Nurith Porat

Summary

Affiliation: Ben-Gurion University of the Negev
Country: Israel

Publications

  1. pmc Differential circulation of Streptococcus pneumoniae serotype 6C clones in two Israeli pediatric populations
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center, P O Box 151, Beer Sheva 84101, Israel
    J Clin Microbiol 48:4649-51. 2010
  2. pmc Baseline epidemiology and genetic structure of Streptococcus pneumoniae serotype 6D in southern Israel prior to introduction of pneumococcal conjugate vaccines
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center, and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Clin Microbiol 51:1580-2. 2013
  3. pmc Clonal distribution of common pneumococcal serotypes not included in the 7-valent conjugate vaccine (PCV7): marked differences between two ethnic populations in southern Israel
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Clin Microbiol 50:3472-7. 2012
  4. pmc Streptococcus pneumoniae serotype 3 among Costa Rican children with otitis media: clinical, epidemiological characteristics and antimicrobial resistance patterns
    Arturo Abdelnour
    Instituto de Atención Pediátrica, San Jose, Costa Rica
    BMC Pediatr 9:52. 2009
  5. ncbi request reprint The important role of nontypable Streptococcus pneumoniae international clones in acute conjunctivitis
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84101, Israel
    J Infect Dis 194:689-96. 2006
  6. doi request reprint Increasing importance of multidrug-resistant serotype 6A Streptococcus pneumoniae clones in acute otitis media in southern Israel
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 29:126-30. 2010
  7. doi request reprint Serotype coverage of invasive and mucosal pneumococcal disease in Israeli children younger than 3 years by various pneumococcal conjugate vaccines
    Dror S Shouval
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 28:277-82. 2009
  8. doi request reprint An international serotype 3 clone causing pediatric noninvasive infections in Israel, Costa Rica, and Lithuania
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 27:709-12. 2008
  9. doi request reprint The effect of an alternative reduced-dose infant schedule and a second year catch-up schedule with 7-valent pneumococcal conjugate vaccine on pneumococcal carriage: a randomized controlled trial
    Ron Dagan
    The Pediatric Infectious Disease Unit, The Faculty of Health Sciences, Ben Gurion University of the Negev and Soroka University Medical Center, Beer Sheva, Israel
    Vaccine 30:5132-40. 2012
  10. doi request reprint Persistence of pathogens despite clinical improvement in antibiotic-treated acute otitis media is associated with clinical and bacteriologic relapse
    Elad Asher
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 27:296-301. 2008

