Hagit Cohen

Summary

Affiliation: Ben-Gurion University of the Negev
Country: Israel

Publications

  1. doi request reprint Reducing post-traumatic anxiety by immunization
    Gil M Lewitus
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Brain Behav Immun 22:1108-14. 2008
  2. pmc Upregulation of neurotrophic factors selectively in frontal cortex in response to olfactory discrimination learning
    Ari Naimark
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neural Plast 2007:13427. 2007
  3. pmc The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder
    Hagit Cohen
    Anxiety and Stress Research Unit, Beer Sheva Mental Health Center, The State of Israel Ministry of Health, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychopharmacology 37:350-63. 2012
  4. doi request reprint Animal model for PTSD: from clinical concept to translational research
    Hagit Cohen
    Israel Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 4600, Beer Sheva 84170, Israel
    Neuropharmacology 62:715-24. 2012
  5. ncbi request reprint Anxiolytic effect and memory improvement in rats by antisense oligodeoxynucleotide to 5-hydroxytryptamine-2A precursor protein
    Hagit Cohen
    Ben Gurion University of the Negev, Beer Sheva, Israel
    Depress Anxiety 22:84-93. 2005
  6. ncbi request reprint Unsupervised fuzzy clustering analysis supports behavioral cutoff criteria in an animal model of posttraumatic stress disorder
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84170, Israel
    Biol Psychiatry 58:640-50. 2005
  7. doi request reprint Hippocampal microinfusion of oxytocin attenuates the behavioural response to stress by means of dynamic interplay with the glucocorticoid-catecholamine responses
    H Cohen
    Ministry of Health, Beer Sheva Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Neuroendocrinol 22:889-904. 2010
  8. doi request reprint Early post-stressor intervention with propranolol is ineffective in preventing posttraumatic stress responses in an animal model for PTSD
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur Neuropsychopharmacol 21:230-40. 2011
  9. ncbi request reprint Long-lasting behavioral effects of juvenile trauma in an animal model of PTSD associated with a failure of the autonomic nervous system to recover
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84170, Israel
    Eur Neuropsychopharmacol 17:464-77. 2007
  10. ncbi request reprint Blunted HPA axis response to stress influences susceptibility to posttraumatic stress response in rats
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biol Psychiatry 59:1208-18. 2006

Collaborators

Detail Information

Publications76

  1. doi request reprint Reducing post-traumatic anxiety by immunization
    Gil M Lewitus
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Brain Behav Immun 22:1108-14. 2008
    ....
  2. pmc Upregulation of neurotrophic factors selectively in frontal cortex in response to olfactory discrimination learning
    Ari Naimark
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neural Plast 2007:13427. 2007
    ..These findings suggest that different brain areas may be preferentially involved in different learning/memory tasks...
  3. pmc The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder
    Hagit Cohen
    Anxiety and Stress Research Unit, Beer Sheva Mental Health Center, The State of Israel Ministry of Health, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychopharmacology 37:350-63. 2012
    ..The protective qualities attributed to NPY are supported by the extreme reduction of its expression in animals severely affected by the stressor and imply a role in promoting resilience and/or recovery...
  4. doi request reprint Animal model for PTSD: from clinical concept to translational research
    Hagit Cohen
    Israel Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 4600, Beer Sheva 84170, Israel
    Neuropharmacology 62:715-24. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  5. ncbi request reprint Anxiolytic effect and memory improvement in rats by antisense oligodeoxynucleotide to 5-hydroxytryptamine-2A precursor protein
    Hagit Cohen
    Ben Gurion University of the Negev, Beer Sheva, Israel
    Depress Anxiety 22:84-93. 2005
    ..Receptor downregulation has been proposed as one of the central mechanisms for anxiolytic drug actions. Antisense-mediated downmanipulation of receptors in this study, especially of 5-HT2A, supports this theory...
  6. ncbi request reprint Unsupervised fuzzy clustering analysis supports behavioral cutoff criteria in an animal model of posttraumatic stress disorder
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84170, Israel
    Biol Psychiatry 58:640-50. 2005
    ....
