Research Topics
Genomes and Genes | Angela ChetritSummaryCountry: Israel Publications
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Publications
Obesity among Arabs and Jews in Israel: a population-based studyOfra Kalter-Leibovici
Unit of Cardiovascular Epidemiology, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, Israel
Isr Med Assoc J 9:525-30. 2007..Arabs in Israel have high morbidity and mortality from diabetes and cardiovascular disease. Obesity is a risk factor for both conditions...
Effect of BRCA1/2 mutations on long-term survival of patients with invasive ovarian cancer: the national Israeli study of ovarian cancerAngela Chetrit
Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
J Clin Oncol 26:20-5. 2008..To evaluate the long-term survival of ovarian cancer (OvC) patients in total and by BRCA1/2 mutation status...
Risk of thyroid cancer after childhood exposure to ionizing radiation for tinea capitisSiegal Sadetzki
Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
J Clin Endocrinol Metab 91:4798-804. 2006..We examined the effect of low doses of ionizing radiation (4.5-49.5 cGy) on the risk of developing thyroid cancer after long latent periods of up to 54 yr after childhood exposure...
The sequence of vessel interruption during lobectomy: does it affect the amount of blood retained in the lobe?Alon Yellin
Department of Thoracic Surgery, Sheba Medical Center, Tel Hashomer, and the Sackler Faculty of Medicine, Tel Aviv University, Israel
Eur J Cardiothorac Surg 31:711-3. 2007..The aim of the present study was to determine whether SVI has an impact on the amount of blood retained in the resected lobe...
Basal-state hyperinsulinemia in healthy normoglycemic adults is predictive of type 2 diabetes over a 24-year follow-up: a preliminary reportRachel Dankner
Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel
Diabetes Care 32:1464-6. 2009..CONCLUSIONS Basal hyperinsulinemia in normoglycemic adults constitutes an independent risk factor for developing dysglycemia over 24 years...
Lifestyle intervention in obese Arab women: a randomized controlled trialOfra Kalter-Leibovici
Units of Cardiovascular Epidemiology, Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Ramat Gan 52621, Israel
Arch Intern Med 170:970-6. 2010..Few randomized controlled trials on lifestyle interventions have been reported in non-Western populations; none have been reported in Arab populations...
Epidemiology of gliomas in Israel: a nationwide studySiegal Sadetzki
Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
Neuroepidemiology 31:264-9. 2008..Glial brain tumors span a wide range of neoplasms with distinct clinical and histopathological features. This report presents the descriptive epidemiology of glial tumors by histological subtype and tumor behavior...
Smoking and risk of parotid gland tumors: a nationwide case-control studySiegal Sadetzki
Cancer and Radiation Epidemiology Unit, Gertner Institute, Sheba Medical Center, Tel Hashomer, Israel
Cancer 112:1974-82. 2008..The objective of the current study was to assess the association between smoking and benign and malignant parotid gland tumors (PGTs) in a nationwide study...
Cellular phone use and risk of benign and malignant parotid gland tumors--a nationwide case-control studySiegal Sadetzki
Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
Am J Epidemiol 167:457-67. 2008..A positive dose-response trend was found for these measurements. Based on the largest number of benign PGT patients reported to date, our results suggest an association between cellular phone use and PGTs...
Childhood exposure to ionizing radiation to the head and risk of schizophreniaSiegal Sadetzki
Cancer and Radiation Epidemiology Unit, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, Israel
Radiat Res 176:670-7. 2011..More research on possible effects of early exposure to ionizing radiation on schizophrenia specifically and brain tissue in general is needed...
Glucose tolerance status and 20 year cancer incidenceRachel Dankner
Unit for Cardiovascular Epidemiology, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, Israel
Isr Med Assoc J 9:592-6. 2007..Type 2 diabetes, an extreme state of glucose intolerance, has been found to be associated with cancer mortality; less is known about impaired glucose tolerance and cancer incidence...
Time trends in the incidence and causes of blindness in IsraelAlon Skaat
Goldschleger Eye Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel
Am J Ophthalmol 153:214-221.e1. 2012..To evaluate time trends in the incidence and causes of new cases of blindness in Israel between 1999 and 2008...
