Inbal Azran

Summary

Affiliation: Ben-Gurion University of the Negev
Country: Israel

Publications

  1. pmc Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity
    Inbal Azran
    Department of Microbiology and Immunology, Cancer Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Retrovirology 1:20. 2004
  2. doi request reprint HTLV-1 tax-induced NF-kappaB activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate: mechanism and implications for Tax oncogenicity
    Inbal Azran-Shaish
    Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheba, 84105, Israel
    J Mol Med (Berl) 86:799-814. 2008
  3. ncbi request reprint Dose-dependent dual effect of HTLV-1 tax oncoprotein on p53-dependent nucleotide excision repair in human T-cells
    Yana Schavinsky-Khrapunsky
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Int J Cancer 122:305-16. 2008
  4. doi request reprint The mechanism of HTLV-1 LTR activation by TPA varies in different human T-cell lines: role of specific PKC isoforms
    Rachel Chamias
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Leuk Res 34:93-9. 2010
  5. ncbi request reprint Role of protein kinase C and the Sp1-p53 complex in activation of p21(WAF-1) expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells
    Yana Schavinsky-Khrapunsky
    Department of Microbiology and Immunology, Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Oncogene 22:5315-24. 2003
  6. ncbi request reprint High levels of cytoplasmic HTLV-1 Tax mutant proteins retain a Tax-NF-kappaB-CBP ternary complex in the cytoplasm
    Inbal Azran
    Department of Microbiology and Immunology, Cancer Research Center, Faculty of Health Sciences, Ben Gurion University of Negev, Beer Sheva 84105, Israel
    Oncogene 24:4521-30. 2005
  7. ncbi request reprint Implications of the evolution pattern of human T-cell leukemia retroviruses on their pathogenic virulence (Review)
    Inbal Azran
    Department of Microbiology and Immunology, Cancer Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Int J Mol Med 14:909-15. 2004
  8. ncbi request reprint Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications
    Yulia Tabakin-Fix
    Department of Microbiology and Immunology, Cancer Research Center, Faculty of Health Sciences and Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Carcinogenesis 27:673-81. 2006
  9. doi request reprint Role of caspase 9 in activation of HTLV-1 LTR expression by DNA damaging agents
    Ammar Abou-Kandil
    Shraga Segal Department of Microbiology and Immunology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Cell Cycle 10:3337-45. 2011
  10. ncbi request reprint Activation of simian virus 40 promoter by HTLV-I Tax protein: role of NF-kappaB and CBP
    Yulia Tabakin-Fix
    Department of Microbiology and Immunology and Cancer Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biochem Biophys Res Commun 318:1052-6. 2004

Collaborators

Detail Information

Publications13

  1. pmc Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity
    Inbal Azran
    Department of Microbiology and Immunology, Cancer Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Retrovirology 1:20. 2004
    ..We conclude this review by outlining an hypothetical flow of events from the initial virus infection up to the ultimate ATL development and comment on the risk factors leading to ATL development in some people and to TSP/HAM in others...
  2. doi request reprint HTLV-1 tax-induced NF-kappaB activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate: mechanism and implications for Tax oncogenicity
    Inbal Azran-Shaish
    Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheba, 84105, Israel
    J Mol Med (Berl) 86:799-814. 2008
    ..On this ground, the present study suggests that such conditions may enhance the risk for ATL and TSP-HAM in HTLV-1 carriers by increasing the Tax-induced NF-kappaB activation...
  3. ncbi request reprint Dose-dependent dual effect of HTLV-1 tax oncoprotein on p53-dependent nucleotide excision repair in human T-cells
    Yana Schavinsky-Khrapunsky
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Int J Cancer 122:305-16. 2008
    ..The mechanisms of the NF-kappaB-associated effects on the level and function of the cellular w.t.p53 and of the p53-independent NER noted in our experimental systems are further investigated in our laboratory...
  4. doi request reprint The mechanism of HTLV-1 LTR activation by TPA varies in different human T-cell lines: role of specific PKC isoforms
    Rachel Chamias
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Leuk Res 34:93-9. 2010
    ....
  5. ncbi request reprint Role of protein kinase C and the Sp1-p53 complex in activation of p21(WAF-1) expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells
    Yana Schavinsky-Khrapunsky
    Department of Microbiology and Immunology, Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Oncogene 22:5315-24. 2003
    ....
  6. ncbi request reprint High levels of cytoplasmic HTLV-1 Tax mutant proteins retain a Tax-NF-kappaB-CBP ternary complex in the cytoplasm
    Inbal Azran
    Department of Microbiology and Immunology, Cancer Research Center, Faculty of Health Sciences, Ben Gurion University of Negev, Beer Sheva 84105, Israel
    Oncogene 24:4521-30. 2005
    ..However, if the complex is formed with the cytoplasmic Tax mutants, the resulting moiety is retained in the cytoplasm and is, therefore, devoid of transcriptional activity...
  7. ncbi request reprint Implications of the evolution pattern of human T-cell leukemia retroviruses on their pathogenic virulence (Review)
    Inbal Azran
    Department of Microbiology and Immunology, Cancer Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Int J Mol Med 14:909-15. 2004
    ..This change in the mode of the virus spread creates a serious risk for emergence of HTLV-II strains with higher virulence...
  8. ncbi request reprint Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications
    Yulia Tabakin-Fix
    Department of Microbiology and Immunology, Cancer Research Center, Faculty of Health Sciences and Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Carcinogenesis 27:673-81. 2006
    ..In this review article, we discuss the various mechanisms proposed for Tax interference with p53 functions and their clinical and therapeutic implications...
  9. doi request reprint Role of caspase 9 in activation of HTLV-1 LTR expression by DNA damaging agents
    Ammar Abou-Kandil
    Shraga Segal Department of Microbiology and Immunology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Cell Cycle 10:3337-45. 2011
    ..This finding can help in designing effective preventing strategies against ATL development in clinically latent HTLV-1 carriers...
  10. ncbi request reprint Activation of simian virus 40 promoter by HTLV-I Tax protein: role of NF-kappaB and CBP
    Yulia Tabakin-Fix
    Department of Microbiology and Immunology and Cancer Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biochem Biophys Res Commun 318:1052-6. 2004
    ..Finally, the present study proves that the nuclear Tax plays a critical role in Tax-induced NF-kappaB-mediated SV40 activation...
  11. ncbi request reprint Activation of HTLV-I long terminal repeat by apoptosis inducing agents: mechanism and implications for HTLV-I pathogenicity (review)
    Yana Schavinsky-Khrapunsky
    Department of Microbiology and Immunology, Cancer Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Int J Mol Med 11:3-11. 2003
    ..Since the development of both TSP/HAM and ATL seems to depend on the viral Tax protein, we describe a possible system for anti Tax gene-therapy approach based on a negative transdominant mutant Tax gene...
  12. ncbi request reprint Molecular mechanisms of cellular transformation by HTLV-1 Tax
    Ralph Grassmann
    Institut fur Klinische und Molekulare Virologie, Universitat Erlangen Nurnberg, Schlossgarten 4, Germany
    Oncogene 24:5976-85. 2005
    ..g. p53, DLG). Moreover, Tax silences cellular checkpoints, which guard against DNA structural damage and chromosomal missegregation, thereby favoring the manifestation of a mutator phenotype in cells...
  13. ncbi request reprint Life, death, and tax: role of HTLV-I oncoprotein in genetic instability and cellular transformation
    Kuan Teh Jeang
    Laboratory of Molecular Microbiology, Nattional Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:31991-4. 2004