Hagit Cohen

Summary

Affiliation: Ben-Gurion University of the Negev
Country: Israel

Publications

  1. ncbi request reprint Administration of high-dose ketoconazole, an inhibitor of steroid synthesis, prevents posttraumatic anxiety in an animal model
    H Cohen
    Ministry of Health, Beer Sheva Mental Health Center, Anxiety and Stress Research Unit, P O 4600, Beer Sheva, Israel
    Eur Neuropsychopharmacol 10:429-35. 2000
  2. ncbi request reprint Autonomic nervous system derangement in fibromyalgia syndrome and related disorders
    H Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Isr Med Assoc J 3:755-60. 2001
  3. ncbi request reprint Abnormal sympathovagal balance in men with fibromyalgia
    H Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Rheumatol 28:581-9. 2001
  4. ncbi request reprint Effect of intraperitoneal mRNA antisense-oligodeoxynucleotides to cholecystokinin on anxiety-like and learning behaviors in rats: association with pre-experimental stress
    Hagit Cohen
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Anxiety and Stress Research Unit, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropeptides 36:341-52. 2002
  5. ncbi request reprint Autonomic dysregulation in panic disorder and in post-traumatic stress disorder: application of power spectrum analysis of heart rate variability at rest and in response to recollection of trauma or panic attacks
    H Cohen
    Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Psychiatry Res 96:1-13. 2000
  6. ncbi request reprint Impaired heart rate variability in euthymic bipolar patients
    Hagit Cohen
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Bipolar Disord 5:138-43. 2003
  7. ncbi request reprint Repetitive transcranial magnetic stimulation of the right dorsolateral prefrontal cortex in posttraumatic stress disorder: a double-blind, placebo-controlled study
    Hagit Cohen
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Am J Psychiatry 161:515-24. 2004
  8. ncbi request reprint Setting apart the affected: the use of behavioral criteria in animal models of post traumatic stress disorder
    Hagit Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychopharmacology 29:1962-70. 2004
  9. ncbi request reprint Normalization of heart rate variability in post-traumatic stress disorder patients following fluoxetine treatment: preliminary results
    H Cohen
    Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Isr Med Assoc J 2:296-301. 2000
  10. ncbi request reprint An animal model of posttraumatic stress disorder: the use of cut-off behavioral criteria
    Hagit Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 4600, Beer Sheva 84170, Israel
    Ann N Y Acad Sci 1032:167-78. 2004

Collaborators

Detail Information

Publications78

  1. ncbi request reprint Administration of high-dose ketoconazole, an inhibitor of steroid synthesis, prevents posttraumatic anxiety in an animal model
    H Cohen
    Ministry of Health, Beer Sheva Mental Health Center, Anxiety and Stress Research Unit, P O 4600, Beer Sheva, Israel
    Eur Neuropsychopharmacol 10:429-35. 2000
    ..Results in this model implicate corticosterone, but not ACTH, in the pathogenesis of chronic anxiety following acute psychological stress...
  2. ncbi request reprint Autonomic nervous system derangement in fibromyalgia syndrome and related disorders
    H Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Isr Med Assoc J 3:755-60. 2001
    ..It raises the potentially important prognostic implications of protracted autonomic dysfunction in patient populations with fibromyalgia and related disorders, especially for cardiovascular morbidity and mortality...
  3. ncbi request reprint Abnormal sympathovagal balance in men with fibromyalgia
    H Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Rheumatol 28:581-9. 2001
    ....
  4. ncbi request reprint Effect of intraperitoneal mRNA antisense-oligodeoxynucleotides to cholecystokinin on anxiety-like and learning behaviors in rats: association with pre-experimental stress
    Hagit Cohen
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Anxiety and Stress Research Unit, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropeptides 36:341-52. 2002
    ..We demonstrated that intracerebroventricular administration of Cholecystokinin-antisense oligodeoxynucleotides (ASODN) for 3 days significantly diminished anxiety-like behavior in rats...
  5. ncbi request reprint Autonomic dysregulation in panic disorder and in post-traumatic stress disorder: application of power spectrum analysis of heart rate variability at rest and in response to recollection of trauma or panic attacks
    H Cohen
    Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Psychiatry Res 96:1-13. 2000
    ..HRV analysis demonstrates significant differences in autonomic regulation of PTSD and PD patients compared to each other and to control subjects. HRV analysis may augment biochemical studies of peripheral measures in these disorders...
