Aharon Kessel

Summary

Affiliation: Bnai Zion Medical Center
Country: Israel

Publications

  1. ncbi request reprint Anti-C-reactive protein antibodies in chronic hepatitis C infection: correlation with severity and autoimmunity
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    Hum Immunol 68:844-8. 2007
  2. ncbi request reprint Abnormal spirometry in children with persistent allergic rhinitis due to mite sensitization: the benefit of nasal corticosteroids
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Department of Clinical Microbiology, Faculty of Medicine Technion, Haifa, Israel
    Pediatr Allergy Immunol 19:61-6. 2008
  3. ncbi request reprint Elevated serum B-cell activating factor in patients with chronic urticaria
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion Faculty of Medicine, Haifa 31048, Israel
    Hum Immunol 73:620-2. 2012
  4. doi request reprint Higher expression of latency-associated peptide on the surface of peripheral blood monocytes in patients with rheumatoid arthritis may be protective against articular erosions
    Gleb Slobodin
    Internal Medicine A, Bnai Zion Medical Center, P O Box 4940, Haifa, 31048, Israel
    Inflammation 36:1075-8. 2013
  5. ncbi request reprint Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    Autoimmun Rev 11:670-7. 2012
  6. doi request reprint Regulatory T cells (CD4(+)CD25(bright)FoxP3(+)) expansion in systemic sclerosis correlates with disease activity and severity
    Gleb Slobodin
    Department of Internal Medicine A, Bnai Zion Medical Center and Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Cell Immunol 261:77-80. 2010
  7. doi request reprint Endothelin-1 does not change the function of monocyte-derived dendritic cells grown from patients with systemic sclerosis
    Gleb Slobodin
    Department of Internal Medicine, Bnai Zion Medical Center and Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Immunol Invest 37:841-8. 2008
  8. ncbi request reprint A regulatory role for CD72 expression on B cells in systemic lupus erythematosus
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Semin Arthritis Rheum 43:767-71. 2014
  9. doi request reprint B-regulatory cells in autoimmunity and immune mediated inflammation
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    FEBS Lett 587:2074-8. 2013
  10. pmc Semaphorin 3A is a marker for disease activity and a potential immunoregulator in systemic lupus erythematosus
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa 31048, Israel
    Arthritis Res Ther 14:R146. 2012

