G Walsh

Summary

Affiliation: University of Limerick
Country: Ireland

Publications

  1. ncbi Biopharmaceuticals and biotechnology medicines: an issue of nomenclature
    Gary Walsh
    Industrial Biochemistry Program, University of Limerick, Limerick, Ireland
    Eur J Pharm Sci 15:135-8. 2002
  2. ncbi Post-translational modifications of protein biopharmaceuticals
    Gary Walsh
    Department of Chemical and Environmental Sciences and the Materials and Surface Science Institute, University of Limerick, Limerick City, Ireland
    Drug Discov Today 15:773-80. 2010
  3. ncbi Post-translational modifications in the context of therapeutic proteins
    Gary Walsh
    Industrial Biochemistry Program, University of Limerick, Castletroy, Limerick City, Ireland
    Nat Biotechnol 24:1241-52. 2006
  4. ncbi Biopharmaceutical benchmarks 2006
    Gary Walsh
    Industrial Biochemistry Programme, University of Limerick, Limerick, Ireland
    Nat Biotechnol 24:769-76. 2006
  5. ncbi Protein engineering: Case studies of commercialized engineered products
    Gary Walsh
    Industrial Biochemistry Program, Chemical and Environmental Sciences Department, University of Limerick, Limerick City, Ireland
    Biochem Mol Biol Educ 35:2-8. 2007
  6. ncbi Biopharmaceuticals: recent approvals and likely directions
    Gary Walsh
    Industrial Biochemistry Program, University of Limerick, Castletroy, Limerick City, Ireland
    Trends Biotechnol 23:553-8. 2005
  7. ncbi Therapeutic insulins and their large-scale manufacture
    Gary Walsh
    Industrial Biochemistry Program, University of Limerick, Limerick City, Ireland
    Appl Microbiol Biotechnol 67:151-9. 2005
  8. ncbi Quantification of supplemental enzymes in animal feedingstuffs by radial enzyme diffusion
    G Walsh
    Department of Chemical and Environmental Science, University of Limerick, Limerick, Ireland
    Appl Microbiol Biotechnol 67:70-4. 2005
  9. ncbi Pharmaceutical biotechnology products approved within the European Union
    Gary Walsh
    Industrial Biochemistry Program, University of Limerick, Limerick City, Ireland
    Eur J Pharm Biopharm 55:3-10. 2003
  10. ncbi Second-generation biopharmaceuticals
    Gary Walsh
    Department of Chemical and Environmental Sciences, Industrial Biochemistry Program, University of Limerick, Limerick, Ireland
    Eur J Pharm Biopharm 58:185-96. 2004

Collaborators

  • Roy Jefferis
  • A Boyce
  • Anne Casey
  • Angela Boyce
  • S O'Connell
  • Gwilym Williams
  • Anna V Piterina