  6. ncbi request reprint Impaired heart rate variability in euthymic bipolar patients
    Hagit Cohen
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Bipolar Disord 5:138-43. 2003
    ..Power spectral analysis of heart rate variability (HRV) has recently been shown to be a reliable non-invasive test for quantitative assessment of the central sympathovagal interaction that modulates cardiovascular autonomic function...
  7. ncbi request reprint Repetitive transcranial magnetic stimulation of the right dorsolateral prefrontal cortex in posttraumatic stress disorder: a double-blind, placebo-controlled study
    Hagit Cohen
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Am J Psychiatry 161:515-24. 2004
    ..The efficacy of repetitive transcranial magnetic stimulation (rTMS) of the right prefrontal cortex was studied in patients with posttraumatic stress disorder (PTSD) under double-blind, placebo-controlled conditions...
  8. ncbi request reprint Setting apart the affected: the use of behavioral criteria in animal models of post traumatic stress disorder
    Hagit Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychopharmacology 29:1962-70. 2004
    ..As setting the affected individuals apart from the unaffected approximates clinical studies, it might also help to clarify some of the pending issues in PTSD research...
  9. ncbi request reprint Normalization of heart rate variability in post-traumatic stress disorder patients following fluoxetine treatment: preliminary results
    H Cohen
    Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Isr Med Assoc J 2:296-301. 2000
    ..Our previous study shows that patients with post-traumatic stress disorder have significantly lower HRV compared to controls, reflecting a basal autonomic state characterized by increased sympathetic and decreased parasympathetic tone...
  10. ncbi request reprint An animal model of posttraumatic stress disorder: the use of cut-off behavioral criteria
    Hagit Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 4600, Beer Sheva 84170, Israel
    Ann N Y Acad Sci 1032:167-78. 2004
    ..Overlooking heterogeneity in responses obscures the results of biobehavioral data analysis. We submit that animals exposed to trauma should be divided into groups according to the magnitude of their response and be studied accordingly...
  11. ncbi request reprint Power spectrum analysis and cardiovascular morbidity in anxiety disorders
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 4600, Beer Sheva, Israel
    Auton Neurosci 128:1-8. 2006
    ..The authors call for further studies, especially in patients with co-existing anxiety disorders and heart disease, incorporating assessment of HRV...
  12. ncbi request reprint Power spectral analysis of heart rate variability in psychiatry
    H Cohen
    Ministry of Health, Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Psychother Psychosom 68:59-66. 1999
    ..It raises the potentially important prognostic implications of protracted autonomic dysfunction in psychiatric patient populations, especially for cardiovascular morbidity and mortality...
  13. ncbi request reprint Association of autonomic dysfunction and clozapine. Heart rate variability and risk for sudden death in patients with schizophrenia on long-term psychotropic medication
    H Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Br J Psychiatry 179:167-71. 2001
    ..Antipsychotic medications cause a wide range of adverse effects and have been associated with sudden death in psychiatric patients...
  14. ncbi request reprint Protein synthesis inhibition before or after stress exposure results in divergent endocrine and BDNF responses disassociated from behavioral responses
    Nitsan Kozlovsky
    Ministry of Health Beer Sheva Mental Health Center, Anxiety and Stress Research Unit, Ben Gurion University of the Negev, Beer Sheva, Israel
    Depress Anxiety 25:E24-34. 2008
    ....
  15. ncbi request reprint The immediate early gene Arc is associated with behavioral resilience to stress exposure in an animal model of posttraumatic stress disorder
    Nitsan Kozlovsky
    Ministry of Health Beer Sheva Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, PO Box 4600, Beer Sheva 84170, Israel
    Eur Neuropsychopharmacol 18:107-16. 2008
    ....
  16. doi request reprint Pre-pubertal stress exposure affects adult behavioral response in association with changes in circulating corticosterone and brain-derived neurotrophic factor
    Noam Bazak
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 4600, Beer Sheva 84170, Beer Sheva, Israel
    Psychoneuroendocrinology 34:844-58. 2009
    ..The concomitant changes in BDNF and corticosterone levels may mediate the changes in neural plasticity and synaptic functioning underlying clinical manifestations of PTSD...
