demented PD patients, while improving cognition...
  25. pmc A common cognitive profile in elderly fallers and in patients with Parkinson's disease: the prominence of impaired executive function and attention
    Jeffrey M Hausdorff
    Movement Disorders Unit, Tel Aviv Sourasky Medical Center
    Exp Aging Res 32:411-29. 2006
    ..e., variability of response timing) and underscore the importance of executive function and attention as potential targets for fall risk screening and interventions...
  26. pmc How does explicit prioritization alter walking during dual-task performance? Effects of age and sex on gait speed and variability
    Galit Yogev-Seligmann
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Phys Ther 90:177-86. 2010
    ..Previous studies have demonstrated that the performance of a secondary task during walking alters gait...
  27. doi request reprint Effects of cognitive function on gait and dual tasking abilities in patients with Parkinson's disease suffering from motor response fluctuations
    Meir Plotnik
    Movement Disorders Unit, Department of Neurology, Laboratory for Gait and Neurodynamcis, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Exp Brain Res 208:169-79. 2011
    ....
  28. ncbi request reprint Effects of methylphenidate on cognitive function and gait in patients with Parkinson's disease: a pilot study
    Eitan Auriel
    Movement Disorders Unit, NPF Center of Excellence, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Clin Neuropharmacol 29:15-7. 2006
    ..These findings suggest a new potential pharmacologic means of enhancing mobility and decreasing fall risk in Parkinson's disease...
  29. doi request reprint Do we always prioritize balance when walking? Towards an integrated model of task prioritization
    Galit Yogev-Seligmann
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Mov Disord 27:765-70. 2012
    ..2012 Movement Disorder Society...
  30. doi request reprint Appreciation of humor is decreased among patients with Parkinson's disease
    Avner Thaler
    Movement Disorders Unit, Department of Neurology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel
    Parkinsonism Relat Disord 18:144-8. 2012
    ..To test whether appreciation of humor might be a non-motor function affected by Parkinson's disease (PD)...
  31. doi request reprint Homozygosity for the MTX1 c.184T>A (p.S63T) alteration modifies the age of onset in GBA-associated Parkinson's disease
    Ziv Gan-Or
    The Genetic Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
    Neurogenetics 12:325-32. 2011
    ..184A/A genotype (35.9%, compared to 13.6-17.5%, p = 0.028). Our results raise the possibility that alteration on the opposite allele, which is in trans to the GBA mutant allele, may affect the clinical course of GBA-associated PD...
  32. doi request reprint Association of sequence alterations in the putative promoter of RAB7L1 with a reduced parkinson disease risk
    Ziv Gan-Or
    Genetic Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Arch Neurol 69:105-10. 2012
    ....
  33. pmc Properties of the 'timed up and go' test: more than meets the eye
    Talia Herman
    Laboratory for Gait Analysis and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Gerontology 57:203-10. 2011
    ..We speculated that its properties may be different from other performance-based tests and assessed whether cognitive function may contribute to the differences among these tests in a cohort of healthy older adults...
  34. ncbi request reprint Gait dynamics in Parkinson's disease: relationship to Parkinsonian features, falls and response to levodopa
    Joanna D Schaafsma
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel
    J Neurol Sci 212:47-53. 2003
    ....
  35. pmc Dual-task decrements in gait: contributing factors among healthy older adults
    Jeffrey M Hausdorff
    Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    J Gerontol A Biol Sci Med Sci 63:1335-43. 2008
    ..We hypothesized that cognitive and motor reserve (e.g., executive function [EF], postural control, and walking abilities) and affect (e.g., anxiety, depressive symptoms) influence the DT decrements (DTDs) in gait...
  36. doi request reprint Can an accelerometer enhance the utility of the Timed Up & Go Test when evaluating patients with Parkinson's disease?
    Aner Weiss
    Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Med Eng Phys 32:119-25. 2010
    ..We tested the hypothesis that body-fixed accelerometers can provide insight into TUG performance in PD patients...
  37. doi request reprint Gait alterations in healthy carriers of the LRRK2 G2019S mutation
    Anat Mirelman
    Movement Disorders Unit, Department of NeurologyTel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Ann Neurol 69:193-7. 2011
    ..These findings support the possibility of previously unidentified, presymptomatic motor changes among relatives who have an increased risk of developing PD...
  38. ncbi request reprint Gait asymmetry in patients with Parkinson's disease and elderly fallers: when does the bilateral coordination of gait require attention?
