P Puri

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. ncbi request reprint Endoscopic treatment of moderate and high grade vesicoureteral reflux in infants using dextranomer/hyaluronic acid
    Prem Puri
    National Children s Hospital, Dublin, Ireland
    J Urol 178:1714-6; discussion 1717. 2007
  2. doi request reprint Variants of Hirschsprung disease
    Prem Puri
    National Children s Research Centre, Our Lady s Children s Hospital, Crumlin, Dublin, Ireland
    Semin Pediatr Surg 21:310-8. 2012
  3. pmc Congenital diaphragmatic hernia and retinoids: searching for an etiology
    Sandra Montedonico
    The Children s Research Centre, Our Lady s Children s Hospital, Dublin 12, Ireland
    Pediatr Surg Int 24:755-61. 2008
  4. doi request reprint Genetics of vesicoureteral reflux
    Prem Puri
    National Children s Research Centre, Our Lady s Children s Hospital, Crumlin, Dublin 12, Ireland
    Nat Rev Urol 8:539-52. 2011
  5. ncbi request reprint Subureteral dextranomer/hyaluronic acid injection as first line treatment in the management of high grade vesicoureteral reflux
    Prem Puri
    National Children s Hospital, and Children s Research Centre, Our Lady s Hospital for Sick Children, University College Dublin, Crumlin, Dublin 2, Ireland
    J Urol 176:1856-9; discussion 1859-60. 2006
  6. ncbi request reprint Variant Hirschsprung's disease
    Prem Puri
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Semin Pediatr Surg 13:293-9. 2004
  7. ncbi request reprint Megacystis microcolon intestinal hypoperistalsis syndrome
    Prem Puri
    Children s Research Centre, Our Lady s Hospital for Sick Children, University College Dublin, Ireland
    Semin Pediatr Surg 14:58-63. 2005
  8. ncbi request reprint The effect of vagal neural crest ablation on the chick embryo cloaca
    A M O Donnell
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin, Ireland
    Pediatr Surg Int 21:180-3. 2005
  9. ncbi request reprint Adriamycin induces notochord hypertrophy with conservation of sonic hedgehog expression in abnormal ectopic notochord in the adriamycin rat model
    A Mortell
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin, Ireland
    J Pediatr Surg 39:859-63. 2004
  10. ncbi request reprint Increased fibronectin expression in developing embryos is associated with abnormal notochord in the Adriamycin rat model
    A Mortell
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 20:276-82. 2004

Collaborators

Detail Information

Publications140 found, 100 shown here

  1. ncbi request reprint Endoscopic treatment of moderate and high grade vesicoureteral reflux in infants using dextranomer/hyaluronic acid
    Prem Puri
    National Children s Hospital, Dublin, Ireland
    J Urol 178:1714-6; discussion 1717. 2007
    ..We prospectively evaluated the effectiveness and safety of dextranomer/hyaluronic acid copolymer for high grade vesicoureteral reflux in infants...
  2. doi request reprint Variants of Hirschsprung disease
    Prem Puri
    National Children s Research Centre, Our Lady s Children s Hospital, Crumlin, Dublin, Ireland
    Semin Pediatr Surg 21:310-8. 2012
    ..This review article summarizes the current knowledge of the aforementioned entities of variant HD...
  3. pmc Congenital diaphragmatic hernia and retinoids: searching for an etiology
    Sandra Montedonico
    The Children s Research Centre, Our Lady s Children s Hospital, Dublin 12, Ireland
    Pediatr Surg Int 24:755-61. 2008
    ..Finally, we describe the existing evidence of a disruption of the retinoid-signaling pathway in CDH...
  4. doi request reprint Genetics of vesicoureteral reflux
    Prem Puri
    National Children s Research Centre, Our Lady s Children s Hospital, Crumlin, Dublin 12, Ireland
    Nat Rev Urol 8:539-52. 2011
    ..Improvements in genome-scan techniques and continuously increasing knowledge of the genetic basis of VUR should help us to further understand its pathogenesis...
  5. ncbi request reprint Subureteral dextranomer/hyaluronic acid injection as first line treatment in the management of high grade vesicoureteral reflux
    Prem Puri
    National Children s Hospital, and Children s Research Centre, Our Lady s Hospital for Sick Children, University College Dublin, Crumlin, Dublin 2, Ireland
    J Urol 176:1856-9; discussion 1859-60. 2006
    ..We prospectively evaluated the effectiveness of dextranomer/hyaluronic acid copolymer (Deflux) as first line treatment for high grade vesicoureteral reflux...
  6. ncbi request reprint Variant Hirschsprung's disease
    Prem Puri
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Semin Pediatr Surg 13:293-9. 2004
    ..The outcome of smooth muscle disorders is generally fatal. The need for surgical intervention should be weighed carefully and individualized because most explorations have not been helpful and are probably not necessary...
  7. ncbi request reprint Megacystis microcolon intestinal hypoperistalsis syndrome
    Prem Puri
    Children s Research Centre, Our Lady s Hospital for Sick Children, University College Dublin, Ireland
    Semin Pediatr Surg 14:58-63. 2005
    ..Most patients with MMIHS are not able to void spontaneously. This article reviews the pathogenesis of MMIHS as well as the clinical, radiological, surgical and histological findings in all reported cases of this syndrome...
