E M Quigley

Summary

Affiliation: University College Cork
Country: Ireland

Publications

  1. doi request reprint Prebiotics and probiotics; modifying and mining the microbiota
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Pharmacol Res 61:213-8. 2010
  2. ncbi request reprint Bacteria: a new player in gastrointestinal motility disorders--infections, bacterial overgrowth, and probiotics
    Eamonn M M Quigley
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, Clinical Sciences Building, Cork University Hospital, Cork, Ireland
    Gastroenterol Clin North Am 36:735-48, xi. 2007
  3. pmc Microflora modulation of motility
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    J Neurogastroenterol Motil 17:140-7. 2011
  4. ncbi request reprint Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation
    I L Khalif
    State Scientific Center for Coloproctology, Moscow, Russia
    Dig Liver Dis 37:838-49. 2005
  5. ncbi request reprint Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics)
    Igor L Khalif
    State Scientific Centre for Coloproctology, Moscow, Russia
    J Gastrointestin Liver Dis 18:17-22. 2009
  6. doi request reprint Overlap of functional dyspepsia and GERD--diagnostic and treatment implications
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Nat Rev Gastroenterol Hepatol 10:175-86. 2013
  7. doi request reprint Randomised clinical trials: linaclotide phase 3 studies in IBS-C - a prespecified further analysis based on European Medicines Agency-specified endpoints
    E M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Aliment Pharmacol Ther 37:49-61. 2013
  8. doi request reprint Bugs on the brain; brain in the gut--seeking explanations for common gastrointestinal symptoms
    E M M Quigley
    Department of Medicine, Alimentary Pharmbiotic Centre, University College Cork, Cork University Hospital, Clinical Sciences Building, Cork, Ireland
    Ir J Med Sci 182:1-6. 2013
  9. doi request reprint Probiotics in the management of functional bowel disorders: promise fulfilled?
    Eamonn M M Quigley
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Gastroenterol Clin North Am 41:805-19. 2012
  10. ncbi request reprint Irritable bowel syndrome; update on pathophysiology and management
    Eamonn M M Quigley
    University College Cork, Alimentary Pharmabiotic Centre, Cork, Ireland
    Turk J Gastroenterol 23:313-22. 2012

Collaborators

Detail Information

Publications91

  1. doi request reprint Prebiotics and probiotics; modifying and mining the microbiota
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Pharmacol Res 61:213-8. 2010
    ..Prebiotics promote the growth of "good" bacteria and, while a variety of health benefits have been attributed to their use, prebiotics have been subjected to few large scale clinical trials...
  2. ncbi request reprint Bacteria: a new player in gastrointestinal motility disorders--infections, bacterial overgrowth, and probiotics
    Eamonn M M Quigley
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, Clinical Sciences Building, Cork University Hospital, Cork, Ireland
    Gastroenterol Clin North Am 36:735-48, xi. 2007
    ..However, in the long term, safety issues will favor the probiotic approach; results of long-term studies with these agents are eagerly awaited...
  3. pmc Microflora modulation of motility
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    J Neurogastroenterol Motil 17:140-7. 2011
    ..In health, as well as in disease states, this is a truly bi-directional relationship: not only can gut motor patterns influence the microbiota but changes in the microbiota can exert profound influences on gut sensori-motor function...
  4. ncbi request reprint Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation
    I L Khalif
    State Scientific Center for Coloproctology, Moscow, Russia
    Dig Liver Dis 37:838-49. 2005
    ..Disturbances in bowel function in chronic constipation could result in changes in the colonic flora and lead to disordered immunity and to decreased resistance to pathogenic flora...
  5. ncbi request reprint Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics)
    Igor L Khalif
    State Scientific Centre for Coloproctology, Moscow, Russia
    J Gastrointestin Liver Dis 18:17-22. 2009
    ..to evaluate and correlate the symptomatic, motor and sensory responses to two widely used categories of spasmolytic agents in irritable bowel syndrome (IBS)...
