Mira Barda-Saad

Summary

Affiliation: Bar-Ilan University
Country: Israel

Publications

  1. pmc Cooperative interactions at the SLP-76 complex are critical for actin polymerization
    Mira Barda-Saad
    Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    EMBO J 29:2315-28. 2010
  2. doi request reprint Studying the dynamics of SLP-76, Nck, and Vav1 multimolecular complex formation in live human cells with triple-color FRET
    Maor H Pauker
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Sci Signal 5:rs3. 2012
  3. pmc WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site
    Maor H Pauker
    From The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel
    J Biol Chem 289:34503-19. 2014
  4. doi request reprint Ubiquitylation-dependent downregulation of Nck regulates its functional activity
    Noah Joseph
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel
    FEBS Lett 588:3808-15. 2014
  5. doi request reprint Triple-color FRET analysis reveals conformational changes in the WIP-WASp actin-regulating complex
    Sophia Fried
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel
    Sci Signal 7:ra60. 2014
  6. pmc Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics
    Barak Reicher
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Mol Cell Biol 32:3153-63. 2012
  7. pmc Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization
    Maor H Pauker
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Mol Cell Biol 31:2653-66. 2011
  8. doi request reprint WIP: more than a WASp-interacting protein
    Sophia Fried
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    J Leukoc Biol 96:713-27. 2014
  9. doi request reprint Wiskott-Aldrich syndrome protein--dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes
    Omri Matalon
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Immunol Rev 256:10-29. 2013
  10. doi request reprint The calcium feedback loop and T cell activation: how cytoskeleton networks control intracellular calcium flux
    Noah Joseph
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel
    Biochim Biophys Acta 1838:557-68. 2014

Collaborators

  • Jordan H Chill
  • Ronit Sarid
  • Jon C D Houtman
  • Lawrence E Samelson
  • Naoto Shirasu
  • Barak Reicher
  • Maor H Pauker
  • Noah Joseph
  • Omri Matalon
  • Sophia Fried
  • Elad Noy
  • Orly Perl
  • Hila Elazari-Shalom
  • Hadassa Shaked
  • Tatyana Borodianskiy-Shteinberg
  • Ahuvit David
  • Noam Y Haba
  • Xavier Salvatella
  • Santiago Esteban-Martín
  • Sarit Kipper
  • Shlomi Jakubowicz
  • Inna Kalt
  • Nofar Nachum
  • Shani Eliyahu
  • Shiri Katz
  • Inbal Wortzel
  • Doron Gerber
  • Jiří Nováček
  • Lukáš Zídek
  • Renana Gross
  • Nirit Hassan
  • Sophie Fried

Detail Information

Publications13

  1. pmc Cooperative interactions at the SLP-76 complex are critical for actin polymerization
    Mira Barda-Saad
    Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    EMBO J 29:2315-28. 2010
    ..Disruption of the VAV1:Nck interaction deleteriously affected actin polymerization. These novel findings shed new light on the mechanism of actin polymerization after T-cell activation...
  2. doi request reprint Studying the dynamics of SLP-76, Nck, and Vav1 multimolecular complex formation in live human cells with triple-color FRET
    Maor H Pauker
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Sci Signal 5:rs3. 2012
    ..We suggest that these findings revise the accepted model of the formation of a complex of SLP-76, Nck, and Vav1 and demonstrate the use of 3FRET as a tool to study signal transduction in live cells...
  3. pmc WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site
    Maor H Pauker
    From The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel
    J Biol Chem 289:34503-19. 2014
    ..Our experiments demonstrate that WASp and WAVE2 differ in their dynamics and their associated proteins. Thus, this study reveals the differential mechanisms regulating the function of these cytoskeletal proteins. ..
  4. doi request reprint Ubiquitylation-dependent downregulation of Nck regulates its functional activity
    Noah Joseph
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel
    FEBS Lett 588:3808-15. 2014
    ..We identified the molecular determinants and mediators involved in this process. Our data suggest that Nck ubiquitylation might serve as a mechanism controlling Nck-mediated effector functions during cellular activation. ..
  5. doi request reprint Triple-color FRET analysis reveals conformational changes in the WIP-WASp actin-regulating complex
    Sophia Fried
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel
    Sci Signal 7:ra60. 2014
    ..Our molecular analysis of the WIP-WASp interaction provides insight into the regulation of actin-dependent processes. ..
  6. pmc Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics
    Barak Reicher
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Mol Cell Biol 32:3153-63. 2012
    ..Our data suggest that regulated degradation of activated WASp might be an efficient strategy by which the duration and localization of actin rearrangement and the intensity of T-cell activation are controlled...
  7. pmc Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization
    Maor H Pauker
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Mol Cell Biol 31:2653-66. 2011
    ..Functional cooperation between Nck and ADAP mediates SLP76-WASp interactions and actin rearrangement. We also reveal the molecular mechanism linking ADAP to actin reorganization...
  8. doi request reprint WIP: more than a WASp-interacting protein
    Sophia Fried
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    J Leukoc Biol 96:713-27. 2014
    ..Here, we review the current information on WIP in human and mouse systems, focusing on its associated proteins, its molecular-regulatory mechanisms, and its role as a key regulator of actin-based processes in the immune system...
  9. doi request reprint Wiskott-Aldrich syndrome protein--dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes
    Omri Matalon
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Immunol Rev 256:10-29. 2013
    ..Thus, we focus here on the regulation of WASp expression and function and the mechanisms whereby they control actin machinery and T-cell effector functions. ..
  10. doi request reprint The calcium feedback loop and T cell activation: how cytoskeleton networks control intracellular calcium flux
    Noah Joseph
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel
    Biochim Biophys Acta 1838:557-68. 2014
    ..This article is part of a Special Issue entitled: Reciprocal influences between cell cytoskeleton and membrane channels, receptors and transporters. Guest Editor: Jean Claude Hervé. ..
  11. doi request reprint New insights into the role of the disordered WIP N-terminal domain revealed by NMR structural characterization
    Hila Elazari-Shalom
    Department of Chemistry, Bar Ilan University, Ramat Gan, Israel
    FEBS J 282:700-14. 2015
    ....
  12. doi request reprint The nucleolar PICT-1/GLTSCR2 protein forms homo-oligomers
    Tatyana Borodianskiy-Shteinberg
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel 5290002
    J Mol Biol 426:2363-78. 2014
    ..Our findings add another layer of complexity in understanding the different functions of PICT-1 and may help provide insights regarding the activities of this protein. ..
  13. pmc NMR determines transient structure and dynamics in the disordered C-terminal domain of WASp interacting protein
    Noam Y Haba
    Department of Chemistry, Bar Ilan University, Ramat Gan, Israel
    Biophys J 105:481-93. 2013
    ..Thus, we conclude that the disordered WIP(C) fragment is comprised of regions with latent structure connected by flexible loops, an architecture with implications for binding affinity and function...