R H Belmaker

Summary

Affiliation: Ben-Gurion University of the Negev
Country: Israel

Publications

  1. doi request reprint Major depressive disorder
    R H Belmaker
    Ben Gurion University of the Negev, Beersheba, Israel
    N Engl J Med 358:55-68. 2008
  2. pmc Individual differences and evidence-based psychopharmacology
    Rh Belmaker
    Ben Gurion University of the Negev, Beersheva, Israel
    BMC Med 10:110. 2012
  3. ncbi request reprint Lithium-pilocarpine seizures as a model for lithium action in mania
    R H Belmaker
    Ben Gurion University of the Negev, Beersheva Mental Health Center, P O Box 4600, Beersheva, Israel
    Neurosci Biobehav Rev 31:843-9. 2007
  4. ncbi request reprint The future of depression psychopharmacology
    R H Belmaker
    Beer Sheva Mental Health Center, Ben Gurion University of the Negev, Israel
    CNS Spectr 13:682-7. 2008
  5. doi request reprint Omega 3 fatty acid treatment in autism
    Gal Meiri
    Soroka University Medical Center, Beersheba, Israel
    J Child Adolesc Psychopharmacol 19:449-51. 2009
  6. doi request reprint Glycogen synthase kinase-3beta heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results
    Yuly Bersudsky
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    Behav Pharmacol 19:217-24. 2008
  7. ncbi request reprint Possible involvement of post-dopamine D2 receptor signalling components in the pathophysiology of schizophrenia
    Shirly Amar
    Stanley Research Center, Faculty of Health Science, Ben Gurion University of the Negev, and Mental Health Center, Beer Sheva, Israel
    Int J Neuropsychopharmacol 11:197-205. 2008
  8. ncbi request reprint Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia
    Joseph Levine
    Stanley Research Center and Beersheva Mental Health Center, Ben Gurion University of the Negev, Beersheva, Israel
    Biol Psychiatry 60:265-9. 2006
  9. doi request reprint Knockout mice in understanding the mechanism of action of lithium
    Galila Agam
    Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biochem Soc Trans 37:1121-5. 2009
  10. doi request reprint Normobaric hyperoxia treatment of schizophrenia
    Yehudit Bloch
    From the Ben Gurion University of the Negev, Beersheva Mental Health Center, Beersheva, Israel
    J Clin Psychopharmacol 32:525-30. 2012

Collaborators

Detail Information

Publications91

  1. doi request reprint Major depressive disorder
    R H Belmaker
    Ben Gurion University of the Negev, Beersheba, Israel
    N Engl J Med 358:55-68. 2008
  2. pmc Individual differences and evidence-based psychopharmacology
    Rh Belmaker
    Ben Gurion University of the Negev, Beersheva, Israel
    BMC Med 10:110. 2012
    ..While stratification can be of value in large studies, the individual patient history is the most effective currently available guide for personalized medicine in psychopharmacology...
  3. ncbi request reprint Lithium-pilocarpine seizures as a model for lithium action in mania
    R H Belmaker
    Ben Gurion University of the Negev, Beersheva Mental Health Center, P O Box 4600, Beersheva, Israel
    Neurosci Biobehav Rev 31:843-9. 2007
    ..Thus, the Li-pilocarpine seizure model may, despite its lack of face validity, be a biochemical marker for a model of mania treatment in animals...
  4. ncbi request reprint The future of depression psychopharmacology
    R H Belmaker
    Beer Sheva Mental Health Center, Ben Gurion University of the Negev, Israel
    CNS Spectr 13:682-7. 2008
    ..Thus, perhaps only some kinds of depression are responsive to monoamine affecting antidepressants....
  5. doi request reprint Omega 3 fatty acid treatment in autism
    Gal Meiri
    Soroka University Medical Center, Beersheba, Israel
    J Child Adolesc Psychopharmacol 19:449-51. 2009
    ..The purpose of this study was to determine the efficacy and safety of omega-3 fatty acids for children with autistic spectrum disorder (ASD)...
  6. doi request reprint Glycogen synthase kinase-3beta heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results
    Yuly Bersudsky
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    Behav Pharmacol 19:217-24. 2008
    ....
