Cormac T Taylor

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. doi request reprint The role of NF-kappaB in hypoxia-induced gene expression
    Cormac T Taylor
    UCD Conway Institute, School of Medicine and Medical Science, College of Life Science, University College Dublin, Belfield, Dublin, Ireland
    Ann N Y Acad Sci 1177:178-84. 2009
  2. pmc Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia
    Katrina M Comerford
    The Conway Institute for Biomolecular and Biomedical Research, University College, Dublin, D4 Ireland
    Proc Natl Acad Sci U S A 100:986-91. 2003
  3. ncbi request reprint Oxygen, hypoxia, and stress
    Cormac T Taylor
    UCD Conway Institute, University Colleg Dublin, Belfield, D4, Ireland
    Ann N Y Acad Sci 1113:87-94. 2007
  4. ncbi request reprint Mitochondria and cellular oxygen sensing in the HIF pathway
    Cormac T Taylor
    UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Biochem J 409:19-26. 2008
  5. doi request reprint Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans
    Cormac T Taylor
    UCD Conway Institute, Systems Biology Ireland and School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
    Physiology (Bethesda) 25:272-9. 2010
  6. ncbi request reprint Regulation of intestinal epithelial gene expression in hypoxia
    Cormac T Taylor
    Dept Medicine and Therapeutics, The Conway Institute, University College, Dublin, Ireland
    Kidney Int 66:528-31. 2004
  7. pmc Regulation of gene expression by carbon dioxide
    Cormac T Taylor
    UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Physiol 589:797-803. 2011
  8. pmc Interdependent roles for hypoxia inducible factor and nuclear factor-kappaB in hypoxic inflammation
    Cormac T Taylor
    UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Physiol 586:4055-9. 2008
  9. ncbi request reprint Hypoxia and gastrointestinal disease
    Cormac T Taylor
    UCD Conway Institute, School of Medicine and Medical Science, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
    J Mol Med (Berl) 85:1295-300. 2007
  10. doi request reprint NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells
    Eoin P Cummins
    UCD Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland
    J Immunol 185:4439-45. 2010

Collaborators

Detail Information

Publications61

  1. doi request reprint The role of NF-kappaB in hypoxia-induced gene expression
    Cormac T Taylor
    UCD Conway Institute, School of Medicine and Medical Science, College of Life Science, University College Dublin, Belfield, Dublin, Ireland
    Ann N Y Acad Sci 1177:178-84. 2009
    ....
  2. pmc Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia
    Katrina M Comerford
    The Conway Institute for Biomolecular and Biomedical Research, University College, Dublin, D4 Ireland
    Proc Natl Acad Sci U S A 100:986-91. 2003
    ..Furthermore, we hypothesize that such an event stabilizes and promotes nuclear localization of CREB and thus complements an endogenous resolution phase for hypoxia-induced inflammatory processes...
  3. ncbi request reprint Oxygen, hypoxia, and stress
    Cormac T Taylor
    UCD Conway Institute, University Colleg Dublin, Belfield, D4, Ireland
    Ann N Y Acad Sci 1113:87-94. 2007
    ....
  4. ncbi request reprint Mitochondria and cellular oxygen sensing in the HIF pathway
    Cormac T Taylor
    UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Biochem J 409:19-26. 2008
    ....
  5. doi request reprint Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans
    Cormac T Taylor
    UCD Conway Institute, Systems Biology Ireland and School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
    Physiology (Bethesda) 25:272-9. 2010
    ..Thus atmospheric oxygen levels may have provided a selection force on the development of cellular oxygen-sensing pathways...
  6. ncbi request reprint Regulation of intestinal epithelial gene expression in hypoxia
    Cormac T Taylor
    Dept Medicine and Therapeutics, The Conway Institute, University College, Dublin, Ireland
    Kidney Int 66:528-31. 2004
    ..Here we review our understanding of the molecular mechanisms underlying the regulation of CREB activity in intestinal epithelial cells in hypoxia...
  7. pmc Regulation of gene expression by carbon dioxide
    Cormac T Taylor
    UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Physiol 589:797-803. 2011
    ..This latter, transcriptional regulatory role for CO(2), has been largely attributed to altered activity of the NF-B family of transcription factors. Here, we review our evolving understanding of how CO(2) impacts upon gene transcription...
