Research Topics
Genomes and Genes
| Cormac T TaylorSummaryAffiliation: University College Dublin Country: Ireland Publications
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Detail Information
Publications
The role of NF-kappaB in hypoxia-induced gene expressionCormac T Taylor
UCD Conway Institute, School of Medicine and Medical Science, College of Life Science, University College Dublin, Belfield, Dublin, Ireland
Ann N Y Acad Sci 1177:178-84. 2009....
Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxiaKatrina M Comerford
The Conway Institute for Biomolecular and Biomedical Research, University College, Dublin, D4 Ireland
Proc Natl Acad Sci U S A 100:986-91. 2003..Furthermore, we hypothesize that such an event stabilizes and promotes nuclear localization of CREB and thus complements an endogenous resolution phase for hypoxia-induced inflammatory processes...
Oxygen, hypoxia, and stressCormac T Taylor
UCD Conway Institute, University Colleg Dublin, Belfield, D4, Ireland
Ann N Y Acad Sci 1113:87-94. 2007....- Mitochondria and cellular oxygen sensing in the HIF pathwayCormac T Taylor
UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Biochem J 409:19-26. 2008.... - Interdependent roles for hypoxia inducible factor and nuclear factor-kappaB in hypoxic inflammationCormac T Taylor
UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
J Physiol 586:4055-9. 2008..Recent studies indicate that these pathways may represent important new therapeutic targets in diseases characterized by hypoxic inflammation... - Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoansCormac T Taylor
UCD Conway Institute, Systems Biology Ireland and School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
Physiology (Bethesda) 25:272-9. 2010..Thus atmospheric oxygen levels may have provided a selection force on the development of cellular oxygen-sensing pathways... - Regulation of intestinal epithelial gene expression in hypoxiaCormac T Taylor
Dept Medicine and Therapeutics, The Conway Institute, University College, Dublin, Ireland
Kidney Int 66:528-31. 2004..Here we review our understanding of the molecular mechanisms underlying the regulation of CREB activity in intestinal epithelial cells in hypoxia... - Hypoxia and gastrointestinal diseaseCormac T Taylor
UCD Conway Institute, School of Medicine and Medical Science, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
J Mol Med (Berl) 85:1295-300. 2007..In this paper, we review this pathway in detail and examine the therapeutic potential for targeting HIF hydroxylases in intestinal mucosal inflammatory disease... - Regulation of gene expression by carbon dioxideCormac T Taylor
UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
J Physiol 589:797-803. 2011..This latter, transcriptional regulatory role for CO(2), has been largely attributed to altered activity of the NF-B family of transcription factors. Here, we review our evolving understanding of how CO(2) impacts upon gene transcription... - NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cellsEoin P Cummins
UCD Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland
J Immunol 185:4439-45. 2010..These results suggest the existence of a molecular CO(2) sensor in mammalian cells that is linked to the regulation of genes involved in innate immunity and inflammation... - Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signalingKathryn M Oliver
School of Medicine and Medical Science, UCD Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
J Biol Chem 287:14004-11. 2012..Taken together, these data demonstrate that RelB is a CO(2)-sensitive NF-κB family member that may contribute to the beneficial effects of hypercapnia in inflammatory diseases of the lung... - PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cellsKathleen A O'Hagan
Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Proc Natl Acad Sci U S A 106:2188-93. 2009.... - An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxiaSusan F Fitzpatrick
UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
J Immunol 186:1091-6. 2011..These results implicate an essential role for NF-κB signaling in inflammatory gene expression in response to hypoxia both through the regulation of HIF-1 and through direct effects upon target gene expression... - Glucose reintroduction triggers the activation of Nrf2 during experimental ischemia reperfusionDaniel Crean
Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland
Mol Cell Biochem 366:231-8. 2012..We suggest these findings represent a previously unreported mechanism for the activation of Nrf2 as a cytoprotective pathway in IRI... - Hypoxia selectively activates the CREB family of transcription factors in the in vivo lungMartin O Leonard
University College Dublin, School of Medicine and Medical Science, and Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland
Am J Respir Crit Care Med 178:977-83. 2008..The pulmonary vascular changes in response to hypoxia, both structural and functional, are unique to this circulation... - Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activityEoin P Cummins
Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
Proc Natl Acad Sci U S A 103:18154-9. 2006.... - Identification of cyclic AMP response element-binding protein-dependent transcriptional responses in hypoxia by microarray analysisMartin O Leonard
The Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Ireland
Methods Enzymol 381:511-24. 2004 - Gremlin plays a key role in the pathogenesis of pulmonary hypertensionEdwina Cahill
University College Dublin, School of Medicine and Medical Sciences, Belfield, Dublin 4, Ireland
Circulation 125:920-30. 2012..Subsequently, it was demonstrated that BMP signaling was also reduced in common forms of pulmonary hypertension, including hypoxic pulmonary hypertension; however, the mechanism of this reduction has not previously been elucidated... - MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxiaUlrike Bruning
School of Medicine and Medical Science and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Mol Cell Biol 31:4087-96. 2011.... - Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent mannerSusan M O'Reilly
UCD Conway Institute, University College Dublin, Dublin, Ireland
Am J Physiol Cell Physiol 290:C592-600. 2006..These data also further support a role for CREB as an HIF-independent hypoxia-responsive transcription factor in the regulation of intestinal epithelial gene expression... - Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxiaTerence A Agbor
UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
J Biol Chem 286:4718-26. 2011..In summary, we hypothesize that SUMO modification of key metabolic enzymes plays an important role in shifting cellular metabolic strategies toward increased flux through the glycolytic pathway during periods of hypoxic stress... - A critical role for p38 map kinase in NF-kappaB signaling during intermittent hypoxia/reoxygenationSilke Ryan
School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Biochem Biophys Res Commun 355:728-33. 2007..Furthermore, depletion of p38 using siRNA significantly reduces IHR-induced NF-kappaB activity. Thus, IHR activates NF-kappaB in an IKK-dependent manner signaled at least in part via activation of p38 MAPK... - NFκB and HIF display synergistic behaviour during hypoxic inflammationUlrike Bruning
Conway Institute, University College Dublin, Ireland
Cell Mol Life Sci 69:1319-29. 2012..Furthermore, we demonstrate synergistic activity between these two transcription factors on the regulation of the COX-2 promoter, implicating a co-ordinated role for both HIF and NFκB in the expression of COX-2 in hypoxic inflammation... - Hypoxia activates NF-kappaB-dependent gene expression through the canonical signaling pathwayKathryn M Oliver
UCD Conway Institute, University College Dublin, Belfield, Ireland
Antioxid Redox Signal 11:2057-64. 2009..In summary, we hypothesize that hypoxia enhances NF-kappaB activity primarily through affecting the canonical pathway... - The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cellsEmily Hams
Institute of Molecular Medicine, Trinity College, Dublin, Ireland
Shock 36:295-302. 2011..This study demonstrates cell type-specific roles for hydroxylase inhibition in vivo and provides insight into the mechanism underlying the protection conveyed by DMOG in models of endotoxic shock... - Enhanced sensitivity of protein kinase B/Akt to insulin in hypoxia is independent of HIF1alpha and promotes cell viabilityRobert E Barry
UCD School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Eur J Cell Biol 86:393-403. 2007..Thus, PKB/Akt may regulate specific cellular responses to growth factors such as insulin under adverse conditions such as hypoxia... - Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptorMartin O Leonard
Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland
J Immunol 174:2250-7. 2005.... - The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxiaMartin O Leonard
Conway Institute of Biomolecular and Biomedical Research and the Dublin Molecular Medicine Centre, University College Dublin, Belfield, Dublin 4, Ireland
J Biol Chem 278:40296-304. 2003..Our data indicate that although this event may rely heavily on HIF-1-dependent gene transcription, it is likely that separate hypoxia-dependent transcriptional regulators also play a role... - Regulation of protein phosphatase 1gamma activity in hypoxia through increased interaction with NIPP1: implications for cellular metabolismKathrina M Comerford
School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Ireland
J Cell Physiol 209:211-8. 2006.... - c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxiaKatrina M Comerford
Department of Medicine and Therapeutics, The Conway Institute for Biomolecular and Biomedical Research and the Dublin Molecular Medicine Centre, University College, Dublin, Ireland