  8. ncbi request reprint The effect of vagal neural crest ablation on the chick embryo cloaca
    A M O Donnell
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin, Ireland
    Pediatr Surg Int 21:180-3. 2005
    ....
  9. ncbi request reprint Adriamycin induces notochord hypertrophy with conservation of sonic hedgehog expression in abnormal ectopic notochord in the adriamycin rat model
    A Mortell
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin, Ireland
    J Pediatr Surg 39:859-63. 2004
    ....
  10. ncbi request reprint Increased fibronectin expression in developing embryos is associated with abnormal notochord in the Adriamycin rat model
    A Mortell
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 20:276-82. 2004
    ..This study was designed to investigate FN expression in ARM embryos...
  11. ncbi request reprint Structural immaturity of the heart in congenital diaphragmatic hernia in rats
    N Guarino
    Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland
    J Pediatr Surg 36:770-3. 2001
    ..The reduced production of cardiac ECM may contribute to a contractile dysfunction, which makes the heart unable to respond to the hemodynamic load accompanying persistent pulmonary hypertension (PPH)...
  12. ncbi request reprint Bilateral megaureters in the Adriamycin rat model
    A Mortell
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 21:212-6. 2005
    ..This simple experimental model of bilateral megaureter may allow further research into the pathophysiology of this condition...
  13. ncbi request reprint The Adriamycin rat/mouse model and its importance to the paediatric surgeon
    J Gillick
    Children s Researche Centre, Our Lady s Children s Hospital, Crumlin, Ireland
    Pediatr Surg Int 24:113-8. 2008
    ..This article reviews the establishment of the Adriamycin rat and mouse models, examines their impact on various congenital malformations, and suggests targets for further research...
  14. ncbi request reprint Cardiac gene expression and synthesis of atrial natriuretic peptide in the nitrofen model of congenital diaphragmatic hernia in rats: effect of prenatal dexamethazone treatment
    N Guarino
    Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland
    J Pediatr Surg 36:1497-501. 2001
    ..ANP or drugs such as steroids, which raise endogenous ANP levels, may have a therapeutic application in CDH complicated by PPH...
  15. ncbi request reprint Three-dimensional morphology of gut innervation in total intestinal aganglionosis using whole-mount preparation
    L Nemeth
    Children's Research Centre, Our Lady's Hospital for Sick Children, The Children's Hospital, Temple St, Dublin, Ireland
    J Pediatr Surg 36:291-5. 2001
    ....
  16. ncbi request reprint Bacterial colonization of the prepuce in boys with vesicoureteral reflux who receive antibiotic prophylaxis
    S Cascio
    National Children's Hospital, Tallaght, Dublin, Ireland
    J Pediatr 139:160-2. 2001
    ..Antibiotic prophylaxis in patients with VUR was not effective in reducing the bacterial colonization of the prepuce. We recommend circumcision in boys, particularly infants with VUR, to reduce the risk of urinary tract infections...
  17. ncbi request reprint Three-dimensional morphology of c-Kit-positive cellular network and nitrergic innervation in the human gut
    L Nemeth
    Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland
    Arch Pathol Lab Med 125:899-904. 2001
    ..The characteristic profiles of the c-Kit-positive cellular network and nitrergic neuronal network and their relationship with the smooth muscle fibers provide a morphologic basis for investigating intestinal motility disorders...
  18. ncbi request reprint Selective neurotrophin deficiency in infantile hypertrophic pyloric stenosis
    N Guarino
    Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland
    J Pediatr Surg 36:1280-4. 2001
    ..The lack of TrkA-positive nerve fibers in pyloric muscle may explain the abnormal intramuscular innervation in IHPS...
  19. ncbi request reprint Differences in nitrergic innervation of the developing chick cloaca and colorectum
    A M O'Donnell
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Ireland
    Pediatr Surg Int 22:90-4. 2006
    ..These results highlight the need for a further in-depth analysis of the enteric nervous system's development within the embryonic cloaca...
  20. ncbi request reprint Alterations in smooth muscle contractile and cytoskeleton proteins and interstitial cells of Cajal in megacystis microcolon intestinal hypoperistalsis syndrome
    A Piaseczna Piotrowska
    Children s Research Centre, Our Lady s Hospital for Sick Children, University College Dublin, Dublin, Ireland
    J Pediatr Surg 38:749-55. 2003
    ..Contractile and cytoskeleton proteinase are important structural and functional components of SMCs. The aim of study was to examine the expression of contractile and cytoskeleton proteins in SMCs and distribution of ICCs in MMIHS bowel...
  21. ncbi request reprint Notochord anomalies in the adriamycin rat model: A morphologic and molecular basis for the VACTERL association
    J Gillick
    Children s Research Centre, Our Lady s Hospital for Sick Children and University College Dublin, Dublin, Ireland
    J Pediatr Surg 38:469-73; discussion 469-73. 2003
    ..The authors hypothesised that notochord anomalies allow ectopic expression of molecular signals in the developing embryo and thus lead to VACTERL malformations. This study was designed to investigate this hypothesis...
