Igor Sukhotnik

Summary

Affiliation: Bnai Zion Medical Center
Country: Israel

Publications

  1. doi request reprint Effect of simvastatin on intestinal recovery following gut ischemia-reperfusion injury in a rat
    Nadav Slijper
    Laboratory of Intestinal Adaptation and Recovery, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Pediatr Surg Int 26:105-10. 2010
  2. pmc Dietary transforming growth factor-beta 2 (TGF-β2) supplementation reduces methotrexate-induced intestinal mucosal injury in a rat
    Shani Ben-Lulu
    Laboratory of Intestinal Adaptation and Recovery, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    PLoS ONE 7:e45221. 2012
  3. doi request reprint Wnt/β-catenin signaling cascade down-regulation following massive small bowel resection in a rat
    Igor Sukhotnik
    Laboratory of Intestinal Adaptation and Recovery, Department of Pediatric Surgery and Pathology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Pediatr Surg Int 30:173-80. 2014
  4. doi request reprint Methotrexate induces germ cell apoptosis and impairs spermatogenesis in a rat
    Igor Sukhotnik
    The Bruce Rappaport Faculty of Medicine, Laboratory of Intestinal Adaptation and Recovery, Technion Israel Institute of Technology, Haifa, Israel
    Pediatr Surg Int 29:179-84. 2013
  5. doi request reprint PDGF-α stimulates intestinal epithelial cell turnover after massive small bowel resection in a rat
    Igor Sukhotnik
    Technion Israel Institute of Technology, The Ruth and Bruce Rappaport Faculty of Medicine, Laboratory of Intestinal Adaptation and Recovery, Bnai Zion Medical Center, Haifa, Israel
    Am J Physiol Gastrointest Liver Physiol 302:G1274-81. 2012
  6. doi request reprint Bilirubin impairs intestinal regrowth following massive small bowel resection in a rat model
    Igor Sukhotnik
    Department of Pediatric Surgery, Bnai Zion Medical Center, 47 Golomb St, PO Box 4940, Haifa 31048, Israel
    J Pediatr Gastroenterol Nutr 49:16-22. 2009
  7. ncbi request reprint Oral glutamine prevents gut mucosal injury and improves mucosal recovery following lipopolysaccharide endotoxemia in a rat
    Igor Sukhotnik
    Department of Pediatric Surgery, B nai Zion Medical Center, Technion Israel Institute of Technology, Haifa, Israel
    J Surg Res 143:379-84. 2007
  8. ncbi request reprint Bombesin stimulates enterocyte turnover following massive small bowel resection in a rat
    Igor Sukhotnik
    Department of Pediatric Surgery, Pediatrics and Pathology, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 47 Golomb St, P O B 4940, Haifa 31048, Israel
    Pediatr Surg Int 23:397-404. 2007
  9. ncbi request reprint Dietary glutamine supplementation prevents mucosal injury and modulates intestinal epithelial restitution following ischemia-reperfusion injury in the rat
    Igor Sukhotnik
    Department of Pediatric Surgery B, Bnai Zion Medical Center, Haifa, Israel
    Dig Dis Sci 52:1497-504. 2007
  10. doi request reprint Parenteral omega-3 fatty acids (Omegaven) modulate intestinal recovery after intestinal ischemia-reperfusion in a rat model
    Igor Sukhotnik
    The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Laboratory of Intestinal Adaptation and Recovery, Haifa 35254, Israel
    J Pediatr Surg 46:1353-60. 2011

Detail Information

Publications71

  1. doi request reprint Effect of simvastatin on intestinal recovery following gut ischemia-reperfusion injury in a rat
    Nadav Slijper
    Laboratory of Intestinal Adaptation and Recovery, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Pediatr Surg Int 26:105-10. 2010
    ..The purpose of the present study was to examine the effect of simvastatin on intestinal recovery and enterocyte turnover after intestinal IR injury in rats...
  2. pmc Dietary transforming growth factor-beta 2 (TGF-β2) supplementation reduces methotrexate-induced intestinal mucosal injury in a rat
    Shani Ben-Lulu
    Laboratory of Intestinal Adaptation and Recovery, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    PLoS ONE 7:e45221. 2012
    ....
  3. doi request reprint Wnt/β-catenin signaling cascade down-regulation following massive small bowel resection in a rat
    Igor Sukhotnik
    Laboratory of Intestinal Adaptation and Recovery, Department of Pediatric Surgery and Pathology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Pediatr Surg Int 30:173-80. 2014
    ..The purpose of this study was to evaluate the role of Wnt/β-catenin signaling during late stages of intestinal adaptation in a rat model of short bowel syndrome (SBS)...
