Noah Isakov

Summary

Affiliation: Ben-Gurion University of the Negev
Country: Israel

Publications

  1. ncbi request reprint ITAMs: immunoregulatory scaffolds that link immunoreceptors to their intracellular signaling pathways
    N Isakov
    Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Receptors Channels 5:243-53. 1998
  2. ncbi request reprint Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products
    N Isakov
    Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Biochem 267:3413-21. 2000
  3. ncbi request reprint Protein kinase C(theta) in T cell activation
    Noah Isakov
    Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Annu Rev Immunol 20:761-94. 2002
  4. doi request reprint Protein kinase C-theta in platelet activation
    Sagit Cohen
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    FEBS Lett 585:3208-15. 2011
  5. doi request reprint Hodgkin's lymphoma cells exhibit high expression levels of the PICOT protein
    Ariel Ohayon
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Immunotoxicol 7:8-14. 2010
  6. pmc Protein kinase C θ deficiency increases resistance of C57BL/6J mice to Plasmodium berghei infection-induced cerebral malaria
    Ariel Ohayon
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Infect Immun 78:4195-205. 2010
  7. pmc Widespread expression of PICOT in mouse and human tissues with predominant localization to epithelium
    Ariel Ohayon
    Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Histochem Cytochem 58:799-806. 2010
  8. doi request reprint A new twist to adaptor proteins contributes to regulation of lymphocyte cell signaling
    Noah Isakov
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Trends Immunol 29:388-96. 2008
  9. doi request reprint PKCtheta is required for hemostasis and positive regulation of thrombin-induced platelet aggregation and alpha-granule secretion
    Sagit Cohen
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, P O Box 653, Beer Sheva 84105, Israel
    Biochem Biophys Res Commun 385:22-7. 2009
  10. ncbi request reprint T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315
    Sigal Gelkop
    Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Immunol 175:8123-32. 2005

Collaborators

  • Amnon Altman
  • Tony Pawson
  • Ariel Ohayon
  • Sagit Cohen
  • Yael Babichev
  • Sigal Gelkop
  • Alex Braiman
  • George Shubinsky
  • Ami Tamir
  • Daniel Benharroch
  • Ofra Ohana-Malka
  • Guangyu Dong
  • Jacob Golenser
  • Moran Galperin
  • Ronit Pasvolsky
  • Rosa Sinay
  • Ignacio Sztarkier
  • Yaakov Pollack
  • Gerrald D Gish
  • Martin Sacks
  • Giora Shubinsky
  • Jacob Gopas
  • Isebrand Prinsloo
  • Rachel Kalifa

Detail Information

Publications12

  1. ncbi request reprint ITAMs: immunoregulatory scaffolds that link immunoreceptors to their intracellular signaling pathways
    N Isakov
    Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Receptors Channels 5:243-53. 1998
    ..Recruitment and binding of these molecules to phospho-ITAMs initiate a cascade of biochemical events that lead to cell proliferation, differentiation, and acquisition of unique effector functions...
  2. ncbi request reprint Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products
    N Isakov
    Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Biochem 267:3413-21. 2000
    ..In addition, understanding the regulation of Lck activity by viral proteins may serve as a basis for the development of new drugs capable of modifying Lck activity in different pathological situations...
  3. ncbi request reprint Protein kinase C(theta) in T cell activation
    Noah Isakov
    Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Annu Rev Immunol 20:761-94. 2002
    ..The selective expression of PKC theta in T cells and its essential role in mature T cell activation establish it as an attractive drug target for immunosuppression in transplantation and autoimmune diseases...
  4. doi request reprint Protein kinase C-theta in platelet activation
    Sagit Cohen
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    FEBS Lett 585:3208-15. 2011
    ..The present review focuses on the latest observations relevant to the role of PKCθ in platelet activation...
  5. doi request reprint Hodgkin's lymphoma cells exhibit high expression levels of the PICOT protein
    Ariel Ohayon
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Immunotoxicol 7:8-14. 2010
    ....
  6. pmc Protein kinase C θ deficiency increases resistance of C57BL/6J mice to Plasmodium berghei infection-induced cerebral malaria
    Ariel Ohayon
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Infect Immun 78:4195-205. 2010
    ..These data implicate PKCθ in CD4(+) Th1(+) and CD8(+) T-cell-mediated immune responses during PbA infection that contribute to the development of ECM...
  7. pmc Widespread expression of PICOT in mouse and human tissues with predominant localization to epithelium
    Ariel Ohayon
    Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Histochem Cytochem 58:799-806. 2010
    ....
  8. doi request reprint A new twist to adaptor proteins contributes to regulation of lymphocyte cell signaling
    Noah Isakov
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Trends Immunol 29:388-96. 2008
    ..This emerging new function of PPIases is the subject of the current review...
  9. doi request reprint PKCtheta is required for hemostasis and positive regulation of thrombin-induced platelet aggregation and alpha-granule secretion
    Sagit Cohen
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, P O Box 653, Beer Sheva 84105, Israel
    Biochem Biophys Res Commun 385:22-7. 2009
    ....
  10. ncbi request reprint T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315
    Sigal Gelkop
    Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Immunol 175:8123-32. 2005
    ....
  11. ncbi request reprint Involvement of crk adapter proteins in regulation of lymphoid cell functions
    Sigal Gelkop
    Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Immunol Res 28:79-91. 2003
    ..This article describes selected studies of Crk, performed predominantly in lymphocytes, and discusses their potential relevance to the role of Crk in the regulation of lymphocyte functions...
  12. ncbi request reprint Selectins and anti-CD15 (Lewis x/a) antibodies transmit activation signals in Hodgkin's lymphoma-derived cell lines
    Ofra Ohana-Malka
    Department of Microbiology and Immunology, and the Cancer Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Exp Hematol 31:1057-65. 2003
    ..In this work, we studied the contribution of CD15 to cell adhesion and the activation of signaling cascades in two HL-derived cell lines, KMH-2 and L428...