  6. doi request reprint Overlap of functional dyspepsia and GERD--diagnostic and treatment implications
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Nat Rev Gastroenterol Hepatol 10:175-86. 2013
    ..A further limitation of existing studies is their failure to differentiate between the various diagnostic categories into which the individual presenting with heartburn might belong...
  7. doi request reprint Randomised clinical trials: linaclotide phase 3 studies in IBS-C - a prespecified further analysis based on European Medicines Agency-specified endpoints
    E M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Aliment Pharmacol Ther 37:49-61. 2013
    ..Treatment options that improve overall symptoms of irritable bowel syndrome with constipation (IBS-C) are lacking...
  8. doi request reprint Bugs on the brain; brain in the gut--seeking explanations for common gastrointestinal symptoms
    E M M Quigley
    Department of Medicine, Alimentary Pharmbiotic Centre, University College Cork, Cork University Hospital, Clinical Sciences Building, Cork, Ireland
    Ir J Med Sci 182:1-6. 2013
    ..For some, such symptoms can prove to be chronic and disabling...
  9. doi request reprint Probiotics in the management of functional bowel disorders: promise fulfilled?
    Eamonn M M Quigley
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Gastroenterol Clin North Am 41:805-19. 2012
    ..Although strategies that seek to modify the microbiota, such as the use of probiotics, offer much promise in IBS and CC, more high-quality trials and, studies of longer duration are required...
  10. ncbi request reprint Irritable bowel syndrome; update on pathophysiology and management
    Eamonn M M Quigley
    University College Cork, Alimentary Pharmabiotic Centre, Cork, Ireland
    Turk J Gastroenterol 23:313-22. 2012
    ....
  11. doi request reprint A global perspective on irritable bowel syndrome: a consensus statement of the World Gastroenterology Organisation Summit Task Force on irritable bowel syndrome
    Eamonn M M Quigley
    Department of Medicine, Cork University Hospital, Cork, Ireland
    J Clin Gastroenterol 46:356-66. 2012
    ....
  12. doi request reprint Prebiotics and probiotics: their role in the management of gastrointestinal disorders in adults
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, Department of Medicine, Cork University Hospital, Cork, Ireland
    Nutr Clin Pract 27:195-200. 2012
    ..Prebiotics promote the growth of "good" bacteria, and although a variety of health benefits have been attributed to their use, prebiotics have been subjected to few large-scale clinical trials...
  13. doi request reprint First WGO regional meeting with the TSG: a template for future regional gastroenterology collaborations
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Expert Rev Gastroenterol Hepatol 6:141-3. 2012
    ....
  14. pmc Esophageal intramural pseudodiverticulosis characterized by barium esophagography: a case report
    Owen J O'Connor
    Department of Radiology, Mercy University Hospital, Cork, Ireland
    J Med Case Reports 4:145. 2010
    ..Esophageal intramural pseudodiverticulosis is a rare condition characterized by the dilatation of the submucosal glands...
  15. pmc Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort
    Gerard Clarke
    Department of Psychiatry, University College Cork, Cork, Ireland
    BMC Gastroenterol 9:6. 2009
    ..In this study, we investigated tryptophan degradation in a male IBS cohort (n = 10) and control subjects (n = 26)...
  16. ncbi request reprint Impact of pregnancy and parturition on the anal sphincters and pelvic floor
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Best Pract Res Clin Gastroenterol 21:879-91. 2007
    ..In contrast, the contribution of such intra-partum events to the later onset of incontinence is far from clear and may well have been over-estimated...
  17. ncbi request reprint Non-erosive reflux disease, functional heartburn and gastroesophageal reflux disease; insights into pathophysiology and clinical presentation
    Eamonn M M Quigley
    National University of Ireland, Cork, Ireland
    Chin J Dig Dis 7:186-90. 2006
    ..An appreciation of the range of entities, of different etiology and pathology, within NERD will foster the development of effective approaches to the assessment and therapy of this challenging disorder...
