Alon Friedman

Summary

Affiliation: Ben-Gurion University of the Negev
Country: Israel

Publications

  1. pmc Acetylcholinesterase loosens the brain's cholinergic anti-inflammatory response and promotes epileptogenesis
    Yehudit Gnatek
    Departments of Physiology and Neurobiology, Zlotowski Center of Neuroscience, Ben Gurion University of the Negev Beer Sheva, Israel
    Front Mol Neurosci 5:66. 2012
  2. pmc Breaching the blood-brain barrier as a gate to psychiatric disorder
    Hadar Shalev
    Department of Psychiatry, Soroka University Medical Center Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Cardiovasc Psychiatry Neurol 2009:278531. 2009
  3. pmc Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy
    Alon Friedman
    Department of Physiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Epilepsy Res 85:142-9. 2009
  4. pmc Molecular cascades that mediate the influence of inflammation on epilepsy
    Alon Friedman
    Department of Physiology and Neurobiology, Faculty of Health Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Epilepsia 52:33-9. 2011
  5. pmc Breakdown of Inter-Hemispheric Connectivity Is Associated with Posttraumatic Symptomatology and Memory Impairment
    Rotem Saar-Ashkenazy
    Department of Brain and Cognitive Neuroscience, The Zlotowski center for Neuroscience Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 11:e0144766. 2016
  6. doi request reprint Angiographic evidence of proliferative retinopathy predicts neuropsychiatric morbidity in diabetic patients
    Yonatan Serlin
    Department of Physiology and Cell Biology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Psychoneuroendocrinology 67:163-70. 2016
  7. doi request reprint Altered processing of visual emotional stimuli in posttraumatic stress disorder: an event-related potential study
    Rotem Saar-Ashkenazy
    Department of Cognitive Neuroscience and Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel Department of Psychology and the School of Social work, Ashkelon Academic College, Ashkelon, Israel Department of Psychology, Achva Academic College, Beer Tuvia Regional Council, Israel
    Psychiatry Res 233:165-74. 2015
  8. doi request reprint Differential TGF-β Signaling in Glial Subsets Underlies IL-6-Mediated Epileptogenesis in Mice
    Nitzan Levy
    Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel Department of Physiology and Cell Biology, Faculty of Health Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel and
    J Immunol 195:1713-22. 2015
  9. pmc Stimulation of the sphenopalatine ganglion induces reperfusion and blood-brain barrier protection in the photothrombotic stroke model
    Haviv Levi
    Department of Physiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 7:e39636. 2012
  10. pmc Losartan prevents acquired epilepsy via TGF-β signaling suppression
    Guy Bar-Klein
    Departments of Physiology and Cell Biology, Cognitive and Brain Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Ann Neurol 75:864-75. 2014

Collaborators

  • Jaime Levy
  • Alon Monsonego
  • Ora Kofman
  • Andrea Berger
  • U Heinemann
  • Gytis Baranauskas
  • Shai Shrot
  • Meir Bialer
  • Gal Ifergane
  • Roee Admon
  • Gaby S Pell
  • Gerald Seifert
  • Christian Steinhäuser
  • Annamaria Vezzani
  • Dominik Zumsteg
  • Lev Pavlovsky
  • Ilan Shelef
  • Yonatan Serlin
  • Rotem Saar-Ashkenazy
  • Itai Weissberg
  • Hadar Shalev
  • Jonathan E Cohen
  • Yoash Chassidim
  • Lyn Kamintsky
  • Ronel Veksler
  • Guy Bar-Klein
  • Karl Schoknecht
  • Daniela Kaufer
  • Ofer Prager
  • Yaron David
  • Jonathan Guez
  • Boris Knyazer
  • Nitzan Levy
  • Federica Frigerio
  • Oren Tomkins
  • Haviv Levi
  • Dan Z Milikovsky
  • Lydia Wood
  • Yisrael Parmet
  • Michael Fassler
  • Oliver Braganza
  • Yehudit Gnatek
  • Luisa P Cacheaux
  • Dan Shlosberg
  • Hermona Soreq
  • R Orie Browne
  • Yael Jacob
  • Aaron Winter
  • Ehud Ur
  • Marina Shneck
  • Tali Shafat
  • Oscar Vazquez
  • Carolyn Ardizzone
  • Marion S Buckwalter
  • Maya Ketzef
  • Ilya Fleidervish
  • Albert Becker
  • Shai Abutbul
  • John R Huguenard
  • Ekaterina Vinogradov
  • Allyson Alexander
  • Magdalena K Kanthak
  • Hannah Oppenheim
  • Soo Young Kim
  • Yechiel Hubary
  • Paul Cheng
  • Tawfeeq Shekh-Ahmad
  • Arik Eisenkraft
  • Szendro Gabi
  • Chris Gasho
  • Evyatar Swissa
  • Liran Stetlander
  • Ran Taube
  • Geva Tal
  • Svetlana Lublinsky
  • Christopher J Gasho
  • Talma Hendler
  • Shy Hefetz
  • Lavi J Shachar
  • Felipe Diaz-Griffero
  • Kerstin Hüttmann
  • Yael Goll
  • Francesco M Noé
  • Peter Bedner
  • Gabriel Zimmerman
  • Naim Najami
  • Angelisa Frasca
  • Sara Parrella
  • Elena von Staden
  • Akiva Feintuch