  22. ncbi request reprint The timing of enteric neural crest cell colonisation of the chick embryo cloaca
    A M O'Donnell
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin, Ireland
    Pediatr Surg Int 20:229-32. 2004
    ..Further studies, involving quail-chick chimeras, are required to establish the true origin of cloacal NCCs and to establish the relationship between NCCs and persistent cloaca...
  23. ncbi request reprint Multiple gastrointestinal atresias result from disturbed morphogenesis
    L Fourcade
    Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin, Ireland
    Pediatr Surg Int 17:361-4. 2001
    ..The injection of adriamycin early in gestation, the high incidence of associated malformations, and the anatomic and histologic findings in MGA indicate that MGA is a result of a malformative rather than an ischemic process...
  24. ncbi request reprint Gene expression of insulin-like growth factor-1 and epidermal growth factor is downregulated in the heart of rats with nitrofen-induced diaphragmatic hernia
    H Teramoto
    Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 17:284-7. 2001
    ..05). Decreased cardiac gene expression of IGF-I and EGF in the hypoplastic heart suggests that cardiac hypoplasia in nitrofen-induced rat CDH may be due to reduced synthesis of IGF-I and EGF by myocytes in the developing heart...
  25. ncbi request reprint Histopathological differences between recto-sigmoid Hirschsprung's disease and total colonic aganglionosis
    V Solari
    Children s Research Centre, Our Lady s Hospital for Sick Children, University College, Dublin 12, Ireland
    Pediatr Surg Int 19:349-54. 2003
    ..Our findings demonstrate clear histopathological differences between rectosigmoid Hirschsprung's disease and total colonic aganglionosis...
  26. ncbi request reprint Evidence of an inflammatory pathologic condition in "normal" appendices following emergency appendectomy
    L Nemeth
    Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland
    Arch Pathol Lab Med 125:759-64. 2001
    ..The initiating signal for this and all other forms of clinical appendicitis still remains elusive...
  27. ncbi request reprint Animal models in pediatric surgery
    A Mortell
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 22:111-28. 2006
  28. ncbi request reprint Reflux nephropathy in infancy: a comparison of infants presenting with and without urinary tract infection
    B Sweeney
    Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland
    J Urol 166:648-50. 2001
    ..Early treatment of grade V vesicoureteral reflux made possible by screening may prevent renal damage...
  29. ncbi request reprint Jejunoileal atresia and associated malformations: correlation with the timing of in utero insult
    B Sweeney
    Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland
    J Pediatr Surg 36:774-6. 2001
    ..CONCLUSION: The higher incidence of associated major congenital extraintestinal malformations in JA compared with IA patients suggests that some cases of JA may arise from a malformative process...
  30. ncbi request reprint Renal parenchymal damage in sibling vesicoureteric reflux
    S Cascio
    The National Children s Hospital, Dublin, Ireland
    Acta Paediatr 92:17-20. 2003
    ....
  31. ncbi request reprint Internal anal sphincter achalasia: outcome after internal sphincter myectomy
    D De Caluwe
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    J Pediatr Surg 36:736-8. 2001
    ..Altered intramuscular innervation has been reported in IASA. The purpose of this study was to review the outcome after internal sphincter myectomy in patients with IASA...
  32. doi request reprint COUP-TFII gene expression is upregulated in embryonic pleuroperitoneal folds in the nitrofen-induced congenital diaphragmatic hernia rat model
    J Dingemann
    National Children s Research Centre, Our Lady s Children s Hospital, Dublin, Ireland
    Eur J Pediatr Surg 22:21-5. 2012
    ..We designed this study to investigate the hypothesis that COUP-TFII gene expression is upregulated during early diaphragmatic development in the PPF...
  33. ncbi request reprint Cell-adhesion molecules and fibroblast growth factor signalling in Hirschsprung's disease
    A Yoneda
    Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 17:299-303. 2001
    ..The markedly decreased expression of CAMs on nerve fibres within the muscle of AG bowel suggests that CAM-FGF signalling is altered in HD, resulting in failure of enteric neuroblast migration...
  34. ncbi request reprint Megaprepuce associated with vesicoureteric reflux
    S Cascio
    National Children's Hospital, Tallaght, Dublin, Ireland
    Eur Urol 40:696-8. 2001
    ..CONCLUSION: These cases demonstrate for the first time the association of megaprepuce with VUR. VUR associated with megaprepuce is usually resolved after circumcision...
  35. ncbi request reprint Intestinal neuronal dysplasia: results of treatment in 33 patients
    J Gillick
    Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland
    J Pediatr Surg 36:777-9. 2001
    ..CONCLUSION: The majority of patients with IND can be treated successfully with conservative treatment...
  36. doi request reprint Down-regulation of lung Kruppel-like factor in the nitrofen-induced hypoplastic lung
    A Lukošiūtė
    National Children s Research Centre, Our Lady s Children s Hospital, Dublin, Ireland
    Eur J Pediatr Surg 21:38-41. 2011
    ..We therefore designed this study to test the hypothesis that the LKLF gene is down-regulated during later stages of lung development in nitrofen-induced hypoplastic lungs...
