Geoffrey K Isbister

Summary

Publications

  1. pmc A prospective study of high dose sedation for rapid tranquilisation of acute behavioural disturbance in an acute mental health unit
    Leonie Calver
    Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
    BMC Psychiatry 13:225. 2013
  2. ncbi request reprint Snakebite in Australia: a practical approach to diagnosis and treatment
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
    Med J Aust 199:763-8. 2013
  3. doi request reprint Diagnostic 20-min whole blood clotting test in Russell's viper envenoming delays antivenom administration
    G K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Edith St, Waratah, NSW 2298, Australia
    QJM 106:925-32. 2013
  4. doi request reprint A randomized controlled trial of fresh frozen plasma for treating venom-induced consumption coagulopathy in cases of Australian snakebite (ASP-18)
    G K Isbister
    Department of Clinical Toxicology and Pharmacology, School of Medicine and Public Health, University of Newcastle, Calvary Mater Newcastle, Newcastle, NSW, Australia
    J Thromb Haemost 11:1310-8. 2013
  5. pmc Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW 2298, Australia
    Br J Clin Pharmacol 76:48-57. 2013
  6. doi request reprint Bites in Australian snake handlers--Australian snakebite project (ASP-15)
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Calvary Mater Newcastle, Waratah NSW 2298, Australia
    QJM 105:1089-95. 2012
  7. doi request reprint Oxycodone overdose causes naloxone responsive coma and QT prolongation
    I Berling
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah, NSW, Australia
    QJM 106:35-41. 2013
  8. pmc A randomised controlled trial of two infusion rates to decrease reactions to antivenom
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, New South Wales, Australia
    PLoS ONE 7:e38739. 2012
  9. doi request reprint Restricting cough and cold medicines in children
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Calvary Mater Newcastle, Newcastle, Australia
    J Paediatr Child Health 48:91-8. 2012
  10. doi request reprint Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia
    Ann Emerg Med 56:392-401.e1. 2010

Collaborators

Detail Information

Publications91

  1. pmc A prospective study of high dose sedation for rapid tranquilisation of acute behavioural disturbance in an acute mental health unit
    Leonie Calver
    Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
    BMC Psychiatry 13:225. 2013
    ..This study aimed to investigate sedation for ABD in an acute mental healthcare unit, including the effectiveness and safety of high dose sedation...
  2. ncbi request reprint Snakebite in Australia: a practical approach to diagnosis and treatment
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
    Med J Aust 199:763-8. 2013
    ..However, recovery may be delayed as many clinical and laboratory effects of venom are not immediately reversible. For expert advice on envenoming, contact the National Poisons Information Centre on 13 11 26...
  3. doi request reprint Diagnostic 20-min whole blood clotting test in Russell's viper envenoming delays antivenom administration
    G K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Edith St, Waratah, NSW 2298, Australia
    QJM 106:925-32. 2013
    ..The 20-min whole blood clotting test (WBCT20) is widely used for the identification of coagulopathy in snake envenoming, but its performance in practice has not been evaluated...
  4. doi request reprint A randomized controlled trial of fresh frozen plasma for treating venom-induced consumption coagulopathy in cases of Australian snakebite (ASP-18)
    G K Isbister
    Department of Clinical Toxicology and Pharmacology, School of Medicine and Public Health, University of Newcastle, Calvary Mater Newcastle, Newcastle, NSW, Australia
    J Thromb Haemost 11:1310-8. 2013
    ..Venom-induced consumption coagulopathy (VICC) is a major effect of snake envenoming...
  5. pmc Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW 2298, Australia
    Br J Clin Pharmacol 76:48-57. 2013
    ..This risk assessment then allows the safer commencement of drugs therapeutically or management of drug induced effects in overdose...
  6. doi request reprint Bites in Australian snake handlers--Australian snakebite project (ASP-15)
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Calvary Mater Newcastle, Waratah NSW 2298, Australia
    QJM 105:1089-95. 2012
    ..Snakebites in snake handlers are an important clinical problem that may differ to bites in the general population...