Detail Information

Publications33

  1. pmc Acetylcholinesterase loosens the brain's cholinergic anti-inflammatory response and promotes epileptogenesis
    Yehudit Gnatek
    Departments of Physiology and Neurobiology, Zlotowski Center of Neuroscience, Ben Gurion University of the Negev Beer Sheva, Israel
    Front Mol Neurosci 5:66. 2012
    ..Our results highlight the cholinergic system as a potential new target for the prevention of seizures and epilepsy...
  2. pmc Breaching the blood-brain barrier as a gate to psychiatric disorder
    Hadar Shalev
    Department of Psychiatry, Soroka University Medical Center Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Cardiovasc Psychiatry Neurol 2009:278531. 2009
    ..We propose that molecular mechanisms controlling BBB permeability, astrocytic functions, and inflammation may become novel targets for the prevention and treatment of psychiatric disorders...
  3. pmc Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy
    Alon Friedman
    Department of Physiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Epilepsy Res 85:142-9. 2009
    ..We propose that primary vascular injury, and specifically BBB breakdown and repair, are key elements in altered interactions within the neurovascular unit and thus may serve as new therapeutic targets...
  4. pmc Molecular cascades that mediate the influence of inflammation on epilepsy
    Alon Friedman
    Department of Physiology and Neurobiology, Faculty of Health Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Epilepsia 52:33-9. 2011
    ..To what extent targeting the immune system is successful in preventing epileptogenesis, and which signaling pathway should be beleaguered is still under intensive research...
  5. pmc Breakdown of Inter-Hemispheric Connectivity Is Associated with Posttraumatic Symptomatology and Memory Impairment
    Rotem Saar-Ashkenazy
    Department of Brain and Cognitive Neuroscience, The Zlotowski center for Neuroscience Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 11:e0144766. 2016
    ..This study demonstrates meaningful clinical and cognitive correlates of microstructural connectivity. These results have implications for diagnostic tools and future studies aimed at identifying individuals at risk for PTSD. ..
  6. doi request reprint Angiographic evidence of proliferative retinopathy predicts neuropsychiatric morbidity in diabetic patients
    Yonatan Serlin
    Department of Physiology and Cell Biology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Psychoneuroendocrinology 67:163-70. 2016
    ....
  7. doi request reprint Altered processing of visual emotional stimuli in posttraumatic stress disorder: an event-related potential study
    Rotem Saar-Ashkenazy
    Department of Cognitive Neuroscience and Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel Department of Psychology and the School of Social work, Ashkelon Academic College, Ashkelon, Israel Department of Psychology, Achva Academic College, Beer Tuvia Regional Council, Israel
    Psychiatry Res 233:165-74. 2015
    ..We interpret these findings as a brain-circuit response tendency towards negative overgeneralization in PTSD...
  8. doi request reprint Differential TGF-β Signaling in Glial Subsets Underlies IL-6-Mediated Epileptogenesis in Mice
    Nitzan Levy
    Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel Department of Physiology and Cell Biology, Faculty of Health Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel and
    J Immunol 195:1713-22. 2015
    ..Whereas IL-6 is epileptogenic in C57BL/6 mice, its upregulation by TGF-β1 is more profound in FVB/N mice characterized as a relatively more susceptible strain to seizure-induced cell death. ..
  9. pmc Stimulation of the sphenopalatine ganglion induces reperfusion and blood-brain barrier protection in the photothrombotic stroke model
    Haviv Levi
    Department of Physiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 7:e39636. 2012
    ..However, the detailed effects of SPG stimulation on the injured brain are not known...
  10. pmc Losartan prevents acquired epilepsy via TGF-β signaling suppression
    Guy Bar-Klein
    Departments of Physiology and Cell Biology, Cognitive and Brain Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Ann Neurol 75:864-75. 2014
    ..Here we investigated albumin-mediated TGF-β signaling and tested the efficacy of blocking the TGF-β pathway in preventing epilepsy...
