Ran Taube

Summary

Affiliation: Ben-Gurion University of the Negev
Country: Israel

Publications

  1. pmc A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat
    Nina Verstraete
    Institut de Biologie de l Ecole Normale Supérieure, Paris F 75005, France
    Retrovirology 11:50. 2014
  2. pmc A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription
    Alona Kuzmina
    The Shraga Segal Department of Microbiology, Immunology and Genetics Faculty of Health Sciences, Ben Gurion University of the Negev, P, O, Box 653, Beer Sheva 84105, Israel
    Retrovirology 11:51. 2014
  3. pmc Preferential lentiviral targeting of astrocytes in the central nervous system
    Michael Fassler
    The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Israel
    PLoS ONE 8:e76092. 2013
  4. pmc Lost in transcription: molecular mechanisms that control HIV latency
    Ran Taube
    The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 653, Beer Sheva 84105, Israel
    Viruses 5:902-27. 2013
  5. ncbi request reprint Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherin
    Avis Dafa-Berger
    Department of Virology and Developmental Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 653, Beer Sheva, Israel
    Virology 428:98-111. 2012
  6. ncbi request reprint Functional characterization of a human cyclin T1 mutant reveals a different binding surface for Tat and HEXIM1
    Alona Kuzmina
    Department of Virology and Developmental Genetics Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    Virology 426:152-61. 2012

Collaborators

  • Koh Fujinaga
  • Yonat Shemer-Avni
  • Felipe Diaz-Griffero
  • Alona Kuzmina
  • Nina Verstraete
  • Michael Fassler
  • Olivier Bensaude
  • Avis Dafa-Berger
  • Monika Ludanyi
  • Gaelle Diribarne
  • Maayan Maatook
  • Sigal Galker
  • Van Trung Nguyen
  • Lydia Kobbi
  • Alon Friedman
  • Itai Weissberg
  • Nitzan Levy
  • Alon Monsonego
  • Uzi Hadad
  • Hila Yitzhak-Asraf

Detail Information

Publications6

  1. pmc A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat
    Nina Verstraete
    Institut de Biologie de l Ecole Normale Supérieure, Paris F 75005, France
    Retrovirology 11:50. 2014
    ..P-TEFb activity is inhibited by direct binding of its subunit Cyclin T (1 or 2) with Hexim (1 or 2), a cellular protein, bound to the 7SK small nuclear RNA. Hexim1 competes with Tat for P-TEFb binding...
  2. pmc A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription
    Alona Kuzmina
    The Shraga Segal Department of Microbiology, Immunology and Genetics Faculty of Health Sciences, Ben Gurion University of the Negev, P, O, Box 653, Beer Sheva 84105, Israel
    Retrovirology 11:51. 2014
    ..The viral Tat protein recruits the Positive Transcription Elongation Factor b (P-TEFb) and the Super Elongation Complex (SEC) to the HIV promoter and enhances transcription by host RNA polymerase II...
  3. pmc Preferential lentiviral targeting of astrocytes in the central nervous system
    Michael Fassler
    The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Israel
    PLoS ONE 8:e76092. 2013
    ..As such, it can open a window to visualize and genetically manipulate astrocytes or other cells of the CNS as means of research and treatment. ..
  4. pmc Lost in transcription: molecular mechanisms that control HIV latency
    Ran Taube
    The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 653, Beer Sheva 84105, Israel
    Viruses 5:902-27. 2013
    ....
  5. ncbi request reprint Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherin
    Avis Dafa-Berger
    Department of Virology and Developmental Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 653, Beer Sheva, Israel
    Virology 428:98-111. 2012
    ..5-BST-2. We conclude that BST-2 moderately restricts HCV production and release from Huh-7.5 hepatocytes, while the virus lacks mechanisms to counteract this restriction...
  6. ncbi request reprint Functional characterization of a human cyclin T1 mutant reveals a different binding surface for Tat and HEXIM1
    Alona Kuzmina
    Department of Virology and Developmental Genetics Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    Virology 426:152-61. 2012
    ..We conclude that cyclin T1-U7 sequesters Tat from P-TEFb and inhibits HIV transcription. Importantly, N-terminal residues in cyclin T1 are specifically involved in the binding of cyclin T1 to HEXIM1 but not to Tat...