Fergus Shanahan

Summary

Affiliation: University College Cork
Country: Ireland

Publications

  1. ncbi request reprint Intestinal lymphoepithelial communication
    F Shanahan
    Department of Medicine, National University of Ireland, Cork, Ireland
    Adv Exp Med Biol 473:1-9. 1999
  2. ncbi request reprint Probiotics and the immune response: how much can we expect?
    Fergus Shanahan
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    J Pediatr Gastroenterol Nutr 39:S748-9. 2004
  3. ncbi request reprint Review article: colitis-associated cancer -- time for new strategies
    F Shanahan
    Department of Medicine, Cork University Hospital and University College Cork, National University of Ireland, Ireland
    Aliment Pharmacol Ther 18:6-9. 2003
  4. ncbi request reprint Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics
    F Shanahan
    Department of Medicine, Cork University Hospital and National University of Ireland, Cork, Ireland
    Gastroenterology 120:622-35. 2001
  5. ncbi request reprint Nutrient tasting and signaling mechanisms in the gut V. Mechanisms of immunologic sensation of intestinal contents
    F Shanahan
    Department of Medicine, National University of Ireland, University College Cork and Cork University Hospital, Ireland
    Am J Physiol Gastrointest Liver Physiol 278:G191-6. 2000
  6. ncbi request reprint Immunology. Therapeutic manipulation of gut flora
    F Shanahan
    Department of Medicine, Cork University Hospital, Cork, Ireland
    Science 289:1311-2. 2000
  7. pmc Modulation of pathogen-induced CCL20 secretion from HT-29 human intestinal epithelial cells by commensal bacteria
    Shomik Sibartie
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    BMC Immunol 10:54. 2009
  8. pmc Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius
    Ann M O'Hara
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Immunology 118:202-15. 2006
  9. doi request reprint The vexed relationship between Clostridium difficile and inflammatory bowel disease: an assessment of carriage in an outpatient setting among patients in remission
    Evelyn M Clayton
    Alimentary Pharmabiotic Centre at Moorepark Food Research Centre, Teagasc, Fermoy Co, Cork, Ireland
    Am J Gastroenterol 104:1162-9. 2009
  10. doi request reprint Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity
    Eileen F Murphy
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Gut 62:220-6. 2013

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint Intestinal lymphoepithelial communication
    F Shanahan
    Department of Medicine, National University of Ireland, Cork, Ireland
    Adv Exp Med Biol 473:1-9. 1999
    ..Disruption of any aspect of the mucosal microenvironment, as has been achieved with selective genetically engineered murine models, is associated with impaired mucosal defence and inflammation...
  2. ncbi request reprint Probiotics and the immune response: how much can we expect?
    Fergus Shanahan
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    J Pediatr Gastroenterol Nutr 39:S748-9. 2004
  3. ncbi request reprint Review article: colitis-associated cancer -- time for new strategies
    F Shanahan
    Department of Medicine, Cork University Hospital and University College Cork, National University of Ireland, Ireland
    Aliment Pharmacol Ther 18:6-9. 2003
    ..In this review article, the pitfalls of dysplasia surveillance are summarized and the need for novel chemopreventive and perhaps pharmabiotic approaches for prevention are highlighted...
  4. ncbi request reprint Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics
    F Shanahan
    Department of Medicine, Cork University Hospital and National University of Ireland, Cork, Ireland
    Gastroenterology 120:622-35. 2001
    ..Notwithstanding the widening range of options for drug therapy in IBD, other outcome modifiers and well-established principles of managing chronic disease are as important as ever...
  5. ncbi request reprint Nutrient tasting and signaling mechanisms in the gut V. Mechanisms of immunologic sensation of intestinal contents
    F Shanahan
    Department of Medicine, National University of Ireland, University College Cork and Cork University Hospital, Ireland
    Am J Physiol Gastrointest Liver Physiol 278:G191-6. 2000
    ....
  6. ncbi request reprint Immunology. Therapeutic manipulation of gut flora
    F Shanahan
    Department of Medicine, Cork University Hospital, Cork, Ireland
    Science 289:1311-2. 2000
    ....
  7. pmc Modulation of pathogen-induced CCL20 secretion from HT-29 human intestinal epithelial cells by commensal bacteria
    Shomik Sibartie
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    BMC Immunol 10:54. 2009
    ..CCL20 and interleukin (IL)-8 secretion and nuclear factor (NF)-kappaB activation were measured using enzyme-linked immunosorbent assays...
  8. pmc Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius
    Ann M O'Hara
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Immunology 118:202-15. 2006
    ..infantis or L. salivarius, these commensal bacteria exert immunomodulatory effects on intestinal immune cells that mediate host responses to flagellin and enteric pathogens...