  7. doi request reprint Oxycodone overdose causes naloxone responsive coma and QT prolongation
    I Berling
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah, NSW, Australia
    QJM 106:35-41. 2013
    ..Given the high prescription rate and increasing use of oxycodone, an understanding of its effects and treatment in overdose is necessary...
  8. pmc A randomised controlled trial of two infusion rates to decrease reactions to antivenom
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, New South Wales, Australia
    PLoS ONE 7:e38739. 2012
    ..This study aimed to investigate whether the rate of infusion of antivenom reduced the frequency of severe systemic hypersensitivity reactions...
  9. doi request reprint Restricting cough and cold medicines in children
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Calvary Mater Newcastle, Newcastle, Australia
    J Paediatr Child Health 48:91-8. 2012
    ..We aimed to systematically review the evidence for the effectiveness and safety of cough and cold medicines in children...
  10. doi request reprint Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia
    Ann Emerg Med 56:392-401.e1. 2010
    ..We determine whether droperidol, midazolam, or the combination is more effective for intramuscular sedation in violent and acute behavioral disturbance in the emergency department (ED)...
  11. doi request reprint Factor deficiencies in venom-induced consumption coagulopathy resulting from Australian elapid envenomation: Australian Snakebite Project (ASP-10)
    G K Isbister
    School of Medicine and Public Health, University of Newcastle, NSW, Australia
    J Thromb Haemost 8:2504-13. 2010
    ..Limited information exists on the dynamics of hemostasis in patients with venom-induced consumption coagulopathy (VICC) from snake envenomation...
  12. doi request reprint Endogenous thrombin potential as a novel method for the characterization of procoagulant snake venoms and the efficacy of antivenom
    Geoffrey K Isbister
    Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia
    Toxicon 56:75-85. 2010
    ..ETP is a useful assay to investigate mechanisms of other procoagulant venoms and is a robust method of assessing antivenom efficacy...
  13. doi request reprint How do we use drug concentration data to improve the treatment of overdose patients?
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, University of Newcastle, New South Wales, Australia
    Ther Drug Monit 32:300-4. 2010
    ..Using such an approach means that the use of drug concentration data in research will improve the risk assessment in overdose patients, without requiring these assays to be rapidly available in the acute health setting...
  14. doi request reprint Procoagulant snake toxins: laboratory studies, diagnosis, and understanding snakebite coagulopathy
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Semin Thromb Hemost 35:93-103. 2009
    ..A better understanding of the coagulation effects arising from human envenoming will also improve treatment with antivenom and define the role of adjuvant therapies such as factor replacement...
  15. doi request reprint Indications for single-dose activated charcoal administration in acute overdose
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle and Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
    Curr Opin Crit Care 17:351-7. 2011
    ..There has been a significant decrease in the use of single-dose activated charcoal (SDAC) in recent years based on little new evidence and possibly because the overall mortality in overdose patients is low...
  16. doi request reprint Spider bite
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
    Lancet 378:2039-47. 2011
    ..Antivenoms are an important treatment for spider envenomation but have been less successful than have those for snake envenomation, with concerns about their effectiveness for both latrodectism and loxoscelism...
  17. doi request reprint Clinical effects and treatment of envenoming by Hoplocephalus spp. snakes in Australia: Australian Snakebite Project (ASP-12)
    G K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Australia
    Toxicon 58:634-40. 2011
    ..envenoming. Based on in vitro studies reported here, patients may be treated with one vial of TSAV, although one vial of brown snake antivenom may also be sufficient...
  18. ncbi request reprint Current use of Australian snake antivenoms and frequency of immediate-type hypersensitivity reactions and anaphylaxis
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, NT
    Med J Aust 188:473-6. 2008
    ..To investigate current use of Australian snake antivenoms and the frequency and severity of immediate-type hypersensitivity reactions...
