Iris Dotan

Summary

Country: Israel

Publications

  1. ncbi request reprint Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells
    Matthieu Allez
    Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 123:1516-26. 2002
  2. ncbi request reprint Correlated expression of high-sensitivity C-reactive protein in relation to disease activity in inflammatory bowel disease: lack of differences between Crohn's disease and ulcerative colitis
    Liaz Zilberman
    Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel
    Digestion 73:205-9. 2006
  3. pmc Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory bowel disease
    Lael Werner
    IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Theranostics 3:40-6. 2013
  4. doi request reprint Maternal inflammatory bowel disease has short and long-term effects on the health of their offspring: a multicenter study in Israel
    Iris Dotan
    IBD Center, Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Crohns Colitis 7:542-50. 2013
  5. doi request reprint CXCL12 is a constitutive and inflammatory chemokine in the intestinal immune system
    Iris Dotan
    IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv University, Tel Aviv, Israel
    Inflamm Bowel Dis 16:583-92. 2010
  6. ncbi request reprint [Infliximab in inflammatory bowel diseases--conference summary and suggested guidelines]
    Iris Dotan
    Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Harefuah 145:844-9, 860. 2006
  7. doi request reprint Serologic markers in inflammatory bowel disease: tools for better diagnosis and disease stratification
    Iris Dotan
    IBD Center, Tel Aviv Sourasky Medical Center, Department of Gastroenterology and Liver Diseases, 6 Weizmann Street, Tel Aviv 64239, Israel
    Expert Rev Gastroenterol Hepatol 1:265-74. 2007
  8. ncbi request reprint Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn's disease
    Iris Dotan
    IBD Service, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Gastroenterology 131:366-78. 2006
  9. doi request reprint Disease behavior in adult patients: are there predictors for stricture or fistula formation?
    Iris Dotan
    IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Dig Dis 27:206-11. 2009
  10. doi request reprint A randomised placebo-controlled multicentre trial of intravenous semapimod HCl for moderate to severe Crohn's disease
    Iris Dotan
    IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, 64239, Israel
    Gut 59:760-6. 2010