  9. doi request reprint The vexed relationship between Clostridium difficile and inflammatory bowel disease: an assessment of carriage in an outpatient setting among patients in remission
    Evelyn M Clayton
    Alimentary Pharmabiotic Centre at Moorepark Food Research Centre, Teagasc, Fermoy Co, Cork, Ireland
    Am J Gastroenterol 104:1162-9. 2009
    ..Retrospective analyses have suggested community acquisition; to address this we conducted a prospective analysis of C. difficile carriage in IBD patients using molecular methods specifically in an outpatient setting...
  10. doi request reprint Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity
    Eileen F Murphy
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Gut 62:220-6. 2013
    ..This study explored two antimicrobial strategies for their impact on metabolic abnormalities in murine diet-induced obesity: oral vancomycin and a bacteriocin-producing probiotic (Lactobacillus salivarius UCC118 Bac(+))...
  11. doi request reprint Mucosal cytokine imbalance in irritable bowel syndrome
    John Macsharry
    Alimentary Health Ltd, Cork, Ireland
    Scand J Gastroenterol 43:1467-76. 2008
    ..To systematically examine mucosal biopsies for differences in cytokine gene expression and protein secretion...
  12. doi request reprint Loss of vagal anti-inflammatory effect: in vivo visualization and adoptive transfer
    Caitlin O'Mahony
    Alimentary Pharmabiotic Centre, National University of Ireland, Cork, Ireland
    Am J Physiol Regul Integr Comp Physiol 297:R1118-26. 2009
    ..The proinflammatory effect of vagotomy is transferable using splenic T cells and highlights a previously unappreciated cellular mechanism for linking central parasympathetic processes with mucosal inflammation and immune homeostasis...
  13. doi request reprint Recombinant lactobacilli expressing linoleic acid isomerase can modulate the fatty acid composition of host adipose tissue in mice
    Eva Rosberg-Cody
    Alimentary Pharmabiotic Centre APC, Cork, Ireland
    Microbiology 157:609-15. 2011
    ..These data demonstrate that a single gene (encoding linoleic acid isomerase) expressed in an intestinal microbe can influence the fatty acid composition of host fat...
  14. pmc Natural killer cells protect against mucosal and systemic infection with the enteric pathogen Citrobacter rodentium
    Lindsay J Hall
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Infect Immun 81:460-9. 2013
    ..NK cell-depleted mice also developed disseminated systemic infection, unlike control infected mice. NK cells were also cytotoxic to C. rodentium in vitro...
  15. doi request reprint Carriage of Clostridium difficile in outpatients with irritable bowel syndrome
    Evelyn M Clayton
    Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland
    J Med Microbiol 61:1290-4. 2012
    ..Although no significant difference was observed between IBS patients and healthy volunteers, these findings support the concept that a subpopulation of IBS patients may be susceptible to gastrointestinal infection...
  16. doi request reprint Irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease: a real association or reflection of occult inflammation?
    John Keohane
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Am J Gastroenterol 105:1788, 1789-94; quiz 1795. 2010
    ....
  17. pmc Commensal-induced regulatory T cells mediate protection against pathogen-stimulated NF-kappaB activation
    Caitlin O'Mahony
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    PLoS Pathog 4:e1000112. 2008
    ....
  18. doi request reprint Contrasting effects of Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 on the composition of murine brain fatty acids and gut microbiota
    Rebecca Wall
    Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
    Am J Clin Nutr 95:1278-87. 2012
    ..We previously showed that microbial metabolism in the gut influences the composition of bioactive fatty acids in host adipose tissue...
  19. doi request reprint Mycobacterium avium subsp. Paratuberculosis (MAP) as a modifying factor in Crohn's disease
    Shomik Sibartie
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Inflamm Bowel Dis 16:296-304. 2010
    ..Our aim was to examine the influence of MAP on T-cell proliferation and cytokine responses in patients with inflammatory bowel disease (IBD)...
  20. pmc Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome
    Eoin Barrett
    Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
    PLoS ONE 7:e48159. 2012
    ..Administration of B. breve DPC6330 to maternally separated rats significantly modified the palmitoleic acid, arachidonic acid and docosahexaenoic acid contents in tissues. The effect was not observed in non-separated animals...
  21. doi request reprint Impact of administered bifidobacterium on murine host fatty acid composition
    Rebecca Wall
    Alimentary Pharmabiotic Centre, Co Cork, Ireland
    Lipids 45:429-36. 2010
    ..This interaction between administered microbes and fatty acids could result in a highly effective nutritional approach to the therapy of a variety of inflammatory and neurodegenerative conditions...
  22. doi request reprint Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis
    Pauline D Scanlan
    Department of Microbiology, University College Cork, Cork, Ireland
    Environ Microbiol 10:789-98. 2008
    ..The intestinal microbiota and their metabolites are significantly altered in both colorectal cancer and polypectomized subjects compared with controls...