  17. ncbi request reprint Long-lasting behavioral effects of juvenile trauma in an animal model of PTSD associated with a failure of the autonomic nervous system to recover
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84170, Israel
    Eur Neuropsychopharmacol 17:464-77. 2007
    ....
  18. ncbi request reprint Post-traumatic stress behavioural responses in inbred mouse strains: can genetic predisposition explain phenotypic vulnerability?
    Hagit Cohen
    Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Int J Neuropsychopharmacol 11:331-49. 2008
    ..The response of the individual to stress is multifactorial and environmental factors play a predominant role in characterizing the individual response to stress exposure, although there are significant genetic underpinnings...
  19. pmc Post-exposure sleep deprivation facilitates correctly timed interactions between glucocorticoid and adrenergic systems, which attenuate traumatic stress responses
    Shlomi Cohen
    Department of Psychology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychopharmacology 37:2388-404. 2012
    ..Post-exposure SD may disrupt the consolidation of aversive or fearful memories by facilitating correctly timed interactions between glucocorticoid and adrenergic systems...
  20. doi request reprint The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder
    Nitsan Kozlovsky
    State of Israel Ministry of Health, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biol Psychiatry 65:383-91. 2009
    ....
  21. ncbi request reprint Gender-related qualitative differences in baseline and post-stress anxiety responses are not reflected in the incidence of criterion-based PTSD-like behaviour patterns
    Adi Mazor
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    World J Biol Psychiatry 10:856-69. 2009
    ..In order to explore gender-related PTSD-like stress-responses more thoroughly, we applied an animal model that focuses selectively on individual patterns of behavioural responses...
  22. doi request reprint Alprazolam treatment immediately after stress exposure interferes with the normal HPA-stress response and increases vulnerability to subsequent stress in an animal model of PTSD
    Michael A Matar
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur Neuropsychopharmacol 19:283-95. 2009
    ....
  23. ncbi request reprint Blunted HPA axis response to stress influences susceptibility to posttraumatic stress response in rats
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biol Psychiatry 59:1208-18. 2006
    ..This study investigated the role of cortisol in the manifestation of anxiety- and fear-like symptoms in an animal model of PTSD...
  24. ncbi request reprint Different pathways mediated by CCK1 and CCK2 receptors: effect of intraperitonal mrna antisense oligodeoxynucleotides to cholecystokinin on anxiety-like and learning behaviors in rats
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Depress Anxiety 20:139-52. 2004
    ..The present study showed an anxiolytic effect of i.p. CCK-ASODN in the presence of CCK2R, but not CCK1R...
  25. doi request reprint Mapping the brain pathways of traumatic memory: inactivation of protein kinase M zeta in different brain regions disrupts traumatic memory processes and attenuates traumatic stress responses in rats
    Hagit Cohen
    Ministry of Health, Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur Neuropsychopharmacol 20:253-71. 2010
    ..Recent studies reported that local application of ZIP, a membrane-permeant PKMzeta inhibitor, into the insular cortex (IC) of behaving rats abolished long-term memory of taste associations...
  26. ncbi request reprint The effect of early poststressor intervention with sertraline on behavioral responses in an animal model of post-traumatic stress disorder
    Michael A Matar
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychopharmacology 31:2610-8. 2006
    ..SSRI drugs are thus worthy of further investigation as agents of secondary prevention in the acute aftermath of stress-exposure...
  27. ncbi request reprint Long-term down-regulation of BDNF mRNA in rat hippocampal CA1 subregion correlates with PTSD-like behavioural stress response
    Nitsan Kozlovsky
    Ministry of Health Beer Sheva Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    Int J Neuropsychopharmacol 10:741-58. 2007
    ..The corresponding changes in neural plasticity and synaptic functioning may mediate clinical manifestations of PTSD...
  28. doi request reprint A distinct pattern of intracellular glucocorticoid-related responses is associated with extreme behavioral response to stress in an animal model of post-traumatic stress disorder
    Nitsan Kozlovsky
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur Neuropsychopharmacol 19:759-71. 2009
    ..Glucocorticoids induce expression of Zif/268 through two distinct mechanisms: a rapid-onset, MAPK-independent pathway and a slower-onset, MAPK-dependent mechanism...
  29. doi request reprint Early post-stressor intervention with high-dose corticosterone attenuates posttraumatic stress response in an animal model of posttraumatic stress disorder
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biol Psychiatry 64:708-17. 2008
    ..We used an animal model of posttraumatic stress disorder (PTSD) to assess long-term behavioral effects of a single administration of various doses of corticosterone (CORT), administered immediately after exposure to psychogenic stress...