  7. ncbi request reprint Possible involvement of post-dopamine D2 receptor signalling components in the pathophysiology of schizophrenia
    Shirly Amar
    Stanley Research Center, Faculty of Health Science, Ben Gurion University of the Negev, and Mental Health Center, Beer Sheva, Israel
    Int J Neuropsychopharmacol 11:197-205. 2008
    ....
  8. ncbi request reprint Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia
    Joseph Levine
    Stanley Research Center and Beersheva Mental Health Center, Ben Gurion University of the Negev, Beersheva, Israel
    Biol Psychiatry 60:265-9. 2006
    ..Recently, several studies have reported that homocysteine levels are elevated in many schizophrenic patients. Homocysteine levels can be lowered by oral folic acid, B-12, and pyridoxine...
  9. doi request reprint Knockout mice in understanding the mechanism of action of lithium
    Galila Agam
    Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biochem Soc Trans 37:1121-5. 2009
    ..These data support the role of inositol-related processes rather than GSK3beta in the mechanism of the therapeutic action of lithium...
  10. doi request reprint Normobaric hyperoxia treatment of schizophrenia
    Yehudit Bloch
    From the Ben Gurion University of the Negev, Beersheva Mental Health Center, Beersheva, Israel
    J Clin Psychopharmacol 32:525-30. 2012
    ..These results are a proof of concept, and normobaric hyperoxia should be studied in patients with milder forms of the illness and earlier in the course of illness...
  11. ncbi request reprint Omega-3 treatment of childhood depression: a controlled, double-blind pilot study
    Hanah Nemets
    Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    Am J Psychiatry 163:1098-100. 2006
    ..Because of success in a previous study on omega-3 fatty acids in adult major depressive disorder, the authors planned a pilot study of omega-3 fatty acids in childhood major depression...
  12. doi request reprint Valnoctamide as a valproate substitute with low teratogenic potential in mania: a double-blind, controlled, add-on clinical trial
    Y Bersudsky
    Stanley Center for Bipolar Research, Ministry of Health Mental Health Center, Faculty of Health Sciences, Department of Psychiatry, Ben Gurion University of the Negev, Beer Sheva, Israel
    Bipolar Disord 12:376-82. 2010
    ..In mice, valnoctamide has been shown to be distinctly less teratogenic than valproate. Valnoctamide is an anticonvulsant, and we hypothesized that valnoctamide is antimanic...
  13. ncbi request reprint Inhibition by antibiotic tetracyclines of rat cortical noradrenergic adenylate cyclase and amphetamine-induced hyperactivity
    O Kofman
    Beer Sheva Mental Health Centre, Ben Gurion University of the Negev, Israel
    Pharmacol Biochem Behav 37:417-24. 1990
    ..Unlike lithium, however, DMC did not reverse reserpine-induced hypoactivity...
  14. doi request reprint The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test
    Liza Shtein
    Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Psychopharmacology (Berl) 227:503-8. 2013
    ..Attenuation of the phosphatidylinositol signal transduction pathway as a consequence of inhibition of inositol monophosphatase (IMPase) has been proposed as one of the possible mechanisms for lithium-induced mood stabilization...
  15. ncbi request reprint Behavioural phenotyping of sodium-myo-inositol cotransporter heterozygous knockout mice with reduced brain inositol
    A Shaldubina
    Stanley Research Centre, Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    Genes Brain Behav 6:253-9. 2007
    ..Reduction of brain inositol by more than 25% may be required to elicit neurobehavioural effects...
  16. ncbi request reprint Inositol monophosphatase activity in brain and lymphocyte-derived cell lines of bipolar patients
    G Shaltiel
    Stanley Research Center, Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel
    World J Biol Psychiatry 2:95-8. 2001
    ..CONCLUSIONS: A reduction in lymphocyte-derived IMPase activity without a parallel reduction in cortical IMPase activity could be due to the fact that most leukocyte IMPase activity is the product of the IMPA-2 gene...
  17. ncbi request reprint Neuropsychological correlates of homocysteine levels in euthymic bipolar patients
    Yamima Osher
    Beer Sheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Affect Disord 105:229-33. 2008
    ..The current study was designed to extend this finding by examining the relationship between neuropsychological functioning and homocysteine levels in euthymic bipolar patients...