  37. ncbi request reprint Nerve growth factor receptor staining of suction biopsies in the diagnosis of Hirschsprung's disease
    H Kobayashi
    Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin, Ireland
    J Pediatr Surg 29:1224-7. 1994
    ..Because the technique uses an immunocytochemical rather than a histochemical technique and the results were easier to interpret, NGFR staining may be an important additional technique to diagnose HD...
  38. ncbi request reprint Mucinous cystadenoma of the ovary in perimenarchal girls
    T Sri Paran
    Children s Research Centre and Our Lady s Hospital for Sick Children, Crumlin, Dublin, Ireland
    Pediatr Surg Int 22:224-7. 2006
    ..MCA in perimenarchal girls usually affects the left ovary. Although this tumour is rare, this diagnosis should be considered in 11 to 15-year-old girls presenting with a very large abdominal mass...
  39. ncbi request reprint Adriamycin effects on the chick embryo
    A Mortell
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 19:359-64. 2003
    ..Despite examining different administration routes and mimicking the ARM, by giving Adriamycin to embryos at gastrulation, we were unable to re-create the anomalies seen in the ARM...
  40. pmc A genome-wide scan for genes involved in primary vesicoureteric reflux
    H Kelly
    The National Centre for Medical Genetics, University College Dublin Department of Medical Genetics, Our Lady s Children s Hospital Crumlin, Dublin 12, Ireland
    J Med Genet 44:710-7. 2007
    ..VUR is seen in approximately 1-2% of Caucasian newborns and is frequently familial. Objective and..
  41. ncbi request reprint Gastroschisis and exomphalos in Ireland 1998-2004. Does antenatal diagnosis impact on outcome?
    F L Murphy
    Department of Paediatric Surgery, Our Lady s Hospital for Sick Children, Crumlin 12, Dublin 12, Ireland
    Pediatr Surg Int 23:1059-63. 2007
    ..Despite this result, the importance of antenatal screening and prenatal management of complex foetal conditions with consultation with experienced paediatric and neonatal staff is without doubt...
  42. doi request reprint Downregulation of FGFRL1 contributes to the development of the diaphragmatic defect in the nitrofen model of congenital diaphragmatic hernia
    J Dingemann
    Our Lady s Children s Hospital, National Children s Research Centre, Dublin, Ireland
    Eur J Pediatr Surg 21:46-9. 2011
    ..The aim of this study was to investigate the hypothesis that FGFRL1 gene expression in the diaphragm is downregulated during the later gestational stages in the nitrofen CDH model...
  43. ncbi request reprint Interstitial cells of Cajal in the human normal urinary bladder and in the bladder of patients with megacystis-microcolon intestinal hypoperistalsis syndrome
    Anna Piaseczna Piotrowska
    Children s Research Centre, University College Dublin, Our Lady s Hospital for Sick Children, Dublin, Ireland
    BJU Int 94:143-6. 2004
    ....
  44. ncbi request reprint Endoscopic management of vesicoureteral reflux: does it stand the test of time?
    Boris Chertin
    Children s Research Centre, Our Lady s Hospital for Sick Children, University College Dublin, Dublin, Ireland
    Eur Urol 42:598-606; discussion 606. 2002
    ..In terms of effectiveness and long-term successful results, polytetrafluoroethylene is still the most reliable injectable material for the endoscopic treatment of VUR...
  45. ncbi request reprint Endoscopic treatment for high grade vesicoureteral reflux in infants
    Michael J Dawrant
    National Children s Hospital, and Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 2, Ireland
    J Urol 176:1847-50. 2006
    ..We determined the long-term efficacy and safety of this treatment for high grade reflux in infants...
  46. doi request reprint Evidence against a direct role for oxidative stress in cadmium-induced axial malformation in the chick embryo
    Jennifer Thompson
    School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland
    Toxicol Appl Pharmacol 243:390-8. 2010
    ..Furthermore, MDA levels 24 hours after treatment were identical in malformed and normal embryos exposed to Cd. Hence, we conclude that oxidative stress may not have a direct role in Cd teratogenesis...
  47. ncbi request reprint Conservative management of appendix mass in children
    J Gillick
    The Chidren's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland
    Br J Surg 88:1539-42. 2001
    ..8 per cent of appendices removed at elective appendicectomy. CONCLUSION: Non-operative management of an appendix mass followed by elective appendicectomy is a safe and effective method of management...
  48. ncbi request reprint Renal parenchymal damage in male infants with high grade vesicoureteral reflux diagnosed after the first urinary tract infection
    S Cascio
    The National Children s Hospital and Childrens Research Center, Our Lady s Hospital for Sick Children, Dublin, Ireland
    J Urol 168:1708-10; discussion 1710. 2002
    ..We evaluate the incidence of renal damage in a large series of male infants with high grade vesicoureteral reflux diagnosed after the first urinary tract infection...