  30. ncbi request reprint Anisomycin, a protein synthesis inhibitor, disrupts traumatic memory consolidation and attenuates posttraumatic stress response in rats
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biol Psychiatry 60:767-76. 2006
    ....
  31. doi request reprint IFN-gamma enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer's disease
    Rona Baron
    The Shraga Segal Dept of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    FASEB J 22:2843-52. 2008
    ..We demonstrate that limited amounts of IFN-gamma in the brain shape the neuropoietic milieu to enhance neurogenesis, possibly representing the normal function of the immune system in controlling brain inflammation and repair...
  32. ncbi request reprint Decreased circulatory levels of neuroactive steroids in behaviourally more extremely affected rats subsequent to exposure to a potentially traumatic experience
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Int J Neuropsychopharmacol 10:203-9. 2007
    ....
  33. ncbi request reprint The effect of sudden clozapine discontinuation on management of schizophrenic patients: A retrospective controlled study
    Chanoch Miodownik
    Division of Psychiatry, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Clin Psychiatry 67:1204-8. 2006
    ....
  34. ncbi request reprint Unsupervised fuzzy clustering analysis supports behavioral cutoff criteria in an animal model of posttraumatic stress disorder
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84170, Israel
    Biol Psychiatry 58:640-50. 2005
    ....
  35. doi request reprint Irreversibility of cardiac autonomic dysfunction in female adolescents diagnosed with anorexia nervosa after short- and long-term weight gain
    Moshe Lachish
    Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    World J Biol Psychiatry 10:503-11. 2009
    ....
  36. doi request reprint Exposure to extreme stress impairs contextual odour discrimination in an animal model of PTSD
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Int J Neuropsychopharmacol 12:291-303. 2009
    ....
  37. doi request reprint Early post-stressor intervention with propranolol is ineffective in preventing posttraumatic stress responses in an animal model for PTSD
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur Neuropsychopharmacol 21:230-40. 2011
    ..Traumatic stress-related processes appear to be affected differently than the others...
  38. ncbi request reprint Olfactory learning prevents MK-801-induced psychosis-like behaviour in an animal model of schizophrenia
    Ari Naimark
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Ben Gurion University, Beer Sheva, Israel
    World J Biol Psychiatry 9:135-46. 2008
    ..Our data support the notion that learning-induced protection against schizophrenic behaviour is maintained by non-NMDA-mediated enhanced activation of local connections in the relevant cortical networks...
  39. ncbi request reprint Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4+CD25+ cells
    Hagit Cohen
    Ministry of Health Mental Health Center Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Neurobiol 66:552-63. 2006
    ..They might also point the way to development of immune-based therapies for mental disorders, based either on up-regulation of T cells that partially cross-react with self-antigens or on weakening of the activity of regulatory T cells...
  40. ncbi request reprint [Vitamin B6 add-on therapy in treatment of schizophrenic patients with psychotic symptoms and movement disorders]
    Chanoch Miodownik
    Ministry of Health, Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheba, Israel
    Harefuah 142:592-6, 647. 2003
    ..In this study vitamin B6 treatment was provided to 15 patients who suffered from schizophrenia and schizoaffective disorder with positive psychotic symptoms and tardive dyskinesia...
  41. doi request reprint Chronic exposure to stress predisposes to higher autoimmune susceptibility in C57BL/6 mice: glucocorticoids as a double-edged sword
    Idan Harpaz
    Anxiety and Stress Research Unit, Beer Sheva Mental Health Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Immunol 43:758-69. 2013
    ....
  42. doi request reprint The long-term abnormalities in circadian expression of Period 1 and Period 2 genes in response to stress is normalized by agomelatine administered immediately after exposure
    Ori Koresh
    Beer Sheva Mental Health Center, The State of Israel Ministry of Health, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    Eur Neuropsychopharmacol 22:205-21. 2012
    ....
  43. pmc The characteristic long-term upregulation of hippocampal NF-κB complex in PTSD-like behavioral stress response is normalized by high-dose corticosterone and pyrrolidine dithiocarbamate administered immediately after exposure
    Hagit Cohen
    The State of Israel Ministry of Health, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychopharmacology 36:2286-302. 2011
    ....