  23. pmc Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut
    David Groeger
    Alimentary Health Ltd, Cork, Ireland
    Gut Microbes 4:325-39. 2013
    ..In conclusion, these data show that the immunomodulatory effects of the microbiota in humans are not limited to the mucosal immune system but extend to the systemic immune system. ..
  24. pmc Antimicrobials: Strategies for targeting obesity and metabolic health?
    Eileen F Murphy
    Alimentary Health Ltd, Cork, Ireland
    Gut Microbes 4:48-53. 2013
    ..In addition, we will explore some of the mechanisms that may contribute to microbiota-induced susceptibility to obesity and metabolic diseases...
  25. doi request reprint Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production
    Eiji Miyauchi
    Department of Microbiology, University College Cork, National University of Ireland, Cork, Ireland
    Am J Physiol Gastrointest Liver Physiol 303:G1029-41. 2012
    ..Furthermore, bacteriocin production appears to have an attenuating influence on lactobacillus-mediated barrier protection...
  26. pmc The sphingosine-1-phosphate analogue FTY720 impairs mucosal immunity and clearance of the enteric pathogen Citrobacter rodentium
    Carola T Murphy
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Infect Immun 80:2712-23. 2012
    ..The data demonstrate that the S1P analogue FTY720 adversely affects the immune response to and clearance of C. rodentium...
  27. pmc Differential intestinal M-cell gene expression response to gut commensals
    Susan Lapthorne
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Immunology 136:312-24. 2012
    ..These results demonstrate that M cells have the ability to discriminate between different commensal bacteria and modify subsequent immune responses...
  28. pmc Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection
    Saranna Fanning
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Proc Natl Acad Sci U S A 109:2108-13. 2012
    ..This finding enforces the probiotic concept and provides mechanistic insights into health-promoting benefits for both animal and human hosts...
  29. pmc Bifidobacterium animalis AHC7 protects against pathogen-induced NF-κB activation in vivo
    David O'Mahony
    Alimentary Health Ltd, National University of Ireland, Cork, Ireland
    BMC Immunol 11:63. 2010
    ..The aim of this study was to investigate the potential molecular and cellular mechanisms underpinning the Bifidobacterium animalis AHC7 protective effect...
  30. doi request reprint A molecular analysis of fecal and mucosal bacterial communities in irritable bowel syndrome
    Caroline Codling
    Department of Medicine, Alimentary Pharmabiotic Centre, Cork University Hospital, Cork, Ireland
    Dig Dis Sci 55:392-7. 2010
    ....
  31. ncbi request reprint Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?
    Timothy G Dinan
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Gastroenterology 130:304-11. 2006
    ..The primary aim of this study was to examine the hypothalamic-pituitary-adrenal axis in patients with IBS and to relate such response to plasma cytokine profiles...
  32. pmc Bacterial signalling overrides cytokine signalling and modifies dendritic cell differentiation
    Julie M Davies
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Immunology 128:e805-15. 2009
    ..This may account for some of the features of mucosal immune tolerance to the microbiota...
  33. ncbi request reprint Fas ligand promotes tumor immune evasion of colon cancer in vivo
    Aideen E Ryan
    Department of Medicine, National University of Ireland Cork, Cork, Ireland
    Cell Cycle 5:246-9. 2006
    ....
  34. ncbi request reprint Bacterial DNA within granulomas of patients with Crohn's disease--detection by laser capture microdissection and PCR
    Paul Ryan
    Alimentary Pharmabiotic Centre and Departments of Medicine, Histopathology, Microbiology, and Surgery, University College Cork, National University of Ireland, Ireland
    Am J Gastroenterol 99:1539-43. 2004
    ..The aim of this study was to determine whether DNA from nonmycobacterial commensals, such as Escherichia coli, is also increased in the granulomas of Crohn's disease...
  35. pmc Differential regulation of Toll-like receptor signalling in spleen and Peyer's patch dendritic cells
    Julie M Davies
    Alimentary Pharmabiotic Centre, National University of Ireland, University College Cork, Cork, Ireland
    Immunology 131:438-48. 2010
    ..Differential regulation of TLR signalling was also evident in bacteria-conditioned bone-marrow-derived cells indicating that bacterial signalling may be a mechanism for inducing altered gene regulation in PP DCs...
  36. doi request reprint Culture-independent analysis of desulfovibrios in the human distal colon of healthy, colorectal cancer and polypectomized individuals
    Pauline D Scanlan
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    FEMS Microbiol Ecol 69:213-21. 2009
    ....