  19. doi request reprint Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, Australia
    J Clin Psychopharmacol 30:391-5. 2010
    ..Amisulpride overdose commonly causes QT prolongation, bradycardia, and hypotension. Torsades de pointes occurred commonly enough to suggest that amisulpride is highly cardiotoxic in overdose...
  20. ncbi request reprint Efficacy of antivenom against the procoagulant effect of Australian brown snake (Pseudonaja sp.) venom: in vivo and in vitro studies
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NSW, Australia
    Toxicon 49:57-67. 2007
    ..One vial of antivenom appears to be sufficient to bind and neutralise all venom in patients with severe brown snake envenoming...
  21. ncbi request reprint Activated charcoal decreases the risk of QT prolongation after citalopram overdose
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Ann Emerg Med 50:593-600, 600.e1-46. 2007
    ..We determine whether single-dose activated charcoal (SDAC) administration after citalopram overdose reduces the proportion of patients developing abnormal QT prolongation...
  22. pmc Death adder envenoming causes neurotoxicity not reversed by antivenom--Australian Snakebite Project (ASP-16)
    Christopher I Johnston
    School of Medicine Sydney, University of Notre Dame Australia, Darlinghurst, New South Wales, Australia
    PLoS Negl Trop Dis 6:e1841. 2012
    ..Death adders (Acanthophis spp) are found in Australia, Papua New Guinea and parts of eastern Indonesia. This study aimed to investigate the clinical syndrome of death adder envenoming and response to antivenom treatment...
  23. ncbi request reprint Aspiration pneumonitis in an overdose population: frequency, predictors, and outcomes
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Australia
    Crit Care Med 32:88-93. 2004
    ....
  24. ncbi request reprint Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    J Toxicol Clin Toxicol 42:277-85. 2004
    ..Objective: To determine the effect of SSRIs in overdose, as a group, and the relative toxicity of five different SSRIs...
  25. doi request reprint Inter-rater reliability of manual QT measurement and prediction of abnormal QT,HR pairs
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Waratah, NSW, Australia geoffrey isbister menzies edu au
    Clin Toxicol (Phila) 47:884-8. 2009
    ..To assess interobserver agreement when trained healthcare staff measure the QT interval using a standardized approach across a range of QT lengths...
  26. ncbi request reprint Latrodectism: a prospective cohort study of bites by formally identified redback spiders
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298
    Med J Aust 179:88-91. 2003
    ..To determine the spectrum of severity and early diagnostic predictors of redback spider bites (Latrodectus hasselti), and to examine the effect of intramuscular redback antivenom...
  27. pmc The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department
    Leonie A Calver
    Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
    BMC Emerg Med 10:14. 2010
    ..Acute behavioural disturbance (ABD) is an increasing problem in emergency departments. This study aimed to determine the impact of a structured intramuscular (IM) sedation protocol on the duration of ABD in the emergency department...
  28. doi request reprint Antivenom efficacy or effectiveness: the Australian experience
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia
    Toxicology 268:148-54. 2010
    ....
  29. ncbi request reprint Funnel-web spider bite: a systematic review of recorded clinical cases
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, NT
    Med J Aust 182:407-11. 2005
    ..To investigate species-specific envenoming rates and spectrum of severity of funnel-web spider bites, and the efficacy and adverse effects of funnel-web spider antivenom...
  30. doi request reprint Human anti-snake venom IgG antibodies in a previously bitten snake-handler, but no protection against local envenoming
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, New South Wales, Australia
    Toxicon 55:646-9. 2010
    ..However, despite the presence of antibodies to death adder venom and free venom not being detected, the patient still developed significant local myotoxicity...
  31. ncbi request reprint Effects of envenoming by comb-footed spiders of the genera Steatoda and Achaearanea (family Theridiidae: Araneae) in Australia
    Geoffrey K Isbister
    University of Newcastle, Newcastle, Australia
    J Toxicol Clin Toxicol 41:809-19. 2003
    ..The family Theridiidae (comb-footed spiders) contains the well-known and medically important widow spider group (Latrodectus spp.). Little is known about the effects of envenoming by other common members of this family...