  4. doi request reprint Methotrexate induces germ cell apoptosis and impairs spermatogenesis in a rat
    Igor Sukhotnik
    The Bruce Rappaport Faculty of Medicine, Laboratory of Intestinal Adaptation and Recovery, Technion Israel Institute of Technology, Haifa, Israel
    Pediatr Surg Int 29:179-84. 2013
    ..The primary toxic effects of methotrexate (MTX) are myelosuppression and/or intestinal mucositis. The objective of the present study is to investigate the effect of MTX on germ cell apoptosis and spermatogenesis in a rat...
  5. doi request reprint PDGF-α stimulates intestinal epithelial cell turnover after massive small bowel resection in a rat
    Igor Sukhotnik
    Technion Israel Institute of Technology, The Ruth and Bruce Rappaport Faculty of Medicine, Laboratory of Intestinal Adaptation and Recovery, Bnai Zion Medical Center, Haifa, Israel
    Am J Physiol Gastrointest Liver Physiol 302:G1274-81. 2012
    ..In conclusion, in a rat model of SBS, PDGF-α stimulates enterocyte turnover, which is correlated with upregulated PDGF-α receptor expression in the remaining small intestine...
  6. doi request reprint Bilirubin impairs intestinal regrowth following massive small bowel resection in a rat model
    Igor Sukhotnik
    Department of Pediatric Surgery, Bnai Zion Medical Center, 47 Golomb St, PO Box 4940, Haifa 31048, Israel
    J Pediatr Gastroenterol Nutr 49:16-22. 2009
    ..The purpose of the present study was to evaluate the effects of exogenous bilirubin on structural intestinal adaptation, cell proliferation, and apoptosis in a rat model of short bowel syndrome (SBS)...
  7. ncbi request reprint Oral glutamine prevents gut mucosal injury and improves mucosal recovery following lipopolysaccharide endotoxemia in a rat
    Igor Sukhotnik
    Department of Pediatric Surgery, B nai Zion Medical Center, Technion Israel Institute of Technology, Haifa, Israel
    J Surg Res 143:379-84. 2007
    ..To evaluate the effects of oral glutamine in preventing mucosal damage caused by lipopolysaccharide (LPS) endotoxemia in a rat...
  8. ncbi request reprint Bombesin stimulates enterocyte turnover following massive small bowel resection in a rat
    Igor Sukhotnik
    Department of Pediatric Surgery, Pediatrics and Pathology, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 47 Golomb St, P O B 4940, Haifa 31048, Israel
    Pediatr Surg Int 23:397-404. 2007
    ..In conclusion, in a rat model of SBS, BBS enhances enterocyte turnover and stimulates structural intestinal adaptation. Decreased Bax expression may be responsible for the inhibitory effect of BBS on enterocyte apoptosis...
  9. ncbi request reprint Dietary glutamine supplementation prevents mucosal injury and modulates intestinal epithelial restitution following ischemia-reperfusion injury in the rat
    Igor Sukhotnik
    Department of Pediatric Surgery B, Bnai Zion Medical Center, Haifa, Israel
    Dig Dis Sci 52:1497-504. 2007
    ..In conclusion, pretreatment with oral glutamine prevents mucosal injury and improves intestinal recovery following IR injury in the rat...
  10. doi request reprint Parenteral omega-3 fatty acids (Omegaven) modulate intestinal recovery after intestinal ischemia-reperfusion in a rat model
    Igor Sukhotnik
    The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Laboratory of Intestinal Adaptation and Recovery, Haifa 35254, Israel
    J Pediatr Surg 46:1353-60. 2011
    ..The purpose of the present study was to examine the effects of 3PUFAs on intestinal structural changes, enterocyte proliferation, and apoptosis after intestinal IR in a rat...
  11. ncbi request reprint The effect of leptin on intestinal recovery following ischemia-reperfusion injury in a rat
    Igor Sukhotnik
    Deparment of Pediatric Surgery and Pathology, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 47 Golomb St, P O B 4940, Haifa 31048, Israel
    Pediatr Surg Int 23:473-8. 2007
    ..In conclusion, pre-treatment with leptin prevents gut mucosal damage and improves intestinal rehabilitation following intestinal IR in a rat...
  12. ncbi request reprint Adverse effects of increased intra-abdominal pressure on small bowel structure and bacterial translocation in the rat
    Igor Sukhotnik
    Department of Pediatric Surgery B, Bnai Zion Medical Center, Haifa, Israel
    J Laparoendosc Adv Surg Tech A 16:404-10. 2006
    ..The purpose of this study was to evaluate the effects of elevated intra-abdominal pressure (IAP) on intestinal structures and bacterial translocation in the rat...