  7. doi request reprint Hippocampal microinfusion of oxytocin attenuates the behavioural response to stress by means of dynamic interplay with the glucocorticoid-catecholamine responses
    H Cohen
    Ministry of Health, Beer Sheva Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Neuroendocrinol 22:889-904. 2010
    ..Oxytocin is actively involved in the neurobiological response to predator scent stress processes and thus warrants further study as a potential therapeutic avenue for the treatment of anxiety-related disorders...
  8. doi request reprint Early post-stressor intervention with propranolol is ineffective in preventing posttraumatic stress responses in an animal model for PTSD
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur Neuropsychopharmacol 21:230-40. 2011
    ..Traumatic stress-related processes appear to be affected differently than the others...
  9. ncbi request reprint Long-lasting behavioral effects of juvenile trauma in an animal model of PTSD associated with a failure of the autonomic nervous system to recover
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84170, Israel
    Eur Neuropsychopharmacol 17:464-77. 2007
    ....
  10. ncbi request reprint Blunted HPA axis response to stress influences susceptibility to posttraumatic stress response in rats
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biol Psychiatry 59:1208-18. 2006
    ..This study investigated the role of cortisol in the manifestation of anxiety- and fear-like symptoms in an animal model of PTSD...
  11. pmc Gender differences in animal models of posttraumatic stress disorder
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Dis Markers 30:141-50. 2011
    ..The examination of these gender-related differences can deepen our understanding of the risk or the pathophysiology of stress-related disorders...
  12. ncbi request reprint Decreased circulatory levels of neuroactive steroids in behaviourally more extremely affected rats subsequent to exposure to a potentially traumatic experience
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Int J Neuropsychopharmacol 10:203-9. 2007
    ....
  13. ncbi request reprint Anisomycin, a protein synthesis inhibitor, disrupts traumatic memory consolidation and attenuates posttraumatic stress response in rats
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biol Psychiatry 60:767-76. 2006
    ....
  14. ncbi request reprint Post-traumatic stress behavioural responses in inbred mouse strains: can genetic predisposition explain phenotypic vulnerability?
    Hagit Cohen
    Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Int J Neuropsychopharmacol 11:331-49. 2008
    ..The response of the individual to stress is multifactorial and environmental factors play a predominant role in characterizing the individual response to stress exposure, although there are significant genetic underpinnings...
  15. ncbi request reprint The contribution of an animal model toward uncovering biological risk factors for PTSD
    Hagit Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84170, Israel
    Ann N Y Acad Sci 1071:335-50. 2006
    ....
  16. doi request reprint Early post-stressor intervention with high-dose corticosterone attenuates posttraumatic stress response in an animal model of posttraumatic stress disorder
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biol Psychiatry 64:708-17. 2008
    ..We used an animal model of posttraumatic stress disorder (PTSD) to assess long-term behavioral effects of a single administration of various doses of corticosterone (CORT), administered immediately after exposure to psychogenic stress...
  17. doi request reprint Exposure to extreme stress impairs contextual odour discrimination in an animal model of PTSD
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Int J Neuropsychopharmacol 12:291-303. 2009
    ....
  18. doi request reprint Mapping the brain pathways of traumatic memory: inactivation of protein kinase M zeta in different brain regions disrupts traumatic memory processes and attenuates traumatic stress responses in rats
    Hagit Cohen
    Ministry of Health, Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur Neuropsychopharmacol 20:253-71. 2010
    ..Recent studies reported that local application of ZIP, a membrane-permeant PKMzeta inhibitor, into the insular cortex (IC) of behaving rats abolished long-term memory of taste associations...
  19. ncbi request reprint The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia
    H Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Clin Exp Rheumatol 27:S51-6. 2009
    ..The association between Val/Met polymorphism at the COMT gene was evaluated in FM disorder...