  37. ncbi request reprint Neurokinin-1 receptor (NK-1R) expression is induced in human colonic epithelial cells by proinflammatory cytokines and mediates proliferation in response to substance P
    Triona Goode
    Department of Medicine, National University of Ireland, Cork, Ireland
    J Cell Physiol 197:30-41. 2003
    ..Our results therefore demonstrate that proinflammatory cytokines induce expression of NK-1R in human colonic epithelial cell lines, and that SP induces proliferation of the epithelial cells via cytokine-induced NK-1R...
  38. doi request reprint Metabolic activity of the enteric microbiota influences the fatty acid composition of murine and porcine liver and adipose tissues
    Rebecca Wall
    Alimentary Pharmabiotic Centre, Cork, Ireland
    Am J Clin Nutr 89:1393-401. 2009
    ..Recent reports suggest that the metabolic activity of the gut microbiota may contribute to the pathogenesis of obesity and hepatic steatosis...
  39. doi request reprint Technical Advance: Function and efficacy of an {alpha}4-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis
    Carola T Murphy
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    J Leukoc Biol 88:1271-8. 2010
    ..Furthermore, in vivo bioluminescence imaging is a valuable strategy for preclinical evaluation of potential therapeutics that target leukocyte trafficking in inflammatory diseases...
  40. doi request reprint The colonic microbiota and colonic disease
    Fergus Shanahan
    Department of Medicine and Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Dublin, Ireland
    Curr Gastroenterol Rep 14:446-52. 2012
    ..The possibility that the therapeutic solution to some of these disorders may reside within the microbiota will also be addressed...
  41. doi request reprint Selection of symptomatic patients with Crohn's disease for abdominopelvic computed tomography: role of serum C-reactive protein
    Alan N Desmond
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland and Cork University Hospital, Cork, Ireland
    Can Assoc Radiol J 63:267-74. 2012
    ..This study examines if serum C-reactive protein (CRP) concentration predicts which symptomatic patients with CD are likely to have significant disease activity or disease complications (such as abscess) detected on abdominopelvic CT...
  42. doi request reprint Immunomodulatory effects of feeding with Bifidobacterium longum on allergen-induced lung inflammation in the mouse
    John Macsharry
    Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
    Pulm Pharmacol Ther 25:325-34. 2012
    ..The aim of the current study was to examine how robust the effects of feeding with the commensal strain, Bifidobacterium longum (Bif) were on the pulmonary responses to allergen sensitization and challenge...
  43. doi request reprint Gut microbiota composition correlates with diet and health in the elderly
    Marcus J Claesson
    Department of Microbiology, University College Cork, Ireland
    Nature 488:178-84. 2012
    ..Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing...
  44. pmc Human methanogen diversity and incidence in healthy and diseased colonic groups using mcrA gene analysis
    Pauline D Scanlan
    Alimentary Pharmabiotic Centre, National University of Ireland, University College Cork, Cork, Ireland
    BMC Microbiol 8:79. 2008
    ....
  45. doi request reprint Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors
    Timothy G Dinan
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Am J Gastroenterol 103:2570-6. 2008
    ..We tested the hypothesis that the pro-inflammatory cytokine profile in IBS is driven by the cholinergic system and determined if the responses are mediated by muscarinic receptors...
  46. doi request reprint Evaluation of colostrum-derived human mammary-associated serum amyloid A3 (M-SAA3) protein and peptide derivatives for the prevention of enteric infection: in vitro and in murine models of intestinal disease
    Gillian E Gardiner
    Teagasc, Moorepark Food Research Center, Fermoy Co, Cork, Ireland
    FEMS Immunol Med Microbiol 55:404-13. 2009
    ..Overall, although promising anti-infective activity was demonstrated in vitro, neither the 42-mer M-SAA3 protein nor a 10-mer peptide derivative prevented enteric infection in the animal models tested...
  47. ncbi request reprint Gut microbiota: mining for therapeutic potential
    Fergus Shanahan
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Clin Gastroenterol Hepatol 5:274-84. 2007
    ..It follows that elucidating the molecular mechanisms of host-microbial interactions is now a prerequisite for a "bugs to drugs" program of discovery...
  48. doi request reprint Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with toll-like receptor 4 expression and plasma levels of interleukin 8
    Ahmed Abu Shanab
    Alimentary Pharmabiotic Centre, Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland
    Dig Dis Sci 56:1524-34. 2011
    ..Liver injury and fibrosis could be related to exposure to bacterial products of intestinal origin and, most notably, endotoxin, including lipopolysaccharide (LPS)...
  49. doi request reprint Differential expression of toll-like receptors in patients with irritable bowel syndrome
    Elizabeth K Brint
    Department of Pathology, University College Cork, National University of Ireland, and Alimentary Pharmabiotic Centre, Cork University Hospital, Cork, Ireland
    Am J Gastroenterol 106:329-36. 2011
    ..The aim of this study was to evaluate the potential involvement of TLRs in IBS to further understand the involvement of the innate immune system in this complex disorder...