  49. ncbi request reprint Demonstration of neuronal networks in the human upper urinary tract using confocal laser scanning microscopy
    L Nemeth
    Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland
    J Urol 166:255-8. 2001
    ..Our findings suggest that the autonomic nervous system of the human upper urinary tract may have a significant role in the propagation, coordination and modulation of ureteropelvic peristalsis...
  50. ncbi request reprint Penile malignant peripheral nerve sheath tumour (schwannoma) in a three-year-old child without evidence of neurofibromatosis
    A Mortell
    Our Lady s Children s Hospital, Crumlin, Dublin 12, Ireland
    Eur J Pediatr Surg 17:428-30. 2007
    ..A diagnosis of intermediate grade malignant peripheral nerve sheath tumour was made. Malignant schwannoma is rare in children and is previously unreported in the penis in the paediatric age group without evidence of neurofibromatosis...
  51. ncbi request reprint Alterations in cholinergic and neuropeptide innervation of urinary bladder following partial bladder outlet obstruction
    B Chertin
    Children s Research Centre, Our Lady s Hospital for Sick Children, University College Dublin, Dublin, Ireland
    Pediatr Surg Int 19:427-31. 2003
    ..The marked reduction in sensory innervation of the bladder and simultaneous increase in cholinergic innervation following BOO may lead to bladder instability and decrease in bladder compliance...
  52. ncbi request reprint Regional differences in nitrergic neuronal density in the developing porcine urinary bladder
    M E Pirker
    Children s Research Centre, Our Lady s Hospital for Sick Children and University College Dublin, Dublin, Ireland
    Pediatr Surg Int 21:161-8. 2005
    ..001), predominantly due to an increase in cytoplasm. Our data on whole-mount preparations demonstrate that significant maturation in nitrergic neuronal density and morphology occurs in the porcine urinary bladder, at least until birth...
  53. ncbi request reprint Megacystis-microcolon-intestinal hypoperistalsis syndrome: evidence of intestinal myopathy
    Udo Rolle
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 18:2-5. 2002
    ..These findings suggest that the intestinal obstruction in MMIHS is due to an abnormality of the smooth-muscle cells...
  54. doi request reprint Hypoganglionic colorectum in the chick embryo: a model of human hypoganglionosis
    Anne Marie O'Donnell
    Children s Research Centre, Our Lady s Children s Hospital Dublin, University College Dublin, Dublin, Ireland
    Pediatr Surg Int 25:885-8. 2009
    ....
  55. ncbi request reprint The role of endoscopic treatment in the management of grade v primary vesicoureteral reflux
    Maria N Menezes
    The National Children s Hospital, Dublin, Ireland
    Eur Urol 52:1505-9. 2007
    ..In this study we reviewed our 21-yr experience of endoscopic treatment in children with grade V primary VUR...
  56. ncbi request reprint Childhood femoral hernia: a commonly misdiagnosed condition
    D De Caluwe
    Children s Research Centre, Our Lady s Hospital for Sick Children, University College Dublin, Crumlin, 12 Dublin, Ireland
    Pediatr Surg Int 19:608-9. 2003
    ..This study shows that femoral hernia is still a commonly misdiagnosed condition. A correct preoperative diagnosis will lead to appropriate surgical management, thus avoiding unnecessary morbidity and preventing unnecessary reoperations...
  57. doi request reprint The spatio-temporal patterning of Hoxa9 and Hoxa13 in the developing zebrafish enteric nervous system
    R Doodnath
    National Children s Research Centre, Our Lady s Children s Hospital, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 28:115-21. 2012
    ..The aim of this study was to determine the spatio-temporal pattern of Hoxa9 and Hoxa13 in enteric nervous system (ENS) development using the zebrafish model...
  58. ncbi request reprint Characterisation of the local inflammatory response in appendicitis
    M Tsuji
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin, Ireland
    J Pediatr Gastroenterol Nutr 16:43-8. 1993
    ....
  59. ncbi request reprint Endoscopic correction of vesicoureteral reflux
    P Puri
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin, Ireland
    Curr Opin Urol 10:593-7. 2000
    ..In terms of effectiveness and long term successful results, PTFE is the most reliable injectable product for the endoscopic treatment of all grades of VUR...
  60. ncbi request reprint Altered gene level expression of thyroid hormone receptors alpha-1 and beta-1 in the lung of nitrofen-induced diaphragmatic hernia
    H Teramoto
    Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland
    J Pediatr Surg 36:1675-8. 2001
    ....
  61. doi request reprint IGFBP-4 gene overexpression in the nitrofen-induced hypoplastic lung
    E M Ruttenstock
    Our Lady s Children s Hospital, National Children s Research Centre, Dublin, Ireland
    Eur J Pediatr Surg 21:42-5. 2011
    ..We hypothesized that IGFBP-4 gene expression is increased during the later stages of lung development in the nitrofen-induced CDH lung...
  62. doi request reprint Histochemical staining of rectal suction biopsies as the first investigation in patients with chronic constipation
    Sandra Montedonico
    The Children s Research Centre, Our Lady s Children s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 24:785-92. 2008
    ..The combination of two histochemical stainings techniques provides a high level of accuracy in the diagnosis of intestinal dysganglionosis...