  18. ncbi request reprint Controlled double-blind trial of phenytoin vs. fluoxetine in major depressive disorder
    Boris Nemets
    Stanley Research Center and Beersheva Mental Health Center, Ben Gurion University of the Negev, Beersheva, Israel
    J Clin Psychiatry 66:586-90. 2005
    ..We therefore undertook a controlled trial of phenytoin versus fluoxetine in major depressive disorder...
  19. ncbi request reprint Low GSK-3 activity in frontal cortex of schizophrenic patients
    N Kozlovsky
    Stanley Foundation International Research Center, Ben-Gurion University of the Negev, Beersheva, Israel
    Schizophr Res 52:101-5. 2001
    ..27, df=3, p=0.04). The other two diagnostic groups showed no difference from the control group. Our results are consistent with the notion that schizophrenia involves neurodevelopmental pathology...
  20. pmc Is phosphoadenosine phosphate phosphatase a target of lithium's therapeutic effect?
    G Shaltiel
    Psychiatry Research Unit, Mental Health Center, Ben Gurion University of the Negev, Beersheba, Israel
    J Neural Transm 116:1543-9. 2009
    ..A statistically significant 25% reduced brain ADP/ATP ratio was found following lithium treatment in line with lithium's suggested neuroprotective effects...
  21. ncbi request reprint High homocysteine serum levels in young male schizophrenia and bipolar patients and in an animal model
    Joseph Levine
    Ben Gurion University, Beersheva, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 29:1181-91. 2005
    ..No homocysteine-induced defects were found in any behavioral test until month 5 when mild but statistically significant abnormalities in the Morris Water Maze were detected...
  22. doi request reprint Nicotinamide-N-methyltransferase (NNMT) in schizophrenia: genetic association and decreased frontal cortex mRNA levels
    Anna Bromberg
    Department of Clinical Biochemistry, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Int J Neuropsychopharmacol 15:727-37. 2012
    ..Post-mortem frontal cortex NNMT mRNA levels were ~35% lower in schizophrenia patients vs. control subjects. Our study favours the notion that NNMT is involved in the aetiology of schizophrenia...
  23. doi request reprint No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients
    A Bromberg
    Faculty of Health Sciences, Stanley Research Center, Ben Gurion University of the Negev and Beersheva Mental Health Center, Beersheva, Israel
    Schizophr Res 101:50-7. 2008
    ..032). Although leukocytes may be a useful cell model to evaluate epigenetic changes such as global DNA methylation in brain, future studies should compare global DNA methylation in peripheral tissue vs. brain in laboratory animals...
  24. ncbi request reprint The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors
    H Einat
    Beer Sheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 4600, Beer Sheva, Israel
    Behav Brain Res 118:77-83. 2001
    ..The present data indicates that the antidepressant effect of inositol may involve 5-HT(2) receptors. It is thus possible that the effects of reuptake antidepressant drugs and the effects of inositol may have a common final pathway...
  25. ncbi request reprint The effect of lithium on expression of genes for inositol biosynthetic enzymes in mouse hippocampus; a comparison with the yeast model
    Alon Shamir
    Stanley Foundation Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Brain Res Mol Brain Res 115:104-10. 2003
    ..The fact that lithium treatment upregulates both MIP synthase and IMPA1 mRNA levels in mouse hippocampus may reflect a compensatory response of both genes to inositol depletion...
  26. pmc Copy number variation of the SELENBP1 gene in schizophrenia
    Shirly Amar
    Psychiatry Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, and Mental Health Center, Beersheva, Israel
    Behav Brain Funct 6:40. 2010
    ..We hypothesized that CN mutations in the SELENBP1 locus could associate with the disorder and that these mutations could alter the gene product's activity in patients...
  27. ncbi request reprint Elevated urinary ADAM12 protein levels in lithium-treated bipolar patients
    C Nadri
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, and Mental Health Center, Beersheva, Israel
    J Neural Transm 114:473-7. 2007
    ..The 68 kDa form of urine ADAM12 protein levels did not differ. Future experiments are needed to explore a potential link between ADAM12 protein level elevation and lithium response...
  28. ncbi request reprint Single-dose intravenous valproate in acute mania
    Katrina Phrolov
    Stanley Research Center, Ministry of Health Mental Health Center, Ben Gurion University of the Negev, Beersheva, Israel
    J Clin Psychiatry 65:68-70. 2004
    ..We hypothesized that very high dose intravenous (IV) valproate might have even more rapid effects equivalent to effects in status epilepticus that occur within 20 minutes...
