Oxycodone overdose causes naloxone responsive coma and QT prolongationI Berling
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah, NSW, Australia
QJM 106:35-41. 2013
..Given the high prescription rate and increasing use of oxycodone, an understanding of its effects and treatment in overdose is necessary...
- Bites in Australian snake handlers--Australian snakebite project (ASP-15)
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Calvary Mater Newcastle, Waratah NSW 2298, Australia
QJM 105:1089-95. 2012
..Snakebites in snake handlers are an important clinical problem that may differ to bites in the general population...
A randomised controlled trial of two infusion rates to decrease reactions to antivenomGeoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, New South Wales, Australia
PLoS ONE 7:e38739. 2012
..This study aimed to investigate whether the rate of infusion of antivenom reduced the frequency of severe systemic hypersensitivity reactions...
- Restricting cough and cold medicines in children
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Calvary Mater Newcastle, Newcastle, Australia
J Paediatr Child Health 48:91-8. 2012
..We aimed to systematically review the evidence for the effectiveness and safety of cough and cold medicines in children...
- Indications for single-dose activated charcoal administration in acute overdose
Geoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle and Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
Curr Opin Crit Care 17:351-7. 2011
..There has been a significant decrease in the use of single-dose activated charcoal (SDAC) in recent years based on little new evidence and possibly because the overall mortality in overdose patients is low...
- How do we use drug concentration data to improve the treatment of overdose patients?
Geoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, University of Newcastle, New South Wales, Australia
Ther Drug Monit 32:300-4. 2010
..Using such an approach means that the use of drug concentration data in research will improve the risk assessment in overdose patients, without requiring these assays to be rapidly available in the acute health setting...
- Factor deficiencies in venom-induced consumption coagulopathy resulting from Australian elapid envenomation: Australian Snakebite Project (ASP-10)
G K Isbister
School of Medicine and Public Health, University of Newcastle, NSW, Australia
J Thromb Haemost 8:2504-13. 2010
..Limited information exists on the dynamics of hemostasis in patients with venom-induced consumption coagulopathy (VICC) from snake envenomation...
- Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study
Geoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia
Ann Emerg Med 56:392-401.e1. 2010
..We determine whether droperidol, midazolam, or the combination is more effective for intramuscular sedation in violent and acute behavioral disturbance in the emergency department (ED)...
- Spider bite
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
Lancet 378:2039-47. 2011
..Antivenoms are an important treatment for spider envenomation but have been less successful than have those for snake envenomation, with concerns about their effectiveness for both latrodectism and loxoscelism...
- Endogenous thrombin potential as a novel method for the characterization of procoagulant snake venoms and the efficacy of antivenom
Geoffrey K Isbister
Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia
Toxicon 56:75-85. 2010
..ETP is a useful assay to investigate mechanisms of other procoagulant venoms and is a robust method of assessing antivenom efficacy...
- Clinical effects and treatment of envenoming by Hoplocephalus spp. snakes in Australia: Australian Snakebite Project (ASP-12)
G K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Australia
Toxicon 58:634-40. 2011
..envenoming. Based on in vitro studies reported here, patients may be treated with one vial of TSAV, although one vial of brown snake antivenom may also be sufficient...
- Procoagulant snake toxins: laboratory studies, diagnosis, and understanding snakebite coagulopathy
Geoffrey K Isbister
Menzies School of Health Research, Charles Darwin University, Darwin, Australia
Semin Thromb Hemost 35:93-103. 2009
..A better understanding of the coagulation effects arising from human envenoming will also improve treatment with antivenom and define the role of adjuvant therapies such as factor replacement...
Current use of Australian snake antivenoms and frequency of immediate-type hypersensitivity reactions and anaphylaxisGeoffrey K Isbister
Menzies School of Health Research, Charles Darwin University, Darwin, NT
Med J Aust 188:473-6. 2008
..To investigate current use of Australian snake antivenoms and the frequency and severity of immediate-type hypersensitivity reactions...
- Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes
Geoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, Australia
J Clin Psychopharmacol 30:391-5. 2010
..Amisulpride overdose commonly causes QT prolongation, bradycardia, and hypotension. Torsades de pointes occurred commonly enough to suggest that amisulpride is highly cardiotoxic in overdose...