  18. ncbi request reprint Bacterial flora in irritable bowel syndrome: role in pathophysiology, implications for management
    Eamonn M M Quigley
    Alimentary Pharmabiotic Center, University College Cork, Cork, Ireland
    J Dig Dis 8:2-7. 2007
    ..While this approach to the management of IBS is in its infancy, it is evident that manipulation of the flora, whether through the administration of antibiotics or probiotics, deserves further attention in IBS...
  19. ncbi request reprint Probiotics in irritable bowel syndrome: an immunomodulatory strategy?
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    J Am Coll Nutr 26:684S-90S. 2007
    ..The role of the enteric flora is evidently an area of great potential in IBS; we are on the threshold of a new era of research and therapy for this common disorder...
  20. ncbi request reprint Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date
    E M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neurogastroenterol Motil 19:166-72. 2007
    ..This is evidently an area of great potential in IBS and deserves further study at all levels...
  21. ncbi request reprint What is the evidence for the use of probiotics in functional disorders?
    Eamonn M M Quigley
    Department of Medicine, Clinical Sciences Building, Cork University Hospital, Cork, Ireland
    Curr Gastroenterol Rep 10:379-84. 2008
    ..The interpretation of much of the literature in this area is complicated by lack of quality control, use of many different species and strains, and, above all, significant deficiencies in trial methodology...
  22. ncbi request reprint Probiotics in the management of colonic disorders
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Curr Gastroenterol Rep 9:434-40. 2007
    ..difficile-related colitis. Even here, not to mention other colonic disorders, further adequately powered and appropriately designed trials are needed...
  23. doi request reprint Probiotics in functional gastrointestinal disorders: what are the facts?
    Eamonn M M Quigley
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Curr Opin Pharmacol 8:704-8. 2008
    ..Several other issues complicate the interpretation of much of the literature in this area: lack of quality control, use of many different species, and, strains and, above all, significant deficiencies in trial methodology...
  24. doi request reprint The enteric microbiota in the pathogenesis and management of constipation
    E M M Quigley
    Department of Medicine, Clinical Sciences Building, Cork University Hospital, Alimentary Pharmabiotic Centre, Ireland
    Best Pract Res Clin Gastroenterol 25:119-26. 2011
    ..While benefits for fiber and, perhaps, for certain prebiotic and probiotic preparations in constipation appear to be extant there is a real need for large well-conducted clinical trials in this important area of human medicine...
  25. doi request reprint Therapies aimed at the gut microbiota and inflammation: antibiotics, prebiotics, probiotics, synbiotics, anti-inflammatory therapies
    Eamonn M M Quigley
    Department of Medicine, Alimentary Pharmabiotic Centre, Cork University Hospital, University College Cork, Clinical Sciences Building, Cork, Ireland
    Gastroenterol Clin North Am 40:207-22. 2011
    ..Consequent on these hypotheses, several therapeutic categories have found their way into the armamentarium of those who care for IBS sufferers. These agents include probiotics, prebiotics, antibiotics, and anti-inflammatory agents...
  26. pmc Do Patients with Functional Gastrointestinal Disorders have an Altered Gut Flora?
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, Department of Medicine, University College Cork, Cork, Ireland
    Therap Adv Gastroenterol 2:23-30. 2009
    ..The latter is eagerly awaited and may yet provide a firm rationale for the use of certain probiotics and antibiotics in IBS, whose benefits have now been described with some consistency...
  27. doi request reprint Probiotics in gastrointestinal disorders
    Eamonn M M Quigley
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Hosp Pract (1995) 38:122-9. 2010
    ..Although this area holds much promise, more high-quality trials of probiotics in digestive disorders, as well as laboratory investigations of their mechanisms of action, are required...
  28. doi request reprint Small intestinal bacterial overgrowth
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Infect Dis Clin North Am 24:943-59, viii-ix. 2010
    ..Treatment is similarly supported by a scant evidence base and the most commonly used antibiotic regimens owe more to custom than clinical trials...
