Alon Friedman

Summary

Affiliation: Ben-Gurion University of the Negev
Country: Israel

Publications

  1. pmc Novel fluorescein angiography-based computer-aided algorithm for assessment of retinal vessel permeability
    Yonatan Serlin
    Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 8:e61599. 2013
  2. pmc Stimulation of the sphenopalatine ganglion induces reperfusion and blood-brain barrier protection in the photothrombotic stroke model
    Haviv Levi
    Department of Physiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 7:e39636. 2012
  3. pmc Acetylcholinesterase loosens the brain's cholinergic anti-inflammatory response and promotes epileptogenesis
    Yehudit Gnatek
    Departments of Physiology and Neurobiology, Zlotowski Center of Neuroscience, Ben Gurion University of the Negev Beer Sheva, Israel
    Front Mol Neurosci 5:66. 2012
  4. pmc Breaching the blood-brain barrier as a gate to psychiatric disorder
    Hadar Shalev
    Department of Psychiatry, Soroka University Medical Center Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Cardiovasc Psychiatry Neurol 2009:278531. 2009
  5. pmc Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy
    Alon Friedman
    Department of Physiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Epilepsy Res 85:142-9. 2009
  6. pmc Molecular cascades that mediate the influence of inflammation on epilepsy
    Alon Friedman
    Department of Physiology and Neurobiology, Faculty of Health Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Epilepsia 52:33-9. 2011
  7. pmc Dynamic in vivo imaging of cerebral blood flow and blood-brain barrier permeability
    Ofer Prager
    Department of Physiology, Soroka University Medical Center and Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuroimage 49:337-44. 2010
  8. pmc Losartan prevents acquired epilepsy via TGF-β signaling suppression
    Guy Bar-Klein
    Departments of Physiology and Cell Biology, Cognitive and Brain Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Ann Neurol 75:864-75. 2014
  9. ncbi request reprint Motor inhibition and learning impairments in school-aged children following exposure to organophosphate pesticides in infancy
    Ora Kofman
    Department of Behavioral Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Pediatr Res 60:88-92. 2006
  10. ncbi request reprint Pathogenesis of stress-associated skin disorders: exploring the brain-skin axis
    Lev Pavlovsky
    Department of Physiology, Soroka University Hospital and Zlotowski Center of Neuroscience, Ben Gurion University, Beersheva, Israel
    Curr Probl Dermatol 35:136-45. 2007

Collaborators

  • Andrea Berger
  • Ora Kofman
  • U Heinemann
  • Gal Ifergane
  • Jaime Levy
  • Roee Admon
  • Gaby S Pell
  • Christian Steinhäuser
  • Gerald Seifert
  • Annamaria Vezzani
  • Dominik Zumsteg
  • Lev Pavlovsky
  • Ilan Shelef
  • Yoash Chassidim
  • Karl Schoknecht
  • Itai Weissberg
  • Yonatan Serlin
  • Ofer Prager
  • Hadar Shalev
  • Jonathan E Cohen
  • Oren Tomkins
  • Haviv Levi
  • Daniela Kaufer
  • Yaron David
  • Rotem Saar-Ashkenazy
  • Guy Bar-Klein
  • Michael Fassler
  • Yehudit Gnatek
  • Federica Frigerio
  • Oliver Braganza
  • Luisa P Cacheaux
  • Dan Shlosberg
  • Hermona Soreq
  • R Orie Browne
  • Paul Cheng
  • Chris Gasho
  • Jonathan Guez
  • Lydia Wood
  • Szendro Gabi
  • Lyn Kamintsky
  • Soo Young Kim
  • Shy Hefetz
  • Geva Tal
  • Ronel Veksler
  • Christopher J Gasho
  • Alon Monsonego
  • Talma Hendler
  • Boris Knyazer
  • Yisrael Parmet
  • Nitzan Levy
  • Ran Taube
  • Lavi J Shachar
  • Svetlana Lublinsky
  • Felipe Diaz-Griffero
  • Kerstin Hüttmann
  • Gabriel Zimmerman
  • Elena von Staden
  • Peter Bedner
  • Angelisa Frasca
  • Sara Parrella
  • Francesco M Noé
  • Naim Najami
  • Yael Goll
  • Akiva Feintuch
  • Avi Cohen
  • Moni Benifla
  • Mony Benifla
  • Chen Klein
  • Sebastian Ivens
  • Ezequiel Lapilover
  • Liat Ben Moyal-Segal