- Efficacy of antivenom against the procoagulant effect of Australian brown snake (Pseudonaja sp.) venom: in vivo and in vitro studies
Geoffrey K Isbister
Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NSW, Australia
Toxicon 49:57-67. 2007
..One vial of antivenom appears to be sufficient to bind and neutralise all venom in patients with severe brown snake envenoming...
- Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
J Toxicol Clin Toxicol 42:277-85. 2004
..Objective: To determine the effect of SSRIs in overdose, as a group, and the relative toxicity of five different SSRIs...
- Aspiration pneumonitis in an overdose population: frequency, predictors, and outcomes
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Australia
Crit Care Med 32:88-93. 2004
..Patients with aspiration pneumonitis have a significantly increased mortality and length of stay in the hospital...
- Death adder envenoming causes neurotoxicity not reversed by antivenom--Australian Snakebite Project (ASP-16)
Christopher I Johnston
School of Medicine Sydney, University of Notre Dame Australia, Darlinghurst, New South Wales, Australia
PLoS Negl Trop Dis 6:e1841. 2012
..Death adders (Acanthophis spp) are found in Australia, Papua New Guinea and parts of eastern Indonesia. This study aimed to investigate the clinical syndrome of death adder envenoming and response to antivenom treatment...
- The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department
Leonie A Calver
Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
BMC Emerg Med 10:14. 2010
..Acute behavioural disturbance (ABD) is an increasing problem in emergency departments. This study aimed to determine the impact of a structured intramuscular (IM) sedation protocol on the duration of ABD in the emergency department...
- Activated charcoal decreases the risk of QT prolongation after citalopram overdose
Geoffrey K Isbister
Menzies School of Health Research, Charles Darwin University, Darwin, Australia
Ann Emerg Med 50:593-600, 600.e1-46. 2007
..We determine whether single-dose activated charcoal (SDAC) administration after citalopram overdose reduces the proportion of patients developing abnormal QT prolongation...
- Funnel-web spider bite: a systematic review of recorded clinical cases
Geoffrey K Isbister
Menzies School of Health Research, Charles Darwin University, Darwin, NT
Med J Aust 182:407-11. 2005
..To investigate species-specific envenoming rates and spectrum of severity of funnel-web spider bites, and the efficacy and adverse effects of funnel-web spider antivenom...
- Antivenom efficacy or effectiveness: the Australian experience
Geoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia
Toxicology 268:148-54. 2010
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- Human anti-snake venom IgG antibodies in a previously bitten snake-handler, but no protection against local envenoming
Geoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, New South Wales, Australia
Toxicon 55:646-9. 2010
..However, despite the presence of antibodies to death adder venom and free venom not being detected, the patient still developed significant local myotoxicity...
- Clinically applicable laboratory end-points for treating snakebite coagulopathy
Geoffrey K Isbister
Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
Pathology 38:568-72. 2006
..To determine which coagulation tests best reflect the return of clotting function after snakebite venom induced consumptive coagulopathy (VICC)...
- An examination of the activity of expired and mistreated commercial Australian antivenoms
Margaret A O'Leary
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
Trans R Soc Trop Med Hyg 103:937-42. 2009
..CSL antivenoms are more robust than indicated on their label and maintain useful activity long past their nominated expiry dates...
- Latrodectism: a prospective cohort study of bites by formally identified redback spiders
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298
Med J Aust 179:88-91. 2003
..To determine the spectrum of severity and early diagnostic predictors of redback spider bites (Latrodectus hasselti), and to examine the effect of intramuscular redback antivenom...
- Cross-neutralisation of Australian brown snake, taipan and death adder venoms by monovalent antibodies
Geoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
Vaccine 28:798-802. 2010
..However, they did cross-neutralise the procoagulant effects of both procoagulant venoms. This supports the idea of developing antivenoms against groups of snake toxins rather than individual snake venoms...
- Digital Holter measurement of QT prolongation in ziprasidone overdose
Ingrid Berling
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, Australia
Clin Toxicol (Phila) 49:694-6. 2011
..We report a case of ziprasidone overdose with QT prolongation, demonstrating different methods of measuring the QT interval...
- Sedation assessment tool to score acute behavioural disturbance in the emergency department
Leonie A Calver
Discipline of Clinical Pharmacology, Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia
Emerg Med Australas 23:732-40. 2011
..The objective of the study was to evaluate the effectiveness of the sedation assessment tool (SAT) in assessing patient response to treatment for acute behavioural disturbance (ABD)...