  32. doi request reprint Sedation assessment tool to score acute behavioural disturbance in the emergency department
    Leonie A Calver
    Discipline of Clinical Pharmacology, Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia
    Emerg Med Australas 23:732-40. 2011
    ..The objective of the study was to evaluate the effectiveness of the sedation assessment tool (SAT) in assessing patient response to treatment for acute behavioural disturbance (ABD)...
  33. doi request reprint An examination of the activity of expired and mistreated commercial Australian antivenoms
    Margaret A O'Leary
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    Trans R Soc Trop Med Hyg 103:937-42. 2009
    ..CSL antivenoms are more robust than indicated on their label and maintain useful activity long past their nominated expiry dates...
  34. ncbi request reprint Clinically applicable laboratory end-points for treating snakebite coagulopathy
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Pathology 38:568-72. 2006
    ..To determine which coagulation tests best reflect the return of clotting function after snakebite venom induced consumptive coagulopathy (VICC)...
  35. doi request reprint Digital Holter measurement of QT prolongation in ziprasidone overdose
    Ingrid Berling
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, Australia
    Clin Toxicol (Phila) 49:694-6. 2011
    ..We report a case of ziprasidone overdose with QT prolongation, demonstrating different methods of measuring the QT interval...
  36. doi request reprint Cross-neutralisation of Australian brown snake, taipan and death adder venoms by monovalent antibodies
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    Vaccine 28:798-802. 2010
    ..However, they did cross-neutralise the procoagulant effects of both procoagulant venoms. This supports the idea of developing antivenoms against groups of snake toxins rather than individual snake venoms...
  37. doi request reprint A turbidimetric assay for the measurement of clotting times of procoagulant venoms in plasma
    Margaret A O'Leary
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    J Pharmacol Toxicol Methods 61:27-31. 2010
    ..Assessment of the procoagulant effect of snake venoms is important for understanding their effects. The aim of this study was to develop a simple automated method to measure clotting times to assess procoagulant venoms...
  38. pmc Moclobemide poisoning: toxicokinetics and occurrence of serotonin toxicity
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Australia
    Br J Clin Pharmacol 56:441-50. 2003
    ..To investigate the spectrum of toxicity of moclobemide overdose, the occurrence of serotonin toxicity, and to estimate toxicokinetic parameters...
  39. ncbi request reprint Enzyme immunoassays in brown snake (Pseudonaja spp.) envenoming: detecting venom, antivenom and venom-antivenom complexes
    Margaret A O'Leary
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Waratah NSW, Australia
    Toxicon 48:4-11. 2006
    ..Quantification of venom and antivenom will help to determine the dose of antivenom required to bind venom and to establish appropriate end points for antivenom treatment...
  40. doi request reprint Structured team approach to the agitated patient in the emergency department
    Michael A Downes
    Emergency Department, Calvary Mater Newcastle Hospital, Waratah, New South Wales
    Emerg Med Australas 21:196-202. 2009
    ..Behavioural disturbance and aggression in the ED is an increasing problem. The present study describes the characteristics of patients with acute behavioural disturbance and their emergent treatment in an ED with a structured team approach...
  41. ncbi request reprint Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures?
    Margaret A O'Leary
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, Newcastle, NSW, Australia
    Toxicon 50:206-13. 2007
    ..Single-polyvalent antivenom for brown snake and tiger snake may be feasible in the future...
  42. ncbi request reprint Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13)
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW
    Med J Aust 197:173-7. 2012
    ..To describe the clinical syndrome associated with definite tiger snake (Notechis spp) envenoming and to examine the ability of tiger snake antivenom (TSAV) to bind free venom in vivo...
  43. doi request reprint Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal
    Geoffrey K Isbister
    aDepartment of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, Australia
    Int Clin Psychopharmacol 24:174-80. 2009
    ..SDAC seems to have only modest effects on outcomes but may be considered within 2 h for large ingestions. Electrocardiogram monitoring is unlikely to be necessary...