  29. ncbi request reprint Reduced GSK-3beta mRNA levels in postmortem dorsolateral prefrontal cortex of schizophrenic patients
    N Kozlovsky
    Stanley Research Center, Ben Gurion University of the Negev and Mental Health Center, Beersheva, Israel
    J Neural Transm 111:1583-92. 2004
    ....
  30. ncbi request reprint [Animal models of psychiatric diseases: possibilities, limitations, examples and demonstration of use]
    H Einat
    Beer Sheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Harefuah 140:458-63, 568. 2001
    ..The use of these models in an attempt to examine the range of action of a new potential antidepressant and its mechanisms of action is demonstrated with a recent set of experiments with inositol...
  31. ncbi request reprint Postmortem parietal cortex TPH2 expression is not altered in schizophrenic, unipolar-depressed, and bipolar patients vs control subjects
    Alon Shamir
    Stanley Research Center and Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, and Mental Health Center, Beersheva, Israel
    J Mol Neurosci 26:33-7. 2005
    ....
  32. ncbi request reprint Inositol treatment has no effect on the dexamethasone suppression test
    J Levine
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    World J Biol Psychiatry 2:190-2. 2001
    ..However, after two weeks on inositol, when substantial clinical improvement was noted, he converted to a normal DST. Chronic inositol treatment does not seem to induce false positive DST results...
  33. ncbi request reprint Mitochondrial DNA HV lineage increases the susceptibility to schizophrenia among Israeli Arabs
    Shirly Amar
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Schizophr Res 94:354-8. 2007
    ..However, mitochondrial DNA haplogroups are highly variable in human population and it will be necessary to replicate our results in other human ethnic groups...
  34. ncbi request reprint Nordidemnin potently inhibits inositol uptake in cultured astrocytes and dose-dependently augments lithium's proconvulsant effect in vivo
    M Wolfson
    Department of Microbiology and Immunology and Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Neurosci Res 60:116-21. 2000
    ....
  35. ncbi request reprint Chronic treatment with lithium and pretreatment with excess inositol reduce inositol pool size in astrocytes by different mechanisms
    M Wolfson
    Department of Microbiology and Immunology and Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, P O B 653, Beer Sheva 84105, Israel
    Brain Res 787:34-40. 1998
    ..It is noteworthy that both effects could be observed in astrocytes, suggesting that there might be a significant astrocytic target during clinical treatment...
  36. ncbi request reprint Omega-3 eicosapentaenoic acid in bipolar depression: report of a small open-label study
    Yamima Osher
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Clin Psychiatry 66:726-9. 2005
    ....
  37. ncbi request reprint Bipolar disorder
    R H Belmaker
    Stanley Research Center, Ben Gurion University of the Negev, Beersheba, Israel
    N Engl J Med 351:476-86. 2004
  38. doi request reprint Lithium preferentially inhibits adenylyl cyclase V and VII isoforms
    Liad Mann
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Int J Neuropsychopharmacol 11:533-9. 2008
    ..The marked inhibition of AC-V and AC-VII by lithium suggests that these two isoforms may be involved in mediating the mood-stabilizing effect of lithium...
  39. ncbi request reprint Predominant polarity of bipolar patients in Israel
    Y Osher
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    World J Biol Psychiatry 1:187-9. 2000
    ..Unlike some previous studies, no sex differences were noted in type of illness course. Possible explanations for the main finding, including climate-related factors, are discussed...
  40. ncbi request reprint Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder
    A Shaldubina
    Zlotowski Center for Neuroscience, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    J Neural Transm 109:433-40. 2002
    ..The results suggest that mood-stabilizing anticonvulsant drugs including topiramate may attenuate quinpirole-induced hyperactivity...
  41. ncbi request reprint Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder
    Boris Nemets
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Am J Psychiatry 159:477-9. 2002
    ....
  42. ncbi request reprint Psychotropic drugs affect Ser9-phosphorylated GSK-3 beta protein levels in rodent frontal cortex
    Nitsan Kozlovsky
    Stanley Research Center, Ben Gurion University of the Negev and Mental Health Center, Beersheva, Israel
    Int J Neuropsychopharmacol 9:337-42. 2006
    ..Mice treated chronically with lithium exhibited the most prominent elevation in phospho-Ser9-GSK-3beta. The results support the notion that GSK-3beta may be a common target for mood stabilizers and neuroleptics...
