Jeremy C Simpson

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. doi request reprint Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway
    Jeremy C Simpson
    School of Biology and Environmental Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
    Nat Cell Biol 14:764-74. 2012
  2. doi request reprint Screening the secretion machinery: High throughput imaging approaches to elucidate the secretory pathway
    Jeremy C Simpson
    School of Biology and Environmental Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin UCD, Dublin 4, Ireland
    Semin Cell Dev Biol 20:903-9. 2009
  3. ncbi request reprint Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles
    Fengjuan Wang
    Centre for BioNano Interactions and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Nanoscale 5:10868-76. 2013
  4. pmc Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells
    Juan A Varela
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
    J Nanobiotechnology 10:39. 2012
  5. pmc A method for improved clustering and classification of microscopy images using quantitative co-localization coefficients
    Vasanth R Singan
    School of Biology and Environmental Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Belfield, Ireland
    BMC Res Notes 5:281. 2012
  6. doi request reprint Quantitative image analysis approaches for probing Rab GTPase localization and function in mammalian cells
    Vasanth R Singan
    School of Biology and Environmental Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biochem Soc Trans 40:1389-93. 2012
  7. doi request reprint High-speed imaging of Rab family small GTPases reveals rare events in nanoparticle trafficking in living cells
    Peter Sandin
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology and UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    ACS Nano 6:1513-21. 2012
  8. pmc Human diseases associated with form and function of the Golgi complex
    Mariana G Bexiga
    School of Biology and Environmental Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
    Int J Mol Sci 14:18670-81. 2013
  9. doi request reprint Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line
    Mariana G Bexiga
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin, Ireland
    Nanotoxicology 5:557-67. 2011
  10. pmc Dual channel rank-based intensity weighting for quantitative co-localization of microscopy images
    Vasanth R Singan
    1School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland
    BMC Bioinformatics 12:407. 2011

Detail Information

Publications10

  1. doi request reprint Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway
    Jeremy C Simpson
    School of Biology and Environmental Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
    Nat Cell Biol 14:764-74. 2012
    ..This work provides an important resource for an integrative understanding of global cellular organization and regulation of the secretory pathway in mammalian cells...
  2. doi request reprint Screening the secretion machinery: High throughput imaging approaches to elucidate the secretory pathway
    Jeremy C Simpson
    School of Biology and Environmental Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin UCD, Dublin 4, Ireland
    Semin Cell Dev Biol 20:903-9. 2009
    ..This review highlights how techniques such as high throughput subcellular localisation, RNA interference screening and automated microscopy are now being harnessed to provide new information about secretory pathway function...
  3. ncbi request reprint Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles
    Fengjuan Wang
    Centre for BioNano Interactions and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Nanoscale 5:10868-76. 2013
    ..This is accompanied and sustained by other events, such as increasing ROS levels and autophagy. Using various inhibitors, we also show the interplay between apoptosis and autophagy as a response to NP accumulation in lysosomes. ..
  4. pmc Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells
    Juan A Varela
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
    J Nanobiotechnology 10:39. 2012
    ..Due to the novelty of these applications and to ensure their success, a precise characterization of the interactions between NPs and cells is essential...
  5. pmc A method for improved clustering and classification of microscopy images using quantitative co-localization coefficients
    Vasanth R Singan
    School of Biology and Environmental Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Belfield, Ireland
    BMC Res Notes 5:281. 2012
    ..However, there are currently very few image analysis options able to effectively discriminate proteins with apparently similar distributions in cells, despite this information being important for protein characterization...
  6. doi request reprint Quantitative image analysis approaches for probing Rab GTPase localization and function in mammalian cells
    Vasanth R Singan
    School of Biology and Environmental Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biochem Soc Trans 40:1389-93. 2012
    ..We give specific emphasis to the importance of the quantitative nature of these recent studies and comment on their potential applicability to a high-throughput format...
  7. doi request reprint High-speed imaging of Rab family small GTPases reveals rare events in nanoparticle trafficking in living cells
    Peter Sandin
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology and UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    ACS Nano 6:1513-21. 2012
    ....
  8. pmc Human diseases associated with form and function of the Golgi complex
    Mariana G Bexiga
    School of Biology and Environmental Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
    Int J Mol Sci 14:18670-81. 2013
    ..Here we describe how these proteins have been linked to the Golgi complex, and specifically how they affect either the morphology, membrane traffic or glycosylation ability of this organelle. ..
  9. doi request reprint Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line
    Mariana G Bexiga
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin, Ireland
    Nanotoxicology 5:557-67. 2011
    ..Together these results suggest that amine-modified polystyrene nanoparticles can mediate cell death through an apoptotic mechanism mediated by damage to the mitochondria...
  10. pmc Dual channel rank-based intensity weighting for quantitative co-localization of microscopy images
    Vasanth R Singan
    1School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland
    BMC Bioinformatics 12:407. 2011
    ..Furthermore, this choice of whether co-occurrence or correlation is the best approach for quantifying co-localization remains controversial...