Long-term follow-up for brain tumor development after childhood exposure to ionizing radiation for tinea capitisSiegal Sadetzki
Cancer and Radiation Epidemiology Unit, Sheba Medical Center, Tel Hashomer, Israel
Radiat Res 163:424-32. 2005..56 to 0.47 (P = 0.037), while no trend with age was seen for benign meningiomas. The ERR for both types of tumor remains elevated at 30-plus years after exposure...
Hormone replacement therapy is more prevalent among Jewish BRCA1/2 mutation carriersRevital Bruchim Bar Sade
The Susanne Levy Gertner Oncogenetics Unit, The Danek Gertner Institute of Human Genetics, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Eur J Cancer 42:650-5. 2006..This study has shown that HRT use is more prevalent among Jewish Ashkenazi mutation carriers, but its role in modifying breast cancer risk in mutation carriers remains unknown...
Dietary intake changes and their association with ovarian cancer riskFlora Lubin
Biostatistics Unit, Gertner Institute, Sheba Medical Center, Tel Hashomer, Israel
J Nutr 136:2362-7. 2006..65/100 kcal (418.4 kJ), 95% CI = 0.50 - 0.85]. Our results suggest that substitution of nonanimal for animal fat during adult life might reduce the risk of ovarian cancer, but this requires confirmation in prospective studies...
Serum adiponectin is associated with homocysteine in elderly men and women, and with 5,10-methylenetetrahydrofolate reductase (MTHFR) in a sex-dependent mannerRachel Dankner
Unit for Cardiovascular Epidemiology, The Gertner Institute, Sheba Medical Center, Tel Hashomer, Israel 52621
Metabolism 59:1767-74. 2010..5). This study demonstrated a positive association between homocysteine and adiponectin in both elderly men and women and a statistically significant association between adiponectin and MTHFR C677T genotypes in women only...
Patterns of drug use among the community-dwelling old-old population in IsraelZahava Fuchs
Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer 52621, Israel
Isr Med Assoc J 5:346-51. 2003..Due to multiple chronic illness and disability, the elderly consume a disproportionately large share of medications...
Prevalence and correlates of psychotropic medication use among older adults in Israel: cross-sectional and longitudinal findings from two cohorts a decade apartTzvia Blumstein
The Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, Israel
Aging Ment Health 16:636-47. 2012..5 years follow-up...
Life-style habits and homocysteine levels in an elderly populationRachel Dankner
Unit for Cardiovascular Epidemiology, Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel
Aging Clin Exp Res 16:437-42. 2004..The aim of our study was to test the hypothesis that there is an association between physical activity, life-style habits and plasma Hcy levels in an elderly population...
Predicting the 20-year diabetes incidence rateRachel Dankner
Unit for Cardiovascular Epidemiology, The Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel
Diabetes Metab Res Rev 23:551-8. 2007..Our objective was to evaluate the efficacy of various glucose-related clinical measurements in predicting the 20-year risk of developing type 2 diabetes (T2DM) in an elderly population...
Weather conditions and visits to the medical wing of emergency rooms in a metropolitan area during the warm season in Israel: a predictive modelIlya Novikov
Unit of Biostatistics, Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel
Int J Biometeorol 56:121-7. 2012..The marginal effect of temperature on the number of ER visits can be attributed to behavioral adaptations, including the use of air-conditioning...
Multidisciplinary intervention for control of diabetes in patients undergoing coronary artery bypass graft (CABG)Ohad Cohen
Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Israel
Cardiovasc Surg 11:195-200. 2003..The means of all values of FBG and of hemoglobin A1c were significantly higher among patients with complications (n=49) than in those without (P=0.01)...
The sequence of vessel interruption during lobectomy for non-small cell lung cancer: is it indeed important?Yael Refaely
Department of Thoracic Surgery and Cancer Epidemiology Unit, Gertner Institute, Sheba Medical Center, Tel Hashomer, Israel
J Thorac Cardiovasc Surg 125:1313-20. 2003..This hypothesis was never confirmed scientifically. The aim of the present study was to determine whether the sequence of vessel interruption during lobectomy (lobar vein or lobar artery first) affects disease recurrence...