  44. ncbi request reprint The dark side of the moon
    Leonie A Calver
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
    Med J Aust 191:692-4. 2009
    ..We investigated the possibility that there is an association between only extreme behavioural disturbance and the full moon...
  45. doi request reprint Risperidone overdose causes extrapyramidal effects but not cardiac toxicity
    Colin B Page
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    J Clin Psychopharmacol 30:387-90. 2010
    ..The aim of this study was to describe the clinical and electrocardiographic features of risperidone overdose, including the frequency of dystonic reactions...
  46. ncbi request reprint A randomised controlled trial of hot water (45 degrees C) immersion versus ice packs for pain relief in bluebottle stings
    Conrad Loten
    Hunter New England Area Health Service, Newcastle, NSW
    Med J Aust 184:329-33. 2006
    ..To investigate the effectiveness of hot water immersion for the treatment of Physalia sp. (bluebottle or Portuguese Man-of-War) stings...
  47. ncbi request reprint A prospective study of definite bites by spiders of the family Sparassidae (huntsmen spiders) with identification to species level
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Clinical Toxicologist and Emergency Physician, Newcastle Mater Misericordiae Hospital, Level 5, Clinical Sciences Building Edith St, Waratah, NSW 2298, Australia
    Toxicon 42:163-71. 2003
    ..The mechanism of effects appeared to be trauma rather than envenoming. There were no major differences between genera, and Neosparassus spp. did not cause major effects...
  48. ncbi request reprint White-tail spider bite: a prospective study of 130 definite bites by Lampona species
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Australia
    Med J Aust 179:199-202. 2003
    ..To investigate the circumstances and clinical effects of bites by white-tail spiders, including the two species Lampona cylindrata and L. murina commonly encountered by humans, and the incidence of necrotic lesions...
  49. ncbi request reprint Baclofen overdose: defining the spectrum of toxicity
    Nicola Y Leung
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    Emerg Med Australas 18:77-82. 2006
    ..To describe the spectrum of toxicity of baclofen in overdose, and investigate dose-related clinical effects...
  50. ncbi request reprint Necrotic arachnidism: the mythology of a modern plague
    Geoffrey K Isbister
    Clinical Envenoming Research Group, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah NSW 2298, Australia
    Lancet 364:549-53. 2004
  51. ncbi request reprint Arsenic trioxide poisoning: a description of two acute overdoses
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
    Hum Exp Toxicol 23:359-64. 2004
    ..Arsenic quantification in blood, urine and faeces suggested that enhanced gastrointestinal decontamination was minimally effective for decontamination and that DMSA for at least two weeks was required...
  52. ncbi request reprint Bupropion overdose: QTc prolongation and its clinical significance
    Geoffrey K Isbister
    University of Newcastle, Waratah, Australia
    Ann Pharmacother 37:999-1002. 2003
    ..To investigate the cardiotoxicity of bupropion hydrochloride in deliberate self-poisoning...
  53. pmc A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Br J Clin Pharmacol 65:139-43. 2008
    ..There are no studies measuring antivenom concentrations following intramuscular administration. This study aimed to compare antivenom concentrations following intravenous and intramuscular administration of redback spider antivenom (RBSAV)...
  54. ncbi request reprint Clinical consequences of spider bites: recent advances in our understanding
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital and the University of Newcastle, Newcastle, NSW 2298, Australia
    Toxicon 43:477-92. 2004
    ..Most spiders only cause minor effects, including a large number of groups that have been implicated in necrotic arachnidism...
  55. doi request reprint Investigating pressure bandaging for snakebite in a simulated setting: bandage type, training and the effect of transport
    Elizabeth Canale
    Tropical Toxinology Program, Menzies School of Health Research, Charles Darwin University, and Northern Territory Clinical School, Royal Darwin Hospital, Darwin, Northern Territory, Australia
    Emerg Med Australas 21:184-90. 2009
    ..The clinical evidence base for the use of pressure bandaging in snakebite is limited. We aimed to investigate if pressure bandages (PB) generated and maintained presumptive optimal pressures in a simulated setting...
