Mira Barda-Saad

Summary

Affiliation: Bar-Ilan University
Country: Israel

Publications

  1. pmc Cooperative interactions at the SLP-76 complex are critical for actin polymerization
    Mira Barda-Saad
    Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    EMBO J 29:2315-28. 2010
  2. doi request reprint Studying the dynamics of SLP-76, Nck, and Vav1 multimolecular complex formation in live human cells with triple-color FRET
    Maor H Pauker
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Sci Signal 5:rs3. 2012
  3. pmc Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics
    Barak Reicher
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Mol Cell Biol 32:3153-63. 2012
  4. pmc Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization
    Maor H Pauker
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Mol Cell Biol 31:2653-66. 2011
  5. ncbi request reprint Triple-Color FRET Analysis Reveals Conformational Changes in the WIP-WASp Actin-Regulating Complex
    Sophia Fried
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel
    Sci Signal 7:ra60. 2014
  6. doi request reprint The calcium feedback loop and T cell activation: how cytoskeleton networks control intracellular calcium flux
    Noah Joseph
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel
    Biochim Biophys Acta 1838:557-68. 2014
  7. ncbi request reprint Wiskott-Aldrich syndrome protein--dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes
    Omri Matalon
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Immunol Rev 256:10-29. 2013
  8. ncbi request reprint The nucleolar PICT-1/GLTSCR2 protein forms homo-oligomers
    Tatyana Borodianskiy-Shteinberg
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel 5290002
    J Mol Biol 426:2363-78. 2014
  9. pmc NMR determines transient structure and dynamics in the disordered C-terminal domain of WASp interacting protein
    Noam Y Haba
    Department of Chemistry, Bar Ilan University, Ramat Gan, Israel
    Biophys J 105:481-93. 2013

Collaborators

Detail Information

Publications9

  1. pmc Cooperative interactions at the SLP-76 complex are critical for actin polymerization
    Mira Barda-Saad
    Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    EMBO J 29:2315-28. 2010
    ..Disruption of the VAV1:Nck interaction deleteriously affected actin polymerization. These novel findings shed new light on the mechanism of actin polymerization after T-cell activation...
  2. doi request reprint Studying the dynamics of SLP-76, Nck, and Vav1 multimolecular complex formation in live human cells with triple-color FRET
    Maor H Pauker
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Sci Signal 5:rs3. 2012
    ..We suggest that these findings revise the accepted model of the formation of a complex of SLP-76, Nck, and Vav1 and demonstrate the use of 3FRET as a tool to study signal transduction in live cells...
  3. pmc Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics
    Barak Reicher
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Mol Cell Biol 32:3153-63. 2012
    ..Our data suggest that regulated degradation of activated WASp might be an efficient strategy by which the duration and localization of actin rearrangement and the intensity of T-cell activation are controlled...
  4. pmc Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization
    Maor H Pauker
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Mol Cell Biol 31:2653-66. 2011
    ..Functional cooperation between Nck and ADAP mediates SLP76-WASp interactions and actin rearrangement. We also reveal the molecular mechanism linking ADAP to actin reorganization...
  5. ncbi request reprint Triple-Color FRET Analysis Reveals Conformational Changes in the WIP-WASp Actin-Regulating Complex
    Sophia Fried
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel
    Sci Signal 7:ra60. 2014
    ..Our molecular analysis of the WIP-WASp interaction provides insight into the regulation of actin-dependent processes. ..
  6. doi request reprint The calcium feedback loop and T cell activation: how cytoskeleton networks control intracellular calcium flux
    Noah Joseph
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel
    Biochim Biophys Acta 1838:557-68. 2014
    ..This article is part of a Special Issue entitled: Reciprocal influences between cell cytoskeleton and membrane channels, receptors and transporters. Guest Editor: Jean Claude Hervé. ..
  7. ncbi request reprint Wiskott-Aldrich syndrome protein--dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes
    Omri Matalon
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Immunol Rev 256:10-29. 2013
    ..Thus, we focus here on the regulation of WASp expression and function and the mechanisms whereby they control actin machinery and T-cell effector functions. ..
  8. ncbi request reprint The nucleolar PICT-1/GLTSCR2 protein forms homo-oligomers
    Tatyana Borodianskiy-Shteinberg
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel 5290002
    J Mol Biol 426:2363-78. 2014
    ..Our findings add another layer of complexity in understanding the different functions of PICT-1 and may help provide insights regarding the activities of this protein. ..
  9. pmc NMR determines transient structure and dynamics in the disordered C-terminal domain of WASp interacting protein
    Noam Y Haba
    Department of Chemistry, Bar Ilan University, Ramat Gan, Israel
    Biophys J 105:481-93. 2013
    ..Thus, we conclude that the disordered WIP(C) fragment is comprised of regions with latent structure connected by flexible loops, an architecture with implications for binding affinity and function...