Eli C Lewis

Summary

Affiliation: Ben-Gurion University of the Negev
Country: Israel

Publications

  1. pmc Pancreatic islet xenograft survival in mice is extended by a combination of alpha-1-antitrypsin and single-dose anti-CD4/CD8 therapy
    Efrat Ashkenazi
    Ben Gurion University of the Negev, Faculty of Health Sciences, Department of Clinical Biochemistry and Pharmacology, Be er Sheva, Israel
    PLoS ONE 8:e63625. 2013
  2. pmc Expanding the clinical indications for α(1)-antitrypsin therapy
    Eli C Lewis
    Ben Gurion University of the Negev, Beer Sheva, Israel
    Mol Med 18:957-70. 2012
  3. doi request reprint Association between renal injury and reduced interleukin-15 and interleukin-15 receptor levels in acute kidney injury
    Hadar Eini
    Clinical Biochemistry Department, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Interferon Cytokine Res 30:1-8. 2010
  4. doi request reprint Lower circulation levels and activity of α-1 antitrypsin in pregnant women with severe preeclampsia
    Guy Twina
    Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Matern Fetal Neonatal Med 25:2667-70. 2012
  5. ncbi request reprint Revascularization of pancreatic islet allografts is enhanced by α-1-antitrypsin under anti-inflammatory conditions
    Keren Bellacen
    Faculty of Health Sciences, Department of Clinical Biochemistry and Pharmacology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Cell Transplant 22:2119-33. 2013
  6. pmc α-1-antitrypsin gene delivery reduces inflammation, increases T-regulatory cell population size and prevents islet allograft rejection
    Galit Shahaf
    Department of Clinical Biochemistry, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Mol Med 17:1000-11. 2011
  7. pmc Human α1-antitrypsin modifies B-lymphocyte responses during allograft transplantation
    Mark Mizrahi
    Faculty of Health Sciences, Department of Clinical Biochemistry and Pharmacology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Immunology 140:362-73. 2013
  8. doi request reprint α-1 antitrypsin promotes semimature, IL-10-producing and readily migrating tolerogenic dendritic cells
    Eyal Ozeri
    Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Immunol 189:146-53. 2012
  9. doi request reprint Interleukin-1beta may mediate insulin resistance in liver-derived cells in response to adipocyte inflammation
    Ori Nov
    Department of Clinical Biochemistry, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84103, Israel
    Endocrinology 151:4247-56. 2010
  10. ncbi request reprint Erythropoietin prevents dialysis fluid-induced apoptosis of mesothelial cells
    Marina Vorobiov
    Department of Nephrology, Soroka Medical University Center, Beer Sheva, Israel
    Perit Dial Int 28:648-54. 2008

Collaborators

  • Amos Douvdevani
  • Eyal Sheiner
  • Joel Baron
  • Israel Sekler
  • Nava Bashan
  • Guy A Rutter
  • Assaf Rudich
  • Daniel Konrad
  • Daniel Khananshvili
  • Galit Shahaf
  • Eyal Ozeri
  • Mark Mizrahi
  • Cidio Chaimovitz
  • Moshe Zlotnik
  • Efrat Ashkenazi
  • Keren Bellacen
  • Iulia I Nita
  • Guy Twina
  • Ori Nov
  • Hadar Eini
  • Marina Vorobiov
  • Sigal Nakav
  • David Ochayon
  • Boris M Baranovski
  • Martin Rosenthal
  • Ziv Kaner
  • Pablo Cal
  • Noa Kalay
  • Peter Kachker
  • Tamar Madar
  • Michal Hershfinkel
  • Moshe Mazor
  • Stefano L Sensi
  • Arnon Wiznitzer
  • Shimrit Yaniv Salem
  • Daniel Fishman
  • Gershon Holcberg
  • Avishag Abecassis
  • Hadas Moser
  • Shani Ben-Shlomo
  • Irit Dvir
  • Ayelet Kohl
  • Sigal Fishman
  • Stephan Wueest
  • Noa Tejman-Yarden
  • Boris Rogachev
  • Myriam Malki
  • Alla Shnaider
  • Ana Basok
  • Yuval Sufaro
  • Gad Shaked
  • David Czeiger

