Noah Isakov


Affiliation: Ben-Gurion University of the Negev
Country: Israel


  1. Pandya P, Pasvolsky R, Babichev Y, Braiman A, Witte S, Altman A, et al. PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene. Biochem Biophys Res Commun. 2018;: pubmed publisher
  2. Isakov N. A new twist to adaptor proteins contributes to regulation of lymphocyte cell signaling. Trends Immunol. 2008;29:388-96 pubmed publisher
    ..This emerging new function of PPIases is the subject of the current review. ..
  3. Nath P, Dong G, Braiman A, Isakov N. Immunophilins control T lymphocyte adhesion and migration by regulating CrkII binding to C3G. J Immunol. 2014;193:3966-77 pubmed publisher
    ..The present data demonstrate that immunophilins regulate CrkII, but not CrkI activity in T cells and suggest that CsA and FK506 inhibit selected effector T cell functions via a CrkII-dependent mechanism. ..
  4. Nath P, Dong G, Braiman A, Isakov N. In vivo regulation of human CrkII by cyclophilin A and FK506-binding protein. Biochem Biophys Res Commun. 2016;470:411-416 pubmed publisher
  5. Dong G, Kalifa R, Nath P, Babichev Y, Gelkop S, Isakov N. Crk adaptor proteins regulate CD3? chain phosphorylation and TCR/CD3 down-modulation in activated T cells. Cell Signal. 2017;36:117-126 pubmed publisher
    ..Furthermore, Crk-dependent increased phosphorylation of CD3? coincided with inhibition of TCR downmodulation, supporting a positive role for Crk adaptor proteins in TCR-mediated signal amplification. ..
  6. Dong G, Kalifa R, Nath P, Gelkop S, Isakov N. TCR crosslinking promotes Crk adaptor protein binding to tyrosine-phosphorylated CD3? chain. Biochem Biophys Res Commun. 2017;488:541-546 pubmed publisher
  7. Isakov N. Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression. Semin Cancer Biol. 2018;48:36-52 pubmed publisher