  20. doi request reprint An association between stress-induced disruption of the hypothalamic-pituitary-adrenal axis and disordered glucose metabolism in an animal model of post-traumatic stress disorder
    H Cohen
    Beer Sheva Mental Health Center, The State of Israel Ministry of Health, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of Negev, Beer Sheva, Israel
    J Neuroendocrinol 21:898-909. 2009
    ..This metabolic response was associated with the characteristic pattern of HPA axis (corticosterone) response, which underlies the behavioural response to stress...
  21. pmc The characteristic long-term upregulation of hippocampal NF-κB complex in PTSD-like behavioral stress response is normalized by high-dose corticosterone and pyrrolidine dithiocarbamate administered immediately after exposure
    Hagit Cohen
    The State of Israel Ministry of Health, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychopharmacology 36:2286-302. 2011
    ....
  22. ncbi request reprint Protein synthesis inhibition before or after stress exposure results in divergent endocrine and BDNF responses disassociated from behavioral responses
    Nitsan Kozlovsky
    Ministry of Health Beer Sheva Mental Health Center, Anxiety and Stress Research Unit, Ben Gurion University of the Negev, Beer Sheva, Israel
    Depress Anxiety 25:E24-34. 2008
    ....
  23. ncbi request reprint The immediate early gene Arc is associated with behavioral resilience to stress exposure in an animal model of posttraumatic stress disorder
    Nitsan Kozlovsky
    Ministry of Health Beer Sheva Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, PO Box 4600, Beer Sheva 84170, Israel
    Eur Neuropsychopharmacol 18:107-16. 2008
    ....
  24. ncbi request reprint Long-term down-regulation of BDNF mRNA in rat hippocampal CA1 subregion correlates with PTSD-like behavioural stress response
    Nitsan Kozlovsky
    Ministry of Health Beer Sheva Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    Int J Neuropsychopharmacol 10:741-58. 2007
    ..The corresponding changes in neural plasticity and synaptic functioning may mediate clinical manifestations of PTSD...
  25. pmc Post-exposure sleep deprivation facilitates correctly timed interactions between glucocorticoid and adrenergic systems, which attenuate traumatic stress responses
    Shlomi Cohen
    Department of Psychology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychopharmacology 37:2388-404. 2012
    ..Post-exposure SD may disrupt the consolidation of aversive or fearful memories by facilitating correctly timed interactions between glucocorticoid and adrenergic systems...
  26. doi request reprint Pre-pubertal stress exposure affects adult behavioral response in association with changes in circulating corticosterone and brain-derived neurotrophic factor
    Noam Bazak
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 4600, Beer Sheva 84170, Beer Sheva, Israel
    Psychoneuroendocrinology 34:844-58. 2009
    ..The concomitant changes in BDNF and corticosterone levels may mediate the changes in neural plasticity and synaptic functioning underlying clinical manifestations of PTSD...
  27. doi request reprint High dose hydrocortisone immediately after trauma may alter the trajectory of PTSD: interplay between clinical and animal studies
    Joseph Zohar
    Division of Psychiatry, The State of Israel Ministry of Health, The Chaim Sheba Medical Center, Sackler Medical School, Tel Aviv University, Tel Hashomer, Israel
    Eur Neuropsychopharmacol 21:796-809. 2011
    ..Thus, evidence from clinical and animal studies suggests that there is a "window of opportunity" in the early aftermath of trauma to help those who are vulnerable to the development of chronic PTSD...
  28. doi request reprint A distinct pattern of intracellular glucocorticoid-related responses is associated with extreme behavioral response to stress in an animal model of post-traumatic stress disorder
    Nitsan Kozlovsky
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur Neuropsychopharmacol 19:759-71. 2009
    ..Glucocorticoids induce expression of Zif/268 through two distinct mechanisms: a rapid-onset, MAPK-independent pathway and a slower-onset, MAPK-dependent mechanism...
  29. ncbi request reprint Gender-related qualitative differences in baseline and post-stress anxiety responses are not reflected in the incidence of criterion-based PTSD-like behaviour patterns
    Adi Mazor
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    World J Biol Psychiatry 10:856-69. 2009
    ..In order to explore gender-related PTSD-like stress-responses more thoroughly, we applied an animal model that focuses selectively on individual patterns of behavioural responses...