- Inter-rater reliability of manual QT measurement and prediction of abnormal QT,HR pairs
Geoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Waratah, NSW, Australia geoffrey isbister menzies edu au
Clin Toxicol (Phila) 47:884-8. 2009
..To assess interobserver agreement when trained healthcare staff measure the QT interval using a standardized approach across a range of QT lengths...
- Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures?
Margaret A O'Leary
Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, Newcastle, NSW, Australia
Toxicon 50:206-13. 2007
..Single-polyvalent antivenom for brown snake and tiger snake may be feasible in the future...
- Structured team approach to the agitated patient in the emergency department
Michael A Downes
Emergency Department, Calvary Mater Newcastle Hospital, Waratah, New South Wales
Emerg Med Australas 21:196-202. 2009
..Behavioural disturbance and aggression in the ED is an increasing problem. The present study describes the characteristics of patients with acute behavioural disturbance and their emergent treatment in an ED with a structured team approach...
- Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13)
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW
Med J Aust 197:173-7. 2012
..To describe the clinical syndrome associated with definite tiger snake (Notechis spp) envenoming and to examine the ability of tiger snake antivenom (TSAV) to bind free venom in vivo...
- Risperidone overdose causes extrapyramidal effects but not cardiac toxicity
Colin B Page
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
J Clin Psychopharmacol 30:387-90. 2010
..The aim of this study was to describe the clinical and electrocardiographic features of risperidone overdose, including the frequency of dystonic reactions...
- A randomised controlled trial of hot water (45 degrees C) immersion versus ice packs for pain relief in bluebottle stings
Conrad Loten
Hunter New England Area Health Service, Newcastle, NSW
Med J Aust 184:329-33. 2006
..039). Systemic effects were uncommon in both groups. CONCLUSIONS: Immersion in water at 45 degrees C for 20 minutes is an effective and practical treatment for pain from bluebottle stings...
- The dark side of the moon
Leonie A Calver
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
Med J Aust 191:692-4. 2009
..We investigated the possibility that there is an association between only extreme behavioural disturbance and the full moon...
- Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal
Geoffrey K Isbister
aDepartment of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, Australia
Int Clin Psychopharmacol 24:174-80. 2009
..SDAC seems to have only modest effects on outcomes but may be considered within 2 h for large ingestions. Electrocardiogram monitoring is unlikely to be necessary...
- White-tail spider bite: a prospective study of 130 definite bites by Lampona species
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Australia
Med J Aust 179:199-202. 2003
..To investigate the circumstances and clinical effects of bites by white-tail spiders, including the two species Lampona cylindrata and L. murina commonly encountered by humans, and the incidence of necrotic lesions...
- Baclofen overdose: defining the spectrum of toxicity
Nicola Y Leung
Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
Emerg Med Australas 18:77-82. 2006
..Doses greater than 200 mg were predictive of patients developing delirium, coma and seizures, requiring long hospital admissions and ICU admission...
- A prospective study of definite bites by spiders of the family Sparassidae (huntsmen spiders) with identification to species level
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Clinical Toxicologist and Emergency Physician, Newcastle Mater Misericordiae Hospital, Level 5, Clinical Sciences Building Edith St, Waratah, NSW 2298, Australia
Toxicon 42:163-71. 2003
..The mechanism of effects appeared to be trauma rather than envenoming. There were no major differences between genera, and Neosparassus spp. did not cause major effects...
- Effects of envenoming by comb-footed spiders of the genera Steatoda and Achaearanea (family Theridiidae: Araneae) in Australia
Geoffrey K Isbister
University of Newcastle, Newcastle, Australia
J Toxicol Clin Toxicol 41:809-19. 2003
..The family Theridiidae (comb-footed spiders) contains the well-known and medically important widow spider group (Latrodectus spp.). Little is known about the effects of envenoming by other common members of this family...
- Arsenic trioxide poisoning: a description of two acute overdoses
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
Hum Exp Toxicol 23:359-64. 2004
..Arsenic quantification in blood, urine and faeces suggested that enhanced gastrointestinal decontamination was minimally effective for decontamination and that DMSA for at least two weeks was required...
- A turbidimetric assay for the measurement of clotting times of procoagulant venoms in plasma
Margaret A O'Leary
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
J Pharmacol Toxicol Methods 61:27-31. 2010
..Assessment of the procoagulant effect of snake venoms is important for understanding their effects. The aim of this study was to develop a simple automated method to measure clotting times to assess procoagulant venoms...
