Affiliation: Ben-Gurion University of the Negev
Pandya P, Pasvolsky R, Babichev Y, Braiman A, Witte S, Altman A, et al
. PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene. Biochem Biophys Res Commun. 2018;: pubmed publisher
Isakov N. A new twist to adaptor proteins contributes to regulation of lymphocyte cell signaling. Trends Immunol. 2008;29:388-96 pubmed publisher
..This emerging new function of PPIases is the subject of the current review. ..
Nath P, Dong G, Braiman A, Isakov N. Immunophilins control T lymphocyte adhesion and migration by regulating CrkII binding to C3G. J Immunol. 2014;193:3966-77 pubmed publisher
..The present data demonstrate that immunophilins regulate CrkII, but not CrkI activity in T cells and suggest that CsA and FK506 inhibit selected effector T cell functions via a CrkII-dependent mechanism. ..
Nath P, Dong G, Braiman A, Isakov N. In vivo regulation of human CrkII by cyclophilin A and FK506-binding protein. Biochem Biophys Res Commun. 2016;470:411-416 pubmed publisher
Dong G, Kalifa R, Nath P, Babichev Y, Gelkop S, Isakov N. Crk adaptor proteins regulate CD3? chain phosphorylation and TCR/CD3 down-modulation in activated T cells. Cell Signal. 2017;36:117-126 pubmed publisher
..Furthermore, Crk-dependent increased phosphorylation of CD3? coincided with inhibition of TCR downmodulation, supporting a positive role for Crk adaptor proteins in TCR-mediated signal amplification. ..
Dong G, Kalifa R, Nath P, Gelkop S, Isakov N. TCR crosslinking promotes Crk adaptor protein binding to tyrosine-phosphorylated CD3? chain. Biochem Biophys Res Commun. 2017;488:541-546 pubmed publisher
Isakov N. Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression. Semin Cancer Biol. 2018;48:36-52 pubmed publisher