Physical activity is inversely associated with total homocysteine levels, independent of C677T MTHFR genotype and plasma B vitaminsRachel Dankner
Unit for Cardiovascular Epidemiology, The Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, 52621, Israel
Age (Dordr) 29:219-27. 2007..This study emphasizes the importance of maintaining a physically active lifestyle in the elderly...
Lifestyle and ethnicity play a role in all-cause mortalityFlora Lubin
Unit for Cardiovascular Epidemiology, The Gertner Institute for Epidemiology and Health Policy Research, Chaim Sheba Medical Center, Tel Hashomer, Israel
J Nutr 133:1180-5. 2003..53 (95% CI: 0.29-0.97)]. Smoking, increased systolic BP, older age and male sex increased mortality risk. We conclude that in our study, although ethnic origin and lifestyle habits are interrelated, each affects mortality independently...
The composition of normal pericardial fluid and its implications for diagnosing pericardial effusionsShomron Ben-Horin
Department of Medicine F, Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
Am J Med 118:636-40. 2005..Moreover, there is little data regarding the normal composition of the physiological pericardial fluid, which could serve as a reference for pathological effusions...
Cancer incidence in a cohort of infertile women who underwent in vitro fertilizationJehoshua Dor
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Fertil Steril 77:324-7. 2002..73 cases expected, respectively. The type of infertility, number of IVF cycles, and treatment outcome did not significantly affect risk for cancer. CONCLUSION(S): In a cohort of women treated with IVF, no excess risk for cancer was noted...
Effects of platelet membrane glycoprotein polymorphisms on the risk of myocardial infarction in young malesNurit Rosenberg
Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel
Isr Med Assoc J 4:411-4. 2002..Platelet adhesion and aggregation are mediated by specific platelet membrane glycoproteins GPla/IIa, GPlb alpha, and GPIIb/IIIa, and are essential steps in thrombus formation and development of acute myocardial infarction...
Characteristics of falls in hospitalized patientsHana Kerzman
Nursing Research Unit, Nursing Division, Chaim Sheba Medical Center, Tel Hashomer, Israel
J Adv Nurs 47:223-9. 2004..Falls may lead to fear, pain, slight or severe injuries, increase the duration of hospital stay, cause patient discomfort and affect quality of life...
Colchicine nonresponsiveness in familial Mediterranean fever: clinical, genetic, pharmacokinetic, and socioeconomic characterizationMerav Lidar
Heller Institute of Medical Research, Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Hashomer, Israel
Semin Arthritis Rheum 33:273-82. 2004..CONCLUSIONS: Colchicine treatment failure in FMF is associated with inadequate colchicine MNC concentration, probably resulting from a genetic defect unrelated to the underlying FMF...
Comparison between primary peritoneal and epithelial ovarian carcinoma: a population-based studyGiulia Barda
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, E. Wolfson Medical Center, Holon, Israel
Am J Obstet Gynecol 190:1039-45. 2004..Diameter of residual disease was associated with better survival only in the OvC group. CONCLUSION: The clinical differences do not enable a preoperative distinction between the neoplasms...
Gynecologic surgeries and risk of ovarian cancer in women with BRCA1 and BRCA2 Ashkenazi founder mutations: an Israeli population-based case-control studyJoni L Rutter
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7246, USA
J Natl Cancer Inst 95:1072-8. 2003..We assessed the level and persistence of reduction of ovarian (including peritoneal) cancer risk after gynecologic surgeries for women who carry BRCA1/2 mutations but were not selected from high-risk clinics...
Endonasal geometry changes in elderly people: acoustic rhinometry measurementsLimor Muallem Kalmovich
Department of Otolaryngology, Assaf Harofeh Medical Center, and Sackler School of Medicine, Tel Aviv University, Zeriffin, 70300, Israel
J Gerontol A Biol Sci Med Sci 60:396-8. 2005..We evaluated endonasal parameters in an elderly population as compared with those in a young group...
The role of risk factor time trends in the steep decline of CHD mortality between two Israeli cohort studiesYariv Gerber
Division of Epidemiology and Preventive Medicine, Sackler Medical Faculty, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, PO Box 39040, Israel
Prev Med 41:85-91. 2005..Over the past few decades, a sizable monotonous decrease in coronary heart disease (CHD) mortality rates was evident in Israel. Our purpose was to evaluate the association of risk factor time trends with this decline...