Detail Information

Publications21

  1. ncbi Biopharmaceuticals and biotechnology medicines: an issue of nomenclature
    Gary Walsh
    Industrial Biochemistry Program, University of Limerick, Limerick, Ireland
    Eur J Pharm Sci 15:135-8. 2002
    ..Such terms often have different meanings for different people and it is perhaps time that they were more formally defined...
  2. ncbi Post-translational modifications of protein biopharmaceuticals
    Gary Walsh
    Department of Chemical and Environmental Sciences and the Materials and Surface Science Institute, University of Limerick, Limerick City, Ireland
    Drug Discov Today 15:773-80. 2010
    ..This review considers the PTMs most often associated with therapeutic proteins and focuses upon more recent advances in engineering PTMs with the aim of improving the application-relevant functional characteristics of these drugs...
  3. ncbi Post-translational modifications in the context of therapeutic proteins
    Gary Walsh
    Industrial Biochemistry Program, University of Limerick, Castletroy, Limerick City, Ireland
    Nat Biotechnol 24:1241-52. 2006
    ..A better understanding of such structural-functional relationships will facilitate the development of second-generation products displaying a PTM profile engineered to optimize therapeutic usefulness...
  4. ncbi Biopharmaceutical benchmarks 2006
    Gary Walsh
    Industrial Biochemistry Programme, University of Limerick, Limerick, Ireland
    Nat Biotechnol 24:769-76. 2006
    ..The rate of biopharmaceutical approvals has leveled off, but some milestones bode well for the future...
  5. ncbi Protein engineering: Case studies of commercialized engineered products
    Gary Walsh
    Industrial Biochemistry Program, Chemical and Environmental Sciences Department, University of Limerick, Limerick City, Ireland
    Biochem Mol Biol Educ 35:2-8. 2007
    ..The case studies may be incorporated into a standard lecture series detailing protein engineering or may form the basis of a class-led post-lecture series discussion...
  6. ncbi Biopharmaceuticals: recent approvals and likely directions
    Gary Walsh
    Industrial Biochemistry Program, University of Limerick, Castletroy, Limerick City, Ireland
    Trends Biotechnol 23:553-8. 2005
    ..An increasing proportion of approvals are engineered in some way and advances in alternative production systems and delivery methods will also likely impact upon the approvals profile over the remainder of this decade...
  7. ncbi Therapeutic insulins and their large-scale manufacture
    Gary Walsh
    Industrial Biochemistry Program, University of Limerick, Limerick City, Ireland
    Appl Microbiol Biotechnol 67:151-9. 2005
    ....
  8. ncbi Quantification of supplemental enzymes in animal feedingstuffs by radial enzyme diffusion
    G Walsh
    Department of Chemical and Environmental Science, University of Limerick, Limerick, Ireland
    Appl Microbiol Biotechnol 67:70-4. 2005
    ....
  9. ncbi Pharmaceutical biotechnology products approved within the European Union
    Gary Walsh
    Industrial Biochemistry Program, University of Limerick, Limerick City, Ireland
    Eur J Pharm Biopharm 55:3-10. 2003
    ....
  10. ncbi Second-generation biopharmaceuticals
    Gary Walsh
    Department of Chemical and Environmental Sciences, Industrial Biochemistry Program, University of Limerick, Limerick, Ireland
    Eur J Pharm Biopharm 58:185-96. 2004
    ..Better understanding of the links between protein structure and function will underpin the development of an increasing number of engineered biopharmaceuticals in the future...
  11. ncbi Biopharmaceutical benchmarks--2003
    Gary Walsh
    Industrial Biochemistry Programme, University of Limerick, Limerick, Ireland
    Nat Biotechnol 21:865-70. 2003
  12. ncbi Comparison of selected physicochemical characteristics of commercial phytases relevant to their application in phosphate pollution abatement
    A Boyce
    Department of Chemical and Environmental Sciences, University of Limerick, Limerick City, Ireland
    J Environ Sci Health A Tox Hazard Subst Environ Eng 41:789-98. 2006
    ..None of the phytases assessed satisfied all of the criteria of an ideal phytase for use in animal feed...
  13. ncbi Assessment of the potential suitability of selected commercially available enzymes for cleaning-in-place (CIP) in the dairy industry
    Angela Boyce
    Department of Chemical and Environmental Sciences, and Materials and Surface Sciences Institute, University of Limerick, Limerick, Ireland
    Biofouling 26:837-50. 2010
    ....
  14. ncbi Application relevant studies of fungal beta-galactosidases with potential application in the alleviation of lactose intolerance
    S O'Connell
    Department of Chemical and Environmental Sciences and Materials and Surface Sciences Institute, University of Limerick, Limerick City, Ireland
    Appl Biochem Biotechnol 149:129-38. 2008
    ..Overall the results indicate that the beta-galactosidases of Aspergillus carbonarius ATCC6276, either individually or in combination, may be suitable for use as a digestive supplement for the alleviation of lactose intolerance...
  15. ncbi Production, purification and application-relevant characterisation of an endo-1,3(4)-beta-glucanase from Rhizomucor miehei
    A Boyce
    Department of Chemical and Environmental Sciences and Materials and Surface Science Institute, University of Limerick, Limerick City, Ireland
    Appl Microbiol Biotechnol 76:835-41. 2007
    ....
  16. ncbi Purification and characterisation of an acid phosphatase with phytase activity from Mucor hiemalis Wehmer
    A Boyce
    Department of Chemical and Environmental Sciences, University of Limerick, Limerick City, Ireland
    J Biotechnol 132:82-7. 2007
    ..This, coupled to the enzyme's functionally relevant physicochemical characteristics, suggests its likely suitability for inclusion in second generation phytase cocktails for application in animal feed...
  17. ncbi Purification and properties of a beta-galactosidase with potential application as a digestive supplement
    G Walsh
    Department of Chemical and Environmental Sciences and MSSI, University of Limerick, Limerick City, Ireland
    Appl Biochem Biotechnol 141:1-14. 2007
    ..This confirms the enzyme's identity and indicates that significant sequence homology exists between these enzymes...
  18. ncbi Physicochemical characteristics of commercial lactases relevant to their application in the alleviation of lactose intolerance
    G Walsh
    Industrial Biochemistry Program, Department of Chemical and Environmental Sciences, University of Limerick, Limerick City, Ireland
    Appl Biochem Biotechnol 134:179-91. 2006
    ....
  19. ncbi Identification and characterization of a phytase of potential commercial interest
    Anne Casey
    Industrial Biochemistry Program, Department of Chemical and Environmental Sciences, University of Limerick, Limerick City, Ireland
    J Biotechnol 110:313-22. 2004
    ..This may render it of industrial interest...
  20. ncbi Purification and characterization of extracellular phytase from Aspergillus niger ATCC 9142
    Anne Casey
    Industrial Biochemistry Programme, Department of Chemical and Environmental Sciences, University of Limerick, Limerick City, Ireland
    Bioresour Technol 86:183-8. 2003
    ..The enzyme displayed higher thermostability at 80 degrees C than did two commercial phytase products. Initial characterisation of the purified enzyme suggested that it could be a potential candidate for use as an animal feed supplement...
  21. ncbi Scaling the biobusiness information mountain
    Gwilym Williams
    Nat Biotechnol 23:147-9. 2005