  30. ncbi request reprint Different pathways mediated by CCK1 and CCK2 receptors: effect of intraperitonal mrna antisense oligodeoxynucleotides to cholecystokinin on anxiety-like and learning behaviors in rats
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Depress Anxiety 20:139-52. 2004
    ..The present study showed an anxiolytic effect of i.p. CCK-ASODN in the presence of CCK2R, but not CCK1R...
  31. doi request reprint The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder
    Nitsan Kozlovsky
    State of Israel Ministry of Health, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biol Psychiatry 65:383-91. 2009
    ....
  32. doi request reprint Alprazolam treatment immediately after stress exposure interferes with the normal HPA-stress response and increases vulnerability to subsequent stress in an animal model of PTSD
    Michael A Matar
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur Neuropsychopharmacol 19:283-95. 2009
    ....
  33. ncbi request reprint The effect of early poststressor intervention with sertraline on behavioral responses in an animal model of post-traumatic stress disorder
    Michael A Matar
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychopharmacology 31:2610-8. 2006
    ..SSRI drugs are thus worthy of further investigation as agents of secondary prevention in the acute aftermath of stress-exposure...
  34. doi request reprint IFN-gamma enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer's disease
    Rona Baron
    The Shraga Segal Dept of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    FASEB J 22:2843-52. 2008
    ..We demonstrate that limited amounts of IFN-gamma in the brain shape the neuropoietic milieu to enhance neurogenesis, possibly representing the normal function of the immune system in controlling brain inflammation and repair...
  35. ncbi request reprint Setting apart the affected: the use of behavioral criteria in animal models of post traumatic stress disorder
    Hagit Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychopharmacology 29:1962-70. 2004
    ..As setting the affected individuals apart from the unaffected approximates clinical studies, it might also help to clarify some of the pending issues in PTSD research...
  36. ncbi request reprint Olfactory learning prevents MK-801-induced psychosis-like behaviour in an animal model of schizophrenia
    Ari Naimark
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Ben Gurion University, Beer Sheva, Israel
    World J Biol Psychiatry 9:135-46. 2008
    ..Our data support the notion that learning-induced protection against schizophrenic behaviour is maintained by non-NMDA-mediated enhanced activation of local connections in the relevant cortical networks...
  37. doi request reprint Irreversibility of cardiac autonomic dysfunction in female adolescents diagnosed with anorexia nervosa after short- and long-term weight gain
    Moshe Lachish
    Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    World J Biol Psychiatry 10:503-11. 2009
    ....
  38. ncbi request reprint The effect of sudden clozapine discontinuation on management of schizophrenic patients: A retrospective controlled study
    Chanoch Miodownik
    Division of Psychiatry, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Clin Psychiatry 67:1204-8. 2006
    ....
  39. ncbi request reprint The relevance of differential response to trauma in an animal model of posttraumatic stress disorder
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biol Psychiatry 53:463-73. 2003
    ..We examined the effect of grouping prestressed rats according to magnitude of response on the statistical analysis of results...
  40. doi request reprint Chronic exposure to stress predisposes to higher autoimmune susceptibility in C57BL/6 mice: glucocorticoids as a double-edged sword
    Idan Harpaz
    Anxiety and Stress Research Unit, Beer Sheva Mental Health Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Immunol 43:758-69. 2013
    ....
  41. ncbi request reprint [Vitamin B6 add-on therapy in treatment of schizophrenic patients with psychotic symptoms and movement disorders]
    Chanoch Miodownik
    Ministry of Health, Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheba, Israel
    Harefuah 142:592-6, 647. 2003
    ..In this study vitamin B6 treatment was provided to 15 patients who suffered from schizophrenia and schizoaffective disorder with positive psychotic symptoms and tardive dyskinesia...
  42. ncbi request reprint Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4+CD25+ cells
    Hagit Cohen
    Ministry of Health Mental Health Center Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Neurobiol 66:552-63. 2006
    ..They might also point the way to development of immune-based therapies for mental disorders, based either on up-regulation of T cells that partially cross-react with self-antigens or on weakening of the activity of regulatory T cells...