    Galit Yogev
    Movement Disorders Unit, Neurology Department, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
    Exp Brain Res 177:336-46. 2007
    ..In contrast, however, when gait becomes impaired and less automatic, GA apparently relies on cognitive input and attention...
  39. doi request reprint The contribution of postural control and bilateral coordination to the impact of dual tasking on gait
    Galit Yogev-Seligmann
    Laboratory for Gait Analysis and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, 64239 Tel Aviv, Israel
    Exp Brain Res 226:81-93. 2013
    ..These findings suggest that walking is especially vulnerable to cognitive loading, in part, because of the unique sensitivity of bilateral coordination of limb movements to the effects of dual tasking...
  40. doi request reprint Smoking and tea consumption delay onset of Parkinson's disease
    Boris Kandinov
    Department of Physiology and Pharmacology, Tel Aviv University, Tel Aviv, Israel
    Parkinsonism Relat Disord 15:41-6. 2009
    ..7 years (p<0.01). Coffee consumption exceeding 3 cups per day advanced the age of PD onset by 4.8 years (p=0.03). Thus, tea consumption and smoking can delay the age of PD onset, while coffee drinking may have the opposite effect...
  41. pmc Self-report of missteps in older adults: a valid proxy of fall risk?
    Jennifer M Srygley
    Movement Disorders Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Arch Phys Med Rehabil 90:786-92. 2009
    ..To evaluate the relationship between missteps and falls and to identify factors associated with missteps, potentially to generate a broader picture of fall risk...
  42. doi request reprint Bilateral coordination of walking and freezing of gait in Parkinson's disease
    Meir Plotnik
    Movement Disorders Unit, Laboratory for Gait and Neurodynamics, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
    Eur J Neurosci 27:1999-2006. 2008
    ..Poor bilateral coordination of walking may predispose to FOG, especially during challenging tasks that demand a high degree of left-right coordination...
  43. ncbi request reprint Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's disease
    Rossitza Baltadjieva
    Laboratory for Gait and Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson s Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel
    Eur J Neurosci 24:1815-20. 2006
    ..PD apparently impinges on the regulation of a consistent gait rhythm, even early in the course of the disease when observed alterations are not the result of any pharmacologic treatment...
  44. ncbi request reprint Is freezing of gait in Parkinson's disease related to asymmetric motor function?
    Meir Plotnik
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Ann Neurol 57:656-63. 2005
    ..Taken together, the results of this study suggest that bilateral uncoordinated gait and marked gait asymmetry, but not asymmetry in motor performance in general, are associated with FOG...
  45. pmc When does walking alter thinking? Age and task associated findings
    Jennifer M Srygley
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Brain Res 1253:92-9. 2009
    ..Age-associated declines in EF apparently contribute to the difference in dual tasking abilities during walking between young and older adults...
  46. pmc The Dynamic Gait Index in healthy older adults: the role of stair climbing, fear of falling and gender
    Talia Herman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
    Gait Posture 29:237-41. 2009
    ..Conversely, ABC scores and fall history were different. These findings suggest that the DGI, although susceptible to ceiling effects, appears to be an appropriate tool for assessing function in healthy older adults...
  47. doi request reprint Postural instability and fall risk in Parkinson's disease: impaired dual tasking, pacing, and bilateral coordination of gait during the "ON" medication state
    Meir Plotnik
    Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 64239, Tel Aviv, Israel
    Exp Brain Res 210:529-38. 2011
    ..These cognitive and motor deficits may increase the likelihood of loss of balance during everyday attention-demanding tasks among patients with PD...
  48. ncbi request reprint A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers
    Avner Thaler
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Sackler School of Medicine, Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 29:823-7. 2014
    ..Patients with Parkinson's disease have reduced gray matter volume and fractional anisotropy in both cortical and sub-cortical structures, yet changes in the pre-motor phase of the disease are unknown...
  49. ncbi request reprint Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers
    Avner Thaler
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel Electronic address
    Cortex 49:2501-11. 2013
    ....
  50. doi request reprint Does the evaluation of gait quality during daily life provide insight into fall risk? A novel approach using 3-day accelerometer recordings
    Aner Weiss
    1Tel Aviv Sourasky Medical Center, Department of Neurology, Tel Aviv, Israel
    Neurorehabil Neural Repair 27:742-52. 2013
    ..Many approaches are used to evaluate fall risk. While their properties and performance vary, most reflect performance at a specific moment or are based on subjective self-report...