  13. doi request reprint Effect of transforming growth factor-alpha on enterocyte apoptosis is correlated with EGF receptor expression along the villus-crypt axis during methotrexate-induced intestinal mucositis in a rat
    Igor Sukhotnik
    Laboratory of Intestinal Adaptation and Recovery, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Apoptosis 13:1344-55. 2008
    ..The inhibiting effect of TGF-alpha on enterocyte apoptosis was strongly correlated with EGFr expression along the villus-crypt axis. In conclusion, treatment with TGF-alpha inhibits enterocyte apoptosis following MTX- injury in the rat...
  14. doi request reprint Effect of oral insulin on diabetes-induced intestinal mucosal growth in rats
    Igor Sukhotnik
    Laboratory of Intestinal Adaptation and Recovery, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Dig Dis Sci 56:2566-74. 2011
    ..To evaluate the intestinal response to the induction of diabetes and to oral insulin (OI) administration in a rat...
  15. ncbi request reprint Oral insulin up-regulates Toll-like receptor 4 expression and enhances intestinal recovery following lipopolysaccharide-induced gut injury in a rat
    Igor Sukhotnik
    Department of Pediatric Surgery B, Bnai Zion Medical Center, Haifa, Israel
    Dig Dis Sci 53:1231-9. 2008
    ..Treatment with OI resulted in a three-fold increase in TLR4 expression in jejunum, compared to LPS animals. In conclusion, OI improves intestinal recovery after LPS endotoxemia in a rat...
  16. ncbi request reprint Effect of 100% oxygen on E-selectin expression, recruitment of neutrophils and enterocyte apoptosis following intestinal ischemia-reperfusion in a rat
    Igor Sukhotnik
    Department of Pediatric Surgery, Bnai Zion Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 47 Golomb St, POB 4940, Haifa, Israel
    Pediatr Surg Int 24:29-35. 2008
    ..05). Hyperoxia inhibits enterocyte apoptosis following intestinal ischemia-reperfusion. Down-regulation of E-selectin expression with subsequent decrease in neutrophil recruitment may be responsible for this effect...
  17. ncbi request reprint Leptin accelerates enterocyte turnover during methotrexate-induced intestinal mucositis in a rat
    Igor Sukhotnik
    The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Laboratory of Intestinal Adaptation and Recovery, Bnai Zion Medical Center, Haifa, Israel
    Cancer Biol Ther 8:899-906. 2009
    ..In conclusion, leptin enhances proliferation and decreases apoptosis in Caco-2 cells pretreated with MTX. In a rat model of MTX-induced mucositis, treatment with leptin improves intestinal recovery and enhances enterocyte turnover...
  18. doi request reprint Effect of oral glutamine on enterocyte turnover during methotrexate-induced mucositis in rats
    Igor Sukhotnik
    Rappaport Faculty of Medicine, Technion, Laboratory of Intestinal Adaptation and Recovery, Bnai Zion Medical Center, Haifa, Israel
    Digestion 79:5-13. 2009
    ..The objective of this study was to evaluate the effects of oral glutamine in preventing intestinal mucosal damage caused by methotrexate (MTX) in rats...
  19. doi request reprint Dietary palmitic acid modulates intestinal re-growth after massive small bowel resection in a rat
    Igor Sukhotnik
    Department of Pediatric Surgery and Pediatrics, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 47 Golomb St, P O Box 4940, Haifa, 31048, Israel
    Pediatr Surg Int 24:1313-21. 2008
    ..The purpose of the present study was to evaluate the effects of palmitic acid (PA) on early intestinal adaptation in rats with short bowel syndrome (SBS)...
  20. doi request reprint Effect of elevated intra-abdominal pressure and 100% oxygen on superior mesenteric artery blood flow and enterocyte turnover in a rat
    Igor Sukhotnik
    Department of Pediatric Surgery B, Bnai Zion Medical Center, 47 Golomb St, P O B 4940, 31048, Haifa, Israel
    Pediatr Surg Int 24:1347-53. 2008
    ..The purpose of the present study was to evaluate the effects of IAP and hyperoxia on superior mesenteric artery (SMA) blood flow, enterocyte proliferation and apoptosis in a rat model of abdominal compartment syndrome (ACS)...
  21. doi request reprint Transforming growth factor-alpha stimulates enterocyte proliferation and accelerates intestinal recovery following methotrexate-induced intestinal mucositis in a rat and a cell culture model
    Igor Sukhotnik
    Laboratory of Intestinal Adaptation and Recovery, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Pediatr Surg Int 24:1303-11. 2008
    ..The purpose of the present study was to evaluate the effect of TGF-alpha on enterocyte proliferation and intestinal recovery following methotrexate (MTX)-induced intestinal mucositis in rats and in Caco-2 cells...
  22. doi request reprint Oral insulin enhances cell proliferation and decreases enterocyte apoptosis during methotrexate-induced mucositis in the rat
    Igor Sukhotnik
    The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Laboratory of Intestinal Adaptation and Recovery, Israel
    J Pediatr Gastroenterol Nutr 47:115-22. 2008
    ..In the present study, we tested whether oral insulin can protect gut epithelial cells from methotrexate (MTX)-induced intestinal damage...
