Gadi Borkow

Summary

Affiliation: Cupron Inc
Country: Israel

Publications

  1. pmc A novel anti-influenza copper oxide containing respiratory face mask
    Gadi Borkow
    Cupron Scientific, Modi in, Israel
    PLoS ONE 5:e11295. 2010
  2. ncbi request reprint A novel small animal model for HIV-1 infection
    Mila Ayash-Rashkovsky
    Hebrew University Hadassah Medical School, Jerusalem, Israel
    FASEB J 19:1149-51. 2005
  3. ncbi request reprint Mouse models for HIV-1 infection
    Gadi Borkow
    Cupron Inc, Kfar Gibton, Israel
    IUBMB Life 57:819-23. 2005
  4. pmc Antiviral propierties of 5,5'-dithiobis-2-nitrobenzoic acid and bacitracin against T-tropic human immunodeficiency virus type 1
    Humberto H Lara
    Laboratorio de Inmunología y Virología, Departamento de Microbiologia e Inmunologia, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Nuevo Leon, Mexico
    Virol J 8:137. 2011
  5. pmc Neutralizing viruses in suspensions by copper oxide-based filters
    Gadi Borkow
    Ruth Ben Ari Institute of Clinical Immunology, Kaplan Medical Center, Rehovot 76100, Israel
    Antimicrob Agents Chemother 51:2605-7. 2007
  6. ncbi request reprint Copper as a biocidal tool
    Gadi Borkow
    Cupron Inc
    Curr Med Chem 12:2163-75. 2005
  7. ncbi request reprint Could chronic wounds not heal due to too low local copper levels?
    Gadi Borkow
    Cupron Inc, PO Box 10973, Greensboro, NC 27404, USA
    Med Hypotheses 70:610-3. 2008
  8. ncbi request reprint Putting copper into action: copper-impregnated products with potent biocidal activities
    Gadi Borkow
    Cupron Inc, New York, New York, USA
    FASEB J 18:1728-30. 2004
  9. ncbi request reprint Biocidal textiles can help fight nosocomial infections
    Gadi Borkow
    Cupron Inc, P O Box 10973, Greensboro, NC 27404, USA
    Med Hypotheses 70:990-4. 2008
  10. pmc Deactivation of human immunodeficiency virus type 1 in medium by copper oxide-containing filters
    Gadi Borkow
    Ruth Ben Ari Institute of Clinical Immunology, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
    Antimicrob Agents Chemother 52:518-25. 2008