  43. doi request reprint Animal models of post-traumatic stress disorder
    Hagit Cohen
    Israel Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Curr Protoc Neurosci . 2013
    ....
  44. doi request reprint The long-term abnormalities in circadian expression of Period 1 and Period 2 genes in response to stress is normalized by agomelatine administered immediately after exposure
    Ori Koresh
    Beer Sheva Mental Health Center, The State of Israel Ministry of Health, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    Eur Neuropsychopharmacol 22:205-21. 2012
    ....
  45. ncbi request reprint Effect of intraperitoneal acetyl-L-carnitine (ALCAR) on anxiety-like behaviours in rats
    Joseph Levine
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Int J Neuropsychopharmacol 8:65-74. 2005
    ..The precise mechanism by which ALCAR decreases anxiety-like behaviour after peripheral administration remains to be determined...
  46. ncbi request reprint Prevalence of post-traumatic stress disorder in fibromyalgia patients: overlapping syndromes or post-traumatic fibromyalgia syndrome?
    Hagit Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Semin Arthritis Rheum 32:38-50. 2002
    ..The influence of gender on measures of PTSD in fibromyalgia (FM) patients also was examined...
  47. ncbi request reprint Stress-related responses after 3 years of exposure to terror in Israel: are ideological-religious factors associated with resilience?
    Zeev Kaplan
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Clin Psychiatry 66:1146-54. 2005
    ....
  48. ncbi request reprint An animal model of posttraumatic stress disorder: the use of cut-off behavioral criteria
    Hagit Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 4600, Beer Sheva 84170, Israel
    Ann N Y Acad Sci 1032:167-78. 2004
    ..Overlooking heterogeneity in responses obscures the results of biobehavioral data analysis. We submit that animals exposed to trauma should be divided into groups according to the magnitude of their response and be studied accordingly...
  49. ncbi request reprint Effect of intraperitoneal mRNA antisense-oligodeoxynucleotides to cholecystokinin on anxiety-like and learning behaviors in rats: association with pre-experimental stress
    Hagit Cohen
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Anxiety and Stress Research Unit, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropeptides 36:341-52. 2002
    ..We demonstrated that intracerebroventricular administration of Cholecystokinin-antisense oligodeoxynucleotides (ASODN) for 3 days significantly diminished anxiety-like behavior in rats...
  50. doi request reprint Post-traumatic stress disorder is not over-represented in a sample population of migraine patients
    Gal Ifergane
    Headache Clinic, Department of Neurology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Intern Med 20:182-5. 2009
    ..PTSD was previously associated with chronic pain and primary pain disorders...
  51. ncbi request reprint A cellular correlate of learning-induced metaplasticity in the hippocampus
    Itay Zelcer
    Department of Physiology, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Cereb Cortex 16:460-8. 2006
    ..In the presence of such enhanced neuronal excitability, the hippocampal network enters into a 'learning mode' in which a variety of hippocampus-dependent skills are acquired rapidly and efficiently...
  52. ncbi request reprint Impaired heart rate variability in euthymic bipolar patients
    Hagit Cohen
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Bipolar Disord 5:138-43. 2003
    ..Power spectral analysis of heart rate variability (HRV) has recently been shown to be a reliable non-invasive test for quantitative assessment of the central sympathovagal interaction that modulates cardiovascular autonomic function...
  53. ncbi request reprint Effects of the cortisol synthesis inhibitor metyrapone on the response to carbon dioxide challenge in panic disorder
    Andrey Belgorodsky
    Division of Psychiatry, Ben Gurion University of the Negev, Beer Sheba, Israel
    Depress Anxiety 21:143-8. 2005
    ..The results support an anxiogenic role for cortisol in stress, and suggest that the pathophysiological mechanism that mediates CO2-induced panic differs from those underlying other kinds of anxiety...
  54. ncbi request reprint Power spectrum analysis and cardiovascular morbidity in anxiety disorders
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 4600, Beer Sheva, Israel
    Auton Neurosci 128:1-8. 2006
    ..The authors call for further studies, especially in patients with co-existing anxiety disorders and heart disease, incorporating assessment of HRV...
