Research Topics
Species | Gadi BorkowSummaryAffiliation: Cupron Inc Country: Israel Publications
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Detail Information
Publications
Mouse models for HIV-1 infectionGadi Borkow
Cupron Inc, Kfar Gibton, Israel
IUBMB Life 57:819-23. 2005....
A novel anti-influenza copper oxide containing respiratory face maskGadi Borkow
Cupron Scientific, Modi in, Israel
PLoS ONE 5:e11295. 2010..Copper oxide displays potent antiviral properties. A platform technology has been developed that permanently introduces copper oxide into polymeric materials, conferring them with potent biocidal properties...- A novel small animal model for HIV-1 infectionMila Ayash-Rashkovsky
Hebrew University Hadassah Medical School, Jerusalem, Israel
FASEB J 19:1149-51. 2005..http://www.fasebj.org/cgi/doi/10.1096/fj.04-3185fje; doi:10.1096/fj.04-3185fje.)... - Antiviral propierties of 5,5'-dithiobis-2-nitrobenzoic acid and bacitracin against T-tropic human immunodeficiency virus type 1Humberto H Lara
Laboratorio de Inmunología y Virología, Departamento de Microbiologia e Inmunologia, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Nuevo Leon, Mexico
Virol J 8:137. 2011..These drugs proved to be leading compounds for further studies against HIV showing antiviral characteristics of interest... - Neutralizing viruses in suspensions by copper oxide-based filtersGadi Borkow
Ruth Ben Ari Institute of Clinical Immunology, Kaplan Medical Center, Rehovot 76100, Israel
Antimicrob Agents Chemother 51:2605-7. 2007..Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses found in filterable suspensions... - Copper as a biocidal toolGadi Borkow
Cupron Inc
Curr Med Chem 12:2163-75. 2005.... - Could chronic wounds not heal due to too low local copper levels?Gadi Borkow
Cupron Inc, PO Box 10973, Greensboro, NC 27404, USA
Med Hypotheses 70:610-3. 2008..This would be done by the release of copper from the wound dressings directly into the wound site inducing angiogenesis and skin regeneration... - Putting copper into action: copper-impregnated products with potent biocidal activitiesGadi Borkow
Cupron Inc, New York, New York, USA
FASEB J 18:1728-30. 2004..These applications address medical issues of the greatest importance, such as viral transmissions; nosocomial, or healthcare-associated, infections; and the spread of antibiotic-resistant bacteria... - Biocidal textiles can help fight nosocomial infectionsGadi Borkow
Cupron Inc, P O Box 10973, Greensboro, NC 27404, USA
Med Hypotheses 70:990-4. 2008.... - Deactivation of human immunodeficiency virus type 1 in medium by copper oxide-containing filtersGadi Borkow
Ruth Ben Ari Institute of Clinical Immunology, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
Antimicrob Agents Chemother 52:518-25. 2008..The successful application of this technology may impact HIV-1 transmission, especially in developing countries where HIV-1 is rampant... - World Summit of Antivirals--BIT Life Sciences' First Annual Summit. Combating severe viral infectionsGadi Borkow
Cupron Inc, Hameyasdim 44, Kfar Gibton 76910, Israel
IDrugs 11:716-9. 2008 
Improvement of facial skin characteristics using copper oxide containing pillowcases: a double-blind, placebo-controlled, parallel, randomized studyG Borkow
Cupron Inc, North Industrial Area, Beth Shemesh, Israel
Int J Cosmet Sci 31:437-43. 2009..In most trial participants, this effect was already noticeable within 2 weeks of using the copper oxide containing pillowcases...- Reducing the risk of skin pathologies in diabetics by using copper impregnated socksGadi Borkow
Cupron Scientific, Modi in, Israel
Med Hypotheses 73:883-6. 2009..Furthermore, we hypothesize that the copper released from the socks may even be beneficial in the healing of cuts, wounds and even hard to treat skin pathologies... - Molecular mechanisms of enhanced wound healing by copper oxide-impregnated dressingsGadi Borkow
Cupron Scientific, Modi in, Israel
Wound Repair Regen 18:266-75. 2010..This study proves the capacity of copper oxide-containing wound dressings to enhance wound healing and sheds light onto the molecular mechanisms by which copper oxide-impregnated dressings stimulate wound healing... - Increased TGF-beta, Cbl-b and CTLA-4 levels and immunosuppression in association with chronic immune activationQibin Leng
R. Ben-Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
Int Immunol 18:637-44. 2006..We suggest that the higher levels of CTLA-4 and TGF-beta, both involved in the induction of Cbl-b, point at potential mechanisms underlying general and antigen-specific immune hyporesponsiveness in chronically infected individuals... - Enhanced HIV-1 specific immune response by CpG ODN and HIV-1 immunogen-pulsed dendritic cells confers protection in the Trimera murine model of HIV-1 infectionMila Ayash-Rashkovsky
Hebrew University Hadassah Medical School, Jerusalem, Israel
FASEB J 19:1152-4. 2005.... - TLR9 expression is related to immune activation but is impaired in individuals with chronic immune activationMila Ayash-Rashkovsky
Ruth Ben Ari Institute of Clinical Immunology, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
Int J Biochem Cell Biol 37:2380-94. 2005.... - CTLA-4 upregulation during agingQibin Leng
Ruth Ben Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, 76100, Rehovot, Israel
Mech Ageing Dev 123:1419-21. 2002..55, P<0.001). We postulate that immune senescence associated with age is caused in part by chronic immune activation with related decrease in CD28 costimulatory molecules and increase in inhibitory CTLA-4 molecules... - Prevention of human immunodeficiency virus breastmilk transmission with copper oxide: proof-of-concept studyGadi Borkow