Detail Information

Publications25

  1. pmc Novel fluorescein angiography-based computer-aided algorithm for assessment of retinal vessel permeability
    Yonatan Serlin
    Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 8:e61599. 2013
    ..To present a novel method for quantitative assessment of retinal vessel permeability using a fluorescein angiography-based computer algorithm...
  2. pmc Stimulation of the sphenopalatine ganglion induces reperfusion and blood-brain barrier protection in the photothrombotic stroke model
    Haviv Levi
    Department of Physiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 7:e39636. 2012
    ..However, the detailed effects of SPG stimulation on the injured brain are not known...
  3. pmc Acetylcholinesterase loosens the brain's cholinergic anti-inflammatory response and promotes epileptogenesis
    Yehudit Gnatek
    Departments of Physiology and Neurobiology, Zlotowski Center of Neuroscience, Ben Gurion University of the Negev Beer Sheva, Israel
    Front Mol Neurosci 5:66. 2012
    ..Our results highlight the cholinergic system as a potential new target for the prevention of seizures and epilepsy...
  4. pmc Breaching the blood-brain barrier as a gate to psychiatric disorder
    Hadar Shalev
    Department of Psychiatry, Soroka University Medical Center Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Cardiovasc Psychiatry Neurol 2009:278531. 2009
    ..We propose that molecular mechanisms controlling BBB permeability, astrocytic functions, and inflammation may become novel targets for the prevention and treatment of psychiatric disorders...
  5. pmc Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy
    Alon Friedman
    Department of Physiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Epilepsy Res 85:142-9. 2009
    ..We propose that primary vascular injury, and specifically BBB breakdown and repair, are key elements in altered interactions within the neurovascular unit and thus may serve as new therapeutic targets...
  6. pmc Molecular cascades that mediate the influence of inflammation on epilepsy
    Alon Friedman
    Department of Physiology and Neurobiology, Faculty of Health Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Epilepsia 52:33-9. 2011
    ..To what extent targeting the immune system is successful in preventing epileptogenesis, and which signaling pathway should be beleaguered is still under intensive research...
  7. pmc Dynamic in vivo imaging of cerebral blood flow and blood-brain barrier permeability
    Ofer Prager
    Department of Physiology, Soroka University Medical Center and Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuroimage 49:337-44. 2010
    ..The new approach may be used to study changes in rCBF, neurovascular coupling and BBB permeability under normal and pathological brain conditions...
  8. pmc Losartan prevents acquired epilepsy via TGF-β signaling suppression
    Guy Bar-Klein
    Departments of Physiology and Cell Biology, Cognitive and Brain Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Ann Neurol 75:864-75. 2014
    ..Here we investigated albumin-mediated TGF-β signaling and tested the efficacy of blocking the TGF-β pathway in preventing epilepsy...
  9. ncbi request reprint Motor inhibition and learning impairments in school-aged children following exposure to organophosphate pesticides in infancy
    Ora Kofman
    Department of Behavioral Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Pediatr Res 60:88-92. 2006
    ..Children with pesticide or kerosene poisoning had a retrieval deficit on the acquisition phase of a verbal learning task...
  10. ncbi request reprint Pathogenesis of stress-associated skin disorders: exploring the brain-skin axis
    Lev Pavlovsky
    Department of Physiology, Soroka University Hospital and Zlotowski Center of Neuroscience, Ben Gurion University, Beersheva, Israel
    Curr Probl Dermatol 35:136-45. 2007
    ..We review here the available knowledge regarding the possible mechanisms underlying stress actions in the pathogenesis and course of skin diseases...
  11. doi request reprint Stress-induced altered cholinergic-glutamatergic interactions in the mouse hippocampus
    Lev Pavlovsky
    Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, POB 653, Beer Sheva 84105, Israel
    Brain Res 1472:99-106. 2012
    ..These changes may underlie specific hippocampal malfunction, including cognitive and emotional disturbances, as observed in patients with post-traumatic stress disorder (PTSD)...
  12. doi request reprint Reduced corpus-callosum volume in posttraumatic stress disorder highlights the importance of interhemispheric connectivity for associative memory
    Rotem Saar-Ashkenazy