Collaborators

Detail Information

Publications39

  1. pmc Differential circulation of Streptococcus pneumoniae serotype 6C clones in two Israeli pediatric populations
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center, P O Box 151, Beer Sheva 84101, Israel
    J Clin Microbiol 48:4649-51. 2010
    ..Sp6C constituted 8.2% of the presumed Sp6A isolates. All of the Sp6C clonal clusters were associated with serogroup 6, mainly Sp6A. Different clonal distributions were found in the two subpopulations...
  2. pmc Baseline epidemiology and genetic structure of Streptococcus pneumoniae serotype 6D in southern Israel prior to introduction of pneumococcal conjugate vaccines
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center, and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Clin Microbiol 51:1580-2. 2013
    ..S. pneumoniae serotype 6D isolates constituted 6.7% of the presumed S. pneumoniae serotype 6B isolates. S. pneumoniae serotype 6D strains belonged to 20 sequence types that were differentially distributed between the two ethnic groups...
  3. pmc Clonal distribution of common pneumococcal serotypes not included in the 7-valent conjugate vaccine (PCV7): marked differences between two ethnic populations in southern Israel
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Clin Microbiol 50:3472-7. 2012
    ..Post-PCV7 surveillance is important in understanding non-PCV7 clonal expansion in the two distinct populations...
  4. pmc Streptococcus pneumoniae serotype 3 among Costa Rican children with otitis media: clinical, epidemiological characteristics and antimicrobial resistance patterns
    Arturo Abdelnour
    Instituto de Atención Pediátrica, San Jose, Costa Rica
    BMC Pediatr 9:52. 2009
    ..To describe the clinical, epidemiological and antimicrobial resistance patterns of Costa Rican children with otitis media caused by Streptococcus pneumoniae serotype 3...
  5. ncbi request reprint The important role of nontypable Streptococcus pneumoniae international clones in acute conjunctivitis
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84101, Israel
    J Infect Dis 194:689-96. 2006
    ..The purpose of the present study was to evaluate the relative importance in causing AC of the absence of capsule versus genotype properties...
  6. doi request reprint Increasing importance of multidrug-resistant serotype 6A Streptococcus pneumoniae clones in acute otitis media in southern Israel
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 29:126-30. 2010
    ..The major aim of this study was to establish the molecular epidemiology dynamics of Streptococcus pneumoniae serotype 6A in acute otitis media, before the introduction of the 7-valent pneumococcal conjugate vaccine...
  7. doi request reprint Serotype coverage of invasive and mucosal pneumococcal disease in Israeli children younger than 3 years by various pneumococcal conjugate vaccines
    Dror S Shouval
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 28:277-82. 2009
    ....
  8. doi request reprint An international serotype 3 clone causing pediatric noninvasive infections in Israel, Costa Rica, and Lithuania
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 27:709-12. 2008
    ..The present study was aimed to evaluate the importance of serotype 3 clones in noninvasive infections in Israel, Costa Rica, and Lithuania...
  9. doi request reprint The effect of an alternative reduced-dose infant schedule and a second year catch-up schedule with 7-valent pneumococcal conjugate vaccine on pneumococcal carriage: a randomized controlled trial
    Ron Dagan
    The Pediatric Infectious Disease Unit, The Faculty of Health Sciences, Ben Gurion University of the Negev and Soroka University Medical Center, Beer Sheva, Israel
    Vaccine 30:5132-40. 2012
    ..We compared the effect of these two schedules on pneumococcal carriage in young children. We also assessed the effect of a 2-dose schedule in the second year ("catch-up" schedule; 0+2)...
  10. doi request reprint Persistence of pathogens despite clinical improvement in antibiotic-treated acute otitis media is associated with clinical and bacteriologic relapse
    Elad Asher
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 27:296-301. 2008
    ..We investigated the relationship between MEF culture-positivity during treatment in patients with clinical improvement/cure, and the occurrence of subsequent AOM...
  11. doi request reprint Distribution, dynamics and antibiotic resistance patterns of Streptococcus pneumoniae serotypes causing acute otitis media in children in southern Israel during the 10 year-period before the introduction of the 7-valent pneumococcal conjugate vaccine
    Ido Somech
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Vaccine 29:4202-9. 2011
    ....
  12. ncbi request reprint Introduction and proliferation of multidrug-resistant Streptococcus pneumoniae serotype 19A clones that cause acute otitis media in an unvaccinated population
    Ron Dagan
    Pediatric Infectious Disease Unit, Soroka University Medical Center, and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Infect Dis 199:776-85. 2009
    ..A causative role of PCV7 was speculated. We prospectively studied the dynamics of acute otitis media (AOM) caused by Sp19A in southern Israel before the introduction of PCV7...
  13. ncbi request reprint Four antibiotic-resistant Streptococcus pneumoniae clones unrelated to the pneumococcal conjugate vaccine serotypes, including 2 new serotypes, causing acute otitis media in southern Israel
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Infect Dis 189:385-92. 2004