  29. doi request reprint What we have learned about colonic motility: normal and disturbed
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, Department of Medicine, University College Cork, Cork, Ireland
    Curr Opin Gastroenterol 26:53-60. 2010
    ....
  30. ncbi request reprint The language of medicine: words as servants and scoundrels
    Eamonn M M Quigley
    Department of Medicine and Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland
    Clin Med 9:131-5. 2009
    ....
  31. doi request reprint Dyspepsia
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Curr Opin Gastroenterol 24:692-7. 2008
    ..Overlap with gastroesophageal reflux and irritable bowel syndrome further complicate clinical definitions...
  32. doi request reprint Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled study
    E M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Aliment Pharmacol Ther 29:315-28. 2009
    ..Chronic constipation may result in disabling symptoms, is often unsatisfactorily treated by laxatives and negatively impacts quality of life (QoL)...
  33. doi request reprint Commensal bacteria: the link between IBS and IBD?
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Curr Opin Clin Nutr Metab Care 14:497-503. 2011
    ..To review interactions between the microbiota and the host in irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), emphasizing areas of commonality and divergence...
  34. doi request reprint Motility disorders in the patient with neurologic disease
    Eamonn M M Quigley
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Gastroenterol Clin North Am 40:741-64. 2011
    ....
  35. ncbi request reprint Prevalence and management of abdominal cramping and pain: a multinational survey
    E M M Quigley
    Alimentary Pharmabiotic Centre, National University of Ireland, Cork, Ireland
    Aliment Pharmacol Ther 24:411-9. 2006
    ..Though functional gastrointestinal complaints are recognised as being common throughout the world, there have been few comparative studies of prevalence...
  36. ncbi request reprint Irritable bowel syndrome: the burden and unmet needs in Europe
    E M M Quigley
    Alimentary Pharmabiotic Centre, Department of Medicine, National University of Ireland, Cork University Hospital, Wilton, Cork, Ireland
    Dig Liver Dis 38:717-23. 2006
    ..The development of pan-European guidelines for irritable bowel syndrome will benefit patients with this condition in Europe...
  37. ncbi request reprint Safety and tolerability of tegaserod in patients with chronic constipation: pooled data from two phase III studies
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, Department of Medicine, Cork University Hospital, Wilton, Cork, Ireland
    Clin Gastroenterol Hepatol 4:605-13. 2006
    ..Studies show that tegaserod effectively relieves the symptoms of chronic constipation/idiopathic constipation (CC). This pooled analysis assessed the safety and tolerability of tegaserod in a large dataset of CC patients...
  38. ncbi request reprint The use of probiotics in functional bowel disease
    Eamonn M M Quigley
    Alimentary Pharmabiotic Center, National University of Ireland, Department of Medicine, Cork University Hospital, Clinical Sciences Building, Cork, Ireland
    Gastroenterol Clin North Am 34:533-45, x. 2005
  39. ncbi request reprint Review article: quality-of-life issues in gastro-oesophageal reflux disease
    E M M Quigley
    Department of Medicine, National University of Ireland, Cork, Ireland
    Aliment Pharmacol Ther 22:41-7. 2005
    ..There is an ongoing need to develop instruments which truly measure the impact of gastro-oesophageal reflux disease and which are readily interpretable to the individual patient and clinician...
  40. ncbi request reprint Disturbances of motility and visceral hypersensitivity in irritable bowel syndrome: biological markers or epiphenomenon
    Eamonn M M Quigley
    Department of Medicine, Alimentary Pharmabiotic Centre, Cork University Hospital, Clinical Sciences Building, Cork, Ireland
    Gastroenterol Clin North Am 34:221-33, vi. 2005
    ..Many factors, including stress and psychopathology,complicate the interpretation of these phenomena and new re-search suggests that mucosal inflammation and luminal factors may be more fundamental to the etiology of this common disorder...