  50. ncbi request reprint The role of substance P in inflammatory disease
    Terence M O'Connor
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    J Cell Physiol 201:167-80. 2004
    ..In this paper, we review the role that SP plays in inflammatory disease...
  51. ncbi request reprint Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles
    Liam O'Mahony
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Gastroenterology 128:541-51. 2005
    ..The aim of this study was to compare the response of symptoms and cytokine ratios in irritable bowel syndrome (IBS) with ingestion of probiotic preparations containing a lactobacillus or bifidobacterium strain...
  52. pmc Targeting the microbiota to address diet-induced obesity: a time dependent challenge
    Siobhan F Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    PLoS ONE 8:e65790. 2013
    ..The results highlight the resilience of the gut microbiota and suggest that interventions may need to be monitored and continually adjusted to ensure sustained modification of the gut microbiota...
  53. doi request reprint Probiotics in transition
    Fergus Shanahan
    Department of Medicine and Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Clin Gastroenterol Hepatol 10:1220-4. 2012
    ..Similarly, the development of new therapeutic strategies, such as the development of phagebiotics, psychobiotics, and genetically modified pharmabiotics, is poised to become a therapeutic reality...
  54. pmc Shining a light on intestinal traffic
    Carola T Murphy
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland
    Clin Dev Immunol 2012:808157. 2012
    ..Vigilance for toxicity and further research is required into this complex and emerging area of IBD therapy...
  55. doi request reprint Induction and activation of adaptive immune populations during acute and chronic phases of a murine model of experimental colitis
    Lindsay J Hall
    Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
    Dig Dis Sci 56:79-89. 2011
    ..Despite its continuing importance as a model system for examining IBD pathogenesis, the mucosal and systemic immune responses have not been comprehensively documented...
  56. doi request reprint Degradation of the extracellular matrix components by bacterial-derived metalloproteases: implications for inflammatory bowel diseases
    Mihaela Pruteanu
    Alimentary Health Ltd, Cork, Ireland
    Inflamm Bowel Dis 17:1189-200. 2011
    ..Whether this proteolytic activity is entirely host-derived, or, in part, produced by the gut microbiota, is unknown...
  57. pmc Composition, variability, and temporal stability of the intestinal microbiota of the elderly
    Marcus J Claesson
    Department of Microbiology, University College, Cork, Ireland
    Proc Natl Acad Sci U S A 108:4586-91. 2011
    ..We conclude that the fecal microbiota of the elderly shows temporal stability over limited time in the majority of subjects but is characterized by unusual phylum proportions and extreme variability...
  58. pmc Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease
    Pauline D Scanlan
    Alimentary Pharmabiotic Centre, National University of Ireland, University College Cork, Cork, Ireland
    J Clin Microbiol 44:3980-8. 2006
    ..Clostridium and Bacteroides spp., which may have implications for the host's gut health, since some genera are involved in production of short-chain fatty acid, e.g., butyrate...
  59. ncbi request reprint Targeting the Fas/Fas ligand pathway in cancer
    Darren I O'Brien
    Department of Medicine, NUIC, Clinical Sciences Building, University Hospital, Cork, Ireland
    Expert Opin Ther Targets 9:1031-44. 2005
    ..This review summarises the current understanding of the Fas/FasL system in tumorigenesis and discusses attempts to utilise the Fas/FasL system in the treatment of cancer...
  60. doi request reprint A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn's disease
    Siobhan B O'Neill
    Department of Radiology, Cork University Hospital, Wilton, Cork, Ireland
    Eur Radiol 23:2503-12. 2013
    ..We studied an IR low-dose CT abdomen/pelvis (LDCTAP) protocol, designed to image at an effective dose (ED) approximating 1 mSv in patients with Crohn's disease (CD)...
  61. doi request reprint Radiation exposure from diagnostic imaging among patients with gastrointestinal disorders
    Alan N Desmond
    Department of Gastroenterology, Cork University Hospital, Cork, Ireland
    Clin Gastroenterol Hepatol 10:259-65. 2012
    ..We quantified imaging studies and estimated the cumulative effective dose (CED) of radiation received by patients with organic and functional GI disorders. We also identified factors and diagnoses associated with high CEDs...
  62. doi request reprint Role of radiologic imaging in irritable bowel syndrome: evidence-based review
    Owen J O'Connor
    Department of Radiology, Cork University Hospital and Alimentary Pharmabiotic Centre, University College Cork, Wilton, Cork, Ireland
    Radiology 262:485-94. 2012
    ....
  63. ncbi request reprint Correlation of probiotic Lactobacillus salivarius growth phase with its cell wall-associated proteome
    Peter Kelly
    Department of Medicine, Cork Cancer Research Centre and Alimentary Pharmabiotic Centre at the National University of Ireland, Cork, Ireland
    FEMS Microbiol Lett 252:153-9. 2005
    ....