    ..Two of these clones have not been described elsewhere. The high prevalence of NVT clones should increase the awareness of the potential for replacement of the vaccine strains with these NVT antibiotic-resistant strains...
  14. doi request reprint Epidemiology of invasive Kingella kingae infections in 2 distinct pediatric populations cohabiting in one geographic area
    Uri Amit
    Clinical Microbiology Laboratory, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 31:415-7. 2012
    ..05). One K. kingae clone was overrepresented among isolates from Jewish children, suggesting that differences in bacterial pathogenicity may contribute to the morbidity excess detected in this population group...
  15. ncbi request reprint Nasopharyngeal carriage of Streptococcus pneumoniae at the completion of successful antibiotic treatment of acute otitis media predisposes to early clinical recurrence
    Shai Libson
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Infect Dis 191:1869-75. 2005
    ..We sought to investigate the role of Streptococcus pneumoniae (SP) nasopharyngeal (NP) colonization after successful antibiotic treatment (Rx) of acute otitis media (AOM) in recurrent AOM (RAOM)...
  16. doi request reprint Dissemination of Kingella kingae in the community and long-term persistence of invasive clones
    Pablo Yagupsky
    Clinical Microbiology Laboratory, Soroka University Medical Center, Ben Gurion University of Negev, Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 28:707-10. 2009
    ..The dissemination of K. kingae in the community was studied in 2 ethnic groups living side-by-side in Southern Israel...
  17. doi request reprint Endogenous H2O2 produced by Streptococcus pneumoniae controls FabF activity
    Rachel Benisty
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Faculty of Health Sciences, Beer Sheva, Israel
    Biochim Biophys Acta 1801:1098-104. 2010
    ..Inhibition of FabF activity by either H2O2 or cerulenin resulted in altered membrane fatty acid composition. We conclude that FabF activity is inhibited by H2O2 produced by S. pneumoniae...
  18. doi request reprint Complicated community acquired pneumonia in children prior to the introduction of the pneumococcal conjugated vaccine
    Aviv D Goldbart
    Department of Paediatrics, Soroka University Medical Centre, Beer Sheva, Israel
    Scand J Infect Dis 41:182-7. 2009
    ..Future introduction of PCV7 or equivalents in the immunization schedule may impact clinical presentation and epidemic trends and will require future consideration...
  19. ncbi request reprint Emergence of penicillin-nonsusceptible Streptococcus pneumoniae clones expressing serotypes not present in the antipneumococcal conjugate vaccine
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel
    J Infect Dis 190:2154-61. 2004
    ..Penicillin-nonsusceptible Streptococcus pneumoniae isolates are confined mainly to a few serogroups. Capsular transformation may serve as a mechanism for spreading antibiotic resistance to new serotypes...
  20. ncbi request reprint Effect of hydrogen peroxide production and the Fenton reaction on membrane composition of Streptococcus pneumoniae
    Stella Pesakhov
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Faculty of Health Sciences P O Box 151, Beer Sheva 84101, Israel
    Biochim Biophys Acta 1768:590-7. 2007
    ..We suggest that endogenous ROS play an important regulatory role in membrane adaptation, allowing the survival of this anaerobic organism at aerobic environments of the host...
  21. ncbi request reprint Site-specific disease potential of individual Streptococcus pneumoniae serotypes in pediatric invasive disease, acute otitis media and acute conjunctivitis
    Dror S Shouval
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 25:602-7. 2006
    ..Our objective was to assess the disease potential of individual S. pneumoniae serotypes causing invasive pneumococcal disease (IPD), acute otitis media (AOM) and acute conjunctivitis (AC) in children...
  22. pmc Thiol peroxidase is an important component of Streptococcus pneumoniae in oxygenated environments
    Barak Hajaj
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Faculty of Health Sciences, Department of Microbiology and Immunology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Infect Immun 80:4333-43. 2012
    ..The findings of this study suggest that TpxD constitutes a component of the organism's fundamental strategy to fine-tune cellular processes in response to H(2)O(2)...
  23. ncbi request reprint Outbreak of Kingella kingae skeletal system infections in children in daycare
    Pablo Yagupsky
    Clinical Microbiology Laboratory, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 25:526-32. 2006
    ..The objective of this study is to describe the investigation of an outbreak of one culture-proven and two presumptive cases of Kingella kingae osteomyelitis detected within a 15-day period in a daycare center in Israel...
  24. pmc Antibiotic-resistant invasive pediatric Streptococcus pneumoniae clones in Israel
    David Greenberg
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Clin Microbiol 41:5541-5. 2003
    ..pneumoniae clones-mainly the three international ones-contribute significantly to increases in antibiotic resistance. Their geographic distribution varies within the country and between the different populations...
  25. ncbi request reprint Recurrent acute otitis media occurring within one month from completion of antibiotic therapy: relationship to the original pathogen
    Eugene Leibovitz
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 22:209-16. 2003
    ....
  26. ncbi request reprint Spread of Streptococcus pneumoniae and antibiotic-resistant S. pneumoniae from day-care center attendees to their younger siblings