- Necrotic arachnidism: the mythology of a modern plague
Geoffrey K Isbister
Clinical Envenoming Research Group, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah NSW 2298, Australia
Lancet 364:549-53. 2004
- Moclobemide poisoning: toxicokinetics and occurrence of serotonin toxicity
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Australia
Br J Clin Pharmacol 56:441-50. 2003
..To investigate the spectrum of toxicity of moclobemide overdose, the occurrence of serotonin toxicity, and to estimate toxicokinetic parameters...
- A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom
Geoffrey K Isbister
Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
Br J Clin Pharmacol 65:139-43. 2008
..There are no studies measuring antivenom concentrations following intramuscular administration. This study aimed to compare antivenom concentrations following intravenous and intramuscular administration of redback spider antivenom (RBSAV)...
- Investigating pressure bandaging for snakebite in a simulated setting: bandage type, training and the effect of transport
Elizabeth Canale
Tropical Toxinology Program, Menzies School of Health Research, Charles Darwin University, and Northern Territory Clinical School, Royal Darwin Hospital, Darwin, Northern Territory, Australia
Emerg Med Australas 21:184-90. 2009
..The clinical evidence base for the use of pressure bandaging in snakebite is limited. We aimed to investigate if pressure bandages (PB) generated and maintained presumptive optimal pressures in a simulated setting...
- Clinical consequences of spider bites: recent advances in our understanding
Geoffrey K Isbister
Emergency Department, Newcastle Mater Misericordiae Hospital and the University of Newcastle, Newcastle, NSW 2298, Australia
Toxicon 43:477-92. 2004
..Most spiders only cause minor effects, including a large number of groups that have been implicated in necrotic arachnidism...
- Bupropion overdose: QTc prolongation and its clinical significance
Geoffrey K Isbister
University of Newcastle, Waratah, Australia
Ann Pharmacother 37:999-1002. 2003
..To investigate the cardiotoxicity of bupropion hydrochloride in deliberate self-poisoning...
- Dexmedetomidine in the emergency department: assessing safety and effectiveness in difficult-to-sedate acute behavioural disturbance
Leonie Calver
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, New South Wales, Australia
Emerg Med J 29:915-8. 2012
..To investigate the safety and effectiveness of dexmedetomidine for sedating patients in whom previous attempts at sedation in the emergency department have failed...
- Two cases of bites by the black-bellied swamp snake (Hemiaspis signata)
Geoffrey K Isbister
Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Locked Bag 7, Hunter Region Main Centre, Newcastle, NSW 2310, Australia
Toxicon 40:317-9. 2002
..These cases indicate the potential for coagulopathy and local symptoms following bites by large specimens of H. signata in young children...
- Failure of intramuscular antivenom in Red-back spider envenoming
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Hospital, Edith St, Waratah NSW 2298, Australia
Emerg Med (Fremantle) 14:436-9. 2002
..Controlled studies should be undertaken to establish the effectiveness of intravenous and intramuscular Red-back antivenom...
- Developing a decision tree algorithm for the diagnosis of suspected spider bites
Geoffrey K Isbister
Emergency Department, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
Emerg Med Australas 16:161-6. 2004
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- Bites by spiders of the family Theraphosidae in humans and canines
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Waratah, NSW 2298, Australia
Toxicon 41:519-24. 2003
..Bites by these spiders are unlikely to cause major problems in humans. The study also demonstrates that the venom is far more toxic to canines...
- Alprazolam is relatively more toxic than other benzodiazepines in overdose
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Australia
Br J Clin Pharmacol 58:88-95. 2004
..To describe alprazolam poisoning and the relative toxicity of alprazolam compared with other benzodiazepines...
- Serotonin toxicity: a practical approach to diagnosis and treatment
Geoffrey K Isbister
Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
Med J Aust 187:361-5. 2007
..Treatment should focus on cessation of the serotonergic medication and supportive care. Some antiserotonergic agents have been used in clinical practice, but the preferred agent, dose and indications are not well defined...
- 'Red as a beet and blind as a bat' Anticholinergic delirium in adolescents: lessons for the paediatrician
Kim A Ramjan
The Children s Hospital at Westmead, Westmead, New South Wales, Australia
J Paediatr Child Health 43:779-80. 2007
..A high index of suspicion is often required in the paediatric setting due to infrequent acute hospital presentation...