  8. pmc Interdependent roles for hypoxia inducible factor and nuclear factor-kappaB in hypoxic inflammation
    Cormac T Taylor
    UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Physiol 586:4055-9. 2008
    ..Recent studies indicate that these pathways may represent important new therapeutic targets in diseases characterized by hypoxic inflammation...
  9. ncbi request reprint Hypoxia and gastrointestinal disease
    Cormac T Taylor
    UCD Conway Institute, School of Medicine and Medical Science, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
    J Mol Med (Berl) 85:1295-300. 2007
    ..In this paper, we review this pathway in detail and examine the therapeutic potential for targeting HIF hydroxylases in intestinal mucosal inflammatory disease...
  10. doi request reprint NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells
    Eoin P Cummins
    UCD Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland
    J Immunol 185:4439-45. 2010
    ..These results suggest the existence of a molecular CO(2) sensor in mammalian cells that is linked to the regulation of genes involved in innate immunity and inflammation...
  11. pmc Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling
    Kathryn M Oliver
    School of Medicine and Medical Science, UCD Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 287:14004-11. 2012
    ..Taken together, these data demonstrate that RelB is a CO(2)-sensitive NF-κB family member that may contribute to the beneficial effects of hypercapnia in inflammatory diseases of the lung...
  12. pmc Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways
    Carsten C Scholz
    Systems Biology Ireland, School of Medicine and Medical Science, and Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 110:18490-5. 2013
    ..Thus, we hypothesize that hydroxylases regulate IL-1β signaling and subsequent inflammatory gene expression. Furthermore, hydroxylase inhibition represents a unique approach to the inhibition of IL-1β-dependent inflammatory signaling. ..
  13. pmc PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
    Kathleen A O'Hagan
    Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 106:2188-93. 2009
    ....
  14. doi request reprint An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia
    Susan F Fitzpatrick
    UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Immunol 186:1091-6. 2011
    ..These results implicate an essential role for NF-κB signaling in inflammatory gene expression in response to hypoxia both through the regulation of HIF-1 and through direct effects upon target gene expression...
  15. doi request reprint Glucose reintroduction triggers the activation of Nrf2 during experimental ischemia reperfusion
    Daniel Crean
    Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland
    Mol Cell Biochem 366:231-8. 2012
    ..We suggest these findings represent a previously unreported mechanism for the activation of Nrf2 as a cytoprotective pathway in IRI...
  16. ncbi request reprint Identification of cyclic AMP response element-binding protein-dependent transcriptional responses in hypoxia by microarray analysis
    Martin O Leonard
    The Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Ireland
    Methods Enzymol 381:511-24. 2004
  17. pmc Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung
    Martin O Leonard
    University College Dublin, School of Medicine and Medical Science, and Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland
    Am J Respir Crit Care Med 178:977-83. 2008
    ..The pulmonary vascular changes in response to hypoxia, both structural and functional, are unique to this circulation...
  18. pmc Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity
    Eoin P Cummins
    Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 103:18154-9. 2006
    ....
  19. doi request reprint Gremlin plays a key role in the pathogenesis of pulmonary hypertension
    Edwina Cahill
    University College Dublin, School of Medicine and Medical Sciences, Belfield, Dublin 4, Ireland
    Circulation 125:920-30. 2012
    ..Subsequently, it was demonstrated that BMP signaling was also reduced in common forms of pulmonary hypertension, including hypoxic pulmonary hypertension; however, the mechanism of this reduction has not previously been elucidated...
  20. pmc MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia
    Ulrike Bruning
    School of Medicine and Medical Science and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Mol Cell Biol 31:4087-96. 2011
    ....
  21. pmc Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia
    Terence A Agbor
    UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 286:4718-26. 2011
    ..In summary, we hypothesize that SUMO modification of key metabolic enzymes plays an important role in shifting cellular metabolic strategies toward increased flux through the glycolytic pathway during periods of hypoxic stress...
  22. ncbi request reprint Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner
    Susan M O'Reilly
    UCD Conway Institute, University College Dublin, Dublin, Ireland
    Am J Physiol Cell Physiol 290:C592-600. 2006
    ..These data also further support a role for CREB as an HIF-independent hypoxia-responsive transcription factor in the regulation of intestinal epithelial gene expression...
  23. doi request reprint A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network
    Lan K Nguyen
    Systems Biology Ireland, University College Dublin, Dublin 4, Ireland
    J Cell Sci 126:1454-63. 2013
    ....
