Varda Deutsch

Summary

Country: Israel

Publications

  1. ncbi request reprint The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34(+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation
    Varda R Deutsch
    Department of Hematology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Exp Hematol 30:1153-61. 2002
  2. doi request reprint Mimicking the haematopoietic niche microenvironment provides a novel strategy for expansion of haematopoietic and megakaryocyte-progenitor cells from cord blood
    Varda Deutsch
    Department of Haematology and Bone Marrow Transplant, Tel Aviv Medical Centre, Tel Aviv University, Israel
    Br J Haematol 149:137-49. 2010
  3. pmc Rapid in vivo testing of drug response in multiple myeloma made possible by xenograft to turkey embryos
    Y Farnoushi
    Department of Hematology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman Street, Tel Aviv Israel
    Br J Cancer 105:1708-18. 2011
  4. ncbi request reprint Megakaryocyte development and platelet production
    Varda R Deutsch
    The Haematology Institute, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel
    Br J Haematol 134:453-66. 2006
  5. ncbi request reprint [Megakaryocyte development and platelet production in normal and disease states]
    Varda Deutsch
    The Hematology Institute, Tel Aviv Medical Center, Tel Aviv
    Harefuah 149:291-7, 336. 2010
  6. ncbi request reprint Comparative analysis of methods for assessment of circulating endothelial progenitor cells
    Jacob George
    The Department of Cardiology, Tel Aviv University, Israel
    Tissue Eng 12:331-5. 2006
  7. pmc Circulating endothelial progenitor cells in patients with cardiac syndrome X
    Haim Shmilovich
    Department of Cardiology, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel
    Heart 93:1071-6. 2007
  8. ncbi request reprint Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses
    Dan Grisaru
    Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Israel
    J Immunol 176:27-35. 2006
  9. ncbi request reprint Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis
    Marjorie Pick
    Department of Hematology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Blood 107:3397-406. 2006
  10. ncbi request reprint The erythrosense as a real-time biomarker to reveal the presence of enhanced red blood cell aggregability in atherothrombosis
    Ori Rogowski
    Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Ther 12:286-92. 2005