  23. doi request reprint Parenteral but not enteral omega-3 fatty acids (Omegaven) modulate intestinal regrowth after massive small bowel resection in rats
    Igor Sukhotnik
    Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Laboratory of Intestinal Adaptation and Recovery, Bnai Zion Medical Center, Haifa, Israel
    JPEN J Parenter Enteral Nutr 34:503-12. 2010
    ..The purpose of the present study was to evaluate the effects of ω-3 fatty acids (Omegaven) on early intestinal adaptation in rats with short bowel syndrome (SBS)...
  24. doi request reprint Leptin affects intestinal epithelial cell turnover in correlation with leptin receptor expression along the villus-crypt axis after massive small bowel resection in a rat
    Igor Sukhotnik
    Department Pediatric Surgery, Bnai Zion Medical Center, 47 Golomb St, P O B 4940, Haifa 31048, Israel
    Pediatr Res 66:648-53. 2009
    ..In conclusion LEP accelerated enterocyte turnover and stimulated intestinal adaptation. The effect of LEP on enterocyte proliferation and enterocyte apoptosis correlated with receptor expression along the villus-crypt axis...
  25. doi request reprint Nutritional supplementation with transforming growth factor-beta inhibits intestinal adaptation after massive small bowel resection in a rat
    Igor Sukhotnik
    Laboratory of Intestinal Adaptation and Recovery, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Pediatr Surg Int 27:211-6. 2011
    ..In the present study, we evaluated the effect of TGF-β2-enriched polymeric diet (Modulen) on enterocyte turnover in a rat model of short bowel syndrome (SBS)...
  26. doi request reprint Effect of alpha-naphthylisothiocyanate-induced liver injury on intestinal adaptation in a rat model of short bowel syndrome
    Igor Sukhotnik
    Laboratory of Intestinal Adaptation and Recovery, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Pediatr Surg Int 28:161-9. 2012
    ..In the current study, we examined the effects of alpha-naphthylisothiocyanate (ANIT)-induced liver injury on intestinal adaptation in a rat model of SBS...
  27. ncbi request reprint Oral insulin enhances intestinal regrowth following massive small bowel resection in rat
    Igor Sukhotnik
    Rappaport Faculty of Medicine, Technion, Department of Pediatric Surgery B, Bnai Zion Medical Center, Haifa, Israel
    Dig Dis Sci 50:2379-85. 2005
    ..In conclusion, in a rat model of SBS, oral INS strongly enhances intestinal adaptation. Possible mechanisms may include increased cell proliferation and decreased enterocyte loss via apoptosis...
  28. ncbi request reprint Effect of leptin on intestinal re-growth following massive small bowel resection in rat
    Igor Sukhotnik
    Department of Pediatric Surgery B, Rappaport Faculty of Medicine, Technion, Bnai Zion Medical Center, 47 Golomb Street, P O B 4940, 31048 Haifa, Israel
    Pediatr Surg Int 22:9-15. 2006
    ..In conclusion, in a rat model of SBS parenteral LEP stimulates structural intestinal adaptation. Increased cell proliferation and decreased cell death via apoptosis may be responsible for this increased cell mass...
  29. ncbi request reprint Peptide growth factors and intestinal adaptation in short bowel syndrome
    Igor Sukhotnik
    Department of Surgery B, Carmel Medical Center, Haifa, Israel
    Isr Med Assoc J 5:184-7. 2003
    ..This review focuses on the mechanisms of action of peptide growth factors in intestinal cell proliferation, and summarizes the effects of these factors on intestinal regrowth in an animal model of short bowel syndrome...
  30. ncbi request reprint Effect of bowel resection and high-fat diet on heart CD36/fatty-acid translocase expression in a rat model of short-bowel syndrome
    Igor Sukhotnik
    Department of Pediatric Surgery, C S Mott Children s Hospital and University of Michigan Medical School, Ann Arbor, USA
    Pediatr Surg Int 18:620-3. 2002
    ..In this rat model of SBS, the heart thus reacts to decreased LCFA delivery by increased tissue CD36/FAT mRNA levels and, consequently, active LCFA uptake. A HFD increased plasma lipid concentrations and decreased CD36/FAT levels...
  31. doi request reprint Intestinal involvement during 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced chronic liver injury in a mouse model
    Igor Sukhotnik
    Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Pediatr Surg 46:1495-502. 2011
    ..In the current study, we studied the effects of chronic liver injury as a primary injury on enterocyte turnover (proliferation and apoptosis) in a mouse model...