    Noga Givon-Lavi
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Infect Dis 186:1608-14. 2002
    ..Vaccinating DCC attendees with a 7-valent pneumococcal conjugate vaccine may play a key role in controlling the spread of antibiotic-resistant pneumococci, because the most resistant serotypes are included in the vaccine...
  27. ncbi request reprint Genotyping of invasive Kingella kingae isolates reveals predominant clones and association with specific clinical syndromes
    Uri Amit
    Clinical Microbiology Laboratory, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Clin Infect Dis 55:1074-9. 2012
    ..A study was conducted to determine the association of K. kingae genotypes with specific clinical syndromes and the temporal and geographic distribution of invasive clones...
  28. doi request reprint Pharyngeal colonization by Kingella kingae in children with invasive disease
    Pablo Yagupsky
    Soroka University Medical Center, Ben Gurion University of the Negev, Negev, Beer Sheva, USA
    Pediatr Infect Dis J 28:155-7. 2009
    ....
  29. doi request reprint Comparative immunogenicity and efficacy of 13-valent and 7-valent pneumococcal conjugate vaccines in reducing nasopharyngeal colonization: a randomized double-blind trial
    Ron Dagan
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Clin Infect Dis 57:952-62. 2013
    ..It was comparable with PCV7 for all other common serotypes. These findings predict vaccine effectiveness through both direct and indirect protection. Clinical Trials Registration. NCT00508742. ..
  30. ncbi request reprint Lack of evidence of transmission of Pseudomonas aeruginosa among cystic fibrosis patients attending health camps at the Dead Sea, Israel
    David Greenberg
    Pediatric Infectious Disease Unit, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Isr Med Assoc J 6:531-4. 2004
    ..Transmission of Pseudomonas aeruginosa among cystic fibrosis patients attending health camps has been reported previously...
  31. pmc Differences in membrane fluidity and fatty acid composition between phenotypic variants of Streptococcus pneumoniae
    Barak Aricha
    Pediatric Infectious Disease Unit, Soroka University Medical Center, P O Box 151, Beer Sheva 84101, Israel
    J Bacteriol 186:4638-44. 2004
    ..The data presented here show a distinct correlation between phase variation and membrane fluidity in S. pneumoniae. The changes in membrane fluidity most probably stem from the observed differences in fatty acid composition...
  32. ncbi request reprint Seasonal distribution of otitis media pathogens among Costa Rican children
    Silvia Guevara
    Instituto de Atención Pediátrica, San Jose, Costa Rica
    Pediatr Infect Dis J 27:12-6. 2008
    ..Otitis media is an important cause of pediatric consultation, and knowledge of yearly pathogen distribution might improve antimicrobial selection...
  33. ncbi request reprint Middle ear fluid Streptococcus pneumoniae serotype distribution in Costa Rican children with otitis media
    Adriano Arguedas
    Instituto de Atención Pediátrica, San Jose, Costa Rica
    Pediatr Infect Dis J 24:631-4. 2005
    ..Previous S. pneumoniae middle ear fluid (MEF) data obtained during the period 1999-2001 from Costa Rican children indicated that serotype 19F was the most common type (75%), but more recently other serotypes have become more prevalent...
  34. ncbi request reprint Nasopharyngeal carriage of Streptococcus pneumoniae by adults and children in community and family settings
    Gili Regev-Yochay
    Infectious Disease Unit, Sheba Medical Center, Tel Hashomer, Israel
    Clin Infect Dis 38:632-9. 2004
    ..In a subanalysis of 151 pairs of children and their parents and of 32 pairs of siblings, intrafamilial transmission of S. pneumoniae could not be demonstrated...
  35. ncbi request reprint Microbiology of otitis media in Costa Rican children, 1999 through 2001
    Adriano Arguedas
    Instituto de Atención Pediátrica, San Jose, Costa Rica
    Pediatr Infect Dis J 22:1063-8. 2003
    ....
  36. ncbi request reprint Genetic relatedness of resistant and multiresistant Streptococcus pneumoniae strains, recovered in the Athens area, to international clones
    Maria N Tsolia
    Second Department of Pediatrics, University of Athens School of Medicine, P and A Kyriakou Children s Hospital, Greece
    Microb Drug Resist 8:219-26. 2002
    ..The introduction and spread of several antibiotic-resistant international clones accounts at least in part for the increase in pneumococcal resistance observed in recent years in the Athens metropolitan area...
  37. pmc Community-acquired methicillin-resistant Staphylococcus aureus in institutionalized adults with developmental disabilities
    Abraham Borer
    Soroka University Medical Center and the Ben Gurion University of the Negev, Beer Sheva, Isreal
    Emerg Infect Dis 8:966-70. 2002
    ..Selective antibiotic pressure may result in the emergence, persistence, and dissemination of MRSA strains, causing prolonged disease...
  38. pmc Cell phones and Acinetobacter transmission
    Abraham Borer
    Emerg Infect Dis 11:1160-1. 2005
  39. ncbi request reprint Interleukin-12 receptor beta1 deficiency presenting as recurrent Salmonella infection
    Orna Staretz-Haham
    Pediatric Department, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel 84101
    Clin Infect Dis 37:137-40. 2003
    ..The episodes of salmonellosis were caused by an identical serovar during a period of 18 months. This is the first case of inherited IL-12Rbeta1 deficiency diagnosed after isolated, recurrent salmonellosis...