Affiliation: Bet Dagan
- Elmann A, Mordechay S, Erlank H, Telerman A, Rindner M, Ofir R. Anti-neuroinflammatory effects of the extract of Achillea fragrantissima. BMC Complement Altern Med. 2011;11:98 pubmed publisher..Thus, phytochemicals present in the Af extract could be beneficial in preventing/treating neurodegenerative diseases in which neuroinflammation is part of the pathophysiology. ..
- Elmann A, Mordechay S, Rindner M, Larkov O, Elkabetz M, Ravid U. Protective Effects of the Essential Oil of Salvia fruticosa and Its Constituents on Astrocytic Susceptibility to Hydrogen Peroxide-Induced Cell Death. J Agric Food Chem. 2009;57:6636-41 pubmed publisher..It is proposed that Sf, by attenuating H2O2-induced cell death, might be used as a functional food or may be offered as a means of therapy in the treatment of neurodegenerative diseases. ..
- Elmann A, Telerman A, Ofir R, Kashman Y. Glutamate Toxicity to Differentiated Neuroblastoma N2a Cells Is Prevented by the Sesquiterpene Lactone Achillolide A and the Flavonoid 3,5,4'-Trihydroxy-6,7,3'-Trimethoxyflavone from Achillea fragrantissima. J Mol Neurosci. 2017;62:99-105 pubmed publisher..We further demonstrate that this protective effect might be, at least partially, due to inhibitory effects of these compounds on the levels of reactive oxygen species produced following treatment with glutamate. ..
- Telerman A, Ofir R, Kashman Y, Elmann A. 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone protects against beta amyloid-induced neurotoxicity through antioxidative activity and interference with cell signaling. BMC Complement Altern Med. 2017;17:332 pubmed publisher..TTF should be studied further as a potential therapeutic means for the treatment of Alzheimer's disease. ..