  55. ncbi request reprint The quantitative electroencephalogram and the low-resolution electrical tomographic analysis in posttraumatic stress disorder
    Doran Todder
    Ben Gurion University, Faculty of Health, Beer Sheva, Israel
    Clin EEG Neurosci 43:48-53. 2012
    ..These results indicate that combining quantitative EEG (QEEG) and the LORETA method, among other methods, may improve the neuroanatomical resolution of EEG data analysis...
  56. ncbi request reprint Repetitive transcranial magnetic stimulation of the right dorsolateral prefrontal cortex in posttraumatic stress disorder: a double-blind, placebo-controlled study
    Hagit Cohen
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Am J Psychiatry 161:515-24. 2004
    ..The efficacy of repetitive transcranial magnetic stimulation (rTMS) of the right prefrontal cortex was studied in patients with posttraumatic stress disorder (PTSD) under double-blind, placebo-controlled conditions...
  57. doi request reprint Accuracy of the diagnosis of fibromyalgia by family physicians: is the pendulum shifting?
    Elena Shleyfer
    Department of Medicine, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel
    J Rheumatol 36:170-3. 2009
    ..We evaluated the accuracy of diagnosis of fibromyalgia (FM) by family physicians...
  58. ncbi request reprint [A model for therapeutic interventions in emotional responses to enforced geographical relocation of populations in Israel]
    Zeev Kaplan
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Harefuah 144:234-6, 304. 2005
    ..These principles seem to us far more suited to the demands of the complex situation ahead, in order to provide relief and assist in adaptation, and to prevent later complications of possible emotional sequelae...
  59. ncbi request reprint Comorbidity of fibromyalgia and psychiatric disorders
    Dan Buskila
    Department of Medicine H, Soroka Medical Center, POB 151, Beer Sheva 84101, Israel
    Curr Pain Headache Rep 11:333-8. 2007
    ..Assessment of comorbid psychiatric disorders in FMS patients has clinical implications because treatment in these patients should focus both on physical and emotional dimensions of dysfunction...
  60. doi request reprint Translationally relevant modeling of PTSD in rodents
    Michael A Matar
    Ministry of Health Beer Sheva Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 4600, Beer Sheva, 84170, Israel
    Cell Tissue Res 354:127-39. 2013
    ..The translational value of the classification method and future directions are discussed. ..
  61. pmc Symptoms of posttraumatic stress disorder after ritual female genital surgery among bedouin in Israel: myth or reality?
    Julia Applebaum
    Ministry of Health, Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva and Clalit Health Services, Family Health Center, Rahat, Israel
    Prim Care Companion J Clin Psychiatry 10:453-6. 2008
    ..This pilot study assessed the mental health of Bedouin women from southern Israel after RFGS compared to age-matched controls without RFGS...
  62. ncbi request reprint Immunity and neuronal repair in the progression of Alzheimer's disease: a brief overview
    Rona Baron
    Department of Microbiology and Immunology and National Institute of Biotechnology in Negev, Faculty of Health Sciences, Ben Gurion University of Negev, PO Box 653, Beer Sheva 84105, Israel
    Exp Gerontol 42:64-9. 2007
    ....
  63. ncbi request reprint A naturalistic prospective open study of the effects of adjunctive therapy of sexual dysfunction in chronic PTSD patients
    Bela Chudakov
    Ministry of Health, Mental Health Center, Faculty of Health Sciences, Anxiety and Stress Research Unit, Ben Gurion University of the Negev, Beersheba, Israel
    Isr J Psychiatry Relat Sci 45:26-32. 2008
    ..This prospective naturalistic follow-up study of a random group of patients was intended to evaluate response to pharmacologic and psychotherapeutic interventions for SD, in terms of both sexual functioning and overall symptomatology...
  64. doi request reprint The influence of aging on poststroke depression using a rat model via middle cerebral artery occlusion
    Matthew Boyko
    Division of Anesthesiology and Critical Care, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, 84101, Israel
    Cogn Affect Behav Neurosci 13:847-59. 2013
    ....