Collaborators

Detail Information

Publications42

  1. ncbi request reprint The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34(+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation
    Varda R Deutsch
    Department of Hematology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Exp Hematol 30:1153-61. 2002
    ..This led us to explore the hematopoietic involvement of AChE-R and its cleavable C-terminal peptide ARP...
  2. doi request reprint Mimicking the haematopoietic niche microenvironment provides a novel strategy for expansion of haematopoietic and megakaryocyte-progenitor cells from cord blood
    Varda Deutsch
    Department of Haematology and Bone Marrow Transplant, Tel Aviv Medical Centre, Tel Aviv University, Israel
    Br J Haematol 149:137-49. 2010
    ....
  3. pmc Rapid in vivo testing of drug response in multiple myeloma made possible by xenograft to turkey embryos
    Y Farnoushi
    Department of Hematology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman Street, Tel Aviv Israel
    Br J Cancer 105:1708-18. 2011
    ..We recently described a rapid low-cost xenograft model of human blood malignancies in pre-immune turkey. Here, we report application of this system for studying MM growth and the preclinical assessment of anticancer therapies...
  4. ncbi request reprint Megakaryocyte development and platelet production
    Varda R Deutsch
    The Haematology Institute, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel
    Br J Haematol 134:453-66. 2006
    ..Herein, we review the regulation of megakaryocytopoiesis and platelet production in normal and disease state, and the new approaches to thrombopoietic therapy...
  5. ncbi request reprint [Megakaryocyte development and platelet production in normal and disease states]
    Varda Deutsch
    The Hematology Institute, Tel Aviv Medical Center, Tel Aviv
    Harefuah 149:291-7, 336. 2010
    ..In this article, the authors review the regulation of megakaryocytopoiesis and platelet production in normal and disease states, and new approaches of thrombopoietic therapy...
  6. ncbi request reprint Comparative analysis of methods for assessment of circulating endothelial progenitor cells
    Jacob George
    The Department of Cardiology, Tel Aviv University, Israel
    Tissue Eng 12:331-5. 2006
    ..These findings may suggest that CD34/KDR is more appropriate for the definition of circulating EPC, whereas CFU numbers are more likely to reflect their ability to proliferate...
  7. pmc Circulating endothelial progenitor cells in patients with cardiac syndrome X
    Haim Shmilovich
    Department of Cardiology, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel
    Heart 93:1071-6. 2007
    ..Endothelial progenitor cells (EPCs) in the peripheral circulation contribute to tissue vascularisation...
  8. ncbi request reprint Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses
    Dan Grisaru
    Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Israel
    J Immunol 176:27-35. 2006
    ..1 and maintained a stable granulocytic state following bacterial LPS exposure. AChE-R accumulation and the consequent inflammatory consequences can thus modulate immune responses to stress stimuli...
  9. ncbi request reprint Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis
    Marjorie Pick
    Department of Hematology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Blood 107:3397-406. 2006
    ..Our findings implicate AChE-R in thrombopoietic recovery, suggesting new therapeutic modalities for supporting platelet production...
  10. ncbi request reprint The erythrosense as a real-time biomarker to reveal the presence of enhanced red blood cell aggregability in atherothrombosis
    Ori Rogowski
    Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Ther 12:286-92. 2005
    ..These findings might help to turn a phenomenon of hemorheological relevance into a diagnostic tool for the detection of individuals at risk of an acute ischemic event...
  11. ncbi request reprint Transfer of endothelial progenitor and bone marrow cells influences atherosclerotic plaque size and composition in apolipoprotein E knockout mice
    Jacob George
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Arterioscler Thromb Vasc Biol 25:2636-41. 2005
    ..We explored the effect of BM cell- or spleen cell-derived EPC transfer on plaque size and stability markers in the apolipoprotein E knockout (apoE KO) mouse model...
  12. ncbi request reprint Erythropoietin promotes endothelial progenitor cell proliferative and adhesive properties in a PI 3-kinase-dependent manner
    Jacob George
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel
    Cardiovasc Res 68:299-306. 2005
    ..We explored the effect of chronic treatment with Epo on the numbers and functional properties of EPC in CHF patients...
  13. ncbi request reprint Integration of automated morphological features resolves a distinct group of atypical chronic lymphocytic leukemias with chromosomal aberrations
    Yair Herishanu
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Leuk Res 38:484-9. 2014
    ..Integration of the automated morphological features discriminates between different CLL phenotypes and distinct chromosomal aberrations. ..
  14. doi request reprint Mesenchymal stromal cells revert multiple myeloma cells to less differentiated phenotype by the combined activities of adhesive interactions and interleukin-6
    Nili Dezorella
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Exp Cell Res 315:1904-13. 2009
    ..Overall, the data indicate that the bone marrow-derived mesenchymal stromal cells revert multiple myeloma cells to less differentiated phenotype by the combined activities of adhesive interactions and interleukin-6...
  15. doi request reprint Correlated expression of D-dimer concentrations with thrombotic burden in acute pulmonary embolism
    Yelena Goldin