  32. ncbi request reprint Effect of dietary fat on fat absorption and concomitant plasma and tissue fat composition in a rat model of short bowel syndrome
    I Sukhotnik
    Carmel Medical Center, Dept of Surg B, 7 Michal str, 34362 Haifa, Israel
    Pediatr Surg Int 20:185-91. 2004
    ..These findings suggest a benefit of a high-fat diet on intestinal adaptation in general and on lipid absorption in particular...
  33. ncbi request reprint Lipopolysaccharide endotoxemia reduces cell proliferation and decreases enterocyte apopotosis during intestinal adaptation in a rat model of short-bowel syndrome
    I Sukhotnik
    Rappoport Faculty of Medicine, Technion, Israel
    Pediatr Surg Int 18:615-9. 2002
    ..A possible mechanism may be decreased cell proliferation. Decreased enterocyte loss via apoptosis may reflect a reduced number of enterocytes. Other mechanisms (necrosis) may be mainly responsible for cell death following LPS injection...
  34. ncbi request reprint Effect of dietary fat on early morphological intestinal adaptation in a rat with short bowel syndrome
    Igor Sukhotnik
    Section of Pediatric Surgery, C S Mott Children s Hospital and University of Michigan Medical School, Ann Arbor, MI, USA
    Pediatr Surg Int 20:419-24. 2004
    ..We conclude that early exposure to HFD both augmented and accelerated structural bowel adaptation in a rat model of SBS...
  35. ncbi request reprint Oral arginine reduces gut mucosal injury caused by lipopolysaccharide endotoxemia in rat
    Igor Sukhotnik
    Rappaport Faculty of Medicine, Technion, Bnai Zion Medical Center, Haifa, Israel
    J Surg Res 122:256-62. 2004
    ..The objective of this study was to evaluate the effects of lipopolysaccharide (LPS) endotoxemia and enteral arginine (ARG) supplementation on intestinal structural changes, enterocyte proliferation, and apoptosis in rat...
  36. ncbi request reprint Oral arginine improves intestinal recovery following ischemia-reperfusion injury in rat
    Igor Sukhotnik
    Department of Pediatric Surgery B, Rappaport Faculty of Medicine, Technion, Bnai Zion Medical Center, 47 Golomb St, 4940, Haifa 31048, Israel
    Pediatr Surg Int 21:191-6. 2005
    ..In conclusion, oral ARG administration improves mucosal recovery following IR injury in the rat...
  37. ncbi request reprint Effect of subcutaneous insulin on intestinal adaptation in a rat model of short bowel syndrome
    Igor Sukhotnik
    Department of Pediatric Surgery B, Rappaport Faculty of Medicine, Technion, Bnai Zion Medical Center, 47 Golomb Street, P O B 4940, Haifa 31048, Israel
    Pediatr Surg Int 21:132-7. 2005
    ..In conclusion, parenteral insulin stimulates structural intestinal adaptation in a rat model of SBS. Increased cell proliferation is the main mechanism responsible for increased cell mass...
  38. ncbi request reprint Effect of sex and sex hormones on structural intestinal adaptation after massive small bowel resection in rats
    Igor Sukhotnik
    Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel
    J Pediatr Surg 40:489-95. 2005
    ..The gonadal steroids play a major role in the regulation of many functions. The purpose of the current study was to evaluate the effect of sex and sex hormones on intestinal adaptation in a rat model of short bowel syndrome (SBS)...
  39. ncbi request reprint Advances in short bowel syndrome: an updated review
    Igor Sukhotnik
    Department of Pediatric Surgery B, Bnai Zion Medical Center, 47 Golomb Street, P O B 4940, Haifa, 31048 Israel
    Pediatr Surg Int 21:947-53. 2005
    ..This review summarizes current research on SBS over the last few years...
  40. ncbi request reprint The basic biology of apoptosis and its implications for pediatric surgery
    I Sukhotnik
    Department of Pediatric Surgery, Rappaport Faculty of Medicine, Technion, Bnai Zion Medical Center, Haifa, Israel
    Eur J Pediatr Surg 15:229-35. 2005
    ..Pro or antiapoptotic interventions may become a future target for cell and organ protection in patients suffering from these diseases...
  41. ncbi request reprint Effect of a high fat diet on lipid absorption and fatty acid transport in a rat model of short bowel syndrome
    Igor Sukhotnik
    Section of Pediatric Surgery, University of Michigan Medical School, F3970 Mott Children s Hospital, Ann Arbor, MI 48109 0245, USA
    Pediatr Surg Int 19:385-90. 2003
    ..However, at molecular and cellular levels HFD decreased mucosal FAT/CD36 mRNA levels and oleic acid uptake by isolated enterocytes...