  41. ncbi request reprint Functional dyspepsia (FD) and non-erosive reflux disease (NERD): overlapping or discrete entities?
    Eamonn M M Quigley
    Department of Medicine, Cork University Hospital, Clinical Sciences Building, Cork, Ireland
    Best Pract Res Clin Gastroenterol 18:695-706. 2004
    ..These patients truly belong in the spectrum of functional gastrointestinal disorders rather than in GORD; attempts to shoe-horn these individuals into the spectrum of GORD will result in therapeutic disappointment and surgical disaster...
  42. pmc From comic relief to real understanding; how intestinal gas causes symptoms
    E M M Quigley
    Department of Medicine, Cork University Hospital, Ireland
    Gut 52:1659-61. 2003
    ..More problematic is extrapolation of the observations relating symptoms to gas transit and retention...
  43. ncbi request reprint New developments in the pathophysiology of gastro-oesophageal reflux disease (GERD): implications for patient management
    E M M Quigley
    Medical School, National University of Ireland, Cork, Ireland
    Aliment Pharmacol Ther 17:43-51. 2003
    ....
  44. ncbi request reprint Small intestinal transplantation
    E M Quigley
    Department of Medicine, Cork University Hospital, Central Sciences Building, Cork, Ireland
    Curr Gastroenterol Rep 3:408-11. 2001
    ..The very fact that such a suggestion has begun to emerge reflects real progress in this challenging field...
  45. ncbi request reprint Why do we have so few effective drugs for irritable bowel syndrome? A European perspective
    Eamonn M M Quigley
    National University of Ireland, Cork, Ireland
    Nat Clin Pract Gastroenterol Hepatol 2:436-7. 2005
  46. ncbi request reprint Small intestinal bacterial overgrowth: roles of antibiotics, prebiotics, and probiotics
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, Department of Medicine, National University of Ireland, Cork, Ireland
    Gastroenterology 130:S78-90. 2006
    ....
  47. pmc Critical care dysmotility: abnormal foregut motor function in the ICU/ITU patient
    E M M Quigley
    Alimentary Pharmabiotic Centre, Department of Medicine, Clinical Sciences Building, Cork University Hospital, Ireland
    Gut 54:1351-2; discussion 1384-90. 2005
  48. ncbi request reprint The efficacy of probiotics in IBS
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, National University of Ireland, Cork, Ireland
    J Clin Gastroenterol 42:S85-90. 2008
    ..The role of the enteric flora is evidently an area of great potential in IBS; we are on the threshold of a new era of research and therapy for this common disorder...
  49. doi request reprint Gut microbiota and the role of probiotics in therapy
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Curr Opin Pharmacol 11:593-603. 2011
    ....
  50. doi request reprint Review article: probiotics for the treatment of irritable bowel syndrome--focus on lactic acid bacteria
    G Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Aliment Pharmacol Ther 35:403-13. 2012
    ..The withdrawal, due to adverse events, of a number of pharmacological agents that were approved for the treatment of IBS has left a therapeutic vacuum for patients suffering from the disorder...
  51. ncbi request reprint Non-erosive reflux disease: part of the spectrum of gastro-oesophageal reflux disease, a component of functional dyspepsia, or both?
    E M Quigley
    Medical School at the National University, Cork, Ireland
    Eur J Gastroenterol Hepatol 13:S13-8. 2001
    ..In practical terms, each diagnosis requires consideration of the other...
  52. ncbi request reprint Review article: gastric emptying in functional gastrointestinal disorders
    E M M Quigley
    Department of Medicine, Cork University Hospital, Cork, Ireland
    Aliment Pharmacol Ther 20:56-60. 2004
    ..Pending the definition of the true significance of delayed gastric emptying in all functional gastrointestinal disorders, caution should be exerted in the interpretation of this finding in a patient with functional symptoms...
  53. doi request reprint Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model
    S O'Mahony
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neurogastroenterol Motil 20:680-8. 2008
    ..In conclusion altered central serotonin responses are found in both IBS and in an animal model...