  44. ncbi request reprint Effect of intraperitoneal acetyl-L-carnitine (ALCAR) on anxiety-like behaviours in rats
    Joseph Levine
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Int J Neuropsychopharmacol 8:65-74. 2005
    ..The precise mechanism by which ALCAR decreases anxiety-like behaviour after peripheral administration remains to be determined...
  45. ncbi request reprint The contribution of an animal model toward uncovering biological risk factors for PTSD
    Hagit Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84170, Israel
    Ann N Y Acad Sci 1071:335-50. 2006
    ....
  46. ncbi request reprint The relevance of differential response to trauma in an animal model of posttraumatic stress disorder
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biol Psychiatry 53:463-73. 2003
    ..We examined the effect of grouping prestressed rats according to magnitude of response on the statistical analysis of results...
  47. pmc The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder
    Hagit Cohen
    Anxiety and Stress Research Unit, Beer Sheva Mental Health Center, The State of Israel Ministry of Health, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychopharmacology 37:350-63. 2012
    ..The protective qualities attributed to NPY are supported by the extreme reduction of its expression in animals severely affected by the stressor and imply a role in promoting resilience and/or recovery...
  48. doi request reprint Post-traumatic stress disorder is not over-represented in a sample population of migraine patients
    Gal Ifergane
    Headache Clinic, Department of Neurology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Intern Med 20:182-5. 2009
    ..PTSD was previously associated with chronic pain and primary pain disorders...
  49. ncbi request reprint Stress-related responses after 3 years of exposure to terror in Israel: are ideological-religious factors associated with resilience?
    Zeev Kaplan
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Clin Psychiatry 66:1146-54. 2005
    ....
  50. ncbi request reprint Anxiolytic effect and memory improvement in rats by antisense oligodeoxynucleotide to 5-hydroxytryptamine-2A precursor protein
    Hagit Cohen
    Ben Gurion University of the Negev, Beer Sheva, Israel
    Depress Anxiety 22:84-93. 2005
    ..Receptor downregulation has been proposed as one of the central mechanisms for anxiolytic drug actions. Antisense-mediated downmanipulation of receptors in this study, especially of 5-HT2A, supports this theory...
  51. ncbi request reprint Prevalence of post-traumatic stress disorder in fibromyalgia patients: overlapping syndromes or post-traumatic fibromyalgia syndrome?
    Hagit Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Semin Arthritis Rheum 32:38-50. 2002
    ..The influence of gender on measures of PTSD in fibromyalgia (FM) patients also was examined...
  52. ncbi request reprint Effects of the cortisol synthesis inhibitor metyrapone on the response to carbon dioxide challenge in panic disorder
    Andrey Belgorodsky
    Division of Psychiatry, Ben Gurion University of the Negev, Beer Sheba, Israel
    Depress Anxiety 21:143-8. 2005
    ..The results support an anxiogenic role for cortisol in stress, and suggest that the pathophysiological mechanism that mediates CO2-induced panic differs from those underlying other kinds of anxiety...
  53. ncbi request reprint The quantitative electroencephalogram and the low-resolution electrical tomographic analysis in posttraumatic stress disorder
    Doran Todder
    Ben Gurion University, Faculty of Health, Beer Sheva, Israel
    Clin EEG Neurosci 43:48-53. 2012
    ..These results indicate that combining quantitative EEG (QEEG) and the LORETA method, among other methods, may improve the neuroanatomical resolution of EEG data analysis...
  54. pmc Upregulation of neurotrophic factors selectively in frontal cortex in response to olfactory discrimination learning
    Ari Naimark
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neural Plast 2007:13427. 2007
    ..These findings suggest that different brain areas may be preferentially involved in different learning/memory tasks...
  55. doi request reprint Accuracy of the diagnosis of fibromyalgia by family physicians: is the pendulum shifting?
    Elena Shleyfer
    Department of Medicine, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel
    J Rheumatol 36:170-3. 2009
    ..We evaluated the accuracy of diagnosis of fibromyalgia (FM) by family physicians...
  56. ncbi request reprint Vitamin B6 as add-on treatment in chronic schizophrenic and schizoaffective patients: a double-blind, placebo-controlled study
    Vladimir Lerner
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Israel
    J Clin Psychiatry 63:54-8. 2002
    ..The aim of this study was to examine whether vitamin B6 therapy influences psychotic symptoms in patients suffering from schizophrenia and schizoaffective disorder...