Detail Information

Publications40

  1. ncbi request reprint Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells
    Matthieu Allez
    Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 123:1516-26. 2002
    ..We have previously shown that T cells activated by intestinal epithelial cells (IECs) are suppressive in function. Our goal was to characterize the phenotype and function of T cells proliferating after interaction with IECs...
  2. ncbi request reprint Correlated expression of high-sensitivity C-reactive protein in relation to disease activity in inflammatory bowel disease: lack of differences between Crohn's disease and ulcerative colitis
    Liaz Zilberman
    Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel
    Digestion 73:205-9. 2006
    ..We addressed the subject of the degree of correlation between the concentration of high-sensitivity CRP (hs-CRP) and the inflammatory IBD activity score...
  3. pmc Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory bowel disease
    Lael Werner
    IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Theranostics 3:40-6. 2013
    ..The current review discusses up to date knowledge of CXCL12 in inflammation, focusing on the involvement of CXCL12 and its receptors, CXCR4 and CXCR7, in inflammatory bowel diseases...
  4. doi request reprint Maternal inflammatory bowel disease has short and long-term effects on the health of their offspring: a multicenter study in Israel
    Iris Dotan
    IBD Center, Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Crohns Colitis 7:542-50. 2013
    ..The aims were to assess the short- and long-term effects of maternal IBD on the morbidity and development of their offspring...
  5. doi request reprint CXCL12 is a constitutive and inflammatory chemokine in the intestinal immune system
    Iris Dotan
    IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv University, Tel Aviv, Israel
    Inflamm Bowel Dis 16:583-92. 2010
    ..CXCL12 is a constitutive chemokine involved in lung, brain, and joint inflammation. We hypothesized that CXCL12 and its receptor, CXCR4, would have a constitutive and inflammatory role in the gut...
  6. ncbi request reprint [Infliximab in inflammatory bowel diseases--conference summary and suggested guidelines]
    Iris Dotan
    Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Harefuah 145:844-9, 860. 2006
    ..These guidelines may assist and direct the gastroenterologist treating inflammatory bowel disease patients with infliximab...
  7. doi request reprint Serologic markers in inflammatory bowel disease: tools for better diagnosis and disease stratification
    Iris Dotan
    IBD Center, Tel Aviv Sourasky Medical Center, Department of Gastroenterology and Liver Diseases, 6 Weizmann Street, Tel Aviv 64239, Israel
    Expert Rev Gastroenterol Hepatol 1:265-74. 2007
    ..Thus, it is expected that they will become useful clinical tools that will enable an improved, 'tailored' approach to inflammatory bowel disease patients...
  8. ncbi request reprint Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn's disease
    Iris Dotan
    IBD Service, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Gastroenterology 131:366-78. 2006
    ..We profiled sugar-binding antibodies to identify novel antiglycan antibodies that may be associated with inflammatory bowel disease...
  9. doi request reprint Disease behavior in adult patients: are there predictors for stricture or fistula formation?
    Iris Dotan
    IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Dig Dis 27:206-11. 2009
    ..These predictors may be used in clinical practice and/or research in order to better stratify CD prognosis. Thus they may be significant in our therapeutic decisions. Models for using these predictors would be presented...
  10. doi request reprint A randomised placebo-controlled multicentre trial of intravenous semapimod HCl for moderate to severe Crohn's disease
    Iris Dotan
    IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, 64239, Israel
    Gut 59:760-6. 2010
    ..Semapimod, a small molecule known to inhibit proinflammatory cytokine activity, was studied to determine the optimal dose necessary to achieve a response in patients with moderate to severe Crohn's disease (CD)...
  11. doi request reprint New serologic markers for inflammatory bowel disease diagnosis
    Iris Dotan
    IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Dig Dis 28:418-23. 2010
    ..Their significance in diagnosing populations at risk, such as unaffected relatives of IBD patients and CD patients prior to diagnosis, is under current investigation...
  12. doi request reprint Normal response to vaccines in inflammatory bowel disease patients treated with thiopurines
    Iris Dotan
    Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, affiliated to tSackler Faculty of Medicine, Tel Aviv Israel
    Inflamm Bowel Dis 18:261-8. 2012
    ..We evaluated the effects of the thiopurines, azathioprine (AZA) and 6-mercaptopurine (6-MP), on cellular and humoral immune responses in IBD patients...
  13. ncbi request reprint Intestinal epithelial cells from inflammatory bowel disease patients preferentially stimulate CD4+ T cells to proliferate and secrete interferon-gamma
    Iris Dotan
    IBD Service, Dept of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Am J Physiol Gastrointest Liver Physiol 292:G1630-40. 2007
    ....
  14. doi request reprint Reciprocal regulation of CXCR4 and CXCR7 in intestinal mucosal homeostasis and inflammatory bowel disease
    Lael Werner
    Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Leukoc Biol 90:583-90. 2011