  11. ncbi request reprint Motor inhibition and learning impairments in school-aged children following exposure to organophosphate pesticides in infancy
    Ora Kofman
    Department of Behavioral Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Pediatr Res 60:88-92. 2006
    ..Children with pesticide or kerosene poisoning had a retrieval deficit on the acquisition phase of a verbal learning task...
  12. ncbi request reprint Pathogenesis of stress-associated skin disorders: exploring the brain-skin axis
    Lev Pavlovsky
    Department of Physiology, Soroka University Hospital and Zlotowski Center of Neuroscience, Ben Gurion University, Beersheva, Israel
    Curr Probl Dermatol 35:136-45. 2007
    ..We review here the available knowledge regarding the possible mechanisms underlying stress actions in the pathogenesis and course of skin diseases...
  13. pmc Anatomy and physiology of the blood-brain barrier
    Yonatan Serlin
    Departments of Physiology, Cell Biology and Cognitive and Brain Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Semin Cell Dev Biol 38:2-6. 2015
    ....
  14. pmc Novel fluorescein angiography-based computer-aided algorithm for assessment of retinal vessel permeability
    Yonatan Serlin
    Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 8:e61599. 2013
    ..To present a novel method for quantitative assessment of retinal vessel permeability using a fluorescein angiography-based computer algorithm...
  15. doi request reprint sec-Butyl-propylacetamide (SPD) and two of its stereoisomers rapidly terminate paraoxon-induced status epilepticus in rats
    Guy Bar-Klein
    Departments of Physiology and Cell Biology, Cognitive and Brain Sciences, The Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Epilepsia 55:1953-8. 2014
    ..SPD is a one carbon homolog of valnoctamide, a central nervous system (CNS)-active constitutional isomer of valproic acid (VPA) corresponding amide valpromide...
  16. pmc Preferential lentiviral targeting of astrocytes in the central nervous system
    Michael Fassler
    The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Israel
    PLoS ONE 8:e76092. 2013
    ..As such, it can open a window to visualize and genetically manipulate astrocytes or other cells of the CNS as means of research and treatment. ..
  17. doi request reprint Reduced corpus-callosum volume in posttraumatic stress disorder highlights the importance of interhemispheric connectivity for associative memory
    Rotem Saar-Ashkenazy
    Department of Cognitive Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel Department of Psychology, Achva Academic College, Beer Tuvia Regional Council, Israel
    J Trauma Stress 27:18-26. 2014
    ..7, p = .010, that was correlated with lower associative performance (r = .76, p = .003). We propose that CC volume reduction is a substrate for the associative memory deficits found in PTSD. ..
  18. doi request reprint Stress-induced altered cholinergic-glutamatergic interactions in the mouse hippocampus
    Lev Pavlovsky
    Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, POB 653, Beer Sheva 84105, Israel
    Brain Res 1472:99-106. 2012
    ..These changes may underlie specific hippocampal malfunction, including cognitive and emotional disturbances, as observed in patients with post-traumatic stress disorder (PTSD)...
  19. pmc Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction coupling
    Oliver Braganza
    Institute of Cellular Neurosciences, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Epilepsia 53:1898-906. 2012
    ..1, the predominating astrocytic K(+) channel subunit, is altered by albumin...
  20. pmc Long-lasting pro-ictogenic effects induced in vivo by rat brain exposure to serum albumin in the absence of concomitant pathology
    Federica Frigerio
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, Milan, Italy
    Epilepsia 53:1887-97. 2012
    ..c.v.) albumin injection in naive rats; (3) measured electroencephalography (EEG) activity in these rats, their susceptibility to kainic acid (KA)-induced seizures, and their hippocampal afterdischarge threshold (ADT)...
  21. pmc Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?
    Yaron David
    Department of Physiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Neurosci 29:10588-99. 2009