Cancer Res 64:9057-61. 2004..Furthermore, these events are independent of the generation of reactive oxygen intermediates. Thus, JNK may represent a therapeutic target in the prevention of tumor resistance to chemotherapeutic treatment... - Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumpsBettina Schaible
Conway Institute, University College Dublin, Belfield, Ireland
Antimicrob Agents Chemother 56:2114-8. 2012..Thus, microenvironmental hypoxia may contribute significantly to the development of antibiotic resistance in P. aeruginosa infecting cystic fibrosis patients... - Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier functionMurtaza M Tambuwala
The Conway Institute, University College Dublin, Ireland
Gastroenterology 139:2093-101. 2010..Hypoxia inducible factor (HIF) prolyl hydroxylase inhibitors are protective in mouse models of inflammatory bowel disease (IBD). Here, we investigated the therapeutic target(s) and mechanism(s) involved... - Hypoxia. Regulation of NFkappaB signalling during inflammation: the role of hydroxylasesKathryn M Oliver
School of Medicine and Medical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Arthritis Res Ther 11:215. 2009..Furthermore, we will discuss the potential for prolylhydroxylase inhibitors in inflammatory disease... - Hypoxia-responsive transcription factorsEoin P Cummins
Department of Medicine and Therapeutics, The Conway Institute for Biomolecular and Biomedical Research and the Dublin Molecular Medicine Centre, University College Dublin, Belfield, Dublin, 4, Ireland
Pflugers Arch 450:363-71. 2005..Understanding such events will enhance our understanding of cellular oxygen sensing... - The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitisEoin P Cummins
UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
Gastroenterology 134:156-65. 2008..Both HIF-1 and NF-kappaB pathways are repressed by the action of hydroxylases through the hydroxylation of key regulatory molecules... - Predictors of elevated nuclear factor-kappaB-dependent genes in obstructive sleep apnea syndromeSilke Ryan
Sleep Research Laboratory, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland
Am J Respir Crit Care Med 174:824-30. 2006..Furthermore, TNF-alpha levels are independently associated with excessive daytime sleepiness... - Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndromeSilke Ryan
Sleep Research Laboratory, St Vincent's University Hospital, Dublin, Ireland
Circulation 112:2660-7. 2005..CONCLUSIONS: These data demonstrate selective activation of inflammatory over adaptive pathways in IHR and OSAS, which may be an important molecular mechanism of cardiovascular disease... - A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) networkLan K Nguyen
Systems Biology Ireland, University College Dublin, Dublin 4, Ireland
J Cell Sci 126:1454-63. 2013.... - Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrheaJoseph B J Ward
Molecular Medicine Laboratories, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
FASEB J 25:535-43. 2011..In conclusion, hydroxylases are important regulators of epithelial Cl(-) and fluid secretion and present a promising target for development of new drugs to treat transport disorders... - Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injuryMartin O Leonard
School of Medicine and Medical Sciences, The Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
FASEB J 20:2624-6. 2006..These results indicate that reoxygenation-dependent Nrf-2 activity facilitates ischemic preconditioning through the induction of antioxidant gene expression and that ROS may be critical in signaling this event... - Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxiaCormac T Taylor
UCD Conway Institute, University College Dublin, Ireland
Arterioscler Thromb Vasc Biol 30:643-7. 2010.... - Hypoxia, innate immunity and infection in the lungBettina Schaible
UCD Conway Institute, University College Dublin, Department of Microbiology, St Vincent s University Hospital, Dublin 4, Ireland
Respir Physiol Neurobiol 174:235-43. 2010..In the current review, we will discuss recent data pertaining to the role of hypoxia in regulating both host and pathogen in the lung during pulmonary disease and how this contributes to innate immunity, infection and inflammation... - Hypoxic regulation of NF-kappaB signalingEoin P Cummins
UCD Conway Institute, University College Dublin, Dublin, Ireland
Methods Enzymol 435:479-92. 2007..This work has implicated a novel role for proline and asparagine hydroxylases in the modulation of NF-kappaB activity. Here, we describe methodologies used to demonstrate and interrogate hypoxic induction of the NF-kappaB pathway... - Alterations in oxidative gene expression in equine skeletal muscle following exercise and trainingSuzanne S Eivers
Animal Genomics Laboratory, University College Dublin School of Agriculture, Food Science and Veterinary Medicine, Dublin, Ireland