    ..Finally, T cells attracted by CXCL12 are mostly of a memory phenotype. In conclusion, the present study suggests that the interplay between CXCL12 and its receptors affects homeostasis and inflammation in the intestinal mucosa...
  15. ncbi request reprint Comparative analysis of Bayer wide-range C-reactive protein (wr-CRP) and the Dade-Behring high sensitivity C-reactive protein (hs-CRP) in patients with inflammatory bowel disease
    Nitsan Maharshak
    Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Dig Dis 9:140-3. 2008
    ..Our aim was to examine whether wr-CRP can substitute for the Dade Behring high sensitivity C-reactive protein (hs-CRP) assay in IBD patients...
  16. pmc Diet of patients after pouch surgery may affect pouch inflammation
    Orit Ianco
    Orit Ianco, Amos Ofer, Erwin Santo, Iris Dotan, Comprehensive Pouch Clinic, IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    World J Gastroenterol 19:6458-64. 2013
    ..To investigate the diet of pouch patients compared to healthy controls, and to correlate pouch patients' diet with disease behavior...
  17. doi request reprint MicroRNA-132 modulates cholinergic signaling and inflammation in human inflammatory bowel disease
    Nitsan Maharshak
    Department of Gastroenterology and Hepatology, Tel Aviv Sourasky Medical Center, The Sackler School of Medicine, Tel Aviv University, Israel
    Inflamm Bowel Dis 19:1346-53. 2013
    ..This study aimed to test whether miR-132 is causally involved in anti-inflammatory reactions of patients with inflammatory bowel disease (IBD) and modulates vagal tone and consequently inflammation in patients with IBD...
  18. ncbi request reprint Inflammatory bowel disease is not associated with increased intimal media thickening
    Nitsan Maharshak
    Department of Internal Medicine T, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Am J Gastroenterol 102:1050-5. 2007
    ..In this work our aim was to determine whether IBD is a risk factor for increased IMT...
  19. doi request reprint Increased strength of erythrocyte aggregates in blood of patients with inflammatory bowel disease
    Nitsan Maharshak
    Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Inflamm Bowel Dis 15:707-13. 2009
    ..This damage may be at least partially attributed to microvascular ischemia caused by enhanced erythrocyte aggregation. The aim of this study was to evaluate the strength of RBC aggregates in the blood of patients with IBD...
  20. doi request reprint A longitudinal study of quality of life and functional outcome of patients with ulcerative colitis after proctocolectomy with ileal pouch-anal anastomosis
    Hagit Tulchinsky
    Comprehensive Pouch Clinic, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Dis Colon Rectum 53:866-73. 2010
    ..The purpose of this study was to longitudinally evaluate the long-term functional outcome and quality of life of ulcerative colitis patients who underwent proctocolectomy with ileal pouch-anal anastomosis...
  21. doi request reprint Long-term functional and quality-of-life outcomes after IPAA in children
    Osnat Zmora
    Department of Pediatric Surgery, Dana Children s Hospital, Tel Aviv Sourasky Medical Center, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Dis Colon Rectum 56:198-204. 2013
    ..The impact of IPAA on long-term outcomes in adults is favorable. Studies on functional outcome and quality of life in children are sparse...
  22. doi request reprint Galectin-3 expression in pouchitis in patients with ulcerative colitis who underwent ileal pouch-anal anastomosis (IPAA)
    Eli Brazowski
    Department of Pathology, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Pathology Institute, Tel Aviv University, Tel Aviv, Israel
    Pathol Res Pract 205:551-8. 2009
    ..Galectin-3 staining was restricted to CD68(+) macrophages and not present in myofibroblasts. Clinical manifestation of pouchitis is inversely correlated with galectin-3 expression in the pouches' subepithelial lamina propria macrophages...
  23. ncbi request reprint Microinflammation in patients with Crohn's disease in clinical remission
    Nitsan Maharshak
    Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 6 Weizman Street, Tel Aviv, 64239 Israel
    J Crohns Colitis 2:310-4. 2008
    ..Our goal in this work was to explore the intensity of the microinflammatory response in a group of Crohn's disease patients in clinical remission...
  24. doi request reprint Comprehensive pouch clinic concept for follow-up of patients after ileal pouch anal anastomosis: report of 3 years' experience in a tertiary referral center
    Hagit Tulchinsky
    Pouch Clinic, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Inflamm Bowel Dis 14:1125-32. 2008
    ....
  25. doi request reprint Idiopathic pancreatitis preceding the diagnosis of inflammatory bowel disease is more frequent in pediatric patients
    Efrat Broide
    Institute of Gastroenterology, Liver Diseases and Nutrition, Assaf Harofeh Medical Center, Zerifin affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Pediatr Gastroenterol Nutr 52:714-7. 2011
    ..We aimed to characterize the demographic, clinical, and laboratory data of patients with IBD in whom AP preceded disease onset and compare the presentation of AP between children and adults...
  26. doi request reprint Gene expression profiles of ileal inflammatory bowel disease correlate with disease phenotype and advance understanding of its immunopathogenesis
    Shay Ben-Shachar
    Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel IBD center, Department of Gastroenterology and Liver Diseases, Tel Aviv Medical Center, Tel Aviv, Israel Departments of Pathology, and Surgery, Tel Aviv Medical Center, Tel Aviv, Israel and Bioinformatics Unit, G S W Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Inflamm Bowel Dis 19:2509-21. 2013