Cupron Scientific, Modi in, Israel
Breastfeed Med 6:165-70. 2011..The development of an approach to inactivate the HIV-1 virions ingested by an infant on a daily basis through breastmilk is thus of critical importance... - Generation of Th1 immune responses to inactivated, gp120-depleted HIV-1 in mice with a dominant Th2 biased immune profile via immunostimulatory [correction of imunostimulatory] oligonucleotides--relevance to AIDS vaccines in developing countriesMila Ayash-Rashkovsky
Ruth Ben-Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
Vaccine 20:2684-92. 2002..These findings strongly support the advisability of using CpG ODN as a Th1 inducing adjuvant when immunizing human populations with a strong pre-existent Th2 immune profile... - Adenovirus expressing a bioluminescence reporter gene and cMAGI cell assay for the detection of HIV-1Gadi Borkow
Ruth Ben Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
Virus Genes 29:257-65. 2004..This method can also be used for discovery of novel anti HIV-1 drugs... - Attenuated signaling associated with immune activation in HIV-1-infected individualsQibin Leng
R. Ben-Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, 76100 Rehovot, Israel
Biochem Biophys Res Commun 298:464-7. 2002..Therefore, targeting immune negative modulators, such as Cbl-b, may serve as a novel approach for controlling HIV-1 disease progression... - NeoR6 inhibits HIV-1-CXCR4 interaction without affecting CXCL12 chemotaxis activityAviva Lapidot
Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
Biochim Biophys Acta 1780:914-20. 2008..g. T140 and AMD3100. This complementary utilization of chemical, biology, and computation analysis provides a powerful approach for designing anti-HIV-1 drugs without interfering with the natural function of CXCL12/CXCR4 binding... - Host background immunity and human immunodeficiency virus protective vaccines, a major consideration for vaccine efficacy in Africa and in developing countriesGadi Borkow
R. Ben-Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot, Israel
Clin Diagn Lab Immunol 9:505-7. 2002 - Blocking of cell-free and cell-associated HIV-1 transmission through human cervix organ culture with UC781Ariela Zussman
R. Ben-Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew Uuniversity Hadassah Medical School, Rehovot, Israel
AIDS 17:653-61. 2003..CONCLUSIONS: Exposure of the cervix to UC781 results in blocking of subsequent HIV-1 transmission with no toxicity. Therefore, UC781 is an excellent candidate microbiocide... - CTLA-4 upregulation during HIV infection: association with anergy and possible target for therapeutic interventionQibin Leng
Ruth Ben-Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
AIDS 16:519-29. 2002..2) Increased levels of CTLA-4 may undermine immune responses and in the HAART-treated patient-immune reconstitution. (3) Blocking of CTLA-4 may offer a novel approach for immune-based therapy in HIV infection... - Can worms defend our hearts? Chronic helminthic infections may attenuate the development of cardiovascular diseasesEli Magen
Ruth Ben An Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot, Israel
Med Hypotheses 64:904-9. 2005..If the hypothesis that helminthic infections impact atherosclerosis is correct, it should be taken into consideration in atherosclerosis immunomodulation therapy and especially in the design of vaccines and vaccine trials... - Chronic parasite infections cause immune changes that could affect successful vaccinationGadi Borkow
Cupron Inc, Hameyasdim 44, Kfar Gibton, Israel
Trends Parasitol 24:243-5. 2008..Underscoring the importance of these issues, a recent report has highlighted several vaccination studies in which nematode-infected mice or pigs failed to mount efficient protective immune responses... - Structure-activity relationship of neomycin, paromomycin, and neamine-arginine conjugates, targeting HIV-1 gp120-CXCR4 binding stepGadi Borkow
Department of Organic Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
Antiviral Res 60:181-92. 2003..The AACs play an important role, not only as HIV-1 RNA binders but also as inhibitors of viral entry into human cells... - Mutations in gp41 and gp120 of HIV-1 isolates resistant to hexa-arginine neomycin B conjugateGadi Borkow
Department of Organic Chemistry, The Weizmann Institute of Science, 76100, Rehovot, Israel
Biochem Biophys Res Commun 312:1047-52. 2003..The AACs may thus represent a novel family of fusion inhibitors... - Attenuated infectivity of HIV type 1 from epithelial cells pretreated with a tight-binding nonnucleoside reverse transcriptase inhibitorGadi Borkow
Lady Davis Institute for Medical Research, McGill University AIDS Centre, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
AIDS Res Hum Retroviruses 18:711-4. 2002.... - Structure-function relationship of novel X4 HIV-1 entry inhibitors - L- and D-arginine peptide-aminoglycoside conjugatesRavi Hegde
Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel
FEBS J 274:6523-36. 2007..This and further structure-function studies of APACs may provide new target(s) and lead compound(s) of more potent HIV-1 cell entry inhibitors... - The helminth HIV connection: time to actZvi Bentwich
Center for Emerging Tropical Diseases and AIDS, Ben Gurion University Faculty of Health Sciences, Beer Sheba, Israel
AIDS 22:1611-4. 2008