  43. doi request reprint The new lithium clinic
    Yamima Osher
    Beer Sheva Mental Health Center, Ministry of Health and Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychobiology 62:17-26. 2010
    ..The evolution of psychopharmacological and psychosocial knowledge in treating bipolar illness has been integrated into our clinic. Case vignettes are presented to illustrate these points. The comparative cost of this model is discussed...
  44. ncbi request reprint The mechanism of lithium action: state of the art, ten years later
    A Shaldubina
    Stanley Center for Bipolar Research, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheba, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 25:855-66. 2001
    ..Biochemical and clinical experiments are necessary to determine the key mechanism of lithium efficacy in treatment and prophylaxis of affective disorders...
  45. ncbi request reprint GSK-3beta in cerebrospinal fluid of schizophrenia patients
    N Kozlovsky
    Stanley Research Center, Department of Clinical Biochemistry, Faculty of Health Sciences, Ben Gurion University of the Negev and Mental Health Center, Beersheva, Israel
    J Neural Transm 111:1093-8. 2004
    ..Our results corroborate other studies in which CSF protein levels reflect the alteration found in these proteins in schizophrenia patients' postmortem brain...
  46. ncbi request reprint Sildenafil effects on sexual function in asymptomatic volunteers: a controlled study
    Ram Kamin
    Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    J Sex Marital Ther 32:37-42. 2006
    ..The findings may be analogous to those with antidepressants, where major effects are seen only in clinically depressed patients, however, normal volunteers have subtle and difficult-to-measure effects...
  47. doi request reprint Acute intracerebroventricular inositol does not reverse the effect of chronic lithium treatment in the forced swim test
    L Toker
    Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychobiology 68:189-92. 2013
    ..This hypothesis postulates that lithium's mood-stabilizing effect is mediated by the depletion of brain inositol levels and the subsequent effect on cellular signaling...
  48. pmc Inositol-Related Gene Knockouts Mimic Lithium's Effect on Mitochondrial Function
    Lilach Toker
    1 Department of Clinical Biochemistry and Pharmacology, Ben Gurion University of the Negev, Beer Sheva, Israel 2 Psychiatry Research Unit, Ben Gurion University of the Negev, Beer Sheva, Israel 3 Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychopharmacology 39:319-28. 2014
    ..The phenotypic similarities between lithium-treated wild-type mice and the two KO models suggest that lithium may affect behavior by altering inositol metabolism. ..
  49. ncbi request reprint The possible involvement of glycogen synthase kinase-3 (GSK-3) in diabetes, cancer and central nervous system diseases
    S Amar
    Psychiatry Research Unit, Ben Gurion University of the Negev, Beer Sheva, Israel
    Curr Pharm Des 17:2264-77. 2011
    ..Further development of GSK-3 inhibitors for clinical trials should be approached with caution...
  50. doi request reprint Gene-expression studies in understanding the mechanism of action of lithium
    Lilach Toker
    Department of Clinical Biochemistry, Ben Gurion University of the Negev, Beer Sheva, Israel
    Expert Rev Neurother 12:93-7. 2012
    ..This review discusses the different design and data analysis strategies applied in the studies and summarizes the possible reasons for the discrepancies among the reports...
  51. ncbi request reprint Genetic correlational analysis of glycogen synthase kinase-3 beta and prepulse inhibition in inbred mice
    S Amar
    Stanley Foundation Research Center and Department of Clinical Biochemistry, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Genes Brain Behav 3:178-80. 2004
    ..This may indicate that investigation of the genetics of GSK-3 beta regulation holds promise for understanding some of the biochemical underpinnings of schizophrenia...
  52. ncbi request reprint Homocysteine levels in newly admitted schizophrenic patients
    Julia Applebaum
    Beer Sheba Mental Health Center, Stanley Research Center, Ben Gurion University of the Negev, Beersheva, Israel
    J Psychiatr Res 38:413-6. 2004
    ..Smoking may raise homocysteine by 1-2 microM/L but this is not a large enough effect to explain our findings...
  53. ncbi request reprint Intravenous fosphenytoin in acute mania
    Julia Applebaum
    Stanley Research Center, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    J Clin Psychiatry 64:408-9. 2003
    ..A new prodrug of phenytoin, fosphenytoin, which has few cardiac or local vein side effects, was used to test this hypothesis...