- Australian scorpion stings: a prospective study of definite stings
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Clinical Sciences Building, Level 5 Edith Street, Waratah, NSW 2298, Australia
Toxicon 41:877-83. 2003
..This differs from other parts of the world, where severe envenoming is reported. The major clinical effect is severe pain, consistent with other scorpion stings. Most stings occurred indoors and at night...
- A pharmacological approach to first aid treatment for snakebite
Megan E Saul
Department of Nuclear Medicine, John Hunter Hospital, New Lambton, New South Wales, Australia
Nat Med 17:809-11. 2011
..This pharmacological approach should give snakebite victims more time to obtain medical care and antivenom treatment...
- Clinical effects of red-bellied black snake (Pseudechis porphyriacus) envenoming and correlation with venom concentrations: Australian Snakebite Project (ASP-11)
Andrew Churchman
Emergency Department, Princess Alexandra Hospital, Brisbane, QLD, Australia
Med J Aust 193:696-700. 2010
..To describe the clinical features and laboratory findings in patients with definite red-bellied black snake (RBBS; Pseudechis porphyriacus) bites, including correlation with results of venom assays...
- Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
Emerg Med (Fremantle) 15:376-82. 2003
..To investigate the pattern and epidemiology of anticholinergic plant poisoning, and to characterize its time course and clinical features...
- Intentional warfarin overdose
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, New South Wales, Australia
Ther Drug Monit 25:715-22. 2003
..Titrating intravenous vitamin K with doses of 0.5 to 2.0 mg when INR > 5 is appropriate to reduce INR without causing warfarin resistance. The high-risk group must be kept anticoagulated, and warfarin resistance avoided...
- Nefazodone poisoning: toxicokinetics and toxicodynamics using continuous data collection
Geoffrey K Isbister
University of Newcastle, Newcastle, Australia
J Toxicol Clin Toxicol 41:167-73. 2003
..Bradycardia, hypotension, and drowsiness are the most significant effects and are maximal in the first 12 hours when parent and metabolite concentrations are high...
- Spotted black snake (Pseudechis guttatus) envenoming
Melanie Jansen
School of Medical Practice and Population Health, University of Newcastle, Newcastle, NSW, Australia
Med J Aust 186:41-2. 2007
..Neither patient developed significant coagulopathy, myolysis or neuromuscular paralysis. Bites by this species appear to cause effects similar to those of the more common red-bellied black snake (P. porphyriacus)...
- Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes
Geoffrey K Isbister
Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NT
Med J Aust 184:354-6. 2006
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- Enzyme immunoassays in brown snake (Pseudonaja spp.) envenoming: detecting venom, antivenom and venom-antivenom complexes
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Waratah NSW, Australia
Toxicon 48:4-11. 2006
..Quantification of venom and antivenom will help to determine the dose of antivenom required to bind venom and to establish appropriate end points for antivenom treatment...
- Application of pharmacokinetic-pharmacodynamic modelling in management of QT abnormalities after citalopram overdose
Geoffrey K Isbister
Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
Intensive Care Med 32:1060-5. 2006
..To develop guidelines for the management of QT prolongation after citalopram overdose, including decontamination with single-dose activated charcoal (SDAC) and cardiac monitoring...
- Electrocardiogram changes and arrhythmias in venlafaxine overdose
Geoffrey K Isbister
Charles Darwin University, Darwin and Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Waratah, Australia
Br J Clin Pharmacol 67:572-6. 2009
..To investigate serial electrocardiogram (ECG) parameters, haemodynamic changes and arrhythmias following venlafaxine overdose...
- The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: a case report
Colin Page
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
J Med Toxicol 5:139-43. 2009
..Although the metoprolol concentrations measured in plasma were approximately 100-200 times therapeutic concentrations, the pharmacokinetics appeared to be similar to therapeutic metoprolol dosing...
- Australian wolf spider bites (Lycosidae): clinical effects and influence of species on bite circumstances
Geoffrey K Isbister
Discipline of Clinical Pharmacology, Newcastle Mater Misericordiae Hospital, University of Newcastle, Waratah, New South Wales, Australia
J Toxicol Clin Toxicol 42:153-61. 2004
..Necrotic arachnidism continues to be attributed to wolf spider bites. This study investigates the clinical effects of bites by wolf spiders in Australia (family Lycosidae)...