  56. ncbi request reprint Suspected snakebite: one year prospective study of emergency department presentations
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle and Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    Emerg Med (Fremantle) 15:160-9. 2003
    ..Snakebite is an uncommon, but potentially life-threatening condition. The more common clinical scenario is suspected snake-bite. Our aim was to characterise the epidemiology, diagnosis and management of patients with suspected snakebites...
  57. ncbi request reprint Nefazodone poisoning: toxicokinetics and toxicodynamics using continuous data collection
    Geoffrey K Isbister
    University of Newcastle, Newcastle, Australia
    J Toxicol Clin Toxicol 41:167-73. 2003
    ..Bradycardia, hypotension, and drowsiness are the most significant effects and are maximal in the first 12 hours when parent and metabolite concentrations are high...
  58. doi request reprint Parenteral sedation of elderly patients with acute behavioral disturbance in the ED
    Leonie Calver
    Department of Clinical Toxicology and Pharmacology, Discipline of Clinical Pharmacology, University of Newcastle, Calvary Mater Newcastle, New South Wales, Australia
    Am J Emerg Med 31:970-3. 2013
    ..This study aimed to investigate sedation of elderly patients with acute behavioral disturbance (ABD) in the emergency department (ED), specifically the safety and effectiveness of droperidol...
  59. doi request reprint Dexmedetomidine in the emergency department: assessing safety and effectiveness in difficult-to-sedate acute behavioural disturbance
    Leonie Calver
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, New South Wales, Australia
    Emerg Med J 29:915-8. 2012
    ..To investigate the safety and effectiveness of dexmedetomidine for sedating patients in whom previous attempts at sedation in the emergency department have failed...
  60. ncbi request reprint Two cases of bites by the black-bellied swamp snake (Hemiaspis signata)
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Locked Bag 7, Hunter Region Main Centre, Newcastle, NSW 2310, Australia
    Toxicon 40:317-9. 2002
    ..These cases indicate the potential for coagulopathy and local symptoms following bites by large specimens of H. signata in young children...
  61. ncbi request reprint Failure of intramuscular antivenom in Red-back spider envenoming
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Hospital, Edith St, Waratah NSW 2298, Australia
    Emerg Med (Fremantle) 14:436-9. 2002
    ..Controlled studies should be undertaken to establish the effectiveness of intravenous and intramuscular Red-back antivenom...
  62. pmc Alprazolam is relatively more toxic than other benzodiazepines in overdose
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Australia
    Br J Clin Pharmacol 58:88-95. 2004
    ..To describe alprazolam poisoning and the relative toxicity of alprazolam compared with other benzodiazepines...
  63. ncbi request reprint Developing a decision tree algorithm for the diagnosis of suspected spider bites
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    Emerg Med Australas 16:161-6. 2004
    ....
  64. ncbi request reprint 'Red as a beet and blind as a bat' Anticholinergic delirium in adolescents: lessons for the paediatrician
    Kim A Ramjan
    The Children s Hospital at Westmead, Westmead, New South Wales, Australia
    J Paediatr Child Health 43:779-80. 2007
    ..A high index of suspicion is often required in the paediatric setting due to infrequent acute hospital presentation...
  65. ncbi request reprint Serotonin toxicity: a practical approach to diagnosis and treatment
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Med J Aust 187:361-5. 2007
    ..Treatment should focus on cessation of the serotonergic medication and supportive care. Some antiserotonergic agents have been used in clinical practice, but the preferred agent, dose and indications are not well defined...
  66. doi request reprint A pharmacological approach to first aid treatment for snakebite
    Megan E Saul
    Department of Nuclear Medicine, John Hunter Hospital, New Lambton, New South Wales, Australia
    Nat Med 17:809-11. 2011
    ..This pharmacological approach should give snakebite victims more time to obtain medical care and antivenom treatment...