  64. doi request reprint The evolving epidemiology of inflammatory bowel disease
    Fergus Shanahan
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Curr Opin Gastroenterol 25:301-5. 2009
    ..In this update, we will summarize how the changing epidemiology of IBD associated with modernization can be reconciled with current concepts of disease mechanisms and will discuss studies of clinically significant comorbidity in IBD...
  65. ncbi request reprint Differential cytokine response from dendritic cells to commensal and pathogenic bacteria in different lymphoid compartments in humans
    Liam O'Mahony
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland
    Am J Physiol Gastrointest Liver Physiol 290:G839-45. 2006
    ..Commensal-pathogen divergence in cytokine responses is more marked in cells isolated from the mucosal immune system compared with PBMCs...
  66. doi request reprint IBS: An epigenetic perspective
    Timothy G Dinan
    Alimentary Pharmabiotic Center, University College Cork, Cork, Ireland
    Nat Rev Gastroenterol Hepatol 7:465-71. 2010
    ..We conclude that applying epigenetic methodology to this common and disabling disorder may help unravel its complex pathophysiology and lead to more effective treatments...
  67. ncbi request reprint The normal intestinal microbiota
    Julian Marchesi
    Alimentary Pharmabiotic Centre, Departments of Microbiology and Medicine, University College Cork, National University of Ireland, Cork, Ireland
    Curr Opin Infect Dis 20:508-13. 2007
    ..This review focuses on the most recent work in these areas...
  68. ncbi request reprint Upregulation of neurokinin-1 receptor expression in the lungs of patients with sarcoidosis
    Terence M O'Connor
    Department of Medicine, Cork University Hospital, Cork, Ireland
    J Clin Immunol 23:425-35. 2003
    ..Upregulated neurokinin-1 receptor expression in patients with sarcoidosis may potentiate substance P-induced proinflammatory cytokine production in patients with sarcoidosis...
  69. ncbi request reprint Colitis-associated cancer and dysplasia surveillance: an opposing perspective
    Fergus Shanahan
    Alimentary Pharmabiotic Centre, Cork University Hospital, University College Cork, National University of Ireland, Department of Medicine, Cork, Ireland
    Curr Gastroenterol Rep 9:175-6. 2007
  70. ncbi request reprint Host-flora interactions in inflammatory bowel disease
    Fergus Shanahan
    Alimentary Pharmabiotic Centre and Department of Medicine, University College Cork, National University of Ireland
    Inflamm Bowel Dis 10:S16-24. 2004
  71. doi request reprint Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity
    Paul Scully
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Am J Gastroenterol 105:2235-43. 2010
    ..This study was designed to examine the cytokine profile among a group of IBS patients with the extra-intestinal co-morbidities fibromyalgia, premenstrual dysmorphic disorder, and chronic fatigue syndrome...
  72. doi request reprint CT-based estimation of intracavitary gas volumes using threshold-based segmentation: in vitro study to determine the optimal threshold range
    Sebastian Robert McWilliams
    Department of Radiology, University College Cork, Cork University Hospital, Wilton, Cork, Ireland
    J Med Imaging Radiat Oncol 56:289-94. 2012
    ..This study investigated the optimal Hounsfield unit (HU) threshold range when using threshold-based segmentation to estimate volumes of contained gas (i.e. intestinal gas) on CT...
  73. pmc Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor
    Mary O'Connell Motherway
    Alimentary Pharmabiotic Centre, National University of Ireland, Cork, Ireland
    Proc Natl Acad Sci U S A 108:11217-22. 2011
    ..Conservation of the Tad pilus-encoding locus among other B. breve strains and among sequenced Bifidobacterium genomes supports the notion of a ubiquitous pili-mediated host colonization and persistence mechanism for bifidobacteria...
  74. ncbi request reprint Rapid and noninvasive metabonomic characterization of inflammatory bowel disease
    Julian R Marchesi
    Alimentary Pharmabiotic Centre and Department of Microbiology, University College Cork, College Road, Cork, Ireland
    J Proteome Res 6:546-51. 2007
    ..This work illustrates the potential of metabonomics to generate novel noninvasive diagnostics for gastrointestinal diseases and may further our understanding of disease mechanisms...
  75. ncbi request reprint CD38 is associated with premenopausal and postmenopausal bone mineral density and postmenopausal bone loss
    Frances J Drummond
    Department of Rheumatology and Medicine, Clinical Sciences Building, Cork University Hospital, National University of Ireland, Cork, Ireland
    J Bone Miner Metab 24:28-35. 2006
    ..024), in postmenopausal women not taking hormone replacement therapy. We suggest that the CD38-PvuII polymorphism may influence the attainment and maintenance of peak BMD and postmenopausal bone loss...