  54. doi request reprint Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models
    E F Murphy
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Gut 59:1635-42. 2010
    ..Therefore, we explored the effect of a high-fat (HF) diet and genetically determined obesity (ob/ob) for changes in microbiota and energy harvesting capacity over time...
  55. doi request reprint The spectrum of functional gastrointestinal disorders in a tertiary referral clinic in Ireland
    K Walsh
    Department of Radiology, Alimentary Pharmabiotic Centre, Cork University Hospital, University College Cork, Wilton, Cork, Ireland
    Ir J Med Sci 181:81-6. 2012
    ..Though common and sometimes disabling, causing considerable social and economic burden, there is little recent literature on presentation or impact of FGIDs in Ireland...
  56. ncbi request reprint Isolation of lactobacilli with probiotic properties from the human stomach
    K A Ryan
    Department of Microbiology, University College Cork, Cork, Ireland
    Lett Appl Microbiol 47:269-74. 2008
    ..Recent evidence suggests that the human gastric microbiota is much more diverse than previously thought. The aim of this study was to assess the potential for isolating lactobacilli from the human stomach...
  57. doi request reprint Altered peripheral toll-like receptor responses in the irritable bowel syndrome
    D P McKernan
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Aliment Pharmacol Ther 33:1045-52. 2011
    ..The immune system is a critical regulator of the brain-gut axis. Toll-like receptors (TLRs) are pattern recognition molecules regulating innate immunity...
  58. ncbi request reprint Pharmacotherapy of gastroparesis
    E M Quigley
    Department of Medicine, National University of Ireland, Clinical Sciences Building, Cork University Hospital, Cork, Ireland
    Expert Opin Pharmacother 1:881-7. 2000
    ..Other novel approaches include strategies to address some of the regional abnormalities in gastric motor function that have been identified in some patients with dyspepsia...
  59. ncbi request reprint Gastric electrical stimulation: a report of two cases
    V Sibartie
    Alimentary Pharmabiotic Centre, Department of Medicine, Cork University Hospital, Wilton
    Ir Med J 98:245-6. 2005
    ..Our results at 6 months show reduction in symptoms and improvement in quality of life, which is encouraging and should prompt further evaluation of GES for patients with gastroparesis refractory to medical therapy...
  60. ncbi request reprint Systematic review: Complementary and alternative medicine in the irritable bowel syndrome
    Z Hussain
    Department of Medicine, Alimentary Pharmabiotic Centre, Cork University Hospital, Cork, Ireland
    Aliment Pharmacol Ther 23:465-71. 2006
    ..Complementary and alternative medical therapies and practices are widely employed in the treatment of the irritable bowel syndrome...
  61. ncbi request reprint The 'con' case. The Rome process and functional gastrointestinal disorders: the barbarians are at the gate!
    E M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neurogastroenterol Motil 19:793-7. 2007
  62. ncbi request reprint Functional dyspepsia and non-erosive reflux disease. A review
    J Keohane
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Minerva Gastroenterol Dietol 52:261-7. 2006
    ..It would appear that the overlap of these two conditions is most apparent between FD and those NERD patients with normal pH studies...
  63. ncbi request reprint Surveillance in Barrett's oesophagus: will a strategy focused on a high-risk group reduce mortality from oesophageal adenocarcinoma?
    R Quera
    Alimentary Pharmabiotic Centre, Department of Medicine, National University of Ireland, Cork, Ireland
    Endoscopy 38:162-9. 2006
    ..This study aimed to determine the effect of surveillance on mortality from oesophageal adenocarcinoma in a group of patients considered to be at high risk of developing Barrett's oesophagus and adenocarcinoma...
  64. ncbi request reprint Applied principles of neurogastroenterology: physiology/motility sensation
    John E Kellow
    Department of Medicine, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    Gastroenterology 130:1412-20. 2006
    ..Based on the conceptual framework established to date, a number of recommendations for further progress can be made...
