Chaya Brodie

Summary

Affiliation: Bar-Ilan University
Country: Israel

Publications

  1. ncbi request reprint PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters
    Chaya Brodie
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Mol Pharmacol 66:76-84. 2004
  2. ncbi request reprint Regulation of cell apoptosis by protein kinase c delta
    C Brodie
    Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Apoptosis 8:19-27. 2003
  3. pmc GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis
    Hae Kyung Lee
    Department of Neurosurgery and Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI 48202, USA
    Neuro Oncol 10:236-43. 2008
  4. pmc Phosphorylation of protein kinase Cdelta on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: role in the apoptotic effect of etoposide
    Stephanie L Lomonaco
    William and Karen Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Biol Chem 283:17731-9. 2008
  5. pmc Cilengitide induces autophagy-mediated cell death in glioma cells
    Stephanie L Lomonaco
    William and Karen Davidson Laboratory of Cell Signaling and Tumorigenesis, Detroit, MI 48202, USA
    Neuro Oncol 13:857-65. 2011
  6. pmc Insulin-like growth factor binding protein 7 mediates glioma cell growth and migration
    Wei Jiang
    Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Neoplasia 10:1335-42. 2008
  7. pmc MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1
    Ariel Bier
    Everard and Mina Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Oncotarget 4:665-76. 2013
  8. doi request reprint RTVP-1 expression is regulated by SRF downstream of protein kinase C and contributes to the effect of SRF on glioma cell migration
    Amotz Ziv-Av
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Cell Signal 23:1936-43. 2011
  9. ncbi request reprint HSP27 mediates SPARC-induced changes in glioma morphology, migration, and invasion
    William A Golembieski
    Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Glia 56:1061-75. 2008
  10. doi request reprint Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes
    Tamar Brutman-Barazani
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    J Cell Biochem 113:2064-76. 2012

