Manuel Irimia



  1. Irimia M, Denuc A, Burguera D, Somorjai I, Mart n Dur n J, Genikhovich G, et al. Stepwise assembly of the Nova-regulated alternative splicing network in the vertebrate brain. Proc Natl Acad Sci U S A. 2011;108:5319-24 pubmed publisher
    ..In addition, we find that tissue-specific Nova expression patterns emerged independently in other lineages, suggesting independent assembly of tissue-specific regulatory networks...
  2. Irimia M, Weatheritt R, Ellis J, Parikshak N, Gonatopoulos Pournatzis T, Babor M, et al. A highly conserved program of neuronal microexons is misregulated in autistic brains. Cell. 2014;159:1511-23 pubmed publisher
    ..The results thus reveal a highly conserved program of dynamic microexon regulation associated with the remodeling of protein-interaction networks during neurogenesis, the misregulation of which is linked to autism. ..
  3. Grau Bove X, Ruiz Trillo I, Irimia M. Origin of exon skipping-rich transcriptomes in animals driven by evolution of gene architecture. Genome Biol. 2018;19:135 pubmed publisher
  4. Irimia M, Rukov J, Penny D, Roy S. Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing. BMC Evol Biol. 2007;7:188 pubmed
    ..A role for alternative splicing in the evolution of multicellularity then would largely have arisen by co-opting the preexisting process. ..
  5. Irimia M, Rukov J, Roy S, Vinther J, Garcia Fernandez J. Quantitative regulation of alternative splicing in evolution and development. Bioessays. 2009;31:40-50 pubmed publisher
    ..We discuss the potential role of changes in developmental regulation of AS as an additional layer in complex gene regulatory networks and in the emergence of genetic novelties. ..
  6. Ariza Cosano A, Visel A, Pennacchio L, Fraser H, Gomez Skarmeta J, Irimia M, et al. Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression. BMC Genomics. 2012;13:713 pubmed publisher
  7. Irimia M, Roy S. Evolutionary convergence on highly-conserved 3' intron structures in intron-poor eukaryotes and insights into the ancestral eukaryotic genome. PLoS Genet. 2008;4:e1000148 pubmed publisher
  8. Irimia M, Maeso I, Roy S, Fraser H. Ancient cis-regulatory constraints and the evolution of genome architecture. Trends Genet. 2013;29:521-8 pubmed publisher
    ..We discuss implications, questions raised, and new research directions arising from these studies, as well as evidence for similar phenomena in other eukaryotic groups. ..
  9. request reprint
    Irimia M, Rukov J, Penny D, Garcia Fernandez J, Vinther J, Roy S. Widespread evolutionary conservation of alternatively spliced exons in Caenorhabditis. Mol Biol Evol. 2008;25:375-82 pubmed
    ..Finally, we demonstrate an inverse relationship between AS and gene duplication, suggesting that the latter may be primarily responsible for the emergence of new functional transcripts in nematodes. ..

More Information


  1. Irimia M, Piñeiro C, Maeso I, Gomez Skarmeta J, Casares F, Garcia Fernandez J. Conserved developmental expression of Fezf in chordates and Drosophila and the origin of the Zona Limitans Intrathalamica (ZLI) brain organizer. Evodevo. 2010;1:7 pubmed publisher
  2. Irimia M, Denuc A, Ferran J, Pernaute B, Puelles L, Roy S, et al. Evolutionarily conserved A-to-I editing increases protein stability of the alternative splicing factor Nova1. RNA Biol. 2012;9:12-21 pubmed publisher
  3. Irimia M, Royo J, Burguera D, Maeso I, G mez Skarmeta J, Garcia Fernandez J. Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties. Sci Rep. 2012;2:433 pubmed publisher
    ..In addition, we show that the linkage of Shh to Lmbr1 and Rnf32, necessary for the unique gnatostomate-specific Shh limb expression, is a vertebrate novelty occurred between the two whole-genome duplications...
  4. Burguera D, Márquez Y, Racioppi C, Permanyer J, Torres Méndez A, Esposito R, et al. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Nat Commun. 2017;8:1799 pubmed publisher
    ..This is likely connected to the origin of an event in Fgfr, which was recruited as an Esrp target in stem chordates and subsequently co-opted into the development of many novel traits in vertebrates. ..