  57. ncbi request reprint [A model for therapeutic interventions in emotional responses to enforced geographical relocation of populations in Israel]
    Zeev Kaplan
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Harefuah 144:234-6, 304. 2005
    ..These principles seem to us far more suited to the demands of the complex situation ahead, in order to provide relief and assist in adaptation, and to prevent later complications of possible emotional sequelae...
  58. ncbi request reprint Comorbidity of fibromyalgia and psychiatric disorders
    Dan Buskila
    Department of Medicine H, Soroka Medical Center, POB 151, Beer Sheva 84101, Israel
    Curr Pain Headache Rep 11:333-8. 2007
    ..Assessment of comorbid psychiatric disorders in FMS patients has clinical implications because treatment in these patients should focus both on physical and emotional dimensions of dysfunction...
  59. ncbi request reprint The role of spa therapy in various rheumatic diseases
    S Sukenik
    Department D, Soroka University Hospital, Beer Sheva, Israel
    Rheum Dis Clin North Am 25:883-97. 1999
    ..These methods may alleviate patient suffering and are almost totally devoid of serious adverse effects. No studies have been reported that evaluate their cost-effectiveness...
  60. ncbi request reprint Balneotherapy at the Dead Sea area for knee osteoarthritis
    S Sukenik
    Department of Rheumatology, Soroka Medical Center, Beer Sheva, Israel
    Isr Med Assoc J 1:83-5. 1999
    ..The efficacy of balneotherapy at the Dead Sea area for the treatment of degenerative rheumatic diseases has not yet been formally evaluated...
  61. ncbi request reprint Influenza virus vaccination of patients with systemic lupus erythematosus: effects on disease activity
    M Abu-Shakra
    Department of Medicine, Soroka Medical Center and Ben Gurion University, Beer Sheva, Israel
    J Rheumatol 27:1681-5. 2000
    ..To determine whether vaccination of patients with systemic lupus erythematosus (SLE) with influenza virus vaccine is associated with exacerbation of SLE...
  62. doi request reprint Safety of vaccination of patients with systemic lupus erythematosus
    M Abu-Shakra
    Rheumatic Diseases Unit, Department of Medicine, Soroka Medical Center and Ben Gurion University, Beer Sheva, Israel
    Lupus 18:1205-8. 2009
    ..In individual cases vaccines exacerbate systemic lupus erythematosus; however, no specific clinical or laboratory variables have been identified to be associated with flare of systemic lupus erythematosus following vaccination...
  63. ncbi request reprint The prevalence of musculoskeletal pain and fibromyalgia in patients hospitalized on internal medicine wards
    D Buskila
    Rheumatic Disease Unit and Epidemiology Department, Ben Gurion University of the Negev and Soroka Medical Center, Beer Sheva, Israel
    Semin Arthritis Rheum 30:411-7. 2001
    ....
  64. ncbi request reprint Antiphospholipid antibody syndrome: the flow cytometric annexin A5 competition assay as a diagnostic tool
    A Tomer
    Blood Bank and Transfusion Medicine, Soroka University Medical Centre, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Br J Haematol 139:113-20. 2007
    ..Our findings suggest that the FCA is practical, sensitive and specific for the detection of clinically relevant aPL in the diagnosis of APS...
  65. ncbi request reprint Quality of life in systemic lupus erythematosus: a controlled study
    M Abu-Shakra
    Rheumatic Unit, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Rheumatol 26:306-9. 1999
    ..To assess the quality of life (QOL) of patients with systemic lupus erythematosus (SLE) and to compare it with that of healthy women and patients with primary fibromyalgia (FM)...
  66. ncbi request reprint Influenza virus vaccination of patients with SLE: effects on generation of autoantibodies
    M Abu-Shakra
    Soroka Medical Center and Ben Gurion University, Beer Sheva, Israel
    Clin Rheumatol 21:369-72. 2002
    ..In summary, although the influenza virus vaccine is clinically safe for patients with SLE it may trigger the generation of autoantibodies. This effect is usually short term and has no clinical significance...
  67. ncbi request reprint Balneotherapy for fibromyalgia at the Dead Sea
    D Buskila
    Division of Internal Medicine, Soroka Medical Center and Ben Gurion University, Beer Sheva, Israel
    Rheumatol Int 20:105-8. 2001
    ..In conclusion, treatment of FM at the Dead Sea is effective and safe and may become an additional therapeutic modality in FM. Future studies should address the outcome and possible mechanisms of this treatment in FM patients...