  42. ncbi request reprint Parenteral arginine impairs intestinal adaptation following massive small bowel resection in a rat model
    Igor Sukhotnik
    Department of Pediatric Surgery, Rappaport Faculty of Medicine, Bnai Zion Medical Center, Technion Israel Institute of Technology, 47 Golomb St, P O Box 4940, Haifa 31048, Israel
    Pediatr Surg Int 21:460-5. 2005
    ..In conclusion, in a rat model of SBS, parenteral arginine inhibits structural intestinal adaptation. Decreased cell proliferation and increased apoptosis are the main mechanisms responsible for decreased cell mass...
  43. ncbi request reprint Beneficial effects of oral insulin on intestinal recovery following ischemia-reperfusion injury in rat
    Igor Sukhotnik
    Department of Pediatric Surgery, B nai Zion Medical Center, Haifa, Israel
    J Surg Res 128:108-13. 2005
    ..The purpose of the present study was to investigate the effect of oral insulin on ischemia-reperfusion (IR) intestinal mucosal injury in rat...
  44. doi request reprint Possible importance of increased intra-abdominal pressure for the development of necrotizing enterocolitis
    I Sukhotnik
    The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Laboratory of Intestinal Adaptation and Recovery, Dept of Pediatric Surgery, Bnai Zion Medical Center, Haifa, Israel
    Eur J Pediatr Surg 19:307-10. 2009
    ....
  45. ncbi request reprint The time relationship between ipsilateral testicular ischemia and germ cell apoptosis in the contralateral testis in rat
    Igor Sukhotnik
    Department of Pediatric Surgery, Rappaport Faculty of Medicine, Bnai Zion Medical Center, P O B 4940, Haifa 31048, Israel
    Pediatr Surg Int 21:512-6. 2005
    ..We conclude that testicular ischemia causes an increase in germ cell apoptosis in the contralateral testis. The extent of apoptosis increases with the duration of the ischemia...
  46. ncbi request reprint Low-fat diet impairs postresection intestinal adaptation in a rat model of short bowel syndrome
    Igor Sukhotnik
    Department of Surgery, Rappaport Faculty of Medicine, Technion, Carmel Medical Center, Haifa, Israel
    J Pediatr Surg 38:1182-7. 2003
    ..The purpose of this study was to investigate the effects of LFD on intestinal adaptation, enterocyte proliferation, and enterocyte cell death in a rat model of SBS...
  47. doi request reprint Reversal of severe methotrexate-induced intestinal damage using enteral n-3 fatty acids
    Tal Koppelmann
    Laboratory of Intestinal Adaptation and Recovery, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Bnai Zion Medical Center, Haifa, Israel
    Br J Nutr 109:89-98. 2013
    ..MTX) was accompanied by decreased Bax mRNA and protein expression and increased Bcl2 mRNA levels. Thus, the treatment with oral n-3 PUFA prevented mucosal injury and improved intestinal recovery following MTX-injury in rats...
  48. ncbi request reprint Effect of transforming growth factor-alpha on intestinal adaptation in a rat model of short bowel syndrome
    Igor Sukhotnik
    Rappaport Faculty of Medicine, Technion, Carmel Medical Center, Haifa 34362, Israel
    J Surg Res 108:235-42. 2002
    ..In the present study we investigated the effect of TGF-alpha on enterocyte proliferation and loss via apoptosis and its effects on intestinal adaptation in a rat following massive bowel resection...
  49. ncbi request reprint Responsiveness of intestinal epithelial cell turnover to TGF-alpha after bowel resection in a rat is correlated with EGF receptor expression along the villus-crypt axis
    Igor Sukhotnik
    Technion Israel Institute of Technology, The Ruth and Bruce Rappaport Faculty of Medicine, Bnai Zion Medical Center, Haifa, Israel
    Pediatr Surg Int 24:21-8. 2008
    ..In a rat model of SBS, TGF-alpha increased enterocyte proliferation and stimulated intestinal adaptation. The effect of TGF-alpha on enterocyte turnover is correlated with EGF receptor expression along the villus-crypt axis...
  50. ncbi request reprint Effect of testicular ischemia-reperfusion on recruitment of neutrophils, E-selectin expression and germ cell apoptosis in the contralateral testis in a rat
    Igor Sukhotnik
    Department of Pediatric Surgery and Pathology, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 47 Golomb St, P O B 4940, Haifa 31048, Israel
    Pediatr Surg Int 23:479-85. 2007
    ..sham animals) were not statistically significant. In conclusion, testicular ischemia causes an increase in germ cell apoptosis in the contralateral testis. Mechanisms other than neutrophil recruitment apparently initiate this process...
  51. ncbi request reprint Relationship between time of reperfusion and E-selectin expression, neutrophil recruitment, and germ cell apoptosis after testicular ischemia in a rat model
    Igor Sukhotnik
    Department of Pediatric Surgery, Bnai Zion Medical Center, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Fertil Steril 90:1517-22. 2008
    ..To examine the relationship between the time of reperfusion and neutrophil recruitment, E-selectin expression, and germ cell apoptosis in the ischemic and contralateral testis after testicular ischemia-reperfusion (IR) injury in a rat...