Demographic and genetic characteristics of patients with borderline ovarian tumors as compared to early stage invasive ovarian cancerWalter H Gotlieb
Department of Gynecologic Oncology, Sheba Medical Center Tel Hashomer, Israel
Gynecol Oncol 97:780-3. 2005..Evaluation whether Jewish founder mutations in BRCA predispose to borderline tumors as they do to early invasive ovarian cancers...
The INTERPHONE study: design, epidemiological methods, and description of the study populationElisabeth Cardis
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon, Cedex 08, France
Eur J Epidemiol 22:647-64. 2007..Particular attention was paid to estimating the amount and direction of potential recall and participation biases and their impact on the study results...
Risk factors for neonatal thrombocytopenia in preterm infantsMario E Beiner
Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel-Hashomer, Tel-Aviv University, Israel
Am J Perinatol 20:49-54. 2003..Screening these high-risk groups for thrombocytopenia might be beneficial in terms of early diagnosis and management...
Insulin-like growth factor I polymorphism and breast cancer risk in Jewish womenArie Figer
Oncology Institute, Sourasky Tel Aviv Medical Center, Tel Aviv, Israel
Isr Med Assoc J 4:759-62. 2002..An attractive candidate is the insulin-like growth factor I, a known mitogen to mammary ductal cells in vivo and in vitro, whose serum levels were reportedly elevated in breast cancer patients...
The metabolic syndrome and glucose tolerance status deterioration over 23-year follow-upRachel S Dankner
Diabetes Care 29:1715-6. 2006
Follow-up of ovarian and primary peritoneal carcinoma: the value of physical examination in patients with pretreatment elevated CA125 levelsJoseph Menczer
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, E Wolfson, Medical Center, Holon, Israel
Gynecol Oncol 103:137-40. 2006..To assess the value of routine periodic physical examination in the follow-up of ovarian (OvC) and primary peritoneal carcinoma (PPC) patients with pretreatment elevated CA125 levels...
High prevalences of vitamin B12 and folic acid deficiency in elderly subjects in IsraelElizabeth Figlin
Department of Hematology, Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Centre, Tel-Hashomer, Israel
Br J Haematol 123:696-701. 2003..69, 95% CI 2.27-6.01). These data suggest that malnutrition is a major cause of the highly prevalent deficiencies of vitamin B12 and/or folic acid in elderly Israeli subjects dwelling at home...
A comparison between different postoperative treatment modalities of uterine carcinosarcomaJoseph Menczer
Departments of Obstetrics and Gynecology, Gynecologic Oncology Units, E Wolfson Medical Center, Holon, Israel
Gynecol Oncol 97:166-70. 2005..e., chemotherapy followed by WPI) in the third...
Evaluation of disease severity in familial Mediterranean feverAdam Mor
Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Semin Arthritis Rheum 35:57-64. 2005..RELEVANCE: The F-SS established may be important for treatment decisions, prognosis evaluation, and comparative analysis of patient populations...
The neurology of cobalamin deficiency in an elderly population in IsraelNatan Gadoth
Dept of Neurology, Meir General Hospital, Kfar Saba 44281, Israel
J Neurol 253:45-50. 2006..To evaluate the neurological status in elderly subjects with cobalamin deficiency (CblD) compared with matched non-deficient subjects before and after cobalamin (Cbl) supplementation...
Primary peritoneal carcinoma--Uterine involvement and hysterectomyJoseph Menczer
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, E Wolfson Medical Center, Holon, Israel
Gynecol Oncol 100:565-9. 2006..To assess the frequency of uterine involvement in primary peritoneal carcinoma (PPC) and to describe selected clinical characteristics in patients with and without hysterectomy...
The role of sonographic assessment of cervical length in the prediction of preterm birth in primigravidae with twin gestation conceived after infertility treatmentDavid Soriano
Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, 52621 Israel
Acta Obstet Gynecol Scand 81:39-43. 2002..To identify the risk factors for preterm birth in primigravidae with twin gestation and the role of transvaginal ultrasonographic assessment of the cervix...