  51. doi request reprint The safety and tolerability of rotigotine transdermal system over a 6-year period in patients with early-stage Parkinson's disease
    Nir Giladi
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, 6 Weizmann Street, 64239, Tel Aviv, Israel
    J Neural Transm 120:1321-9. 2013
    ..The AEs reported were in line with previous studies of rotigotine transdermal system, with typical dopaminergic side effects and application site reactions seen...
  52. pmc White matter hyperintensities in Parkinson's disease: do they explain the disparity between the postural instability gait difficulty and tremor dominant subtypes?
    Talia Herman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    PLoS ONE 8:e55193. 2013
    ..Considering the known association between WMHs and axial symptoms like gait disturbances and postural instability, one can hypothesize that WMHs might contribute to the disparate clinical sub-types of patients with PD...
  53. doi request reprint Cognitive decline after stroke: relation to inflammatory biomarkers and hippocampal volume
    Efrat Kliper
    Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Stroke 44:1433-5. 2013
    ..We tested whether markers of inflammation, erythrocyte sedimentation rate (ESR), and serum levels of C-reactive protein are associated with reduced hippocampal volume and poor cognitive performance among stroke survivors...
  54. pmc Executive function and falls in older adults: new findings from a five-year prospective study link fall risk to cognition
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    PLoS ONE 7:e40297. 2012
    ..Secondary objectives were to assess whether single and dual task walking abilities, an alternative window into EF, were associated with fall risk...
  55. doi request reprint Fighting the risk of developing Parkinson's disease; clinical counseling for first degree relatives of patients with Parkinson's disease
    Nir Giladi
    Movement Disorders Unit, Department of Neurology, Tel Aviv University, Tel Aviv, Israel
    J Neurol Sci 310:17-20. 2011
    ..In Israel, there is a large group of Ashkenazi Jews at risk of developing PD due to high frequency of PD associated mutations in 2 genes (GBA and LRRK2)...
  56. ncbi request reprint Anxiety, depression and swallowing disorders in patients with Parkinson's disease
    Yael Manor
    Movement Disorders Unit, Department of Neurology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Parkinsonism Relat Disord 15:453-6. 2009
    ..The contribution of anxiety or depression to the development or worsening of SDs and their role in treatment strategy warrant further investigation...
  57. ncbi request reprint Rhythmic auditory stimulation modulates gait variability in Parkinson's disease
    Jeffrey M Hausdorff
    Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
    Eur J Neurosci 26:2369-75. 2007
    ....
  58. ncbi request reprint Treadmill walking as an external pacemaker to improve gait rhythm and stability in Parkinson's disease
    Silvi Frenkel-Toledo
    Department of Physical Therapy, Sackler School of Medicine, Tel Aviv, Israel
    Mov Disord 20:1109-14. 2005
    ....
  59. ncbi request reprint Assessing fear of falling: Can a short version of the Activities-specific Balance Confidence scale be useful?
    Chava Peretz
    Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 21:2101-5. 2006
    ..ICCs between the short and the long versions was 0.88 (HLGDs), 0.83 (PDs), and 0.78 (Controls). To conclude, the short version of the ABC has properties analogous to the parent questionnaire and is apparently useful in assessing FOF...
  60. ncbi request reprint The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson's disease: a double blind placebo-controlled pilot study
    Tanya Gurevich
    Movement Disorders Unit, Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Mov Disord 22:880-3. 2007
    ..To assess the effect on freezing of gait (FOG) of botulinum toxin type A (BTX-A) injections in advanced Parkinson's disease (PD) patients...
  61. pmc Heart rate changes during freezing of gait in patients with Parkinson's disease
    Inbal Maidan
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Mov Disord 25:2346-54. 2010
    ..Although further studies are needed to evaluate these associations, the current results provide experimental evidence linking impaired motor blockades to autonomic nervous system function among patients with PD...
  62. pmc Association between performance on timed up and go subtasks and mild cognitive impairment: further insights into the links between cognitive and motor function
    Anat Mirelman
    Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel School of Health Related Professions, Ben Gurion University, Beer Sheba, Israel
    J Am Geriatr Soc 62:673-8. 2014
    ..To assess whether different Timed Up and Go (TUG) subtasks are affected differently in older adults with mild cognitive impairment (MCI) and are specific to different cognitive abilities...