  52. pmc Dietary L-arginine supplementation reduces Methotrexate-induced intestinal mucosal injury in rat
    Tal Koppelmann
    The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Laboratory of Intestinal Adaptation and Recovery, Haifa, Israel
    BMC Gastroenterol 12:41. 2012
    ..In the present study, we evaluated the effects of oral ARG supplementation on intestinal structural changes, enterocyte proliferation and apoptosis following methotrexate (MTX)-induced intestinal damage in a rat...
  53. doi request reprint Oral insulin stimulates intestinal epithelial cell turnover in correlation with insulin-receptor expression along the villus-crypt axis in a rat model of short bowel syndrome
    Shani Ben Lulu
    Laboratory of Intestinal Adaptation and Recovery, Technion Israel Institute of Technology, The Ruth and Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Pediatr Surg Int 26:37-44. 2010
    ..In the present study, we evaluated the effect of OI on enterocyte turnover and correlated it with insulin-receptor expression along the villus-crypt axis in a rat model of short bowel syndrome (SBS)...
  54. ncbi request reprint Intestinal and systemic effects of oral insulin supplementation in rats after weaning
    Raanan Shamir
    Division of Pediatric Gastroenterology and Nutrition and Department of Pediatrics A, Meyer Children s Hospital of Haifa, Haifa, Israel
    Dig Dis Sci 50:1239-44. 2005
    ..We conclude that oral insulin supplementation exerts intestinal trophic effects, as well as systemic effects in the postweaning period in rats...
  55. doi request reprint Effect of lactulose on bacterial translocation and intestinal adaptation in a rat model of short bowel syndrome
    Igor Sukhotnik
    Department of Pediatric Surgery, Technion Israel Institute of Technology, Haifa, Israel
    J Pediatr Gastroenterol Nutr 46:507-13. 2008
    ..Therefore, the aim of this study was to define the effect of lactulose, a nondigestible carbohydrate, on bacterial translocation and intestinal adaptation in a rat model of short bowel syndrome (SBS)...
  56. ncbi request reprint Effects of enteral arginine supplementation on the structural intestinal adaptation in a rat model of short bowel syndrome
    Igor Sukhotnik
    Rappaport Faculty of Medicine, Technion, Department of Surgery, Carmel Medical Center, Haifa, Israel
    Dig Dis Sci 48:1346-51. 2003
    ..We conclude that in a rat model of SBS enteral L-arginine inhibits structural intestinal adaptation. Possible mechanism for this effect may be decreased cell proliferation and increased cell apoptosis...
  57. ncbi request reprint Effect of probiotics on intestinal regrowth and bacterial translocation after massive small bowel resection in a rat
    Jorge G Mogilner
    Department of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Pediatr Surg 42:1365-71. 2007
    ..This study was conducted to determine the effect of PROs on bacterial translocation and intestinal regrowth after massive small bowel resection in a rat...
  58. ncbi request reprint Endotoxemia inhibits intestinal adaptation in a rat model of short bowel syndrome
    Igor Sukhotnik
    Rappaport Faculty of Medicine, Technion, Department of Surgery B and Pathology Carmel Medical Center, Haifa, Israel
    Shock 19:66-70. 2003
    ..In conclusion, in a rat model of SBS-LPS, endotoxemia appears to inhibit structural intestinal adaptation and increase mortality...
  59. ncbi request reprint Effect of diclofenac on germ cell apoptosis following testicular ischemia-reperfusion injury in a rat
    Jorge G Mogilner
    Rappaport Faculty of Medicine, Technion, Department of Pediatric Surgery B, Bnai Zion Medical Center, 47 Golomb St, P O B 4940, 31048 Haifa, Israel
    Pediatr Surg Int 22:99-105. 2006
    ..We conclude that testicular ischemia causes an increase in germ cell apoptosis in the contralateral testis. Diclofenac may be beneficial for spermatogenesis following testicular IR by decreasing germ cell apoptosis...
  60. doi request reprint Oral insulin stimulates intestinal epithelial cell turnover following massive small bowel resection in a rat and a cell culture model
    Shani Ben Lulu
    The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Laboratory of Intestinal Adaptation and Recovery, Haifa, Israel
    Pediatr Surg Int 28:179-87. 2012
    ..The purpose of the present study was to evaluate the effect of OI on intestinal epithelial cell proliferation and apoptosis in a rat model of short bowel syndrome (SBS) and in a cell culture model...