  67. ncbi request reprint Australian scorpion stings: a prospective study of definite stings
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Clinical Sciences Building, Level 5 Edith Street, Waratah, NSW 2298, Australia
    Toxicon 41:877-83. 2003
    ..This differs from other parts of the world, where severe envenoming is reported. The major clinical effect is severe pain, consistent with other scorpion stings. Most stings occurred indoors and at night...
  68. ncbi request reprint Bites by spiders of the family Theraphosidae in humans and canines
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Waratah, NSW 2298, Australia
    Toxicon 41:519-24. 2003
    ..Bites by these spiders are unlikely to cause major problems in humans. The study also demonstrates that the venom is far more toxic to canines...
  69. ncbi request reprint Clinical effects of red-bellied black snake (Pseudechis porphyriacus) envenoming and correlation with venom concentrations: Australian Snakebite Project (ASP-11)
    Andrew Churchman
    Emergency Department, Princess Alexandra Hospital, Brisbane, QLD, Australia
    Med J Aust 193:696-700. 2010
    ..To describe the clinical features and laboratory findings in patients with definite red-bellied black snake (RBBS; Pseudechis porphyriacus) bites, including correlation with results of venom assays...
  70. ncbi request reprint Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    Emerg Med (Fremantle) 15:376-82. 2003
    ..To investigate the pattern and epidemiology of anticholinergic plant poisoning, and to characterize its time course and clinical features...
  71. ncbi request reprint Intentional warfarin overdose
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, New South Wales, Australia
    Ther Drug Monit 25:715-22. 2003
    ..Titrating intravenous vitamin K with doses of 0.5 to 2.0 mg when INR > 5 is appropriate to reduce INR without causing warfarin resistance. The high-risk group must be kept anticoagulated, and warfarin resistance avoided...
  72. ncbi request reprint Spotted black snake (Pseudechis guttatus) envenoming
    Melanie Jansen
    School of Medical Practice and Population Health, University of Newcastle, Newcastle, NSW, Australia
    Med J Aust 186:41-2. 2007
    ..Neither patient developed significant coagulopathy, myolysis or neuromuscular paralysis. Bites by this species appear to cause effects similar to those of the more common red-bellied black snake (P. porphyriacus)...
  73. ncbi request reprint Application of pharmacokinetic-pharmacodynamic modelling in management of QT abnormalities after citalopram overdose
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Intensive Care Med 32:1060-5. 2006
    ..To develop guidelines for the management of QT prolongation after citalopram overdose, including decontamination with single-dose activated charcoal (SDAC) and cardiac monitoring...
  74. ncbi request reprint Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NT
    Med J Aust 184:354-6. 2006
    ....
  75. ncbi request reprint Australian wolf spider bites (Lycosidae): clinical effects and influence of species on bite circumstances
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, Newcastle Mater Misericordiae Hospital, University of Newcastle, Waratah, New South Wales, Australia
    J Toxicol Clin Toxicol 42:153-61. 2004
    ..Necrotic arachnidism continues to be attributed to wolf spider bites. This study investigates the clinical effects of bites by wolf spiders in Australia (family Lycosidae)...
  76. pmc Electrocardiogram changes and arrhythmias in venlafaxine overdose
    Geoffrey K Isbister
    Charles Darwin University, Darwin and Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Waratah, Australia
    Br J Clin Pharmacol 67:572-6. 2009
    ..To investigate serial electrocardiogram (ECG) parameters, haemodynamic changes and arrhythmias following venlafaxine overdose...
  77. pmc The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: a case report
    Colin Page
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
    J Med Toxicol 5:139-43. 2009
    ..Although the metoprolol concentrations measured in plasma were approximately 100-200 times therapeutic concentrations, the pharmacokinetics appeared to be similar to therapeutic metoprolol dosing...
  78. pmc Valproate overdose: a comparative cohort study of self poisonings
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Newcastle, Australia
    Br J Clin Pharmacol 55:398-404. 2003
    ..Based on individual case reports of massive overdoses, valproate is often regarded as having significant toxicity. This study aimed to describe the epidemiology of valproate poisoning and the spectrum of its clinical effects...