  63. ncbi request reprint Six weeks of intensive treadmill training improves gait and quality of life in patients with Parkinson's disease: a pilot study
    Talia Herman
    Movement Disorders Unit, Tel Aviv Sourasky Medical Center, Department of Physical Therapy, Sackler School of Medicine, Tel Aviv University, Israel
    Arch Phys Med Rehabil 88:1154-8. 2007
    ..To evaluate the effects of 6 weeks of intensive treadmill training on gait rhythmicity, functional mobility, and quality of life (QOL) in patients with Parkinson's disease (PD)...
  64. ncbi request reprint A new measure for quantifying the bilateral coordination of human gait: effects of aging and Parkinson's disease
    Meir Plotnik
    Movement Disorders Unit, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv, 64239, Israel
    Exp Brain Res 181:561-70. 2007
    ..This study demonstrates that bilateral coordination of gait deteriorates with aging, further deteriorates in PD, and is not strongly associated with other spatio-temporal features of gait...
  65. doi request reprint Predictors for poststroke outcomes: the Tel Aviv Brain Acute Stroke Cohort (TABASCO) study protocol
    Einor Ben Assayag
    Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Int J Stroke 7:341-7. 2012
    ..About 45% of stroke victims remain with different levels of disability. Identifying factors associated with poststroke cognitive and neurological decline could potentially yield more effective therapeutic opportunities...
  66. ncbi request reprint Sexual dysfunction in Parkinson's disease
    Gila Bronner
    Movement Disorders Unit, Department of Neurology, Tel Aviv Souraski Medical Center, Tel Aviv, Israel
    J Sex Marital Ther 30:95-105. 2004
    ..3% men and 21.9% women). Associated illnesses, use of medications, and advanced stage of PD contributed to sexual dysfunction...
  67. doi request reprint Ashkenazi Parkinson's disease patients with the LRRK2 G2019S mutation share a common founder dating from the second to fifth centuries
    Anat Bar-Shira
    Genetic Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel
    Neurogenetics 10:355-8. 2009
    ..Using a maximum-likelihood method, we estimate that Ashkenazi Jews with G2019S share a common ancestor who lived approximately 1,830 (95% CI 1,560-2,160) years ago, around the second century, after the second Jewish Diaspora...
  68. ncbi request reprint Cerebral vasomotor reactivity in Parkinson's disease, multiple system atrophy and pure autonomic failure
    Tanya Gurevich
    Neurology Department, Tel Aviv Medical Center, Israel Sieratzki Chair of Neurology, Tel Aviv University, Israel
    J Neurol Sci 243:57-60. 2006
    ..We conclude that BFV is normal in PD, MSA and PAF and that the VMR, as investigated by TCD and the Diamox test, did not disclose differences in cerebral vasomotor responses between these conditions...
  69. ncbi request reprint Ropinirole in Gilles de la Tourette syndrome
    Marietta H Anca
    Department of Neurology, Tel Aviv Medical Center, and the Sieratzki Chair of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Neurology 62:1626-7. 2004
    ..All patients completed the study, and most showed an improvement in their tics during treatment. Low-dose ropinirole may improve the motor features in GdlT, but further controlled studies are necessary...
  70. ncbi request reprint Balance and gait in older adults with systemic hypertension
    Jeffrey M Hausdorff
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Cardiol 91:643-5. 2003
  71. ncbi request reprint Walking is more like catching than tapping: gait in the elderly as a complex cognitive task
    Jeffrey M Hausdorff
    Movement Disorders Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Exp Brain Res 164:541-8. 2005
    ....
  72. ncbi request reprint Neuropsychological profile of DYT1 dystonia
    Meirav Balas
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Mov Disord 21:2073-7. 2006
    ..It was concluded that symptomatic DYT1 mutation carriers do not suffer the distinctive cognitive decline that is seen in other primary degenerative extrapyramidal disorders...
  73. ncbi request reprint Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease
    Doron Merims
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Parkinsonism Relat Disord 14:273-80. 2008
    ....
  74. pmc The role of executive function and attention in gait
    Galit Yogev-Seligmann
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Mov Disord 23:329-42; quiz 472. 2008
    ..Lastly, we suggest how assessments of executive function and attention could be applied in the clinical setting as part of the process of identifying and understanding gait disorders and fall risk...
  75. doi request reprint Computer-based, personalized cognitive training versus classical computer games: a randomized double-blind prospective trial of cognitive stimulation
    Chava Peretz
    Department of Epidemiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Neuroepidemiology 36:91-9. 2011
    ..We investigated whether personalized computerized cognitive training provides greater benefits than those obtained by playing conventional computer games...