    ..We suggest that the resulting reduction in the clearance of extracellular potassium underlies frequency-dependent neuronal hyperexcitability and network synchronization...
  22. pmc Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury
    Dan Shlosberg
    Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Nat Rev Neurol 6:393-403. 2010
    ..Finally, we highlight areas for future basic research and clinical studies into TBI...
  23. pmc Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction
    Itai Weissberg
    Departments of Physiology and Cell Biology, Cognitive and Brain Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Neurobiol Dis 78:115-25. 2015
    ..Our findings point to astrocyte-mediated synaptogenesis as a key epileptogenic process and highlight the manipulation of the TGF-β-pathway as a potential strategy for the prevention of PIE. ..
  24. pmc Blood-brain barrier imaging in human neuropathologies
    Ronel Veksler
    Departments of Physiology and Cell Biology, Brain and Cognitive Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Arch Med Res 45:646-52. 2014
    ..We then proceed to review image analysis methods, including quantitative and semi-quantitative methods. The advantages and limitations of each approach are discussed, and future directions and questions are highlighted. ..
  25. doi request reprint Detection of cerebral hyperperfusion syndrome after carotid endarterectomy with CT perfusion
    Karl Schoknecht
    Department of Neuroradiology, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel Institute of Neurophysiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Neuroimaging 24:295-7. 2014
    ..We thus propose CT perfusion as a diagnostic means for cerebral hyperperfusion syndrome, a syndrome that remains underdiagnosed. ..
  26. doi request reprint Emotional brain rhythms and their impairment in post-traumatic patients
    Jonathan E Cohen
    Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Hum Brain Mapp 34:1344-56. 2013
    ..These findings reveal for the first time the importance of brain electrical oscillations and coherence in emotional top-down modulation and point to specific failure of these mechanisms in PTSD...
  27. pmc Quantitative imaging assessment of blood-brain barrier permeability in humans
    Yoash Chassidim
    Departments of Physiology and Cell Biology and Biomedical Engineering, Faculty of Health Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Fluids Barriers CNS 10:9. 2013
    ..Large clinical trials are awaited to fully understand the significance of BBB permeability as a biomarker and target for treatment in neurological disorders...
  28. pmc Blood-brain barrier dysfunction, status epilepticus, seizures, and epilepsy: a puzzle of a chicken and egg?
    Alon Friedman
    Ben Gurion University of the Negev, Beer Sheva, Israel
    Epilepsia 52:19-20. 2011
    ..Transforming growth factor beta (TGF-β) signaling appears to be a potential new target for the prevention of epileptogenesis and secondary damage following status epilepticus...
  29. ncbi request reprint Coding region paraoxonase polymorphisms dictate accentuated neuronal reactions in chronic, sub-threshold pesticide exposure
    R Orie Browne
    Department of Physiology, Soroka University Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel
    FASEB J 20:1733-5. 2006
    ..Thus, gene-environment interactions involving the ACHE/PON1 locus may be causally involved in determining the physiological response to OP exposure...
  30. pmc Dynamic in vivo imaging of cerebral blood flow and blood-brain barrier permeability
    Ofer Prager
    Department of Physiology, Soroka University Medical Center and Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuroimage 49:337-44. 2010
    ..The new approach may be used to study changes in rCBF, neurovascular coupling and BBB permeability under normal and pathological brain conditions...
  31. pmc Blood-brain barrier breakdown following traumatic brain injury: a possible role in posttraumatic epilepsy
    Oren Tomkins
    Departments of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel
    Cardiovasc Psychiatry Neurol 2011:765923. 2011
    ..Based on recent animal studies and the colocalization found between the region of disrupted BBB and abnormal EEG activity, we suggest a role for a vascular lesion in the pathogenesis of PTE...