  65. ncbi request reprint Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome
    Peter J Whorwell
    Department of Medicine, University of Manchester, Manchester, UK
    Am J Gastroenterol 101:1581-90. 2006
    ..Thus, not all species will necessarily have the same therapeutic potential in a particular condition. We have preliminary evidence that Bifidobacterium infantis 35624 may have utility in irritable bowel syndrome (IBS)...
  66. ncbi request reprint Gastrointestinal motility: an academic and research perspective
    Eamonn M M Quigley
    Medical School, National University of Ireland, Cork, Ireland
    Dig Dis 24:218-20. 2006
    ..Never before has this area offered so many opportunities to the budding academician and researcher...
  67. ncbi request reprint New perspectives on the role of the intestinal flora in health and disease
    Eamonn M M Quigley
    J Gastrointestin Liver Dis 15:109-10. 2006
  68. ncbi request reprint Endoluminal delivery of radiofrequency energy to the gastroesophageal junction in uncomplicated GERD: efficacy and potential mechanism of action
    John K DiBaise
    Section of Gastroenterology and Hepatology, University of Nebraska Medical Center, Omaha 68198 2000, USA
    Am J Gastroenterol 97:833-42. 2002
    ..In this single-center trial, we sought to further examine its efficacy and physiological effects in patients with uncomplicated gastroesophageal reflux disease...
  69. ncbi request reprint Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?
    Timothy G Dinan
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Gastroenterology 130:304-11. 2006
    ..The primary aim of this study was to examine the hypothalamic-pituitary-adrenal axis in patients with IBS and to relate such response to plasma cytokine profiles...
  70. ncbi request reprint Celiac disease and irritable bowel-type symptoms
    Clare O'Leary
    Department of Medicine, National University of Ireland, Cork
    Am J Gastroenterol 97:1463-7. 2002
    ..Therefore, we assessed the prevalence of IBS-type symptoms in adult celiac patients and correlated this with dietary compliance with gluten exclusion...
  71. ncbi request reprint Factors that influence therapeutic outcomes in symptomatic gastroesophageal reflux disease
    Eamonn M M Quigley
    Department of Medicine, Clinical Sciences Building, Cork University Hospital, National University of Ireland, Wilton Road, Cork, Ireland
    Am J Gastroenterol 98:S24-30. 2003
    ..Whereas the natural history of symptomatic GERD is still largely undefined, acid-suppressive therapy appears to be the best approach available for both the short-term and long-term management of this disease...
  72. ncbi request reprint Changing face of irritable bowel syndrome
    Eamonn M M Quigley
    World J Gastroenterol 12:1-5. 2006
    ..In the meantime, a model based on a primary role for intestinal inflammation serves to integrate the various strands, which contribute to the presentation of IBS...
  73. ncbi request reprint [Small intestinal bacterial overgrowth. An update]
    Rodrigo Quera P
    Sección de Gastroenterología, Departamento de Medicina, Hospital Clinico de la Universidad de Chile, Santiago, Chile
    Rev Med Chil 133:1361-70. 2005
    ..The treatment usually consists in the eradication of bacterial overgrowth with repeated courses of antimicrobials, nutritional support and when it is possible, the correction of underlying predisposing conditions...
  74. ncbi request reprint A 51-year-old with irritable bowel syndrome: test or treat for bacterial overgrowth?
    Eamonn M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Clin Gastroenterol Hepatol 5:1140-3. 2007
  75. ncbi request reprint Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles
    Liam O'Mahony
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Gastroenterology 128:541-51. 2005
    ..The aim of this study was to compare the response of symptoms and cytokine ratios in irritable bowel syndrome (IBS) with ingestion of probiotic preparations containing a lactobacillus or bifidobacterium strain...