  63. doi request reprint Msx1 and Msx2 gene expression is downregulated in the cadmium-induced omphalocele in the chick model
    Takashi Doi
    The Children s Research Centre, Our Lady s Children s Hospital, Dublin 12, Ireland
    J Pediatr Surg 45:1187-91. 2010
    ..It has been reported that Msx1/Msx2 double-mutant mice display an omphalocele phenotype. We hypothesized that gene expression levels of Msx1 and Msx2 are downregulated in the Cd chick model during the critical period of embryogenesis...
  64. doi request reprint Disruption of calreticulin-mediated cellular adhesion signaling in the cadmium-induced omphalocele in the chick model
    Takashi Doi
    The Children s Research Centre, Our Lady s Children s Hospital, Dublin 12, Ireland
    Pediatr Surg Int 26:91-5. 2010
    ..CRT knockouts display omphalocele. We hypothesized that CRT, E-cadherin and beta-catenin are downregulated during early embryogenesis in the Cd chick model...
  65. ncbi request reprint New contralateral vesicoureteral reflux after endoscopic correction of unilateral reflux--is routine contralateral injection indicated at initial treatment?
    Maria Menezes
    National Children s Hospital, Dublin, Ireland
    J Urol 178:1711-3. 2007
    ..We analyzed the incidence of newly diagnosed contralateral reflux after endoscopic correction of unilateral reflux and identified possible risk factors for its development...
  66. ncbi request reprint Endoscopic treatment of primary grades IV and V vesicoureteral reflux in children with subureteral injection of polytetrafluoroethylene
    Boris Chertin
    Children s Research Centre, Our Lady s Hospital for Sick Children, University College Dublin, Dublin, Ireland
    J Urol 169:1847-9; discussion 1849. 2003
    ..We evaluated our experience with endoscopic STING (subureteral polytetrafluoroethylene injection) for grades IV and V vesicoureteral reflux...
  67. ncbi request reprint Altered distribution of interstitial cells of Cajal in Hirschsprung disease
    Udo Rolle
    Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin, Ireland
    Arch Pathol Lab Med 126:928-33. 2002
    ....
  68. ncbi request reprint Distribution of Ca2+-activated K channels, SK2 and SK3, in the normal and Hirschsprung's disease bowel
    Anna Piaseczna Piotrowska
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin, Ireland
    J Pediatr Surg 38:978-83. 2003
    ..The aim of this study was to investigate the expression and distribution of SK2 and SK3 channels in the normal and Hirschsprung's disease (HD) bowel...
  69. ncbi request reprint Nitric oxide, enhanced by macrophage-colony stimulating factor, mediates renal damage in reflux nephropathy
    Udo Rolle
    Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin, Ireland
    Kidney Int 62:507-13. 2002
    ..The aim of this study was to investigate the expression of inducible NO synthase (iNOS) and M-CSF in the refluxing kidney, in order to further understand the pathogenesis of RN...
  70. ncbi request reprint Treatment of vesicoureteral reflux by endoscopic injection of dextranomer/hyaluronic Acid copolymer: preliminary results
    Prem Puri
    The National Children Hospital and Chidren s Research Centre, Our Lady s Hospital for Sick Children, University College Dublin, Ireland
    J Urol 170:1541-4; discussion 1544. 2003
    ..However, the experience with dextranomer/hyaluronic acid copolymer is limited. We prospectively evaluate the effectiveness of dextranomer/hyaluronic acid copolymer in the endoscopic treatment of VUR...
  71. ncbi request reprint Cyclooxygenase-2 up-regulation in reflux nephropathy
    Valeria Solari
    Children s Research Centre, Our Lady s Hospital for Sick Children and University College, Dublin, Ireland
    J Urol 170:1624-7. 2003
    ..It has been shown that COX-2 up-regulates renin production leading to renovascular hypertension. We investigate COX-2 expression in the kidneys of children with RN...
  72. ncbi request reprint Autoamputation of a congenital oropharyngeal hairy polyp
    D De Caluwe
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Department of Pediatric Surgery, Crumlin, Dublin12, Ireland
    Pediatr Surg Int 18:548-9. 2002
    ..Treatment usually consists of surgical removal. We describe a case of spontaneous resolution of symptoms in an 11-week-old baby due to autoamputation of the lesion...
  73. ncbi request reprint Cervical thymic cysts
    D De Caluwe
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin 12, Dublin, Ireland
    Pediatr Surg Int 18:477-9. 2002
    ..Evolution is benign. Intact, complete surgical excision remains the treatment of choice...
  74. ncbi request reprint Pure alcohol injection of a congenital splenic cyst: a valid alternative?
    D De Caluwe
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    J Pediatr Surg 38:629-32. 2003
    ..The purpose of this case study is to report our experience with ultrasound (US)-guided aspiration and injection of a congenital splenic cyst, which, in our case, did not prove a viable alternative to surgical defenestration...
  75. doi request reprint Investigation of L-type Ca(2+) current in the aganglionic bowel segment in Hirschsprung's disease
    R J Large
    The Smooth Muscle Research Centre, Dundalk Institute of Technology, Dundalk, Co Louth, Ireland
    Neurogastroenterol Motil 24:1126-e571. 2012
    ....