  68. ncbi request reprint Balneotherapy at the Dead Sea area for patients with psoriatic arthritis and concomitant fibromyalgia
    S Sukenik
    Department of Medicine D, Soroka University Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Isr Med Assoc J 3:147-50. 2001
    ..Since no effective treatment exists for this common rheumatic disease, complementary methods of treatment have been attempted...
  69. ncbi request reprint Sense of coherence and its impact on quality of life of patients with systemic lupus erythematosus
    M Abu-Shakra
    Autoimmune Rheumatic Diseases Unit, Department of Medicine D, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel
    Lupus 15:32-7. 2006
    ..SOC was the only variable independently associated with MCS. Education and SOC were significantly associated with the general WHO QOL-Bref. Age, education, SDI and SOC were independently associated with QOL of women with SLE...
  70. ncbi request reprint The effect of balneotherapy at the Dead Sea on the quality of life of patients with fibromyalgia syndrome
    L Neumann
    Soroka Medical Center, Faculty of Health Sciences and Faculty of Humanities and Social Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Clin Rheumatol 20:15-9. 2001
    ..In conclusion, staying at the Dead Sea spa, in addition to balneotherapy, can transiently improve the QoL of patients with FS. Other studies with longer follow-up are needed to support our findings...
  71. ncbi request reprint Fibromyalgia syndrome in men
    D Buskila
    Epidemiology Department, Ben Gurion University of the Negev and Soroka Medical Center, Beer Sheva, Israel
    Semin Arthritis Rheum 30:47-51. 2000
    ..The current study was undertaken to determine whether the clinical characteristics and the spectrum of this disorder are similar in men and women...
  72. doi request reprint Animal models of post-traumatic stress disorder
    Hagit Cohen
    Israel Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Curr Protoc Neurosci . 2013
    ....
  73. doi request reprint Animal model for PTSD: from clinical concept to translational research
    Hagit Cohen
    Israel Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 4600, Beer Sheva 84170, Israel
    Neuropharmacology 62:715-24. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  74. ncbi request reprint A naturalistic prospective open study of the effects of adjunctive therapy of sexual dysfunction in chronic PTSD patients
    Bela Chudakov
    Ministry of Health, Mental Health Center, Faculty of Health Sciences, Anxiety and Stress Research Unit, Ben Gurion University of the Negev, Beersheba, Israel
    Isr J Psychiatry Relat Sci 45:26-32. 2008
    ..This prospective naturalistic follow-up study of a random group of patients was intended to evaluate response to pharmacologic and psychotherapeutic interventions for SD, in terms of both sexual functioning and overall symptomatology...
  75. pmc Symptoms of posttraumatic stress disorder after ritual female genital surgery among bedouin in Israel: myth or reality?
    Julia Applebaum
    Ministry of Health, Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva and Clalit Health Services, Family Health Center, Rahat, Israel
    Prim Care Companion J Clin Psychiatry 10:453-6. 2008
    ..This pilot study assessed the mental health of Bedouin women from southern Israel after RFGS compared to age-matched controls without RFGS...
  76. doi request reprint Gender differences in animal models of posttraumatic stress disorder
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Dis Markers 30:141-50. 2011
    ..The examination of these gender-related differences can deepen our understanding of the risk or the pathophysiology of stress-related disorders...
  77. ncbi request reprint Immunity and neuronal repair in the progression of Alzheimer's disease: a brief overview
    Rona Baron
    Department of Microbiology and Immunology and National Institute of Biotechnology in Negev, Faculty of Health Sciences, Ben Gurion University of Negev, PO Box 653, Beer Sheva 84105, Israel
    Exp Gerontol 42:64-9. 2007
    ....
  78. ncbi request reprint Kingella endocarditis and meningitis in a patient with SLE and associated antiphospholipid syndrome
    T Wolak
    Department of Medicine D, Soroka Medical Center and Ben Gurion University, Beer Sheva, Israel
    Lupus 9:393-6. 2000
    ..Kingella kingae was isolated from her blood cultures. A large mobile vegetation was seen on her mitral valve. The association between SLE, Libman-Sacks endocarditis and bacterial endocarditis is discussed...