  76. ncbi request reprint Bad language in gastroenterology
    Fergus Shanahan
    Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Curr Gastroenterol Rep 10:91-3. 2008
  77. ncbi request reprint Systematic review on the management of chronic constipation in North America
    Lawrence J Brandt
    Division of Gastroenterology, Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Gastroenterol 100:S5-S21. 2005
  78. ncbi request reprint Recommendations for probiotic use--2008
    Martin H Floch
    Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT 06520 8019, USA
    J Clin Gastroenterol 42:S104-8. 2008
    ..Many reports in the "C" recommendations were significant but fell short of receiving stronger ratings because of the size of reported patient studies, and also the factors that limited categories to the "B" rating...
  79. doi request reprint Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors
    Timothy G Dinan
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Am J Gastroenterol 103:2570-6. 2008
    ..We tested the hypothesis that the pro-inflammatory cytokine profile in IBS is driven by the cholinergic system and determined if the responses are mediated by muscarinic receptors...
  80. ncbi request reprint Functional gastrointestinal disease: has the genomic era arrived?
    Eamonn M M Quigley
    Gastroenterology 126:1193-5. 2004
  81. ncbi request reprint Aging and intestinal motility: a review of factors that affect intestinal motility in the aged
    Denis O'Mahony
    Department of Medicine, Clinical Sciences Building, Cork University Hospital, Cork, Ireland
    Drugs Aging 19:515-27. 2002
    ..These drugs include anticholinergics, especially antidepressants with an anticholinergic effect, opioid analgesics and calcium antagonists...
  82. ncbi request reprint Small bowel bacterial overgrowth, celiac disease, and IBS: what are the real associations?
    Clare O'Leary
    Am J Gastroenterol 98:720-2. 2003
  83. ncbi request reprint Irritable bowel syndrome and inflammatory bowel disease: interrelated diseases?
    Eamonn M M Quigley
    Department of Medicine, National University of Ireland, Cork, Ireland
    Chin J Dig Dis 6:122-32. 2005
    ....
  84. ncbi request reprint The spectrum of GERD: a new perspective
    Eamonn M M Quigley
    National University of Ireland, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Drugs Today (Barc) 41:3-6. 2005
    ..These subgroups may respond differently to PPIs and surgery and therefore need to be differentiated...
  85. ncbi request reprint Germs, gas and the gut; the evolving role of the enteric flora in IBS
    Eamonn M M Quigley
    Alimentary Pharmabiotic Center, University College Cork, Cork, Ireland
    Am J Gastroenterol 101:334-5. 2006
    ....
  86. ncbi request reprint Getting categorical on GERD
    Eamonn M M Quigley
    Am J Gastroenterol 102:1130; author reply 1131. 2007
  87. ncbi request reprint Use of evidence in WHO recommendations
    Eamonn M M Quigley
    Lancet 370:824; author reply 826-7. 2007
  88. pmc Functional dyspepsia and nonerosive reflux disease: clinical interactions and their implications
    John Keohane
    Alimentary Pharmabiotic Centre, Department of Medicine, University College Cork, Cork, Ireland
    MedGenMed 9:31. 2007
    ..Several theories have been proposed regarding the etiology of these disorders, including acid exposure, visceral hypersensitivity, impaired fundal accommodation, delayed gastric emptying, and Helicobacter pylori infection...
  89. ncbi request reprint Functional dyspepsia: the role of visceral hypersensitivity in its pathogenesis
    John Keohane
    Department of Medicine, Alimentary Pharmabiotic Centre, Clinical Sciences Building, Cork University Hospital, Cork, Ireland
    World J Gastroenterol 12:2672-6. 2006
    ..In this review, we look at the evidence, to date, for the role of visceral hypersensitivity in the aetiology of FD...
  90. ncbi request reprint Role of GERD in chronic resistant sinusitis: a prospective, open label, pilot trial
    John K DiBaise
    Section of Gastroenterology and Hepatology, University of Nebraska Medical Center, Omaha 68198 2000, USA
    Am J Gastroenterol 97:843-50. 2002
    ..The objective of this study was to determine whether aggressive medical therapy of gastroesophageal reflux disease (GERD) could improve both subjective and objective features of chronic resistant sinusitis (CRS)...