  54. ncbi request reprint Oxygen restriction of neonate rats elevates neuregulin-1alpha isoform levels: possible relationship to schizophrenia
    Carmit Nadri
    Stanley Research Center, Faculty of Health Science, Ben Gurion University of the Negev, and Mental Health Center, Beersheva, Israel
    Neurochem Int 51:447-50. 2007
    ..Frontal-cortex NRG-1alpha was 32% elevated in hypoxia-exposed rats. The data support the role of non-genetic factors, e.g. oxygen restriction, in the expression of genes associated with schizophrenia...
  55. ncbi request reprint Omega-3 fatty acids in depression: a review of three studies
    Yamima Osher
    Ministry of Health Beer Sheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    CNS Neurosci Ther 15:128-33. 2009
    ..This review discusses three studies, all from our group, completed before the clinical trial registry was initiated.)..
  56. ncbi request reprint Omega-3 fatty acids and augmentation strategies in treating resistant depression
    Boris Nemets
    Ben Gurion University of the Negev, Beer Sheva, Israel
    Essent Psychopharmacol 6:59-64. 2004
  57. ncbi request reprint CSF homocysteine is not elevated in schizophrenia
    J Levine
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    J Neural Transm 112:297-302. 2005
    ..No difference was found for CSF homocysteine levels between schizophrenia patients and controls (p=.041 for Study A and p=.52 for Study B)...
  58. ncbi request reprint Transdermal testosterone gel prn application for hypoactive sexual desire disorder in premenopausal women: a controlled pilot study of the effects on the arizona sexual experiences scale for females and sexual function questionnaire
    Bella Chudakov
    Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheba, Israel
    J Sex Med 4:204-8. 2007
    ..Three to 4 hours after reaching testosterone peak, increased genital sensations and sexual lust were reported...
  59. ncbi request reprint Transcranial magnetic stimulation in an amphetamine hyperactivity model of mania
    A Shaldivin
    Stanley Center for Bipolar Research, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheba, Israel
    Bipolar Disord 3:30-4. 2001
    ..CONCLUSIONS: The results suggest that TMS treatment to rats interacts with the effects of amphetamine; the specific effects may be dependent on the schedule of treatment...
  60. doi request reprint Computerized testing of neurocognitive function in euthymic bipolar patients compared to those with mild cognitive impairment and cognitively healthy controls
    Y Osher
    Beer Sheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Psychother Psychosom 80:298-303. 2011
    ..This study compares neuropsychological functioning of euthymic bipolar patients to those with mild cognitive impairment (MCI) as well as healthy controls...
  61. ncbi request reprint Clotiapine compared with chlorpromazine in chronic schizophrenia
    Vadim Geller
    Stanley Research Center, Ben Gurion University of the Negev, Beersheva Mental Health Center, PO Box 4600, 84107, Beersheva, Israel
    Schizophr Res 80:343-7. 2005
    ..We conducted a study of clotiapine vs. chlorpromazine in severe chronic active psychotic hospitalized schizophrenia patients...
  62. ncbi request reprint Effect of inositol on bulimia nervosa and binge eating
    D Gelber
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, P.O. Box 4600, Beersheva, Israel
    Int J Eat Disord 29:345-8. 2001
    ..This increases its parallelism with serotonin selective reuptake inhibitors...
  63. ncbi request reprint Lithium's effect in forced-swim test is blood level dependent but not dependent on weight loss
    Yuly Bersudsky
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev and Mental Health Center, Beer Sheva, Israel
    Behav Pharmacol 18:77-80. 2007
    ..In conclusion these results suggest that lithium effects in mice in the forced-swim test are dose dependent but not owing to lithium-induced weight loss...
  64. ncbi request reprint Personality genetics, 2002
    Jonathan Benjamin
    Barzilai Medical Center, Division of Psychiatry, Ben Gurion University of the Negev, Beersheba, Israel
    Isr J Psychiatry Relat Sci 39:271-9. 2002
    ....
  65. doi request reprint Effects of lithium on lipopolysaccharide-induced inflammation in rat primary glia cells
    Sigalit Nahman
    Department of Clinical Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Innate Immun 18:447-58. 2012
    ..These findings indicate that lithium exhibits a potent anti-inflammatory effect. However, it's important to emphasize that this effect was obtained mainly under treatment with an extra-therapeutic concentration of the drug...
