Affiliation: Ben-Gurion University of the Negev
Felder S, Masasa H, Orenbuch A, Levaot N, Shachar Goldenberg M, Cohen S. Reconstruction of the ovary microenvironment utilizing macroporous scaffold with affinity-bound growth factors. Biomaterials. 2019;205:11-22 pubmed publisher
Ruvinov E, Cohen S. Alginate biomaterial for the treatment of myocardial infarction: Progress, translational strategies, and clinical outlook: From ocean algae to patient bedside. Adv Drug Deliv Rev. 2016;96:54-76 pubmed publisher
Rasmussen T, Follin B, Kastrup J, Brandt Larsen M, Madsen J, Emil Christensen T, et al
. Angiogenesis PET Tracer Uptake (68Ga-NODAGA-E[(cRGDyK)]?) in Induced Myocardial Infarction and Stromal Cell Treatment in Minipigs. Diagnostics (Basel). 2018;8: pubmed publisher
..In summary, indications of angiogenesis were present in the infarcted myocardium. However, no differences between pASC-treated and non-pASC-treated minipigs could be demonstrated. ..
Sapir Lekhovitser Y, Rotenberg M, Jopp J, Friedman G, Polyak B, Cohen S. Magnetically actuated tissue engineered scaffold: insights into mechanism of physical stimulation. Nanoscale. 2016;8:3386-99 pubmed publisher
..This work is our next step in understanding of how to accurately create proper stimulatory microenvironment for promotion of cellular organization to form mature tissue engineered constructs. ..
Forti E, Kryukov O, Elovic E, Goldshtein M, Korin E, Margolis G, et al
. A bridge to silencing: Co-assembling anionic nanoparticles of siRNA and hyaluronan sulfate via calcium ion bridges. J Control Release. 2016;232:215-27 pubmed publisher
..Collectively, anionic NPs prove to be an efficient and cytocompatible delivery system for siRNA. ..
Goldshtein M, Forti E, Ruvinov E, Cohen S. Mechanisms of cellular uptake and endosomal escape of calcium-siRNA nanocomplexes. Int J Pharm. 2016;515:46-56 pubmed publisher
..Collectively, our results indicate that Ca2+ promotes cell internalization and rapid endosomal escape, thus leading to the efficient siRNA-induced target gene silencing elicited by the Ca2+-siRNA nanocomplexes. ..
Korin E, Bejerano T, Cohen S. GalNAc bio-functionalization of nanoparticles assembled by electrostatic interactions improves siRNA targeting to the liver. J Control Release. 2017;266:310-320 pubmed publisher
..We foresee that the combined advantages of site-specific targeting and reversibility of the tri-component NPs as well as the simplicity of their fabrication make them an attractive system for targeted delivery of siRNA. ..