Collaborators

Detail Information

Publications38

  1. ncbi request reprint PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters
    Chaya Brodie
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Mol Pharmacol 66:76-84. 2004
    ..PKCdelta points to the existence of complex cross-talk between various members of the phorbol ester receptors which can have important impact on major signal transduction pathways and cellular processes induced by phorbol esters or DAG..
  2. ncbi request reprint Regulation of cell apoptosis by protein kinase c delta
    C Brodie
    Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Apoptosis 8:19-27. 2003
    ..Recent findings on these aspects of the PKCdelta cascades are the major focus of this review...
  3. pmc GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis
    Hae Kyung Lee
    Department of Neurosurgery and Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI 48202, USA
    Neuro Oncol 10:236-43. 2008
    ..Thus, GRP78 contributes to the increased apoptosis resistance and growth of glioma cells and may provide a target for enhancing the therapeutic responsiveness of these tumors...
  4. pmc Phosphorylation of protein kinase Cdelta on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: role in the apoptotic effect of etoposide
    Stephanie L Lomonaco
    William and Karen Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Biol Chem 283:17731-9. 2008
    ..These results indicate that distinct phosphorylation of PKCdeltaon tyrosines 64 and 187 specifically activates the Erk1/2 pathway by the down-regulation of MKP-1, resulting in the persistent phosphorylation of Erk1/2 and cell apoptosis...
  5. pmc Cilengitide induces autophagy-mediated cell death in glioma cells
    Stephanie L Lomonaco
    William and Karen Davidson Laboratory of Cell Signaling and Tumorigenesis, Detroit, MI 48202, USA
    Neuro Oncol 13:857-65. 2011
    ..We found that cilengitide induced autophagy collectively in glioma cells, xenografts, and GSCs, which contributed to its cytotoxic effects and sensitized these cells to γ-radiation...
  6. pmc Insulin-like growth factor binding protein 7 mediates glioma cell growth and migration
    Wei Jiang
    Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Neoplasia 10:1335-42. 2008
    ..These two factors together suggest that IGFBP-7 can regulate glioma cell migration through the AKT-ERK pathway, thereby playing an important role in glioma growth and migration...
  7. pmc MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1
    Ariel Bier
    Everard and Mina Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Oncotarget 4:665-76. 2013
    ..miR-137 inhibits GSC self-renewal and promotes their differentiation by targeting RTVP-1 which downregulates CXCR4. Thus, miR-137 and RTVP-1 are attractive therapeutic targets for the eradication of GSCs and for the treatment of GBM. ..
  8. doi request reprint RTVP-1 expression is regulated by SRF downstream of protein kinase C and contributes to the effect of SRF on glioma cell migration
    Amotz Ziv-Av
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Cell Signal 23:1936-43. 2011
    ..We conclude that RTVP-1 is a PKC-regulated gene and that this regulation is at least partly mediated by SRF. Moreover, RTVP-1 plays a role in the effect of SRF on glioma cell migration...
  9. ncbi request reprint HSP27 mediates SPARC-induced changes in glioma morphology, migration, and invasion
    William A Golembieski
    Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Glia 56:1061-75. 2008
    ..As such, it is a potential therapeutic target to inhibit SPARC-induced glioma invasion...
  10. doi request reprint Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes
    Tamar Brutman-Barazani
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    J Cell Biochem 113:2064-76. 2012
    ..We conclude that PKCδ, but not PKCα, plays an essential role in insulin-induced glucose uptake and glycogenesis in hepatocytes...
  11. pmc Protein kinase C-epsilon regulates the apoptosis and survival of glioma cells
    Hana Okhrimenko
    Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Cancer Res 65:7301-9. 2005
    ..Our results suggest that the cleavage of PKCepsilon and its down-regulation play important roles in the apoptotic effect of TRAIL. Moreover, PKCepsilon regulates AKT expression and is essential for the survival of glioma cells...
  12. ncbi request reprint The localization of protein kinase Cdelta in different subcellular sites affects its proapoptotic and antiapoptotic functions and the activation of distinct downstream signaling pathways
    Ruth Gomel
    Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Mol Cancer Res 5:627-39. 2007
    ..Our results indicate that the subcellular localization of PKCdelta plays important roles in its proapoptotic and antiapoptotic functions and in the activation of downstream signaling pathways...
  13. ncbi request reprint Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis
    Avi Zrachia
    Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Biol Chem 277:23693-701. 2002
    ..We conclude that PKCdelta exerts an inhibitory effect on the apoptosis induced by SV and that phosphorylation of PKCdelta on specific tyrosines is required for this function...
  14. doi request reprint Insulin stimulation of PKCδ triggers its rapid degradation via the ubiquitin-proteasome pathway
    Chagit Brand
    The Faculty of Life Science, Bar Ilan University, Ramat Gan, Israel
    Biochim Biophys Acta 1803:1265-75. 2010
    ..These studies provide additional evidence for unique effects of insulin on regulation of PKCδ protein levels...
  15. pmc Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells
    Wei Lu
    William and Karen Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA
    Biochem Biophys Res Commun 352:431-6. 2007
    ..These results suggest an important role of tyrosine 311 in the apoptotic function of PKCdelta and implicate c-Abl as the kinase that phosphorylates this tyrosine...
  16. ncbi request reprint Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells
    Cunli Xiang
    Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Health System, Detroit, MI 48202, USA
    Biochem Biophys Res Commun 362:612-8. 2007
    ..Overexpression of RTVP-1b increased glioma cell proliferation but did not affect cell migration. Our results suggest that RTVP-1b represents a potential prognostic marker and therapeutic target in gliomas...
  17. pmc TRAIL conjugated to nanoparticles exhibits increased anti-tumor activities in glioma cells and glioma stem cells in vitro and in vivo
    Benny Perlstein
    Department of Chemistry, Bar Ilan University, Ramat Gan, Israel
    Neuro Oncol 15:29-40. 2013
    ..Therefore, NP-TRAIL represents a targeted anticancer agent with more efficient action for the treatment of GBM and the eradication of GSCs...
  18. doi request reprint The regulatory domain of protein kinase C delta positively regulates insulin receptor signaling
    Avraham I Jacob
    Mina and Everard Goodman Faculty of Life Sciences, Gonda Diagnostic Center, Bar Ilan University, Ramat Gan 52900, Israel
    J Mol Endocrinol 44:155-69. 2010
    ..Thus, the regulatory domain of PKCdelta via interaction with Src appears to determine the role of PKCdelta as a positive regulator of IR signaling in skeletal muscle...