  24. pmc Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosa
    Bettina Schaible
    UCD School of Medicine and Medical Science and The Conway Institute, University College Dublin, Dublin, Ireland
    PLoS ONE 8:e56491. 2013
    ..Thus, hypoxia reduces P. aeruginosa internalization into epithelial cells and pharmacologic manipulation of the host pathways involved may represent new therapeutic targets in the treatment of P. aeruginosa infection...
  25. ncbi request reprint A critical role for p38 map kinase in NF-kappaB signaling during intermittent hypoxia/reoxygenation
    Silke Ryan
    School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Biochem Biophys Res Commun 355:728-33. 2007
    ..Furthermore, depletion of p38 using siRNA significantly reduces IHR-induced NF-kappaB activity. Thus, IHR activates NF-kappaB in an IKK-dependent manner signaled at least in part via activation of p38 MAPK...
  26. doi request reprint NFκB and HIF display synergistic behaviour during hypoxic inflammation
    Ulrike Bruning
    Conway Institute, University College Dublin, Ireland
    Cell Mol Life Sci 69:1319-29. 2012
    ..Furthermore, we demonstrate synergistic activity between these two transcription factors on the regulation of the COX-2 promoter, implicating a co-ordinated role for both HIF and NFκB in the expression of COX-2 in hypoxic inflammation...
  27. doi request reprint Hypoxia activates NF-kappaB-dependent gene expression through the canonical signaling pathway
    Kathryn M Oliver
    UCD Conway Institute, University College Dublin, Belfield, Ireland
    Antioxid Redox Signal 11:2057-64. 2009
    ..In summary, we hypothesize that hypoxia enhances NF-kappaB activity primarily through affecting the canonical pathway...
  28. pmc The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells
    Emily Hams
    Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    Shock 36:295-302. 2011
    ..This study demonstrates cell type-specific roles for hydroxylase inhibition in vivo and provides insight into the mechanism underlying the protection conveyed by DMOG in models of endotoxic shock...
  29. ncbi request reprint Regulation of protein phosphatase 1gamma activity in hypoxia through increased interaction with NIPP1: implications for cellular metabolism
    Kathrina M Comerford
    School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Ireland
    J Cell Physiol 209:211-8. 2006
    ....
  30. ncbi request reprint Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor
    Martin O Leonard
    Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland
    J Immunol 174:2250-7. 2005
    ....
  31. ncbi request reprint c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia
    Katrina M Comerford
    Department of Medicine and Therapeutics, The Conway Institute for Biomolecular and Biomedical Research and the Dublin Molecular Medicine Centre, University College, Dublin, Ireland
    Cancer Res 64:9057-61. 2004
    ..Furthermore, these events are independent of the generation of reactive oxygen intermediates. Thus, JNK may represent a therapeutic target in the prevention of tumor resistance to chemotherapeutic treatment...
  32. ncbi request reprint The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia
    Martin O Leonard
    Conway Institute of Biomolecular and Biomedical Research and the Dublin Molecular Medicine Centre, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 278:40296-304. 2003
    ..Our data indicate that although this event may rely heavily on HIF-1-dependent gene transcription, it is likely that separate hypoxia-dependent transcriptional regulators also play a role...
  33. ncbi request reprint Enhanced sensitivity of protein kinase B/Akt to insulin in hypoxia is independent of HIF1alpha and promotes cell viability
    Robert E Barry
    UCD School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Eur J Cell Biol 86:393-403. 2007
    ..Thus, PKB/Akt may regulate specific cellular responses to growth factors such as insulin under adverse conditions such as hypoxia...
  34. pmc Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps
    Bettina Schaible
    Conway Institute, University College Dublin, Belfield, Ireland
    Antimicrob Agents Chemother 56:2114-8. 2012
    ..Thus, microenvironmental hypoxia may contribute significantly to the development of antibiotic resistance in P. aeruginosa infecting cystic fibrosis patients...
  35. doi request reprint Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function
    Murtaza M Tambuwala
    The Conway Institute, University College Dublin, Ireland
    Gastroenterology 139:2093-101. 2010
    ..Hypoxia inducible factor (HIF) prolyl hydroxylase inhibitors are protective in mouse models of inflammatory bowel disease (IBD). Here, we investigated the therapeutic target(s) and mechanism(s) involved...