Physiol Genomics 40:83-93. 2010..These data highlight the roles of genes responsible for the regulation of oxygen-dependent metabolism, glucose metabolism, and fatty acid utilization in equine skeletal muscle adaptation to exercise... - Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cellsRonan N T Coffey
Department of Surgery, Mater Misericordiae University Hospital, Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Ireland
Cancer 103:1363-74. 2005.... - Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adultsEleanor J Molloy
Department of Surgery, Conway Institute of Biomolecular and Biomedical Research, Mater Misericordiae University Hospital, Dublin, Ireland
Biol Neonate 90:34-9. 2006..Dysfunctional inflammatory responses have been implicated in several neonatal inflammatory disorders following infection and hypoxia... - Lower expression of Nrf2 mRNA in older donor livers: a possible contributor to increased ischemia-reperfusion injury?Muhammad B Zaman
National Liver Unit, St Vincent s University Hospital, Dublin, Ireland
Transplantation 84:1272-8. 2007.... - Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosaBettina Schaible
UCD School of Medicine and Medical Science and The Conway Institute, University College Dublin, Dublin, Ireland
PLoS ONE 8:e56491. 2013..Thus, hypoxia reduces P. aeruginosa internalization into epithelial cells and pharmacologic manipulation of the host pathways involved may represent new therapeutic targets in the treatment of P. aeruginosa infection... - Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analogNiamh E Kieran
Human Genomics and Bioinformatics Research Unit, Department of Medicine and Therapeutics, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Mater Misericordiae Hospital, Dublin 7, Ireland
Kidney Int 64:480-92. 2003..The data presented herein suggest a framework for understanding drivers of kidney injury in ischemia/reperfusion and the molecular basis for renoprotection by lipoxins in this setting... - Hydroxylase-dependent regulation of the NF-κB pathwayCarsten C Scholz
School of Medicine and Medical Science, University College Dublin, Dublin, Ireland
Biol Chem 394:479-93. 2013..Developing our understanding of the role of hydroxylases in hypoxic inflammation may identify novel therapeutic approaches in chronic inflammatory disease... - Hydroxylases as therapeutic targets in inflammatory bowel diseaseEoin P Cummins
School of Medicine and Medical Science and The Conway Institute, University College Dublin, Dublin, Ireland
Lab Invest 93:378-83. 2013..In this review, the mechanism(s) of action and the therapeutic potential of small molecule hydroxylase inhibitors for the treatment of IBD will be discussed... - The impact of hypoxia on cell death pathwaysColin R Lenihan
School of Medicine and Medical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Biochem Soc Trans 41:657-63. 2013..In the present review, we discuss the complex relationship that exists between the presence of hypoxia and the regulation of cell death pathways... - The autonomic nervous system and inflammatory bowel diseaseCormac T Taylor
School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Ireland
Auton Neurosci 133:104-14. 2007..This review aims to synthesize the current understanding of the pathogenesis of IBD with a particular emphasis on the role that the ANS plays in the progression of these diseases... - SUMO, hypoxia and the regulation of metabolismTerence A Agbor
School of Medicine and Medical Science and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Biochem Soc Trans 36:445-8. 2008..Here, we will briefly review the evolving evidence for this pathway in the regulation of a number of metabolic regulators and discuss a possible role for SUMOylation in the regulation of basic metabolic function... - Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alphaThilo Hagen
Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
Science 302:1975-8. 2003..Thus, the signaling consequences of hypoxia may be profoundly modified by nitric oxide... - Cholera toxin potentiates influences of IFN-gamma through activation of NF-kappaB and release of tumor necrosis factor-alphaRichard S Blumberg
Division of Gastroenterology, Brigham and Women's Hospital and Harvard Medical School, 20 Shattuck Street, Boston, MA 02115, USA
J Interferon Cytokine Res 25:209-19. 2005..We conclude that Ctx elicits a proinflammatory phenotype in intestinal epithelia and that potentiation of IFN-gamma-mediated barrier disruption by TNF-alpha may contribute to the overall adjuvant properties of Ctx... - Mitochondria, oxygen sensing, and the regulation of HIF-2alpha. Focus on "Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line"Cormac T Taylor
Am J Physiol Cell Physiol 294:C1300-2. 2008 - Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF1 alpha, a potent epithelial secretagogueSean P Colgan
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Boston, MA
Adv Exp Med Biol 507:107-12. 2002