  19. ncbi request reprint The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells
    Stephanie L Lomonaco
    Department of Neurosurgery, William and Karen Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI 48202, USA
    Int J Cancer 125:717-22. 2009
    ..Collectively, these results indicate that the induction of autophagy contributes to the radioresistance of these cells and autophagy inhibitors may be employed to increase the sensitivity of CD133+ GSCs to gamma-radiation...
  20. pmc Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus
    Einat Deutsch
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Virol 78:10187-92. 2004
    ....
  21. ncbi request reprint Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis
    Hana Okhrimenko
    Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel 52900
    J Biol Chem 280:23643-52. 2005
    ..Our results indicate that PKCdelta protects glioma cells from the apoptosis induced by TRAIL and implicate the phosphorylation of PKCdelta on tyrosine 155 and its cleavage as essential factors in the anti-apoptotic effect of PKCdelta...
  22. ncbi request reprint The phosphorylation of tyrosine 332 is necessary for the caspase 3-dependent cleavage of PKCdelta and the regulation of cell apoptosis
    Wei Lu
    William and Karen Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA
    Cell Signal 19:2165-73. 2007
    ..These results demonstrate that the phosphorylation of tyrosine 332 by Src modulates the cleavage of PKCdelta and the sensitivity of glioma cells to TRAIL and cisplatin...
  23. ncbi request reprint PKCepsilon induces astrocytic differentiation of multipotential neural precursor cells
    Rivka Steinhart
    Gonda Goldschmied Medical Diagnosis Research Center, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Glia 55:224-32. 2007
    ..Our data suggest an important role of PKCepsilon in astrocytic differentiation and implicate Notch1 as a possible mediator of this effect...
  24. pmc Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival
    Chad R Schultz
    The Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Henry Ford Hospital, Detroit, MI 48202, USA
    Mol Cancer 11:20. 2012
    ..As HSP27 and AKT interact to regulate the activity of each other, we determined whether inhibition of HSP27 was better than targeting SPARC as a therapeutic approach to inhibit both SPARC-induced glioma cell invasion and survival...
  25. pmc SPARC-induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion
    Christopher K Yunker
    Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Int J Cancer 122:2735-43. 2008
    ....
  26. pmc FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway
    Wei Jiang
    Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Neoplasia 10:235-43. 2008
    ..In conclusion, our study demonstrates that FKBP5 plays an important role in glioma growth and chemoresistance through regulating signal transduction of the NF-kappaB pathway...
  27. doi request reprint Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency
    Tom Mikkelsen
    Department of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI 48202, USA
    Int J Cancer 124:2719-27. 2009
    ..Our results demonstrate that blockade of alphav integrins mediates an unanticipated rapid potentiation of radiation, and suggests possible clinical translation for glioma therapy...
  28. ncbi request reprint NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKCzeta
    Ilana Kronfeld
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Eur J Immunol 32:136-43. 2002
    ..The results of this study indicate that NGF is involved in B cell survival and that this effect is mediated by PI3-kinase-dependent activation of PKCzeta...
  29. doi request reprint Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressions
    Sarit Kahana
    Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900 CB, Israel
    Cell Signal 23:1348-57. 2011
    ..Combining proteasome inhibitors with TRAIL may be useful therapeutically in the treatment of gliomas and the eradication of GSCs...
  30. ncbi request reprint Protein kinase Calpha regulates insulin receptor signaling in skeletal muscle
    Michal Cipok
    Gonda Diagnostic Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Biochem Biophys Res Commun 345:817-24. 2006
    ..Blockade of PKCalpha increased threonine phosphorylation of PKB. We suggest that PKCalpha regulates insulin signaling in skeletal muscle through its disassociation from IRS-1 and association with PKB...
  31. ncbi request reprint An essential role of ERK signalling in TPA-induced reactivation of Kaposi's sarcoma-associated herpesvirus
    Adina Cohen
    Bar Ilan University, Faculty of Life Sciences, 52900 Ramat Gan, Israel
    J Gen Virol 87:795-802. 2006
    ..c-Fos and c-Jun jointly form an active AP-1 complex, which functions to activate the lytic cascade of KSHV...
  32. ncbi request reprint Related to testes-specific, vespid, and pathogenesis protein-1 (RTVP-1) is overexpressed in gliomas and regulates the growth, survival, and invasion of glioma cells
    Tovit Rosenzweig
    Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Cancer Res 66:4139-48. 2006
    ..Collectively, these findings suggest that RTVP-1 is a potential therapeutic target in gliomas...
  33. pmc Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide
    Michal Blass
    Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Mol Cell Biol 22:182-95. 2002
    ..Our results suggest a role of PKCdelta in the apoptosis induced by etoposide and implicate tyrosine phosphorylation of PKCdelta as an important regulator of this effect...
  34. ncbi request reprint Effect of helium/neon laser irradiation on nerve growth factor synthesis and secretion in skeletal muscle cultures
    Fidi Schwartz
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Photochem Photobiol B 66:195-200. 2002
    ..The NGF is probably responsible for the beneficial effects of low-level light...
  35. pmc Bone marrow stromal cell therapy reduces proNGF and p75 expression in mice with experimental autoimmune encephalomyelitis
    Jing Zhang
    Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA
    J Neurol Sci 279:30-8. 2009
    ..BMSC treatment benefits on EAE mice may be fostered by decreasing the cellular expression of proNGF and p75, thereby reducing oligodendrocyte death...
  36. pmc P2Y6 nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis
    Seong G Kim
    Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0810, USA
    Cell Mol Neurobiol 23:401-18. 2003
    ..6. The addition of phospholipase C (PLC) inhibitors, D609 or U73122, partially antagonized both UDP-induced protection and PKC activation...
  37. pmc Multiple PKCdelta tyrosine residues are required for PKCdelta-dependent activation of involucrin expression--a key role of PKCdelta-Y311
    Ling Zhu
    Department of Physiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Invest Dermatol 128:833-45. 2008
    ..These findings indicate that PKCdelta activity requires Y(311) and a second tyrosine residue; however, any one of the several tyrosine residues can serve in the secondary role...
  38. pmc Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 115:168-76. 2005
    ..Our results demonstrate a central role for PKC-zeta in SDF-1-dependent regulation of hematopoietic stem and progenitor cell motility and development...