  76. ncbi request reprint Intestinal tuberculosis mimicking Crohn's disease: lessons relearned in a new era
    Vikrant Sibartie
    Department of Medicine, University College Cork, National University of Ireland, Ireland
    Eur J Gastroenterol Hepatol 19:347-9. 2007
    ..We highlight the consequences that misdiagnosis can have, in an era where population demographics are changing in Europe and where immunomodulators and biological agents have the potential to do more harm than good...
  77. ncbi request reprint Antimicrobial activity of lacticin 3,147 against clinical Clostridium difficile strains
    Mary C Rea
    Teagasc, Biotechnology Centre, Moorepark Food Research Centre, Moorepark, Fermoy, Cork, Ireland
    J Med Microbiol 56:940-6. 2007
    ..difficile. In light of these findings, the potential of lacticin 3,147 for treatment of CDAD is discussed...
  78. pmc The gut flora as a forgotten organ
    Ann M O'Hara
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    EMBO Rep 7:688-93. 2006
    ..An improved understanding of this hidden organ will reveal secrets that are relevant to human health and to several infectious, inflammatory and neoplastic disease processes...
  79. ncbi request reprint CON: surveillance for ulcerative colitis-associated cancer: time to change the endoscopy and the microscopy
    Fergus Shanahan
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Ireland, UK
    Am J Gastroenterol 99:1633-6. 2004
  80. ncbi request reprint The host-microbe interface within the gut
    Fergus Shanahan
    Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland
    Best Pract Res Clin Gastroenterol 16:915-31. 2002
    ..An improved understanding of this hidden organ holds secrets relevant to several infectious, inflammatory and neoplastic disease mechanisms...
  81. ncbi request reprint Physiological basis for novel drug therapies used to treat the inflammatory bowel diseases I. Pathophysiological basis and prospects for probiotic therapy in inflammatory bowel disease
    Fergus Shanahan
    Alimentary Pharmabiotic Centre, Department of Medicine, Clinical Science Bldg, Cork University Hospital, Cork, Ireland
    Am J Physiol Gastrointest Liver Physiol 288:G417-21. 2005
    ..Moreover, the capacity to engineer food-grade or commensal bacteria to deliver therapeutic molecules to the intestinal mucosa promises to extend the scope of microbial manipulation for the benefit of mankind...
  82. pmc Therapeutic implications of manipulating and mining the microbiota
    Fergus Shanahan
    Department of Medicine, Alimentary Pharmabiotic Centre, Clinical Science Building, Cork University Hospital and University College Cork, Cork, Ireland
    J Physiol 587:4175-9. 2009
    ..While manipulation of the microbiota has become a therapeutic strategy in certain clinical disorders, the prospect of mining host-microbe-dietary interactions for novel drug discovery may become an even more intriguing reality...
  83. ncbi request reprint Persistence of hepatitis C virus in a white population: associations with human leukocyte antigen class 1
    Liam J Fanning
    Hepatitis C Unit, Department of Medicine, Clinical Sciences Building, Cork University Hospital, National University of Ireland, Cork, Ireland
    Hum Immunol 65:745-51. 2004
    ..HLA B*44 is associated with low virus load in human immunodeficiency virus disease, but this association was not evident in this HCV-infected population. Novel HLA class 1 alleles associated with persistence of HCV have been identified...
  84. pmc Fas ligand expression in human and mouse cancer cell lines; a caveat on over-reliance on mRNA data
    Aideen E Ryan
    Department of Medicine, National University of Ireland Cork NUIC, Clinical Science Building, Cork University Hospital, Wilton, Cork, Ireland
    J Carcinog 5:5. 2006
    ....
  85. ncbi request reprint Medicine in the age of " Ulysses ": James Joyce's portrait of life, medicine, and disease on a Dublin day a century ago
    Fergus Shanahan
    Department of Medicine, Clinical Science Building, Alimentary Pharmabiotic Centre, National University of Ireland, University College Cork, Ireland
    Perspect Biol Med 49:276-85. 2006
    ..Ulysses provides perspective on medical and social history and offers a biting commentary of continuing relevance to the doctor-patient relationship...
  86. doi request reprint Pharmabiotic manipulation of the microbiota in gastrointestinal disorders, from rationale to reality
    Fergus Shanahan
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Ireland
    Gastroenterol Clin North Am 39:721-6. 2010
    ....
  87. ncbi request reprint Probiotics and inflammatory bowel disease: from fads and fantasy to facts and future
    Fergus Shanahan
    Department of Medicine, Clinical Sciences Building, Cork University Hospital, Wilton, Ireland
    Br J Nutr 88:S5-9. 2002
    ....