  76. doi request reprint Methylphenidate for the treatment of Parkinson disease and other neurological disorders
    Eitan Auriel
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    Clin Neuropharmacol 32:75-81. 2009
    ....
  77. ncbi request reprint Freezing of gait affects quality of life of peoples with Parkinson's disease beyond its relationships with mobility and gait
    Orna Moore
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Mov Disord 22:2192-5. 2007
    ..On the basis of the present results, special attention should be given to FOG in the treatment of patients with PD...
  78. ncbi request reprint Pharmacokinetics of etilevodopa compared to levodopa in patients with Parkinson's disease: an open-label, randomized, crossover study
    Ruth Djaldetti
    Department of Neurology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49100, Israel
    Clin Neuropharmacol 26:322-6. 2003
    ..Clinical trials with etilevodopa/carbidopa tablets should be carried out in PD patients with response fluctuations such as "delayed on" and "dose failures"...
  79. ncbi request reprint Effects of cognitive challenge on gait variability in patients with Parkinson's disease
    Jeffrey M Hausdorff
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv, Israel
    J Geriatr Psychiatry Neurol 16:53-8. 2003
    ..These results highlight the profound effects of attention on gait and indicate that walking while cognitively challenged impairs the ability of patients with PD to maintain a stable walk...
  80. doi request reprint Medical treatment of freezing of gait
    Nir Giladi
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 23:S482-8. 2008
    ....
  81. ncbi request reprint "Brain Screen": A self-referral, screening program for strokes, falls and dementia risk factors
    Nir Giladi
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
    J Neurol 253:307-15. 2006
    ..Falls, strokes and dementia can be predicted and their occurrence can be delayed or even prevented by treatment of risk factors. The value of screening self-referred adults is unknown...
  82. ncbi request reprint The effect of cigarette smoking, tea, and coffee consumption on the progression of Parkinson's disease
    Boris Kandinov
    Department of Physiology and Pharmacology, Tel Aviv University, Israel
    Parkinsonism Relat Disord 13:243-5. 2007
    ..We found that disease progression was not affected by cigarette smoking, tea or coffee consumption. The present study suggests that these variables do not have a disease modifying effect in already diagnosed PD patients...
  83. ncbi request reprint Oral solution of levodopa ethylester for treatment of response fluctuations in patients with advanced Parkinson's disease
    Ruth Djaldetti
    Department of Neurology, Rabin Medical Center, Petah Tiqva, Israel
    Mov Disord 17:297-302. 2002
    ..Results indicate that LDEE solution is beneficial in ameliorating delayed on and no-on response fluctuations. This effect of LDEE is due to more rapid levodopa absorption...
  84. ncbi request reprint Freezing of gait in multiple system atrophy (MSA)
    Tanya Gurevich
    Department of Neurology, Tel Aviv Sourasky Medical Center Affiliated with Sackler School of Medicine, Tel Aviv University, 6 Weizmann Street, 64239, Tel Aviv, Israel
    Parkinsonism Relat Disord 9:169-74. 2003
    ..Freezing of gait (FOG) is a mysterious symptom, observed in different parkinsonian syndromes, but considered to be rare in multiple system atrophy (MSA)...
  85. ncbi request reprint Validation of a swallowing disturbance questionnaire for detecting dysphagia in patients with Parkinson's disease
    Yael Manor
    Department of Neurology, Movement Disorders Unit, Parkinson Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Mov Disord 22:1917-21. 2007
    ..The SDQ emerged as a validated tool to detect early dysphagia in PD patients...
  86. ncbi request reprint Natural history of Oppenheim's dystonia (DYT1) in Israel
    Marieta H Anca
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Child Neurol 18:325-30. 2003
    ..The modern treatments combining drugs, botulinum toxin, and functional neurosurgery allow most patients with Oppenheim's dystonia to have independence and a relatively good quality of life...
  87. doi request reprint The LRRK2 G2019S mutation as the cause of Parkinson's disease in Ashkenazi Jews
    Avner Thaler
    Department of Neurology, Sourasky Medical Center, Tel Aviv, Israel
    J Neural Transm 116:1473-82. 2009
    ....
  88. ncbi request reprint The power of cueing to circumvent dopamine deficits: a review of physical therapy treatment of gait disturbances in Parkinson's disease
    Tamar C Rubinstein
    Movement Disorders Unit, Neurology Department, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 17:1148-60. 2002
    ....