  66. doi request reprint Disappearance of female genital mutilation from the Bedouin population of Southern Israel
    Suhil Halila
    Beersheva Mental Health Center, Ben Gurion University of the Negev, Beersheva, Israel
    J Sex Med 6:70-3. 2009
    ..Recently, clinicians in Southern Israel perceived that the practice of female genital mutilation had disappeared entirely in the Bedouin population. We previously studied the prevalence of this practice in 1995...
  67. ncbi request reprint No evidence for linkage by transmission disequilibrium test analysis of microsatellite marker D22S278 and schizophrenia in a Palestinian Arab and in a German population
    M Dobrusin
    Beersheva Mental Health Center, Beersheva, Israel
    Am J Med Genet 105:328-31. 2001
    ..11, P = 0.12, df = 9; Beersheva: chi-square = 7.04, P = 0.32, df = 6). Additionally, we examined D22S278 in a group of 114 schizophrenic German triads and failed to observe evidence for linkage (chi-square = 8.13, P = 0.42, df = 8df)...
  68. ncbi request reprint Trafficked female sex workers awaiting deportation: comparison with brothel workers
    J Cwikel
    Center for Women s Health Studies and Promotion and Department of Social Work, Ben Gurion University of the Negev, Beer Sheva, Israel
    Arch Womens Ment Health 7:243-9. 2004
    ..Early exposure to trauma increased the likelihood for work-related trauma, poor health and mental health outcomes...
  69. ncbi request reprint Nutritional and life style determinants of plasma homocysteine in schizophrenia patients
    Z Stahl
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Eur Neuropsychopharmacol 15:291-5. 2005
    ..Only 24% of the variance in male patients was explained by the model. The reason for elevated plasma homocysteine in some schizophrenic populations remains unclear...
  70. ncbi request reprint 3'(2')-phosphoadenosine 5'-phosphate phosphatase is reduced in postmortem frontal cortex of bipolar patients
    G Shaltiel
    Stanley Research Center and Zlotowski Center for Neuroscience, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Bipolar Disord 4:302-6. 2002
    ..3'(2')-Phosphoadenosine 5'-phosphate (PAP) phosphatase is a novel lithium (Li) inhibitable enzyme. Thus the enzyme seemed an important candidate for studies of the molecular etiology of bipolar disorder...
  71. ncbi request reprint Ethnic origin of alcoholics admitted to an Israeli treatment center
    Alexander Kaptsan
    Ben Gurion University of the Negev, Beer Sheba Mental Health Center, Beer Sheba, Israel
    Am J Drug Alcohol Abuse 32:549-53. 2006
    ..These data could support the concept that biological Jewish ethnicity has a protective effect against alcohol abuse, but are also consistent with cultural transmission of Jewish attitudes toward alcohol use...
  72. ncbi request reprint Lithium inhibitable enzymes in postmortem brain of bipolar patients
    Galila Agam
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    J Psychiatr Res 37:433-42. 2003
    ..Only PAP phosphatase protein levels, but not its mRNA levels or enzymatic activity, were found to be significantly decreased in frontal cortex of bipolar patients compared with normal controls...
  73. ncbi request reprint Epi-inositol regulates expression of the yeast INO1 gene encoding inositol-1-P synthase
    A Shaldubina
    Zlotowski Center for Neuroscience, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Mol Psychiatry 7:174-80. 2002
    ....
  74. ncbi request reprint Reduced inositol content in lymphocyte-derived cell lines from bipolar patients
    R H Belmaker
    Stanley Foundation Research Center, Ben Gurion University of the Negev, Beersheva, Israel
    Bipolar Disord 4:67-9. 2002
    ..The study aimed to determine whether low inositol content and uptake previously reported in brain and peripheral tissue of bipolar patients are also reflected in lymphocyte-derived cell lines from these patients...
  75. ncbi request reprint Polymorphisms in the dopamine D4 receptor gene (DRD4) contribute to individual differences in human sexual behavior: desire, arousal and sexual function
    I Z Ben Zion
    Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Mol Psychiatry 11:782-6. 2006
    ....