- Suspected snakebite: one year prospective study of emergency department presentations
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle and Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
Emerg Med (Fremantle) 15:160-9. 2003
..Snakebite is an uncommon, but potentially life-threatening condition. The more common clinical scenario is suspected snake-bite. Our aim was to characterise the epidemiology, diagnosis and management of patients with suspected snakebites...
- Valproate overdose: a comparative cohort study of self poisonings
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Newcastle, Australia
Br J Clin Pharmacol 55:398-404. 2003
..Based on individual case reports of massive overdoses, valproate is often regarded as having significant toxicity. This study aimed to describe the epidemiology of valproate poisoning and the spectrum of its clinical effects...
- Emergency department performance indicators that encompass the patient journey
David Sibbritt
School of Medical Practice and Population Health, University of Newcastle, New South Wales, Australia
Qual Manag Health Care 15:27-38. 2006
..The study aimed to provide a recommended list of performance indicators from routinely collected data that measure most aspects of the patient journey through the emergency department (ED)...
- Antivenom treatment in arachnidism
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle and Newcastle Mater Misericordiae Hospital, Newcastle, NSW, Australia
J Toxicol Clin Toxicol 41:291-300. 2003
..Although envenomation from arthropods is common, no antivenoms exist for these, excepting Lonomia caterpillars in South America, and Ixodes paralysis ticks in Australia...
- Commercial monovalent antivenoms in Australia are polyvalent
Margaret A O'Leary
Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
Toxicon 54:192-5. 2009
..However, it would be possible for the manufacturer to reduce the number of types of snake antivenoms available in Australia to two polyvalent antivenoms which would simplify treatment of snakebite...
- Acute conjunctival inflammation following contact with squashed spider contents
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, and Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
Am J Ophthalmol 136:563-4. 2003
..To report the effects to the eye following contact with spider contents...
- Antivenom, anecdotes and evidence
Geoffrey K Isbister
Emergency Department, Newcastle Mater Misericordiae Hospital, NSW
Med J Aust 181:685-6. 2004
- Snakebite doesn't cause disseminated intravascular coagulation: coagulopathy and thrombotic microangiopathy in snake envenoming
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, and Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah NSW, Australia
Semin Thromb Hemost 36:444-51. 2010
..The existence of the overlapping clinical syndromes of VICC and thrombotic microangiopathy in snake envenoming is the likely reason for the mistaken idea that snakebite causes DIC...
- Changes in serial laboratory test results in snakebite patients: when can we safely exclude envenoming?
Graham Ireland
Emergency Department, Gold Coast Hospital, Gold Coast, QLD, Australia
Med J Aust 193:285-90. 2010
....
- Envenoming by the rough-scaled snake (Tropidechis carinatus): a series of confirmed cases
Melissa Gan
Emergency Department, Gold Coast Hospital, Gold Coast, QLD, Australia
Med J Aust 191:183-6. 2009
..To describe demographic, geographical and clinical features of envenoming by the rough-scaled snake (RSS) (Tropidechis carinatus)...
- Effectiveness of pressure-immobilization first aid for snakebite requires further study
Bart J Currie
Tropical Toxinology Program, Menzies School of Health Research, Charles Darwin University, Northern Territory, Australia
Emerg Med Australas 20:267-70. 2008
....
- Acute allergic reaction following contact with a spider
Geoffrey K Isbister
Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Level 5, Clinical Sciences Building, Edith Street, Waratah, NSW 2298, Australia
Toxicon 40:1495-7. 2002
..He recovered within 6 h and had no further problems. The early allergic reaction in this case was most likely the result of contact with the spider...
- Reviewing deaths in the emergency department: deaths in the department or deaths within 48 h
Sally Clunas
Emergency Department, John Hunter Hospital, Newcastle, NSW, Australia
Emerg Med Australas 21:117-23. 2009
..To investigate an ED death audit process that included deaths occurring within 48 h of admission in addition to deaths in the ED...
- Investigating the relationship between emergency departments and complementary and alternative medicine use in Australia
Geoffrey K Isbister
Emergency Department, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
Emerg Med Australas 16:378-81. 2004
- Pharmacokinetic-pharmacodynamic modelling of QT interval prolongation following citalopram overdoses
Lena E Friberg
School of Pharmacy, University of Queensland, Brisbane, Australia
Br J Clin Pharmacol 61:177-90. 2006
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