  89. ncbi request reprint Advances in the genetics of Parkinson's disease
    Serena Rosner
    The Genetic Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    Acta Pharmacol Sin 29:21-34. 2008
    ..This review outlines the advances in the study of the genetic background of PD and their possible clinical implications...
  90. doi request reprint Red flags for multiple system atrophy
    Martin Köllensperger
    Section for Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 23:1093-9. 2008
    ..9 (+/-7.0) months earlier than with the Consensus criteria alone. We propose a combination of two out of six red flag categories as additional diagnostic criteria for probable MSA-P...
  91. ncbi request reprint Falls and freezing of gait in Parkinson's disease: a review of two interconnected, episodic phenomena
    Bastiaan R Bloem
    Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Mov Disord 19:871-84. 2004
    ....
  92. ncbi request reprint Dissociation between spontaneous and reactive flexibility in early Parkinson's disease
    Rachel Tomer
    Cognitive Neurology Unit, Rambam Medical Center, Haifa, Israel
    Neuropsychiatry Neuropsychol Behav Neurol 15:106-12. 2002
    ..This study was designed to examine the relations between the severity of motor symptoms and impaired cognitive flexibility in Parkinson's disease...
  93. ncbi request reprint Neurological gait disorders in elderly people: clinical approach and classification
    Anke H Snijders
    Department of Neurology and Parkinson Center Nijmegen, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Lancet Neurol 6:63-74. 2007
    ..We conclude by proposing a practical three-step approach to categorise gait disorders and we present a simplified classification system based on clinical signs and symptoms...
  94. ncbi request reprint Effects of pharmacological therapy on gait and cognitive function in depressed patients
    Diana Paleacu
    Neurology Service and Memory Clinic, Abarbanel Mental Health Center, Bat Yam, Israel
    Clin Neuropharmacol 30:63-71. 2007
    ..To investigate the relationship among affective status, cognitive function, and gait in depressed patients and to evaluate the effects of treatment of depression on gait and cognitive function...
  95. ncbi request reprint Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus
    Dipankar Nandi
    University Laboratory of Physiology, Oxford University, UK
    Brain 125:2418-30. 2002
    ..The effect of bicuculline microinjection in the PPN matches that of oral administration of L-dopa. This finding opens up new possibilities in the management of akinesia, the most intractable symptom of advanced Parkinson's disease...
  96. ncbi request reprint Globus pallidus internus deep brain stimulation for dystonic conditions: a prospective audit
    John Yianni
    Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
    Mov Disord 18:436-42. 2003
    ..This study clearly demonstrates that DBS of the GPi provides amelioration of intractable dystonia...
  97. ncbi request reprint Executive cognitive deficits in primary dystonia
    Richard B Scott
    Russell Cairns Unit, Radcliffe Infirmary, Oxford, United Kingdom
    Mov Disord 18:539-50. 2003
    ..The implications of these findings for the pathophysiology of primary dystonia are discussed. This is, to the best of our knowledge, the first report of a significant cognitive deficit in patients with primary dystonia...
  98. ncbi request reprint Thalamic stimulation for parkinsonian tremor: correlation between regional cerebral blood flow and physiological tremor characteristics
    Masafumi Fukuda
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    Neuroimage 21:608-15. 2004
    ..05, uncorrected). Our results suggest that Vim DBS for PD tremor modulates the activity of cerebello-thalamo-cortical pathways. Specific tremor characteristics relate to activity in different nodes of this system...
  99. ncbi request reprint Primary dystonia is more responsive than secondary dystonia to pallidal interventions: outcome after pallidotomy or pallidal deep brain stimulation
    Hazem A Eltahawy
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
    Neurosurgery 54:613-19; discussion 619-21. 2004
    ..In this study, we assessed the postoperative outcome of patients with primary and secondary dystonia undergoing pallidotomy or pallidal deep brain stimulation...
  100. ncbi request reprint Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations
    Christopher G Goetz
    Rush University Medical Center, 1725 W Harrison Street, Chicago, IL 60612, USA
    Mov Disord 19:1020-8. 2004
    ..5 increments, this adaptation warrants clinimetric testing. Without such testing, however, the original five-point scales should be maintained...
  101. ncbi request reprint Health-related quality of life in multiple system atrophy
    Anette Schrag
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
    Mov Disord 21:809-15. 2006
    ....