  76. ncbi request reprint Polyunsaturated fatty acids influence neonatal monocyte survival
    B Sweeney
    Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 17:254-8. 2001
    ..Their effect is dose-dependent and DHA appears to be the most potent of the fatty acids tested. The influence of PUFAs on neonatal monocyte-cell survival suggests a novel mechanism whereby PUFAs may modulate the immune response...
  77. ncbi request reprint Long-term outcome of the retained ureteral stump after lower pole heminephrectomy in duplex kidneys
    D De Caluwe
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin, Ireland
    Eur Urol 42:63-6. 2002
    ..The purpose of our study was to review the long-term outcome of retained ureteral stumps in children undergoing heminephrectomy for non-functioning lower pole moieties in duplex kidneys...
  78. doi request reprint Laparoscopic appendectomy after conservative management of appendix mass
    J Gillick
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 24:299-301. 2008
    ..Not only does it make the dissection and resection of the appendix easier but it also has the added advantage of performing adhesiolysis...
  79. ncbi request reprint Cell death in the early adriamycin rat model
    J Gillick
    The Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin, University College Dublin, Ireland
    Pediatr Surg Int 18:576-80. 2002
    ..The absence of significant apoptosis in the developing embryos in the immediate period following administration of adriamycin suggests that the teratogenic effect of adriamycin is not caused by cell death...
  80. ncbi request reprint Mutation analysis of the RET gene in total intestinal aganglionosis by wave DNA fragment analysis system
    V Solari
    Children s Research Centre, Our Lady s Hospital for Sick Children, University College Dublin, Crumlin, Ireland
    J Pediatr Surg 38:497-501. 2003
    ..The aim of this study was to investigate DNA variants in the RET gene in TIA patients using the WAVE DNA Fragment Analysis System...
  81. ncbi request reprint Risk factors for the development of renal parenchymal damage in familial vesicoureteral reflux
    Akihiro Yoneda
    Childrens Research Center, Our Lady s Hospital for Sick Children, Dublin, Ireland
    J Urol 168:1704-7. 2002
    ..We determine risk factors associated with renal damage in patients with primary familial vesicoureteral reflux...
  82. ncbi request reprint Nitrergic innervation of the normal gut and in motility disorders of childhood
    Udo Rolle
    Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin, Ireland
    J Pediatr Surg 37:551-67. 2002
  83. ncbi request reprint New hypothesis on the pathogenesis of ileocecal intussusception
    Tamas Cserni
    Children s Research Centre, Our Lady s Hospital for Children, University College Dublin, Dublin IZ, Ireland
    J Pediatr Surg 42:1515-9. 2007
    ..The aim of this study was to examine the age-related changes in the nitrergic innervation of the ileocecal valve (ICV) to gain insights into the pathogenesis of intussusception...
  84. ncbi request reprint Up-regulation of angiotensin-converting enzyme (ACE) gene expression induces tubulointerstitial injury in reflux nephropathy
    Boris Chertin
    Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin, University College Dublin, Ireland
    Pediatr Surg Int 18:635-9. 2002
    ..Pharmacologic blockade of ACE may be helpful in preventing the renal fibrosis associated with RN...
  85. ncbi request reprint Demonstration of intrinsic innervation of the guinea pig upper urinary tract using whole-mount preparation
    Udo Rolle
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin, Ireland
    Neurourol Urodyn 27:341-7. 2008
    ..In contrast, the whole-mount preparation technique is a suitable method for visualizing the distribution of the mesh-like neuronal networks within the urinary tract...
  86. doi request reprint Deficient alpha-smooth muscle actin as a cause of functional intestinal obstruction in childhood
    Anne Marie O Donnell
    Children s Research Centre, Our Lady s Children s Hospital, Dublin, Ireland
    Pediatr Surg Int 24:1191-5. 2008
    ..The aim of this study was to describe four patients with functional intestinal obstruction where the only histopathological abnormality was deficient, alpha-smooth muscle actin (alpha-SMA) in the circular muscle of their small bowel...
  87. doi request reprint Downregulation of ROCK-I and ROCK-II gene expression in the cadmium-induced ventral body wall defect chick model
    Takashi Doi
    The Children s Research Centre, Our Lady s Children s Hospital, Dublin 12, Ireland
    Pediatr Surg Int 24:1297-301. 2008
    ..We designed this study to test the hypothesis, that the gene expression levels of ROCK-I and ROCK-II are downregulated during the critical period of embryogenesis in the Cd-induced VBW defect chick model...
  88. ncbi request reprint Selective chemical ablation of the enteric plexus in mice
    Akihiro Yoneda
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 18:234-7. 2002
    ..This model provides the basis for future studies to investigate the pathophysiology of HD and megacolon and for comparison with genetically aganglionic mice...
  89. ncbi request reprint Altered cytoskeleton in smooth muscle of aganglionic bowel
    Laszlo Nemeth
    Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin, Ireland
    Arch Pathol Lab Med 126:692-6. 2002
    ..Desmin and vinculin are functionally related proteins that are present in the membrane-associated dense bodies in the sarcolemma of the smooth muscle cells...