Detail Information

Publications33

  1. pmc A novel anti-influenza copper oxide containing respiratory face mask
    Gadi Borkow
    Cupron Scientific, Modi in, Israel
    PLoS ONE 5:e11295. 2010
    ..Copper oxide displays potent antiviral properties. A platform technology has been developed that permanently introduces copper oxide into polymeric materials, conferring them with potent biocidal properties...
  2. ncbi request reprint A novel small animal model for HIV-1 infection
    Mila Ayash-Rashkovsky
    Hebrew University Hadassah Medical School, Jerusalem, Israel
    FASEB J 19:1149-51. 2005
    ..http://www.fasebj.org/cgi/doi/10.1096/fj.04-3185fje; doi:10.1096/fj.04-3185fje.)...
  3. ncbi request reprint Mouse models for HIV-1 infection
    Gadi Borkow
    Cupron Inc, Kfar Gibton, Israel
    IUBMB Life 57:819-23. 2005
    ....
  4. pmc Antiviral propierties of 5,5'-dithiobis-2-nitrobenzoic acid and bacitracin against T-tropic human immunodeficiency virus type 1
    Humberto H Lara
    Laboratorio de Inmunología y Virología, Departamento de Microbiologia e Inmunologia, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Nuevo Leon, Mexico
    Virol J 8:137. 2011
    ..These drugs proved to be leading compounds for further studies against HIV showing antiviral characteristics of interest...
  5. pmc Neutralizing viruses in suspensions by copper oxide-based filters
    Gadi Borkow
    Ruth Ben Ari Institute of Clinical Immunology, Kaplan Medical Center, Rehovot 76100, Israel
    Antimicrob Agents Chemother 51:2605-7. 2007
    ..Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses found in filterable suspensions...
  6. ncbi request reprint Copper as a biocidal tool
    Gadi Borkow
    Cupron Inc
    Curr Med Chem 12:2163-75. 2005
    ....
  7. ncbi request reprint Could chronic wounds not heal due to too low local copper levels?
    Gadi Borkow
    Cupron Inc, PO Box 10973, Greensboro, NC 27404, USA
    Med Hypotheses 70:610-3. 2008
    ..This would be done by the release of copper from the wound dressings directly into the wound site inducing angiogenesis and skin regeneration...
  8. ncbi request reprint Putting copper into action: copper-impregnated products with potent biocidal activities
    Gadi Borkow
    Cupron Inc, New York, New York, USA
    FASEB J 18:1728-30. 2004
    ..These applications address medical issues of the greatest importance, such as viral transmissions; nosocomial, or healthcare-associated, infections; and the spread of antibiotic-resistant bacteria...
  9. ncbi request reprint Biocidal textiles can help fight nosocomial infections
    Gadi Borkow
    Cupron Inc, P O Box 10973, Greensboro, NC 27404, USA
    Med Hypotheses 70:990-4. 2008
    ....
  10. pmc Deactivation of human immunodeficiency virus type 1 in medium by copper oxide-containing filters
    Gadi Borkow
    Ruth Ben Ari Institute of Clinical Immunology, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
    Antimicrob Agents Chemother 52:518-25. 2008
    ..The successful application of this technology may impact HIV-1 transmission, especially in developing countries where HIV-1 is rampant...
  11. ncbi request reprint World Summit of Antivirals--BIT Life Sciences' First Annual Summit. Combating severe viral infections
    Gadi Borkow
    Cupron Inc, Hameyasdim 44, Kfar Gibton 76910, Israel
    IDrugs 11:716-9. 2008
  12. doi request reprint Improvement of facial skin characteristics using copper oxide containing pillowcases: a double-blind, placebo-controlled, parallel, randomized study
    G Borkow
    Cupron Inc, North Industrial Area, Beth Shemesh, Israel
    Int J Cosmet Sci 31:437-43. 2009
    ..In most trial participants, this effect was already noticeable within 2 weeks of using the copper oxide containing pillowcases...
  13. doi request reprint Reducing the risk of skin pathologies in diabetics by using copper impregnated socks
    Gadi Borkow
    Cupron Scientific, Modi in, Israel
    Med Hypotheses 73:883-6. 2009
    ..Furthermore, we hypothesize that the copper released from the socks may even be beneficial in the healing of cuts, wounds and even hard to treat skin pathologies...
  14. doi request reprint Molecular mechanisms of enhanced wound healing by copper oxide-impregnated dressings
    Gadi Borkow
    Cupron Scientific, Modi in, Israel
    Wound Repair Regen 18:266-75. 2010
    ..This study proves the capacity of copper oxide-containing wound dressings to enhance wound healing and sheds light onto the molecular mechanisms by which copper oxide-impregnated dressings stimulate wound healing...
  15. ncbi request reprint Increased TGF-beta, Cbl-b and CTLA-4 levels and immunosuppression in association with chronic immune activation
    Qibin Leng
    R Ben Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
    Int Immunol 18:637-44. 2006
    ..We suggest that the higher levels of CTLA-4 and TGF-beta, both involved in the induction of Cbl-b, point at potential mechanisms underlying general and antigen-specific immune hyporesponsiveness in chronically infected individuals...
  16. ncbi request reprint Enhanced HIV-1 specific immune response by CpG ODN and HIV-1 immunogen-pulsed dendritic cells confers protection in the Trimera murine model of HIV-1 infection
    Mila Ayash-Rashkovsky
    Hebrew University Hadassah Medical School, Jerusalem, Israel
    FASEB J 19:1152-4. 2005
    ....
  17. ncbi request reprint TLR9 expression is related to immune activation but is impaired in individuals with chronic immune activation
    Mila Ayash-Rashkovsky
    Ruth Ben Ari Institute of Clinical Immunology, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
    Int J Biochem Cell Biol 37:2380-94. 2005
    ....
  18. ncbi request reprint CTLA-4 upregulation during aging
    Qibin Leng
    Ruth Ben Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, 76100, Rehovot, Israel
    Mech Ageing Dev 123:1419-21. 2002