    Department of Cognitive Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel Department of Psychology, Achva Academic College, Beer Tuvia Regional Council, Israel
    J Trauma Stress 27:18-26. 2014
    ..7, p = .010, that was correlated with lower associative performance (r = .76, p = .003). We propose that CC volume reduction is a substrate for the associative memory deficits found in PTSD. ..
  13. pmc Long-lasting pro-ictogenic effects induced in vivo by rat brain exposure to serum albumin in the absence of concomitant pathology
    Federica Frigerio
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, Milan, Italy
    Epilepsia 53:1887-97. 2012
    ..c.v.) albumin injection in naive rats; (3) measured electroencephalography (EEG) activity in these rats, their susceptibility to kainic acid (KA)-induced seizures, and their hippocampal afterdischarge threshold (ADT)...
  14. pmc Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction coupling
    Oliver Braganza
    Institute of Cellular Neurosciences, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Epilepsia 53:1898-906. 2012
    ..1, the predominating astrocytic K(+) channel subunit, is altered by albumin...
  15. pmc Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury
    Dan Shlosberg
    Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Nat Rev Neurol 6:393-403. 2010
    ..Finally, we highlight areas for future basic research and clinical studies into TBI...
  16. pmc Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?
    Yaron David
    Department of Physiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Neurosci 29:10588-99. 2009
    ..We suggest that the resulting reduction in the clearance of extracellular potassium underlies frequency-dependent neuronal hyperexcitability and network synchronization...
  17. pmc Blood-brain barrier breakdown following traumatic brain injury: a possible role in posttraumatic epilepsy
    Oren Tomkins
    Departments of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel
    Cardiovasc Psychiatry Neurol 2011:765923. 2011
    ..Based on recent animal studies and the colocalization found between the region of disrupted BBB and abnormal EEG activity, we suggest a role for a vascular lesion in the pathogenesis of PTE...
  18. ncbi request reprint Detection of cerebral hyperperfusion syndrome after carotid endarterectomy with CT perfusion
    Karl Schoknecht
    Department of Neuroradiology, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel Institute of Neurophysiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Neuroimaging 24:295-7. 2014
    ..We thus propose CT perfusion as a diagnostic means for cerebral hyperperfusion syndrome, a syndrome that remains underdiagnosed. ..
  19. doi request reprint Emotional brain rhythms and their impairment in post-traumatic patients
    Jonathan E Cohen
    Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Hum Brain Mapp 34:1344-56. 2013
    ..These findings reveal for the first time the importance of brain electrical oscillations and coherence in emotional top-down modulation and point to specific failure of these mechanisms in PTSD...
  20. pmc Quantitative imaging assessment of blood-brain barrier permeability in humans
    Yoash Chassidim
    Departments of Physiology and Cell Biology and Biomedical Engineering, Faculty of Health Sciences, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Fluids Barriers CNS 10:9. 2013
    ..Large clinical trials are awaited to fully understand the significance of BBB permeability as a biomarker and target for treatment in neurological disorders...
  21. pmc Blood-brain barrier dysfunction, status epilepticus, seizures, and epilepsy: a puzzle of a chicken and egg?
    Alon Friedman
    Ben Gurion University of the Negev, Beer Sheva, Israel
    Epilepsia 52:19-20. 2011
    ..Transforming growth factor beta (TGF-β) signaling appears to be a potential new target for the prevention of epileptogenesis and secondary damage following status epilepticus...
  22. ncbi request reprint Coding region paraoxonase polymorphisms dictate accentuated neuronal reactions in chronic, sub-threshold pesticide exposure
    R Orie Browne
    Department of Physiology, Soroka University Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel
    FASEB J 20:1733-5. 2006
    ..Thus, gene-environment interactions involving the ACHE/PON1 locus may be causally involved in determining the physiological response to OP exposure...
  23. pmc Preferential lentiviral targeting of astrocytes in the central nervous system
    Michael Fassler
    The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Israel
    PLoS ONE 8:e76092. 2013
    ..As such, it can open a window to visualize and genetically manipulate astrocytes or other cells of the CNS as means of research and treatment. ..