Irimia M, Denuc A, Burguera D, Somorjai I, Mart n Dur n J, Genikhovich G, et al
. Stepwise assembly of the Nova-regulated alternative splicing network in the vertebrate brain. Proc Natl Acad Sci U S A. 2011;108:5319-24 pubmed publisher
..In addition, we find that tissue-specific Nova expression patterns emerged independently in other lineages, suggesting independent assembly of tissue-specific regulatory networks...
Irimia M, Weatheritt R, Ellis J, Parikshak N, Gonatopoulos Pournatzis T, Babor M, et al
. A highly conserved program of neuronal microexons is misregulated in autistic brains. Cell. 2014;159:1511-23 pubmed publisher
..The results thus reveal a highly conserved program of dynamic microexon regulation associated with the remodeling of protein-interaction networks during neurogenesis, the misregulation of which is linked to autism. ..
Grau Bove X, Ruiz Trillo I, Irimia M. Origin of exon skipping-rich transcriptomes in animals driven by evolution of gene architecture. Genome Biol. 2018;19:135 pubmed publisher
Irimia M, Rukov J, Penny D, Roy S. Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing. BMC Evol Biol. 2007;7:188 pubmed
..A role for alternative splicing in the evolution of multicellularity then would largely have arisen by co-opting the preexisting process. ..
Irimia M, Rukov J, Roy S, Vinther J, Garcia Fernandez J. Quantitative regulation of alternative splicing in evolution and development. Bioessays. 2009;31:40-50 pubmed publisher
..We discuss the potential role of changes in developmental regulation of AS as an additional layer in complex gene regulatory networks and in the emergence of genetic novelties. ..
Ariza Cosano A, Visel A, Pennacchio L, Fraser H, Gomez Skarmeta J, Irimia M, et al
. Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression. BMC Genomics. 2012;13:713 pubmed publisher
Irimia M, Roy S. Evolutionary convergence on highly-conserved 3' intron structures in intron-poor eukaryotes and insights into the ancestral eukaryotic genome. PLoS Genet. 2008;4:e1000148 pubmed publisher
Irimia M, Maeso I, Roy S, Fraser H. Ancient cis-regulatory constraints and the evolution of genome architecture. Trends Genet. 2013;29:521-8 pubmed publisher
..We discuss implications, questions raised, and new research directions arising from these studies, as well as evidence for similar phenomena in other eukaryotic groups. ..
Irimia M, Rukov J, Penny D, Garcia Fernandez J, Vinther J, Roy S. Widespread evolutionary conservation of alternatively spliced exons in Caenorhabditis. Mol Biol Evol. 2008;25:375-82 pubmed
..Finally, we demonstrate an inverse relationship between AS and gene duplication, suggesting that the latter may be primarily responsible for the emergence of new functional transcripts in nematodes. ..