Detail Information

Publications15

  1. pmc Pancreatic islet xenograft survival in mice is extended by a combination of alpha-1-antitrypsin and single-dose anti-CD4/CD8 therapy
    Efrat Ashkenazi
    Ben Gurion University of the Negev, Faculty of Health Sciences, Department of Clinical Biochemistry and Pharmacology, Be er Sheva, Israel
    PLoS ONE 8:e63625. 2013
    ..Further studies are required to elucidate the mechanism behind the observed synergy, as well as the applicability of the approach for pig-to-human islet xenotransplantation...
  2. pmc Expanding the clinical indications for α(1)-antitrypsin therapy
    Eli C Lewis
    Ben Gurion University of the Negev, Beer Sheva, Israel
    Mol Med 18:957-70. 2012
    ..Thus, AAT therapy appears to have advanced from replacement therapy, to a safe and potential treatment for a broad spectrum of inflammatory and immune-mediated diseases...
  3. doi request reprint Association between renal injury and reduced interleukin-15 and interleukin-15 receptor levels in acute kidney injury
    Hadar Eini
    Clinical Biochemistry Department, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Interferon Cytokine Res 30:1-8. 2010
    ..69, P = 0.003), suggesting that a decline in renal-derived IL-15 is detrimental to renal cell survival and kidney function during pathological stress...
  4. doi request reprint Lower circulation levels and activity of α-1 antitrypsin in pregnant women with severe preeclampsia
    Guy Twina
    Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Matern Fetal Neonatal Med 25:2667-70. 2012
    ..Since unopposed inflammation might contribute to preeclampsia, we studied whether preeclampsia is associated with lower than normal levels and activity of AAT...
  5. ncbi request reprint Revascularization of pancreatic islet allografts is enhanced by α-1-antitrypsin under anti-inflammatory conditions
    Keren Bellacen
    Faculty of Health Sciences, Department of Clinical Biochemistry and Pharmacology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Cell Transplant 22:2119-33. 2013
    ..We conclude that vasculogenesis toward islet grafts is enhanced in the presence of AAT. Together with the remarkable safety profile of AAT, the study supports its use in the relevant clinical setups. ..
  6. pmc α-1-antitrypsin gene delivery reduces inflammation, increases T-regulatory cell population size and prevents islet allograft rejection
    Galit Shahaf
    Department of Clinical Biochemistry, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Mol Med 17:1000-11. 2011
    ..Future studies may use this in vivo approach to examine the structure-function characteristics of the protective activities of AAT by manipulation of the hAAT plasmid...
  7. pmc Human α1-antitrypsin modifies B-lymphocyte responses during allograft transplantation
    Mark Mizrahi
    Faculty of Health Sciences, Department of Clinical Biochemistry and Pharmacology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Immunology 140:362-73. 2013
    ..These changes support the tolerogenic properties of hAAT during immune responses, and suggest that hAAT may be beneficial in pathologies that involve excessive B-cell responses. ..
  8. doi request reprint α-1 antitrypsin promotes semimature, IL-10-producing and readily migrating tolerogenic dendritic cells
    Eyal Ozeri
    Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Immunol 189:146-53. 2012
    ..Further studies are required to elucidate the mechanism behind the favorable tolerogenic activities of AAT...
  9. doi request reprint Interleukin-1beta may mediate insulin resistance in liver-derived cells in response to adipocyte inflammation
    Ori Nov
    Department of Clinical Biochemistry, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84103, Israel
    Endocrinology 151:4247-56. 2010
    ..Our results suggest that adipocyte-derived IL-1beta may constitute a mediator in the perturbed cross talk between adipocytes and liver cells in response to adipose tissue inflammation...
  10. ncbi request reprint Erythropoietin prevents dialysis fluid-induced apoptosis of mesothelial cells
    Marina Vorobiov
    Department of Nephrology, Soroka Medical University Center, Beer Sheva, Israel
    Perit Dial Int 28:648-54. 2008
    ..Since recombinant human erythropoietin (rHuEPO) induces a range of cytoprotective cellular responses, rHuEPO treatment may reduce PD fluid (PDF)-induced damage...
  11. doi request reprint α1-antitrypsin insufficiency is a possible contributor to preterm premature rupture of membranes
    Joel Baron
    Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Matern Fetal Neonatal Med 25:934-7. 2012
    ..The purpose of this research was to examine whether plasma concentration and activity of AAT differ between these manifestations...
  12. pmc Anti-inflammatory preconditioning by agonists of adenosine A1 receptor
    Sigal Nakav
    Department of Clinical Biochemistry, Soroka Medical University Center and Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 3:e2107. 2008
    ..We previously reported that peak A(1)R expression during leukocyte recruitment, is followed by a peak in A(2A)R during inflammation resolution...
  13. pmc The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion
    Iulia I Nita
    Department of Physiology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 7:e46649. 2012
    ..These findings suggest that the mitochondrial Na(+)/Ca(2+) exchanger, NCLX, shapes glucose-dependent mitochondrial and cytosolic Ca(2+) signals thereby regulating the temporal pattern of insulin secretion in β cells...
  14. ncbi request reprint Involvement of graft-derived interleukin-15 in islet allograft rejection in mice
    Eli C Lewis
    Department of Nephrology, Soroka University Medical Center and Ben Gurion University of the Negev, Faculty of Health Sciences, P O Box 151, Beer Sheva 84101, Israel
    Cytokine 34:106-13. 2006
    ..9% vs. 37.5% and 20%, respectively). Our results suggest that islet-derived IL-15 may be involved in acute islet allograft rejection...