  79. ncbi request reprint Emergency department performance indicators that encompass the patient journey
    David Sibbritt
    School of Medical Practice and Population Health, University of Newcastle, New South Wales, Australia
    Qual Manag Health Care 15:27-38. 2006
    ..The study aimed to provide a recommended list of performance indicators from routinely collected data that measure most aspects of the patient journey through the emergency department (ED)...
  80. ncbi request reprint Acute conjunctival inflammation following contact with squashed spider contents
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, and Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    Am J Ophthalmol 136:563-4. 2003
    ..To report the effects to the eye following contact with spider contents...
  81. doi request reprint Commercial monovalent antivenoms in Australia are polyvalent
    Margaret A O'Leary
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
    Toxicon 54:192-5. 2009
    ..However, it would be possible for the manufacturer to reduce the number of types of snake antivenoms available in Australia to two polyvalent antivenoms which would simplify treatment of snakebite...
  82. ncbi request reprint Antivenom treatment in arachnidism
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle and Newcastle Mater Misericordiae Hospital, Newcastle, NSW, Australia
    J Toxicol Clin Toxicol 41:291-300. 2003
    ..Although envenomation from arthropods is common, no antivenoms exist for these, excepting Lonomia caterpillars in South America, and Ixodes paralysis ticks in Australia...
  83. ncbi request reprint Antivenom, anecdotes and evidence
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital, NSW
    Med J Aust 181:685-6. 2004
  84. doi request reprint Snakebite doesn't cause disseminated intravascular coagulation: coagulopathy and thrombotic microangiopathy in snake envenoming
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, and Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah NSW, Australia
    Semin Thromb Hemost 36:444-51. 2010
    ..The existence of the overlapping clinical syndromes of VICC and thrombotic microangiopathy in snake envenoming is the likely reason for the mistaken idea that snakebite causes DIC...
  85. ncbi request reprint Envenoming by the rough-scaled snake (Tropidechis carinatus): a series of confirmed cases
    Melissa Gan
    Emergency Department, Gold Coast Hospital, Gold Coast, QLD, Australia
    Med J Aust 191:183-6. 2009
    ..To describe demographic, geographical and clinical features of envenoming by the rough-scaled snake (RSS) (Tropidechis carinatus)...
  86. ncbi request reprint Changes in serial laboratory test results in snakebite patients: when can we safely exclude envenoming?
    Graham Ireland
    Emergency Department, Gold Coast Hospital, Gold Coast, QLD, Australia
    Med J Aust 193:285-90. 2010
    ....
  87. ncbi request reprint Acute allergic reaction following contact with a spider
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Level 5, Clinical Sciences Building, Edith Street, Waratah, NSW 2298, Australia
    Toxicon 40:1495-7. 2002
    ..He recovered within 6 h and had no further problems. The early allergic reaction in this case was most likely the result of contact with the spider...
  88. doi request reprint Reviewing deaths in the emergency department: deaths in the department or deaths within 48 h
    Sally Clunas
    Emergency Department, John Hunter Hospital, Newcastle, NSW, Australia
    Emerg Med Australas 21:117-23. 2009
    ..To investigate an ED death audit process that included deaths occurring within 48 h of admission in addition to deaths in the ED...
  89. ncbi request reprint Investigating the relationship between emergency departments and complementary and alternative medicine use in Australia
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    Emerg Med Australas 16:378-81. 2004
  90. doi request reprint Effectiveness of pressure-immobilization first aid for snakebite requires further study
    Bart J Currie
    Tropical Toxinology Program, Menzies School of Health Research, Charles Darwin University, Northern Territory, Australia
    Emerg Med Australas 20:267-70. 2008
    ....
  91. pmc Pharmacokinetic-pharmacodynamic modelling of QT interval prolongation following citalopram overdoses
    Lena E Friberg
    School of Pharmacy, University of Queensland, Brisbane, Australia
    Br J Clin Pharmacol 61:177-90. 2006
    ....