  90. doi request reprint Disruption of noncanonical Wnt/CA2+ pathway in the cadmium-induced omphalocele in the chick model
    Takashi Doi
    The Children s Research Center, Our Lady s Children s Hospital, Dublin, Ireland
    J Pediatr Surg 45:1645-9. 2010
    ..We hypothesized that the Wnt11, PKCalpha, and CaMKII gene expression is downregulated in the Cd-induced VBWD during early embryogenesis...
  91. doi request reprint The development of excitatory neurons in the chick cloaca
    Anne Marie O'Donnell
    Children s Research Centre, Our Lady s Childrens Hospital, Dublin, Ireland
    Pediatr Surg Int 26:111-4. 2010
    ..We hypothesised that the vagal and sacral neural tubes provide the cloaca, with phenotypically similar nerve cells. The aim of our study was to investigate the origin of excitatory neurotransmission in the developing cloaca...
  92. doi request reprint The role of transforming growth factor-beta 2 and 3 in formation of ventral body wall in the cadmium-induced omphalocele chick model
    Takashi Doi
    The Children s Research Center, Our Lady s Children s Hospital, Dublin, Ireland
    J Pediatr Surg 45:898-902. 2010
    ..We designed this study to investigate the messenger RNA (mRNA) levels of TGF-beta2 and TGF-beta3 in the Cd-induced omphalocele chick model during early embryogenesis...
  93. doi request reprint Spatiotemporal alteration in phosphatidylinositide 3-kinase-serine/threonine protein kinase B signaling in the nitrofen-induced hypoplastic lung
    Takashi Doi
    The Children s Research Center, Our Lady s Children s Hospital, Dublin 12, Ireland
    J Pediatr Surg 45:366-71. 2010
    ..We hypothesized that PI3K and AKT gene and protein expression/distribution are altered during epithelial morphogenesis in the nitrofen-induced hypoplastic lung...
  94. ncbi request reprint Fate of the retained ureteral stump after upper pole heminephrectomy in duplex kidneys
    Diane De Caluwe
    Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin, Ireland
    J Urol 168:679-80. 2002
    ..We review the long-term outcome of retained ureteral stumps in children undergoing heminephrectomy for nonfunctioning upper pole moieties in duplex kidneys...
  95. doi request reprint Prevalence of duplex collecting systems in familial vesicoureteral reflux
    Manuela Hunziker
    National Children s Hospital, Dublin, Ireland
    Pediatr Surg Int 26:115-7. 2010
    ..The aim of this study was to determine the prevalence and significance of duplex collecting systems in familial VUR...
  96. doi request reprint Cholinergic innervation in the developing chick cloaca and colorectum
    Anne Marie O'Donnell
    National Children s Hospital, Tallaght, Dublin, Ireland
    J Pediatr Surg 44:392-4. 2009
    ..The aim of our study was to investigate cholinergic innervation in the chick embryo cloaca and colorectum at various stages of development...
  97. doi request reprint New insights into the neuromuscular anatomy of the ileocecal valve
    Tamas Cserni
    Children s Research Centre, Our Lady s Children s Hospital, Crumlin, Dublin, Ireland
    Anat Rec (Hoboken) 292:254-61. 2009
    ..This knowledge may help surgeons in their future attempts at reconstructing more anatomically and functionally suitable ICVs following surgical resection of native ICVs...
  98. ncbi request reprint Immunocolocalization of the heme oxygenase-2 and interstitial cells of Cajal in normal and aganglionic colon
    Anna Piaseczna Piotrowska
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin, Ireland
    J Pediatr Surg 38:73-7. 2003
    ..The aim of this study was to investigate the immunocolocalization of the HO-2 and ICCs in normal and aganglionic bowel of Hirschsprung's disease (HD)...
  99. ncbi request reprint Prenatal and postnatal neuromuscular development of the ureterovesical junction
    Martina E Pirker
    Children Research Centre, Our Lady s Hospital for Sick Children, Dublin, Ireland
    J Urol 177:1546-51. 2007
    ..We analyzed the development of smooth muscle components of the ureterovesical junction and their nerve supply in the fetal, newborn and adolescent pig...
  100. ncbi request reprint Pathogenesis of Hirschsprung's disease and its variants: recent progress
    Prem Puri
    Children s Research Centre, Our Lady s Hospital for Sick Children, University College Dublin, Ireland
    Semin Pediatr Surg 13:18-24. 2004
    ..HOX11L1 knockout mice and endothelin B receptor-deficient rats demonstrated abnormalities of the ENS resembling IND type B in humans. These findings support the concept that IND may be linked to a genetic defect...
  101. ncbi request reprint Abnormal vasculature in intestinal neuronal dysplasia
    Udo Rolle
    Children s Research Centre, Our Lady s Hospital for Sick Children, University College, Dublin 12, Ireland
    Pediatr Surg Int 19:345-8. 2003
    ..Abnormal submucosal vasculature is a common histological finding in isolated IND and IND associated with HD and may be a useful additional diagnostic feature in these patients...