Enhancement of sensitivity to cisplatin by orobol is associated with increased mitochondrial cytochrome c release in human ovarian carcinoma cellsSeiji Isonishi
Department of Obstetrics/Gynecology, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105, Japan
Gynecol Oncol 90:413-20. 2003
..CONCLUSIONS: These results indicate that orobol produced DDP sensitivity in human ovarian carcinoma cells by inducing apoptosis through the MT-dependent signaling pathway...
- [Biomarker in gynecologic malignancies]
Seiji Isonishi
Department of Obstetrics and Gynecology, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-ku, Tokyo 105-8461, Japan
Gan To Kagaku Ryoho 31:1003-7. 2004
..For the trials with bevacizumab, anti-VEGF antibody, VEGF and its associated bFGF, CD-31, and thrombospondin-1 (TSP-1), are leading candidates for monitoring markers...
- Differential regulation of the cytotoxicity activity of paclitaxel by orobol and platelet derived growth factor in human ovarian carcinoma cells
Seiji Isonishi
Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo 125 8506, Japan
Oncol Rep 18:195-201. 2007
..These results indicate that orobol and PDGF regulate PX sensitivity by reciprocally altering the proportion of tubulin isotype expression and PX-induced apoptotic signaling...
Small cell carcinoma of the ovary: clinical and biological studySeiji Isonishi
Department of Obstetrics and Gynecology, Jikei University School of Medicine, Aoto Hospital, 6 41 2 Aoto, Katsushika ku, Tokyo, 125 8506, Japan
Int J Clin Oncol 13:161-5. 2008
..However, an effect of such a regimen was seen in only one patient with early-stage disease, and this questions the validity of chemosensitivity testing...
- Alpha-fetoprotein (AFP)-producing ovarian tumor in an elderly woman
Seiji Isonishi
Department of Obstetrics and Gynecology, Jikei University School of Medicine, Aoto Hospital, Tokyo, Japan
Int J Clin Oncol 14:70-3. 2009
..The patient received secondary cytoreductive surgery of systemic lymphadenectomy, which revealed no evidence of residual tumor...
- Mitochondrial ultrastructure-associated chemotherapy response in ovarian cancer
Motoaki Saitou
Department of Obstetrics Gynecology, Jikei University School of Medicine, Tokyo 105, Japan
Oncol Rep 21:199-204. 2009
..In conclusion, this MT scoring system was excellently correlated to response regardless of histopathologic findings and this strongly suggests that the system is deemed to be of great value as biomarker for the chemosensitivity in OC...
- Characterization of mitochondria in cisplatin-resistant human ovarian carcinoma cells
Masanori Hirama
Department of Obstetrics/Gynecology and Department of Anatomy II, Jikei University School of Medicine, Minato-ku, Tokyo 105, Japan
Oncol Rep 16:997-1002. 2006
..However, the mechanism by which the mitochondrial DNA encoded molecule is involved in cisplatin resistance remains to be determined...
- Primary chemotherapy-associated effect of second-line chemotherapy on survival of patients with advanced ovarian cancer
Seiji Isonishi
Department of Obstetrics and Gynecology, Jikei University School of Medicine, 4 11 1 Izumi honchou, Komae, Tokyo, 201 8601, Japan
Int J Clin Oncol 11:236-42. 2006
..The purpose of this study was to evaluate how to make the selection of second-line agents for patients with recurrent ovarian carcinoma initially diagnosed as stage II to IV...
- Indoleamine 2,3-dioxygenase serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cells
Aikou Okamoto
Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan
Clin Cancer Res 11:6030-9. 2005
..CONCLUSION: The indoleamine 2,3-dioxygenase screened with the GeneChip was positively associated with paclitaxel resistance and with impaired survival in patients with serous-type ovarian cancer...
- Two cases of epidural anesthesia-associated postoperative decubitus
Eri Takahashi
Department of Obstetrics and Gynecology, Jikei University Aoto Hospital, Tokyo, Japan
J Obstet Gynaecol Res 34:763-6. 2008
..Eighteen hours after surgery, the anesthetic effect still continued below the L2 level. We conclude that the extended effect of epidural anesthesia might be one of the mechanisms causing postoperative decubitus...
- Drug sensitivity-related benefit of systematic lymphadenectomy during cytoreductive surgery in optimally debulked stages IIIc and IV ovarian cancer
Seiji Isonishi
Department of Obstetrics and Gynecology, Jikei University School of Medicine, 4 11 1 Izumi honnchou, Komae, Tokyo 201 8601, Japan
Gynecol Oncol 93:647-52. 2004
....
- Favourable prognosis with modified dosing of docetaxel and cisplatin in Japanese patients with ovarian cancer
Daisuke Aoki
Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, 160 8582, Japan
Anticancer Res 29:561-6. 2009
..The long-term efficacy and safety of docetaxel/cisplatin as first-line chemotherapy in Japanese patients was evaluated in order to find an optional regimen for ovarian cancer...
- Side population is increased in paclitaxel-resistant ovarian cancer cell lines regardless of resistance to cisplatin
Yoichi Kobayashi
Department of Obstetrics and Gynecology, St Marianna University School of Medicine, Japan
Gynecol Oncol 121:390-4. 2011
....
- Short-term serum deprivation confers sensitivity to taxanes in platinum-resistant human ovarian cancer cells
Seiji Isonishi
Department of Obstetrics Gynecology, Jikei University Daisan Hospital, Izumi honnchou, Komae shi, Tokyo
Int J Gynecol Cancer 21:1547-54. 2011
..Based on the evidences showing that serum deprivation provokes apoptosis in a variety of cells, we have investigated the effect of serum deprivation on drug sensitivity...
- Analysis of prognostic factors for patients with leiomyoma treated with uterine arterial embolization
Seiji Isonishi
Department of Obstetrics and Gynecology, Jikei University School of Medicine, Aoto Hospital, Tokyo, Japan
Am J Obstet Gynecol 198:270.e1-6. 2008
..The objective of the study was to describe a clinically useful factors index predicting long-term efficacy of uterine artery embolization (UAE)...
- [Latest information in the diagnoses of ovarian carcinoma]
Seiji Isonishi
Dept. of Obstetrics and Gynecology, Jikei University School of Medicine
Gan To Kagaku Ryoho 29:1351-7. 2002
..The best selection for adjuvant chemotherapy is still controversial and a large number of studies are now ongoing...
- [Globalization of anti-cancer therapies]
Hideyuki Akaza
Dept. of Urology, Institute of Clinical Medicine, University of Tsukuba
Gan To Kagaku Ryoho 29:205-14. 2002
..There have been some recent improvements and further progress is expected so that Japanese doctors can play a full role in the evaluation of new therapies...