  65. ncbi request reprint Vitamin B6 as add-on treatment in chronic schizophrenic and schizoaffective patients: a double-blind, placebo-controlled study
    Vladimir Lerner
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Israel
    J Clin Psychiatry 63:54-8. 2002
    ..The aim of this study was to examine whether vitamin B6 therapy influences psychotic symptoms in patients suffering from schizophrenia and schizoaffective disorder...
  66. ncbi request reprint Coping styles in fibromyalgia: effect of co-morbid posttraumatic stress disorder
    Jacob N Ablin
    Institute of Rheumatology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman St, Tel Aviv 64239, Israel
    Rheumatol Int 28:649-56. 2008
    ..Our results may serve to further characterize cognitive and behavioral aspects of FM patients and subsequently guide therapeutic interventions...
  67. ncbi request reprint Relationship between antidepressants and IGF-1 system in the brain: possible role in cognition
    Nurit Grunbaum-Novak
    Lab of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel
    Eur Neuropsychopharmacol 18:431-8. 2008
    ..FLX did not affect cognitive performance. Thus, repeated FLX treatment leads to upregulation of IGF-1 system is FC. It is possible that FLX affect FC neuroplasticity through activation of the IGF-1 system...
  68. ncbi request reprint Juvenile stress induces a predisposition to either anxiety or depressive-like symptoms following stress in adulthood
    Michael Tsoory
    Department of Psychology and The Brain and Behavior Research Center, University of Haifa, Mount Carmel, 31905 Haifa, Israel
    Eur Neuropsychopharmacol 17:245-56. 2007
    ..The results suggest that the presented "Juvenile stress" model may be relevant to the reported predisposition to develop both anxiety and depression following childhood trauma...
  69. ncbi request reprint Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia
    Yechiel Levkovitz
    The Emotion Cognition Research Center, The Shalvata Mental Health Care Center, P O B 94 Hod Hasharon, Israel
    Brain Res 1154:154-62. 2007
    ..The discussion addresses potential mechanisms underlying the effects of minocycline and possible directions for future research...
  70. ncbi request reprint Activity and plasticity in the CA1, the dentate gyrus, and the amygdala following controllable vs. uncontrollable water stress
    Alexandra Kavushansky
    Department of Psychology and Brain and Behavior Research Center, University of Haifa, Israel
    Hippocampus 16:35-42. 2006
    ..These findings provide insight into the differential effects of stress and stress controllability on different hippocampal subregions and the amygdala...
  71. ncbi request reprint Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5- HTTLPR) polymorphism, and relationship to anxiety-related personality traits
    Hagit Cohen
    Arthritis Rheum 46:845-7. 2002
  72. pmc T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions
    Jonathan Kipnis
    Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Proc Natl Acad Sci U S A 101:8180-5. 2004
    ..These findings point to critical factors likely to contribute to age- and AIDS-related dementias and might herald the development of a therapeutic vaccination for fighting off cognitive dysfunction and psychiatric conditions...
  73. ncbi request reprint Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
    Yaniv Ziv
    Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Nat Neurosci 9:268-75. 2006
    ....
  74. pmc Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1
    Oleg Butovsky
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 103:11784-9. 2006
    ..These results suggest that dendritic-like microglia, by facilitating the necessary adjustment, might contribute significantly to the brain's resistance to AD and argue against the use of antiinflammatory drugs...
  75. ncbi request reprint Mechanisms of Disease: genetics of fibromyalgia
    Jacob N Ablin
    Department of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel
    Nat Clin Pract Rheumatol 2:671-8. 2006
    ....
  76. ncbi request reprint Outcomes of naltrexone maintenance following ultra rapid opiate detoxification versus intensive inpatient detoxification
    Jonathan Rabinowitz
    School of Social Work, Bar Ilan University, Ramat Gan, Israel
    Am J Addict 11:52-6. 2002
    ..4 (+/- 3.8) months after detoxification. Naltrexone maintenance and counseling following rapid detoxification may be as effective as intensive inpatient detoxification and counseling...