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Anti-C-reactive protein antibodies in chronic hepatitis C infection: correlation with severity and autoimmunity
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    Hum Immunol 68:844-8. 2007
    ..3 versus 6 +/- 2.9, p = 0.01). An increased prevalence of anti-CRP antibodies was manifested in HCV-infected patients. The presence of anti-CRP antibodies correlated with the presence RF, cryoglobulinemia, and severity of liver disease...
  2. ncbi request reprint Abnormal spirometry in children with persistent allergic rhinitis due to mite sensitization: the benefit of nasal corticosteroids
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Department of Clinical Microbiology, Faculty of Medicine Technion, Haifa, Israel
    Pediatr Allergy Immunol 19:61-6. 2008
    ..Nasal corticosteroids improve the pulmonary function tests of these children with impaired lung function...
  3. ncbi request reprint Elevated serum B-cell activating factor in patients with chronic urticaria
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion Faculty of Medicine, Haifa 31048, Israel
    Hum Immunol 73:620-2. 2012
    ..We conclude that CU patients have higher levels of serum BAFF which associate with disease severity...
  4. doi request reprint Higher expression of latency-associated peptide on the surface of peripheral blood monocytes in patients with rheumatoid arthritis may be protective against articular erosions
    Gleb Slobodin
    Internal Medicine A, Bnai Zion Medical Center, P O Box 4940, Haifa, 31048, Israel
    Inflammation 36:1075-8. 2013
    ..Higher expression of LAP on the surface of the cells of monocyte lineage may be protective of formation of articular erosions in RA. Further studies are needed to elaborate the mechanism of this phenomenon...
  5. ncbi request reprint Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    Autoimmun Rev 11:670-7. 2012
    ..In conclusion, human Breg cells decrease the proliferation of CD4(+) T cells and also enhance the expression of Foxp3 and CTLA-4 in Treg cells by cell-to-cell contact...
  6. doi request reprint Regulatory T cells (CD4(+)CD25(bright)FoxP3(+)) expansion in systemic sclerosis correlates with disease activity and severity
    Gleb Slobodin
    Department of Internal Medicine A, Bnai Zion Medical Center and Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Cell Immunol 261:77-80. 2010
    ..The role and function of T regulatory (Treg) cells have not been fully investigated in patients with systemic sclerosis (SSc)...
  7. doi request reprint Endothelin-1 does not change the function of monocyte-derived dendritic cells grown from patients with systemic sclerosis
    Gleb Slobodin
    Department of Internal Medicine, Bnai Zion Medical Center and Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Immunol Invest 37:841-8. 2008
    ..The examined function of MDDCs from SSc patients and healthy volunteers did not differ under these conditions and was not dependent on the presence of ET-1...
  8. ncbi request reprint A regulatory role for CD72 expression on B cells in systemic lupus erythematosus
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Semin Arthritis Rheum 43:767-71. 2014
    ....
  9. doi request reprint B-regulatory cells in autoimmunity and immune mediated inflammation
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    FEBS Lett 587:2074-8. 2013
    ..Finally, the potentiation of B-reg function should become the aim of many immunomodulatory drugs, contributing to a better control of autoimmune diseases...
  10. pmc Semaphorin 3A is a marker for disease activity and a potential immunoregulator in systemic lupus erythematosus
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa 31048, Israel
    Arthritis Res Ther 14:R146. 2012
    ..This study was undertaken to evaluate the role of sema3A and NP-1 in the pathogenesis of systemic lupus erythematosus (SLE) and the specific effect of sema3A on the auto-reactive properties of B cells in SLE patients...
  11. doi request reprint IVIg attenuates TLR-9 activation in B cells from SLE patients
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa 31048, Israel
    J Clin Immunol 31:30-8. 2011
    ..The aim of this study was to evaluate the influence of intravenous immunoglobulin (IVIg) on CpG oligodeoxynucleotides (ODN-CpG) activated B cells from SLE patients...
  12. doi request reprint Elevated serum total IgE--a potential marker for severe chronic urticaria
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion Faculty of Medicine, Haifa, Israel
    Int Arch Allergy Immunol 153:288-93. 2010
    ..Elevated IgE levels in patients with chronic urticaria have been noted previously, but the significance of these findings has not been appreciated...
  13. pmc Age-related autoimmunity
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Golomb Street 47, Haifa, 31048, Israel
    BMC Med 11:94. 2013
    ..Whatever the reason, the expansion of T-regulatory cells requires payment in terms of an increased incidence of cancer and higher susceptibility to infections...
  14. doi request reprint Etanercept impairs maturation of human monocyte-derived dendritic cells by inhibiting the autocrine TNFalpha-mediated signaling
    Gleb Slobodin
    Department of Internal Medicine A, Bnai Zion Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Inflammation 32:146-50. 2009
    ..The data also suggests the presence of TNFalpha-mediated autocrine signaling, serving to accelerate or catalyze the maturation process of MDDCs...
  15. ncbi request reprint Immunologic and infectious consequences of immediate versus delayed umbilical cord clamping in premature infants: a prospective, randomized, controlled study
    Amir Kugelman
    Department of Neonatology, Bnai Zion Medical Center, The Bruce Rappaport Faculty of Medicine, Haifa, Israel
    J Perinat Med 37:281-7. 2009
    ..To evaluate the immunologic and infectious consequences of delayed versus immediate cord clamping in premature infants (<35 weeks) during the neonatal period...
  16. ncbi request reprint Increased CD8+ T cell apoptosis in scleroderma is associated with low levels of NF-kappa B
    Aharon Kessel