    Department of Medicine D, Tel Aviv University, Tel Aviv, Israel
    Blood Coagul Fibrinolysis 19:153-8. 2008
    ..These findings might have implications regarding the diagnostic yield of D-dimer in patients who are suspected of having an acute pulmonary embolism...
  16. doi request reprint Malignant transformation of normal enterocytes following downregulation of Bak expression
    Eliezer Liberman
    Integrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv, Israel
    Digestion 77:48-56. 2008
    ..COX 2 inhibitors may serve as important agents in the prevention and treatment of CRC as they only inhibit the growth of malignant cells...
  17. doi request reprint Divergence in CD19-mediated signaling unfolds intraclonal diversity in chronic lymphocytic leukemia, which correlates with disease progression
    Yair Herishanu
    Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    J Immunol 190:784-93. 2013
    ..This signaling diversity is associated with physiological implications, including the location of the cells, their responses to anti-CLL therapeutics, and disease progression...
  18. doi request reprint Thrombophilic factors in idiopathic intracranial hypertension: a report of 51 patients and a meta-analysis
    Anat Kesler
    Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Israel
    Blood Coagul Fibrinolysis 21:328-33. 2010
    ..54 (1.54-8.70)]. Obesity often observed in IIH patients is frequently linked with thrombophilic factors. Thus, we believe that dysmetabolism could be the thrombophilic target for treatment in patients with IIH...
  19. ncbi request reprint Erythropoietin improves myocardial performance in doxorubicin-induced cardiomyopathy
    Saher Hamed
    Department of Cardiology, Tel Aviv Sourasky Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, Israel
    Eur Heart J 27:1876-83. 2006
    ..We tested the hypothesis that EPC are compromised in rats with Dox-induced cardiotoxicity and correction of this functional impairment by treatment with Epo could result in attenuation of myocardial dysfunction...
  20. ncbi request reprint Erythrocyte adhesiveness/aggregation: a novel biomarker for the detection of low-grade internal inflammation in individuals with atherothrombotic risk factors and proven vascular disease
    Shlomo Berliner
    Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Am Heart J 149:260-7. 2005
    ....
  21. pmc Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation
    Nitsan Maharshak
    Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel Aviv University, 64239 Tel Aviv, Israel
    World J Gastroenterol 17:5007-13. 2011
    ..To examine whether hepatitis C virus (HCV)-infected patients who carry hypercoagulable mutations suffer from increased rates of liver fibrosis...
  22. doi request reprint The diagnostic yield of D-Dimer in relation to time from symptom onset in patients evaluated for venous thromboembolism in the emergency medicine department
    Yelena Goldin
    Department of Internal Medicine D, The Tel Aviv Sourasky Medical Center, Tel Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel
    J Thromb Thrombolysis 31:1-5. 2011
    ..We suggest not to exclude the eventual presence of acute VTE if quantitative D-Dimer is obtained later than 1 week following the onset of symptoms...
  23. doi request reprint Maternal snoring during pregnancy is associated with enhanced fetal erythropoiesis--a preliminary study
    Riva Tauman
    Pediatric Sleep Center, Dana Children s Hospital, Tel Aviv Souraski Medical Center, Tel Aviv University, Tel Aviv, Israel
    Sleep Med 12:518-22. 2011
    ..We hypothesized that maternal snoring will result in increased levels of fetal circulating nRBCs via increased concentrations of EPO, IL-6, or both...
  24. doi request reprint Absolute monocyte count trichotomizes chronic lymphocytic leukemia into high risk patients with immune dysregulation, disease progression and poor survival
    Yair Herishanu
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Leuk Res 37:1222-8. 2013
    ..In conclusion, AMC quantification during the disease course classifies CLL patients into subgroups with unique clinical features and outcomes. ..
  25. ncbi request reprint Celecoxib but not rofecoxib inhibits the growth of transformed cells in vitro
    Diana Kazanov
    Department of Cancer Prevention, Tel Aviv Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Cancer Res 10:267-71. 2004
    ..The purpose of this study was to compare the growth effects of two specific COX-2 inhibitors, celecoxib (Pfizer, Inc., New York, NY), and rofecoxib (Merck, White House Station, NJ) in normal and transformed enterocytes...
  26. doi request reprint Increased CD39 expression on CD4(+) T lymphocytes has clinical and prognostic significance in chronic lymphocytic leukemia
    Chava Perry
    Department of Hematology and Bone Marrow Transplantation, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, Israel 64239
    Ann Hematol 91:1271-9. 2012
    ..CD39(+) may also serve as a future target for the development of novel therapies with immune-modulating antitumor agents in CLL...
  27. doi request reprint Severe pregnancy complications are associated with elevated factor VIII plasma activity
    Eli Rimon
    Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Blood Coagul Fibrinolysis 23:184-8. 2012
    ..1%) in the control group (P < 0.05). Elevated plasma activity of factor VIII might be a risk factor for severe pregnancy complications...
  28. ncbi request reprint Circulating apoptotic progenitor cells: a novel biomarker in patients with acute coronary syndromes
    Shmuel Schwartzenberg
    Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel
    Arterioscler Thromb Vasc Biol 27:e27-31. 2007
    ..We tested the hypothesis that circulating apoptotic progenitors are detectable in healthy subjects and altered in ACS patients...