  88. ncbi request reprint Crohn's disease
    Fergus Shanahan
    Department of Medicine, Clinical Sciences Building, Cork University Hospital, Cork, Ireland
    Lancet 359:62-9. 2002
    ..Although most conventional drug treatments are directed at modification of host response, therapeutic manipulation of the enteric flora is becoming a realistic option...
  89. ncbi request reprint Bad language in gastroenterology
    Fergus Shanahan
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Curr Gastroenterol Rep 10:91-3. 2008
  90. ncbi request reprint Probiotics in inflammatory bowel disease--therapeutic rationale and role
    Fergus Shanahan
    Alimentary Pharmabiotic Centre, Department of Medicine, Clinical Science Building, Cork University Hospital, University College Cork, National University of Ireland, Wilton, Cork, Ireland
    Adv Drug Deliv Rev 56:809-18. 2004
    ..Notwithstanding, an improved understanding of the normal commensal flora and host-flora interactions has the potential to open up new therapeutic strategies for inflammatory disorders of the gut...
  91. doi request reprint Gut microbes: from bugs to drugs
    Fergus Shanahan
    Department of Medicine and Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland F
    Am J Gastroenterol 105:275-9. 2010
    ..The future of drug discovery in gastroenterology is likely to reside in the lumen!..
  92. doi request reprint The colonic microflora and probiotic therapy in health and disease
    Fergus Shanahan
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Galway, Ireland
    Curr Opin Gastroenterol 27:61-5. 2011
    ..This has led to a resurgence of interest in the colonic microbiota in health and disease. Recent landmark findings are addressed here...
  93. ncbi request reprint The language of medicine: words as servants and scoundrels
    Eamonn M M Quigley
    Department of Medicine and Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland
    Clin Med 9:131-5. 2009
    ....
  94. ncbi request reprint Mechanisms of action of probiotics in intestinal diseases
    Ann M O'Hara
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Ireland
    ScientificWorldJournal 7:31-46. 2007
    ..Scientifically accredited evidence of efficacy and studies to elucidate the molecular mechanisms of host-microbiota interactions are needed to lend credence to the use of pharmabiotic strategies in clinical medicine...
  95. ncbi request reprint Association of NOD2 with Crohn's disease in a homogenous Irish population
    Emer Bairead
    Department of Medicine, University College Cork, Ireland
    Eur J Hum Genet 11:237-44. 2003
    ..1 vs 24 years, P=0.011) and the rare allele of SNP13 was observed to be predominantly linked to ileal disease (P=0.02). This report confirms the importance of NOD2 as a susceptibility gene for CD within the Irish population...
  96. ncbi request reprint Food allergies
    Paula F G O'Leary
    Department of Medicine, Cork University Hospital, Clinical Sciences Building, Wilton, Cork, Ireland
    Curr Gastroenterol Rep 4:373-82. 2002
    ..Both IgE-mediated and non-IgE-mediated immune mechanisms are recognized. Important advances in the clinical features underlying specific food hypersensitivity disorders are reviewed...
  97. ncbi request reprint Activation of the p38 MAPK and ERK1/2 pathways is required for Fas-induced IL-8 production in colonic epithelial cells
    Darren O'Brien
    Department of Medicine, National University of Ireland, Cork, Ireland
    Ann N Y Acad Sci 973:161-5. 2002
    ..This paper aims to examine the contribution of all three of the MAP kinase signaling pathways to Fas-induced IL-8 up-regulation in HT29 colon epithelial cells...
  98. ncbi request reprint Probiotic effects on inflammatory bowel disease
    Barbara Sheil
    Alimentary Pharmabiotic Centre and Department of Medicine, University College Cork, Cork, Ireland
    J Nutr 137:819S-24S. 2007
    ..Increasingly, research suggests that probiotics may offer an alternative or adjuvant approach to conventional therapy by altering the intestinal microflora and modulating the host immune system...
  99. ncbi request reprint Celiac disease and irritable bowel-type symptoms
    Clare O'Leary
    Department of Medicine, National University of Ireland, Cork
    Am J Gastroenterol 97:1463-7. 2002
    ..Therefore, we assessed the prevalence of IBS-type symptoms in adult celiac patients and correlated this with dietary compliance with gluten exclusion...
  100. ncbi request reprint Mycobacterium paratuberculosis detected by nested PCR in intestinal granulomas isolated by LCM in cases of Crohn's disease
    Paul Ryan
    Cork Cancer Research Centre, Mercy Hospital, Cork, Ireland
    Methods Mol Biol 193:205-11. 2002
  101. ncbi request reprint RT-PCR for the assessment of genetically heterogenous populations of the hepatitis C virus
    Brian Mullan
    Hepatitis C Unit, Department of Medicine, National University of Ireland, Cork, Ireland
    Methods Mol Biol 193:171-88. 2002