    Division of Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    J Clin Immunol 24:30-6. 2004
    ..53, P = 0.029). The increased CD4:CD8 ratio in SSC may result from increased CD8+ T cell apoptosis. Increased SSc CD8 T cell apoptosis is associated with low levels of NF-kappa B...
  17. pmc Enhanced apoptosis of peripheral CD5-negative B lymphocytes from chronically hepatitis C virus-infected patients: reversal after antiviral treatment
    Elias Toubi
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, Golomb St 47, P O B 4940, Haifa 31048, Israel
    J Virol 78:11379-84. 2004
    ..The relative resistance of the CD5(pos) B-cell subpopulation to apoptosis may play a role in HCV-related autoimmunity and lymphoproliferation...
  18. pmc Antiviral treatment down-regulates peripheral B-cell CD81 expression and CD5 expansion in chronic hepatitis C virus infection
    Eli Zuckerman
    Department of Internal Medicine A Institute of Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    J Virol 77:10432-6. 2003
    ..The overexpression of CD81 and the expansion of the population of CD5(+) peripheral B cells in HCV-infected patients may possibly play a role in the development of HCV-associated autoimmunity and lymphoproliferation...
  19. ncbi request reprint Increased Toll-like receptor 9 expression by B cells from inflammatory bowel disease patients
    Drora Berkowitz
    Division of Pediatric Gastroenterology, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    Hum Immunol 74:1519-23. 2013
    ..5 μM. TLR9 expression by memory B cells (CD19+CD27+) was assessed by flow cytometry...
  20. doi request reprint The pendulum between food protein-induced enterocolitis syndrome and IgE-mediated milk allergy
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion Faculty of Medicine, Haifa, Israel
    Acta Paediatr 100:e183-5. 2011
    ..After recovering and reintroducing cow's milk formula, they developed disseminated urticaria and positive skin prick test to cow milk compatible with IgE-mediated milk allergy...
  21. ncbi request reprint [Extended cyclosporine-A--treatment for severe chronic urticaria]
    Aharon Kessel
    Division of Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine Technion, Haifa, Israel
    Harefuah 145:411-4, 471. 2006
    ..In such patients CsA given for 1-3 months (3mg/kg/d) was reported to induce in 2/3 of patients a full remission, lasting 3-6 months, and in 1/4 of patients a long-lasting full remission...
  22. doi request reprint The role of T regulatory cells in human sepsis
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    J Autoimmun 32:211-5. 2009
    ..Preliminary studies in animal models suggest that more work is needed to understand the conditions under which such a therapy may be effective...
  23. doi request reprint Legionella pneumophila and Pneumocystis jirovecii coinfection in an infant treated with adrenocorticotropic hormone for infantile spasm: case report and literature review
    Nadira Musallam
    1Pediatric Department, Bnai Zion Medical Center, Haifa, Israel
    J Child Neurol 29:240-2. 2014
    ..Given that ACTH therapy may increase the risk of fatal infection, patients undergoing such treatment should be closely monitored, with particular attention paid to the functioning of the immune system. ..
  24. ncbi request reprint Changes in immunomodulatory constituents of human milk in response to active infection in the nursing infant
    Arieh Riskin
    Department of Neonatology, Bnai Zion Medical Center, Haifa, Israel
    Pediatr Res 71:220-5. 2012
    ..To investigate whether immunologic factors in breast milk change in response to nursing infants' infection...
  25. doi request reprint Participation in leisure activities and sensory modulation deficiencies of children with atopic dermatitis
    Batya Engel-Yeger
    Occupational Therapy Department, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel
    Acta Paediatr 100:e152-7. 2011
    ..To examine whether the complexity of atopic dermatitis (AD) symptoms and the sensory modulation deficiencies (SMD) that accompany it may limit child's preference to participate in leisure activities...
  26. ncbi request reprint Tacrolimus in the treatment of severe chronic idiopathic urticaria: an open-label prospective study
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    J Am Acad Dermatol 52:145-8. 2005
    ..Our preliminary results suggest tacrolimus as a treatment option for patients with severe CIU...
  27. ncbi request reprint Intravenous immunoglobulin therapy affects T regulatory cells by increasing their suppressive function
    Aharon Kessel
    Division of Clinical Immunology, Bnai Zion Medical Centre, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    J Immunol 179:5571-5. 2007
    ..We hereby demonstrate an additional mechanism by which IVIg could maintain self-tolerance and decrease immune-mediated inflammation...
  28. ncbi request reprint Sjögren's syndrome in the community: can serology replace salivary gland biopsy?
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, 47 Golomb Street, P O Box 4940, Haifa, 31048, Israel
    Rheumatol Int 26:337-9. 2006
    ..It is relatively difficult in a community setting to perform salivary gland biopsy or reliable diagnostic tests for salivary gland involvement in a patient suspected to suffer from Sjögren's syndrome (SS)...
  29. ncbi request reprint Interleukin-7 receptor alpha (IL-7Ralpha) deficiency: cellular and molecular bases. Analysis of clinical, immunological, and molecular features in 16 novel patients
    Silvia Giliani
    Angelo Nocivelli Institute of Molecular Medicine, Department of Pediatrics, University of Brescia, Italy
    Immunol Rev 203:110-26. 2005
    ..We also report on the clinical and immunological features of 16 novel patients with IL-7Ralpha deficiency and discuss the results of hematopoietic stem cell transplantation...
  30. ncbi request reprint [Leflunomide in systemic lupus erythematosus]
    Aharon Kessel
    Harefuah 141:355-7, 409. 2002
    ..Recently pilot studies have demonstrated the benefit of leflunomide in systemic lupus erythematosus patients. Herein we describe the successful treatment of two lupus patients with leflunomide and review the current literature...