  36. pmc Hypoxia. Regulation of NFkappaB signalling during inflammation: the role of hydroxylases
    Kathryn M Oliver
    School of Medicine and Medical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Arthritis Res Ther 11:215. 2009
    ..Furthermore, we will discuss the potential for prolylhydroxylase inhibitors in inflammatory disease...
  37. ncbi request reprint Hypoxia-responsive transcription factors
    Eoin P Cummins
    Department of Medicine and Therapeutics, The Conway Institute for Biomolecular and Biomedical Research and the Dublin Molecular Medicine Centre, University College Dublin, Belfield, Dublin, 4, Ireland
    Pflugers Arch 450:363-71. 2005
    ..Understanding such events will enhance our understanding of cellular oxygen sensing...
  38. ncbi request reprint Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome
    Silke Ryan
    Sleep Research Laboratory, St Vincent s University Hospital, Dublin, Ireland
    Circulation 112:2660-7. 2005
    ..We investigated the underlying molecular mechanisms of this association in a translational study...
  39. doi request reprint The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis
    Eoin P Cummins
    UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Gastroenterology 134:156-65. 2008
    ..Both HIF-1 and NF-kappaB pathways are repressed by the action of hydroxylases through the hydroxylation of key regulatory molecules...
  40. ncbi request reprint Predictors of elevated nuclear factor-kappaB-dependent genes in obstructive sleep apnea syndrome
    Silke Ryan
    Sleep Research Laboratory, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Am J Respir Crit Care Med 174:824-30. 2006
    ..Furthermore, TNF-alpha is associated with excessive daytime sleepiness. We investigated the predictors of TNF-alpha and related genes in large, well-selected cohorts of subjects with OSAS and control subjects...
  41. ncbi request reprint Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury
    Martin O Leonard
    School of Medicine and Medical Sciences, The Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    FASEB J 20:2624-6. 2006
    ..These results indicate that reoxygenation-dependent Nrf-2 activity facilitates ischemic preconditioning through the induction of antioxidant gene expression and that ROS may be critical in signaling this event...
  42. doi request reprint Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea
    Joseph B J Ward
    Molecular Medicine Laboratories, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    FASEB J 25:535-43. 2011
    ..In conclusion, hydroxylases are important regulators of epithelial Cl(-) and fluid secretion and present a promising target for development of new drugs to treat transport disorders...
  43. doi request reprint Hypoxia, innate immunity and infection in the lung
    Bettina Schaible
    UCD Conway Institute, University College Dublin, Department of Microbiology, St Vincent s University Hospital, Dublin 4, Ireland
    Respir Physiol Neurobiol 174:235-43. 2010
    ..In the current review, we will discuss recent data pertaining to the role of hypoxia in regulating both host and pathogen in the lung during pulmonary disease and how this contributes to innate immunity, infection and inflammation...
  44. doi request reprint Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxia
    Cormac T Taylor
    UCD Conway Institute, University College Dublin, Ireland
    Arterioscler Thromb Vasc Biol 30:643-7. 2010
    ....
  45. ncbi request reprint Hypoxic regulation of NF-kappaB signaling
    Eoin P Cummins
    UCD Conway Institute, University College Dublin, Dublin, Ireland
    Methods Enzymol 435:479-92. 2007
    ..This work has implicated a novel role for proline and asparagine hydroxylases in the modulation of NF-kappaB activity. Here, we describe methodologies used to demonstrate and interrogate hypoxic induction of the NF-kappaB pathway...
  46. doi request reprint Targeting the HIF pathway in inflammation and immunity
    Carsten C Scholz
    Systems Biology Ireland, School of Medicine and Medical Science and The Conway Institute, University College Dublin, Ireland
    Curr Opin Pharmacol 13:646-53. 2013
    ..Furthermore, we will consider potential therapeutic strategies, which target the HIF pathway in chronic inflammatory and infectious disease. ..
  47. doi request reprint Hydroxylase-dependent regulation of the NF-κB pathway
    Carsten C Scholz
    School of Medicine and Medical Science, University College Dublin, Dublin, Ireland
    Biol Chem 394:479-93. 2013
    ..Developing our understanding of the role of hydroxylases in hypoxic inflammation may identify novel therapeutic approaches in chronic inflammatory disease...