  76. ncbi request reprint GSK-3 and the neurodevelopmental hypothesis of schizophrenia
    Nitsan Kozlovsky
    Stanley Foundation Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Eur Neuropsychopharmacol 12:13-25. 2002
    ..GSK-3 participates in the signal transduction cascade of apoptosis. The possible role of aberrant GSK-3 in the etiology of schizophrenia is discussed...
  77. ncbi request reprint Myo-inositol-1-phosphate (MIP) synthase inhibition: in-vivo study in rats
    H Einat
    Department of Pharmacy Practice and Pharmaceutical Education, College of Pharmacy, University of Minnesota, Duluth, MN, USA
    J Neural Transm 115:55-8. 2008
    ..This lack of effects may stem from the low contribution of de-novo synthesis to cellular inositol supply or to the inhibition of the de-novo synthesis by lithium itself...
  78. ncbi request reprint The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness
    V M Steen
    Dr Einar Martens Research Group for Biological Psychiatry, Center for Molecular Medicine, Haukeland University Hospital, University of Bergen, Norway
    Pharmacogenetics 8:259-68. 1998
    ..Future studies are therefore need to determine whether allelic variants of the INPP1 gene are associated with a favourable efficacy of lithium in manic-depressive illness...
  79. ncbi request reprint SMIT1 haploinsufficiency causes brain inositol deficiency without affecting lithium-sensitive behavior
    Alona Shaldubina
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev and Mental Health Center, Beer Sheva, Israel
    Mol Genet Metab 88:384-8. 2006
    ....
  80. ncbi request reprint Lack of lithium-like behavioral and molecular effects in IMPA2 knockout mice
    Kim Cryns
    Research and Early Development Europe, Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium
    Neuropsychopharmacology 32:881-91. 2007
    ..In conclusion, phenotypic characterization of the IMPA2(-/-) mouse indicates that deleting IMPA2 does not mimic the effects of lithium treatment...
  81. pmc Role of GSK3beta in behavioral abnormalities induced by serotonin deficiency
    R H Belmaker
    Proc Natl Acad Sci U S A 105:E23; author reply E24. 2008
  82. doi request reprint Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders
    C Cleary
    Integrated Biosciences Graduate Program, University of Minnesota, Duluth, MN 55812, USA
    Brain Res Bull 76:469-73. 2008
    ..Additional studies are now planned to further explore the behavioral range of rapamycin's effects as well as the biological mechanisms underlying these effects...
  83. ncbi request reprint Treatment of bipolar depression
    R H Belmaker
    N Engl J Med 356:1771-3. 2007
  84. ncbi request reprint Phenytoin as an augmentation for SSRI failures: a small controlled study
    B Shapira
    Schonbaum Depression Department, Herzog Hospital, Jerusalem, Israel
    J Affect Disord 96:123-6. 2006
    ..We hypothesized that phenytoin, reported to have antimanic, antidepressant and prophylactic effects on affective disorder, might also augment in SSRI failures...
  85. ncbi request reprint Ketogenic diet in bipolar illness
    Yuri Yaroslavsky
    Bipolar Disord 4:75. 2002
  86. ncbi request reprint A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia
    I Murad
    Dr. Kemal Psychiatric Hospital, Bethlehem, Palestine
    Am J Med Genet 105:236-8. 2001
    ..No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi-square = 0.00, NS)...
  87. doi request reprint Do SSRIs or antidepressants in general increase suicidality? WPA Section on Pharmacopsychiatry: consensus statement
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University Munchen, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:3-23. 2008
    ..It is the major problem facing efforts to identify the possible 'suicidal effects' of antidepressants...
  88. doi request reprint World Psychiatric Association Pharmacopsychiatry Section statement on comparative effectiveness of antipsychotics in the treatment of schizophrenia
    Rajiv Tandon
    University of Florida, Tallahassee, USA
    Schizophr Res 100:20-38. 2008
    ....
  89. ncbi request reprint Modafinil add-on in the treatment of bipolar depression
    R H Belmaker
    Am J Psychiatry 164:1143-5. 2007
  90. ncbi request reprint Only tryptophan hydroxylase (TPH)-2 is relevant to the CNS
    G Shaltiel
    Am J Med Genet B Neuropsychiatr Genet 136:106. 2005
  91. ncbi request reprint A rational approach to the use of atypical antipsychotics
    R H Belmaker
    Isr J Psychiatry Relat Sci 40:79-81. 2003