    ..Pouchitis may develop in patients with ulcerative colitis undergoing pouch surgery. We aimed to evaluate the de novo inflammation developing in the ileal pouch, hypothesizing that it may be similar to ileitis in Crohn's disease (CD)...
  27. ncbi request reprint Inflammation-related erythrocyte aggregation in patients with inflammatory bowel disease
    Liaz Zilberman
    Department of Medicine D, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Dig Dis Sci 50:677-83. 2005
    ..An enhanced state of erythrocyte adhesiveness/aggregation was noted in the peripheral blood of patients with IBD. This might have a deleterious effect on intestinal microcirculatory flow and tissue oxygenation...
  28. doi request reprint Directionality of noncoding human RNAs: how to avoid artifacts
    Sivan Tzadok
    Department of Biochemistry and Molecular Biology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Anal Biochem 439:23-9. 2013
    ..Examples for the BRMS1 metastasis suppressor gene, as well as RAR-β2 and CST6 human tumor suppressor genes, in breast carcinoma cell lines are presented...
  29. doi request reprint Antibodies against glycoprotein 2 are novel markers of intestinal inflammation in patients with an ileal pouch
    Lael Werner
    IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Electronic address
    J Crohns Colitis 7:e522-32. 2013
    ..We aimed to assess the prevalence of anti-GP2 antibodies (anti-GP2) in the serum and feces of pouch patients and to correlate them with clinical parameters. Furthermore, we examined mucosal expression of the GP2 protein in the pouch...
  30. doi request reprint Doubling the infliximab dose versus halving the infusion intervals in Crohn's disease patients with loss of response
    Lior Katz
    Gastroenterology Department, Sheba Medical Center, Tel Hashomer, Tel Aviv University, Israel
    Inflamm Bowel Dis 18:2026-33. 2012
    ..We aimed to assess the efficacy of infliximab dose intensification by interval-halving compared with dose-doubling...
  31. ncbi request reprint Probiotics in inflammatory bowel disease: possible mechanisms of action
    Iris Dotan
    IBD Service, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
    Curr Opin Gastroenterol 21:426-30. 2005
    ..The purpose of this review is to discuss the latest findings related to their mechanism of action...
  32. pmc ER-alpha-cDNA as part of a bicistronic transcript gives rise to high frequency, long term, receptor expressing cell clones
    Michal Shenfeld
    Department of Biochemistry and Molecular Biology, Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    PLoS ONE 7:e31977. 2012
    ..Our successful experience with ERα in this system may serve as a paradigm for other genes where ectopic expression meets similar hardships...
  33. doi request reprint Doppler-guided haemorrhoidal artery ligation in patients with Crohn's disease
    Eliad Karin
    Department of Surgery A, Tel Aviv Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Colorectal Dis 14:111-4. 2012
    ..The outcome of Doppler-guided haemorrhoidal artery ligation (DGHAL) was assessed in patients with Crohn's disease (CD) suffering from grade III haemorrhoids...
  34. ncbi request reprint Malabsorption is a major contributor to underweight in Crohn's disease patients in remission
    Nachum Vaisman
    Unit of Clinical Nutrition, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Nutrition 22:855-9. 2006
    ..Undernutrition has been reported in 65-75% of patients with Crohn's disease. The present study aimed at identifying the relative contribution of malnutrition-causing factors in patients with Crohn's disease in remission...
  35. ncbi request reprint The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells
    Atsushi Nakazawa
    Immunobiology Center, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Gastroenterology 126:1347-57. 2004
    ..Our aim was to determine whether IECs express novel B7 family members and whether these molecules play a role in IEC:T-cell interactions...
  36. ncbi request reprint Activation of a unique population of CD8(+) T cells by intestinal epithelial cells
    Matthieu Allez
    Immunobiology Center, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Ann N Y Acad Sci 1029:22-35. 2004
    ..A lack of expansion of these CD8(+) regulatory T cells, probably related to the defective expression of the gp180/CD1d complex, is observed in inflammatory bowel disease...
  37. ncbi request reprint Defects in CD8+ regulatory T cells in the lamina propria of patients with inflammatory bowel disease
    Jens Brimnes
    Immunobiology Center, Mount Sinai Medical Center, New York, NY 10029, USA
    J Immunol 174:5814-22. 2005
    ....
  38. ncbi request reprint The effect of infliximab on extraintestinal manifestations of Crohn's disease
    Ilana Kaufman
    Department of Rheumatology, Sourasky Medical Center and the Sackler Faculty of Medicine, University of Tel Aviv, Israel
    Rheumatol Int 25:406-10. 2005
    ..The purpose of this open pilot study was to assess prospectively the effect of infliximab on extraintestinal manifestations in patients with active Crohn's disease refractory to conventional treatment...
  39. ncbi request reprint Anti-TNF therapy for severe acute alcoholic hepatitis: what went wrong?
    Laurie Blendis
    Gastroenterology 127:1637-9. 2004
  40. ncbi request reprint [Inflammatory bowel diseases: in search of novel cytokines and genes]
    Iris Dotan
    Harefuah 145:817-9, 861. 2006
    ..Although they have found no such association, the editorial addresses the importance of cytokines and novel genes for the understanding of the immunopathogenesis of inflammatory bowel diseases, and its treatment...