  48. doi request reprint Hydroxylases as therapeutic targets in inflammatory bowel disease
    Eoin P Cummins
    School of Medicine and Medical Science and The Conway Institute, University College Dublin, Dublin, Ireland
    Lab Invest 93:378-83. 2013
    ..In this review, the mechanism(s) of action and the therapeutic potential of small molecule hydroxylase inhibitors for the treatment of IBD will be discussed...
  49. doi request reprint Alterations in oxidative gene expression in equine skeletal muscle following exercise and training
    Suzanne S Eivers
    Animal Genomics Laboratory, University College Dublin School of Agriculture, Food Science and Veterinary Medicine, Dublin, Ireland
    Physiol Genomics 40:83-93. 2010
    ..These data highlight the roles of genes responsible for the regulation of oxygen-dependent metabolism, glucose metabolism, and fatty acid utilization in equine skeletal muscle adaptation to exercise...
  50. ncbi request reprint Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells
    Ronan N T Coffey
    Department of Surgery, Mater Misericordiae University Hospital, Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Ireland
    Cancer 103:1363-74. 2005
    ..The authors hypothesized that HIF-1alpha is central to the cell's ability to resist apoptosis induced during the hypoxia selection process...
  51. ncbi request reprint Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults
    Eleanor J Molloy
    Department of Surgery, Conway Institute of Biomolecular and Biomedical Research, Mater Misericordiae University Hospital, Dublin, Ireland
    Biol Neonate 90:34-9. 2006
    ..Dysfunctional inflammatory responses have been implicated in several neonatal inflammatory disorders following infection and hypoxia...
  52. ncbi request reprint Lower expression of Nrf2 mRNA in older donor livers: a possible contributor to increased ischemia-reperfusion injury?
    Muhammad B Zaman
    National Liver Unit, St Vincent s University Hospital, Dublin, Ireland
    Transplantation 84:1272-8. 2007
    ....
  53. doi request reprint The impact of hypoxia on cell death pathways
    Colin R Lenihan
    School of Medicine and Medical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Biochem Soc Trans 41:657-63. 2013
    ..In the present review, we discuss the complex relationship that exists between the presence of hypoxia and the regulation of cell death pathways...
  54. ncbi request reprint Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog
    Niamh E Kieran
    Human Genomics and Bioinformatics Research Unit, Department of Medicine and Therapeutics, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Mater Misericordiae Hospital, Dublin 7, Ireland
    Kidney Int 64:480-92. 2003
    ....
  55. doi request reprint Carbon dioxide-sensing in organisms and its implications for human disease
    Eoin P Cummins
    School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Cell Mol Life Sci 71:831-45. 2014
    ....
  56. doi request reprint SUMO, hypoxia and the regulation of metabolism
    Terence A Agbor
    School of Medicine and Medical Science and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Biochem Soc Trans 36:445-8. 2008
    ..Here, we will briefly review the evolving evidence for this pathway in the regulation of a number of metabolic regulators and discuss a possible role for SUMOylation in the regulation of basic metabolic function...
  57. ncbi request reprint The autonomic nervous system and inflammatory bowel disease
    Cormac T Taylor
    School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Ireland
    Auton Neurosci 133:104-14. 2007
    ..This review aims to synthesize the current understanding of the pathogenesis of IBD with a particular emphasis on the role that the ANS plays in the progression of these diseases...
  58. ncbi request reprint Cholera toxin potentiates influences of IFN-gamma through activation of NF-kappaB and release of tumor necrosis factor-alpha
    Richard S Blumberg
    Division of Gastroenterology, Brigham and Women s Hospital and Harvard Medical School, 20 Shattuck Street, Boston, MA 02115, USA
    J Interferon Cytokine Res 25:209-19. 2005
    ..We conclude that Ctx elicits a proinflammatory phenotype in intestinal epithelia and that potentiation of IFN-gamma-mediated barrier disruption by TNF-alpha may contribute to the overall adjuvant properties of Ctx...
  59. doi request reprint Mitochondria, oxygen sensing, and the regulation of HIF-2alpha. Focus on "Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line"
    Cormac T Taylor
    Am J Physiol Cell Physiol 294:C1300-2. 2008
  60. ncbi request reprint Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha
    Thilo Hagen
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Science 302:1975-8. 2003
    ..Thus, the signaling consequences of hypoxia may be profoundly modified by nitric oxide...
  61. ncbi request reprint Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF1 alpha, a potent epithelial secretagogue
    Sean P Colgan
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, MA
    Adv Exp Med Biol 507:107-12. 2002