  29. ncbi request reprint Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation
    Jacob George
    The Department of Cardiology and the Haematology Institute, Tel Aviv Sourasky Medical Center and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur Heart J 25:1003-8. 2004
    ..We investigated the number and adhesive properties of EPCs from patients with unstable angina and no evidence of cardiac necrosis...
  30. ncbi request reprint Transfer of endothelial progenitor cells improves myocardial performance in rats with dilated cardiomyopathy induced following experimental myocarditis
    Lael Werner
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, 6, Weizmann Street, 63423 Tel Aviv, Israel
    J Mol Cell Cardiol 39:691-7. 2005
    ..EPC transfer is effective in attenuating myocardial damage in a model of non-ischemic dilated cardiomyopathy...
  31. ncbi request reprint The effect of the readthrough acetylcholinesterase variant (AChE-R) on uterine muscle and leiomyomas
    Dan Grisaru
    Department of Obstetrics Gynecology, Tel Aviv University, Tel Aviv, Israel
    Mol Hum Reprod 13:351-4. 2007
    ..AChE-R is involved in the proliferation of the myometrium. The inhibitory effect of ARP on the myometrium may suggest a future therapeutic role of ARP...
  32. doi request reprint Platelet inhibitory effect of clopidogrel in patients treated with omeprazole, pantoprazole, and famotidine: a prospective, randomized, crossover study
    Yaron Arbel
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Cardiol 36:342-6. 2013
    ..The aim of the study was to assess the effect of 2 PPIs and a histamine-2 (H2) receptor-blocker on platelet reactivity in a crossover trial where each patient was alternately treated with each drug...
  33. ncbi request reprint Heparanase modulates heparinoids anticoagulant activities via non-enzymatic mechanisms
    Ben Zion Katz
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Thromb Haemost 98:1193-9. 2007
    ..Altogether, heparanase pro-coagulant activities that were also demonstrated in plasma samples from patients under LMWH treatment, point to a possible use of this molecule as antagonist for heparinoid treatment...
  34. ncbi request reprint Neonatal nucleated red blood cells in infants of overweight and obese mothers
    Galit Sheffer-Mimouni
    Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, 64239, Israel
    J Am Coll Nutr 26:259-63. 2007
    ..We hypothesized that an index of fetal hypoxia, the neonatal nucleated red blood cell (NRBC) count, is elevated in infants of overweight and obese mothers...
  35. ncbi request reprint Sustained leukocyte count during rising cortisol level
    Varda Deutsch
    Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Hashomer, Israel
    Acta Haematol 118:73-6. 2007
    ..To follow the trend of leukocyte counts relative to the serum cortisol levels in hospitalized patients...
  36. doi request reprint Recombinant human granulocyte-colony stimulating factor administration for treating amyotrophic lateral sclerosis: A pilot study
    Beatrice Nefussy
    Departments of Neurology and the ALS Clinic, Tel Aviv Sourasky Medical Centre, Israel
    Amyotroph Lateral Scler 11:187-93. 2010
    ..The treatment had no major side-effects. G-CSF administration in ALS patients caused successful mobilization of autologous bone marrow cells, but was not effective in slowing down disease deterioration...
  37. ncbi request reprint Clinical and laboratory characteristics of patients with atherothrombotic risk factors presenting with low concentrations of highly sensitive C-reactive protein
    David Zeltser
    Tel Aviv Sourasky Medical Center, Department of Internal Medicine D, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Atherosclerosis 176:297-301. 2004
    ..To clarify whether individuals with low concentrations of highly sensitive C-reactive protein (hs-CRP) are free of atherothrombotic risk factors or low-grade inflammation...
  38. ncbi request reprint Pronto ThromboRisk--a novel primer-extension ELISA based assay for the detection of mutations associated with increased risk for thrombophilia
    Noga Carmi
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Israel
    J Clin Lab Anal 18:259-64. 2004
    ....
  39. ncbi request reprint L-arginine attenuates lymphocyte activation and anti-oxidized LDL antibody levels in patients undergoing angioplasty
    Jacob George
    The Department of Cardiology, Tel Aviv Medical Center affiliated to the Sackler Faculty of Medicine, 6 Weizman Street, Tel Aviv University, Tel Aviv, Israel
    Atherosclerosis 174:323-7. 2004
    ..We sought to investigate the effect of L-arginine administration on the extent of lymphocyte activation and anti-oxLDL antibodies in patients with unstable angina undergoing PCI with stent placement...
  40. ncbi request reprint The appearance of aggregated erythrocytes in the peripheral blood of individuals with insulin resistance
    Daniel Justo
    Department of Internal Medicine D, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Diabetes Metab Res Rev 19:386-91. 2003
    ..Insulin resistance is associated with low-grade inflammatory response. The probability that the acute-phase response is associated with enhanced erythrocyte adhesiveness/aggregation was not explored...
  41. ncbi request reprint Oncogenic transformation of normal enterocytes by overexpression of cyclin D1
    Diana Kazanov
    Gastrointestinal Oncology Unit, Tel Aviv Medical Center and Tel Aviv University, Tel Aviv, Israel
    Dig Dis Sci 48:1251-61. 2003
    ..This model may be useful for understanding the role and interrelationships of cyclin D1 in colorectal tumorigenesis...
  42. ncbi request reprint Enhanced erythrocyte adhesiveness/aggregation in obesity corresponds to low-grade inflammation
    Dorit Samocha-Bonet
    Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Obes Res 11:403-7. 2003
    ..nonobese individuals...