    ..55, P<0.001). We postulate that immune senescence associated with age is caused in part by chronic immune activation with related decrease in CD28 costimulatory molecules and increase in inhibitory CTLA-4 molecules...
  19. doi request reprint Prevention of human immunodeficiency virus breastmilk transmission with copper oxide: proof-of-concept study
    Gadi Borkow
    Cupron Scientific, Modi in, Israel
    Breastfeed Med 6:165-70. 2011
    ..The development of an approach to inactivate the HIV-1 virions ingested by an infant on a daily basis through breastmilk is thus of critical importance...
  20. ncbi request reprint Generation of Th1 immune responses to inactivated, gp120-depleted HIV-1 in mice with a dominant Th2 biased immune profile via immunostimulatory [correction of imunostimulatory] oligonucleotides--relevance to AIDS vaccines in developing countries
    Mila Ayash-Rashkovsky
    Ruth Ben Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
    Vaccine 20:2684-92. 2002
    ..These findings strongly support the advisability of using CpG ODN as a Th1 inducing adjuvant when immunizing human populations with a strong pre-existent Th2 immune profile...
  21. ncbi request reprint Adenovirus expressing a bioluminescence reporter gene and cMAGI cell assay for the detection of HIV-1
    Gadi Borkow
    Ruth Ben Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
    Virus Genes 29:257-65. 2004
    ..This method can also be used for discovery of novel anti HIV-1 drugs...
  22. ncbi request reprint Attenuated signaling associated with immune activation in HIV-1-infected individuals
    Qibin Leng
    R Ben Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, 76100 Rehovot, Israel
    Biochem Biophys Res Commun 298:464-7. 2002
    ..Therefore, targeting immune negative modulators, such as Cbl-b, may serve as a novel approach for controlling HIV-1 disease progression...
  23. doi request reprint NeoR6 inhibits HIV-1-CXCR4 interaction without affecting CXCL12 chemotaxis activity
    Aviva Lapidot
    Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biochim Biophys Acta 1780:914-20. 2008
    ..g. T140 and AMD3100. This complementary utilization of chemical, biology, and computation analysis provides a powerful approach for designing anti-HIV-1 drugs without interfering with the natural function of CXCL12/CXCR4 binding...
  24. pmc Host background immunity and human immunodeficiency virus protective vaccines, a major consideration for vaccine efficacy in Africa and in developing countries
    Gadi Borkow
    R Ben Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot, Israel
    Clin Diagn Lab Immunol 9:505-7. 2002
  25. ncbi request reprint Blocking of cell-free and cell-associated HIV-1 transmission through human cervix organ culture with UC781
    Ariela Zussman
    R Ben Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew Uuniversity Hadassah Medical School, Rehovot, Israel
    AIDS 17:653-61. 2003
    ..To determine the efficacy of UC781 in preventing HIV-1 transmission through cervical tissue...
  26. ncbi request reprint CTLA-4 upregulation during HIV infection: association with anergy and possible target for therapeutic intervention
    Qibin Leng
    Ruth Ben Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
    AIDS 16:519-29. 2002
    ..To study the role of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) during HIV infection...
  27. ncbi request reprint Can worms defend our hearts? Chronic helminthic infections may attenuate the development of cardiovascular diseases
    Eli Magen
    Ruth Ben An Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot, Israel
    Med Hypotheses 64:904-9. 2005
    ..If the hypothesis that helminthic infections impact atherosclerosis is correct, it should be taken into consideration in atherosclerosis immunomodulation therapy and especially in the design of vaccines and vaccine trials...
  28. doi request reprint Chronic parasite infections cause immune changes that could affect successful vaccination
    Gadi Borkow
    Cupron Inc, Hameyasdim 44, Kfar Gibton, Israel
    Trends Parasitol 24:243-5. 2008
    ..Underscoring the importance of these issues, a recent report has highlighted several vaccination studies in which nematode-infected mice or pigs failed to mount efficient protective immune responses...
  29. ncbi request reprint Structure-activity relationship of neomycin, paromomycin, and neamine-arginine conjugates, targeting HIV-1 gp120-CXCR4 binding step
    Gadi Borkow
    Department of Organic Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Antiviral Res 60:181-92. 2003
    ..The AACs play an important role, not only as HIV-1 RNA binders but also as inhibitors of viral entry into human cells...
  30. ncbi request reprint Mutations in gp41 and gp120 of HIV-1 isolates resistant to hexa-arginine neomycin B conjugate
    Gadi Borkow
    Department of Organic Chemistry, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Biochem Biophys Res Commun 312:1047-52. 2003
    ..The AACs may thus represent a novel family of fusion inhibitors...
  31. ncbi request reprint Attenuated infectivity of HIV type 1 from epithelial cells pretreated with a tight-binding nonnucleoside reverse transcriptase inhibitor
    Gadi Borkow
    Lady Davis Institute for Medical Research, McGill University AIDS Centre, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    AIDS Res Hum Retroviruses 18:711-4. 2002
    ....
  32. ncbi request reprint Structure-function relationship of novel X4 HIV-1 entry inhibitors - L- and D-arginine peptide-aminoglycoside conjugates
    Ravi Hegde
    Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    FEBS J 274:6523-36. 2007
    ..This and further structure-function studies of APACs may provide new target(s) and lead compound(s) of more potent HIV-1 cell entry inhibitors...
  33. doi request reprint The helminth HIV connection: time to act
    Zvi Bentwich
    Center for Emerging Tropical Diseases and AIDS, Ben Gurion University Faculty of Health Sciences, Beer Sheba, Israel
    AIDS 22:1611-4. 2008