  61. ncbi request reprint Effect of allopurinol on germ cell apoptosis following testicular ischemia-reperfusion injury in a rat
    Igor Sukhotnik
    Department of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Pediatr Surg Int 24:61-6. 2008
    ..05, AI-2- sixfold decrease, P < 0.005) compared to IR animals. In a rat model of testicular IR, treatment with allopurinol decreases germ cell apoptosis in both ischemic and contralateral testes and improves spermatogenesis...
  62. doi request reprint Involvement of the bax and bcl-2 system in the induction of germ cell apoptosis is correlated with the time of reperfusion after testicular ischemia in a rat model
    Igor Sukhotnik
    Department of Pediatric Surgery, Bnai Zion Medical Center, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Fertil Steril 92:1466-9. 2009
    ....
  63. doi request reprint Effect of elevated intra-abdominal pressure on portal vein and superior mesenteric artery blood flow in a rat
    Jorge Mogilner
    Department of Pediatric Surgery, Bnai Zion Medical Center, Israel
    J Laparoendosc Adv Surg Tech A 19:S59-62. 2009
    ..The aim of the present study was to evaluate the effects of IAP on blood flow in the portal vein (PV), compared to the superior mesenteric artery (SMA), and on the systemic mean arterial blood pressure (MABP)...
  64. ncbi request reprint Effect of dexamethasone on germ cell apoptosis in the contralateral testis after testicular ischemia-reperfusion injury in the rat
    Jorge G Mogilner
    Department of Pediatric Surgery, Bruce Rappaport Faculty of Medicine, Technion, Bnai Zion Medical Center, Haifa, Israel
    Fertil Steril 85:1111-7. 2006
    ..To evaluate the effect of dexamethasone on spermatogenesis and germ cell apoptosis in the ipsilateral and contralateral testis after testicular ischemia-reperfusion (IR) in rats...
  65. doi request reprint The effect of 100% oxygen on intestinal preservation and recovery following ischemia-reperfusion injury in rats
    Igor Sukhotnik
    Departmentsof Pediatric Surgery, Bnai Zion Medical Center, Haifa, Israel
    Crit Care Med 37:1054-61. 2009
    ..We examined the effect of hyperoxia on enterocyte turnover and intestinal preservation and rehabilitation following IR injury in rats...
  66. ncbi request reprint Sandostatin impairs postresection intestinal adaptation in a rat model of short bowel syndrome
    Igor Sukhotnik
    Rappaport Faculty of Medicine, Technion, Carmel Medical Center, Department of Surgery B, Haifa, Israel
    Dig Dis Sci 47:2095-102. 2002
    ..We conclude that in a rat model of SBS sandostatin decreases cell proliferation and inhibits structural intestinal adaptation...
  67. ncbi request reprint Gastrointestinal tract as a target organ for orally administered insulin
    Naim Shehadeh
    Department of Pediatrics A, Meyer Children s Hospital of Haifa, Haifa, Israel
    J Pediatr Gastroenterol Nutr 43:276-81. 2006
    ..Systemic effects, at least in animal models, include favorable effects on blood glucose and lipid profile and on the prevention of autoimmunity and attenuating the atherosclerotic process...
  68. ncbi request reprint Divergent effects of oxygen therapy in four models of uncontrolled hemorrhagic shock
    Igor Sukhotnik
    Ischemia Shock Research Laboratory, Carmel Medical Center, Haifa, Israel
    Shock 18:277-84. 2002
    ..05). The results point to differential effects of oxygen in uncontrolled bleeding with benefits in bleeding from small parenchymal vessels and possible detrimental effect in bleeding from large size vessels...
  69. ncbi request reprint Critical validation of ultrasound Doppler in the diagnosis of torsion of undescended testis
    Nadav Slijper
    Departments of Pediatric Surgery, Bnai Zion Medical Center, Haifa, Israel
    Isr Med Assoc J 9:99-101. 2007
    ..Ultrasound Doppler is recognized as the preferred imaging modality for testicular torsion due to its high specificity, sensitivity and availability...
  70. doi request reprint The yield of a continuously patent gastroesophageal junction during upper endoscopy as a predictor of esophagitis in children
    Nataly Zion
    Department of Pediatrics, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    Dig Dis Sci 55:3102-7. 2010
    ..We could not find documentation for these endoscopic findings as a predictor of esophagitis in the literature. We aimed to find an association between these findings and microscopic and macroscopic esophagitis...
  71. ncbi request reprint Radiation induces endothelial dysfunction in murine intestinal arterioles via enhanced production of reactive oxygen species
    Ossama A Hatoum
    Division of Cardiovascular Medicine, Froedtert Memorial Lutheran Hospital, VA Medical Center, Medical College of Wisconsin, Milwaukee, WI, USA
    Arterioscler Thromb Vasc Biol 26:287-94. 2006
    ..The objectives of this study were to assess the acute effect of irradiation on acetylcholine (Ach)-induced dilation of gut submucosal microvessels...