Paul W O'Toole

Summary

Affiliation: University College Cork
Country: Ireland

Publications

  1. pmc Multireplicon genome architecture of Lactobacillus salivarius
    Marcus J Claesson
    Department of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Proc Natl Acad Sci U S A 103:6718-23. 2006
  2. doi request reprint Strain-specific inhibition of Helicobacter pylori by Lactobacillus salivarius and other lactobacilli
    Kieran A Ryan
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    J Antimicrob Chemother 61:831-4. 2008
  3. pmc Genomic diversity of Lactobacillus salivarius
    Emma J Raftis
    Department of Microbiology and Alimentary Pharmabiotic Centre, Food Science Bldg, Western Road, University College Cork, Cork, Ireland
    Appl Environ Microbiol 77:954-65. 2011
  4. doi request reprint Next-generation sequencing technologies and their impact on microbial genomics
    Brian M Forde
    Department of Microbiology, University College Cork, Cork, Ireland
    Brief Funct Genomics 12:440-53. 2013
  5. pmc Catabolic flexibility of mammalian-associated lactobacilli
    Michelle M O'Donnell
    Teagasc Food Research Centre, Moorepark, Co Cork, Fermoy, Ireland
    Microb Cell Fact 12:48. 2013
  6. pmc The effect of environmental conditions on expression of Bacteroides fragilis and Bacteroides thetaiotaomicron C10 protease genes
    Roibeard F Thornton
    Department of Life Sciences, University of Limerick, Limerick, Ireland
    BMC Microbiol 12:190. 2012
  7. doi request reprint Changes in the intestinal microbiota from adulthood through to old age
    P W O'Toole
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College, Cork, Ireland
    Clin Microbiol Infect 18:44-6. 2012
  8. pmc Carbohydrate catabolic flexibility in the mammalian intestinal commensal Lactobacillus ruminis revealed by fermentation studies aligned to genome annotations
    Michelle M O'Donnell
    Teagasc Food Research Centre, Moorepark, Fermoy, Co Cork, Ireland
    Microb Cell Fact 10:S12. 2011
  9. pmc The dissemination of C10 cysteine protease genes in Bacteroides fragilis by mobile genetic elements
    Roibeard F Thornton
    Department of Life Sciences, University of Limerick, Limerick, Ireland
    BMC Microbiol 10:122. 2010
  10. pmc Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen
    Paul W O'Toole
    Department of Microbiology, and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    BMC Genomics 11:164. 2010

Collaborators

Detail Information

Publications62

  1. pmc Multireplicon genome architecture of Lactobacillus salivarius
    Marcus J Claesson
    Department of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Proc Natl Acad Sci U S A 103:6718-23. 2006
    ..The discovery of megaplasmids of widely varying size in L. salivarius suggests a possible mechanism for genome expansion or contraction to adapt to different environments...
  2. doi request reprint Strain-specific inhibition of Helicobacter pylori by Lactobacillus salivarius and other lactobacilli
    Kieran A Ryan
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    J Antimicrob Chemother 61:831-4. 2008
    ..To investigate the anti-Helicobacter pylori activity of 28 strains of Lactobacillus salivarius and 12 other lactobacilli, isolated from different sites and from different geographical regions...
  3. pmc Genomic diversity of Lactobacillus salivarius
    Emma J Raftis
    Department of Microbiology and Alimentary Pharmabiotic Centre, Food Science Bldg, Western Road, University College Cork, Cork, Ireland
    Appl Environ Microbiol 77:954-65. 2011
    ..L. salivarius displays a high level of genomic diversity, and while selection of L. salivarius strains for probiotic use can be informed by CGH or MLST, it also requires pragmatic experimental validation of desired phenotypic traits...
  4. doi request reprint Next-generation sequencing technologies and their impact on microbial genomics
    Brian M Forde
    Department of Microbiology, University College Cork, Cork, Ireland
    Brief Funct Genomics 12:440-53. 2013
    ..With the commercialization of a third generation of sequencing technologies imminent, we discuss the applications of current next-generation sequencing methods and explore their impact on and contribution to microbial genome research. ..
  5. pmc Catabolic flexibility of mammalian-associated lactobacilli
    Michelle M O'Donnell
    Teagasc Food Research Centre, Moorepark, Co Cork, Fermoy, Ireland
    Microb Cell Fact 12:48. 2013
    ..plantarum, Lb. acidophilus, Lb. ruminis, Lb. salivarius, Lb. reuteri and Lb. sakei, to highlight the diversity and inter-relationships between the catabolic nature of species within the genus...
  6. pmc The effect of environmental conditions on expression of Bacteroides fragilis and Bacteroides thetaiotaomicron C10 protease genes
    Roibeard F Thornton
    Department of Life Sciences, University of Limerick, Limerick, Ireland
    BMC Microbiol 12:190. 2012
    ..thetaiotaomicron of four homologues of the gene encoding the C10 cysteine protease SpeB, a potent extracellular virulence factor produced by Streptococcus pyogenes...
  7. doi request reprint Changes in the intestinal microbiota from adulthood through to old age
    P W O'Toole
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College, Cork, Ireland
    Clin Microbiol Infect 18:44-6. 2012
    ..These data support the notion of modulating the intestinal microbiota of older people to promote enhanced nutrition utilization and to improve general health...
  8. pmc Carbohydrate catabolic flexibility in the mammalian intestinal commensal Lactobacillus ruminis revealed by fermentation studies aligned to genome annotations
    Michelle M O'Donnell
    Teagasc Food Research Centre, Moorepark, Fermoy, Co Cork, Ireland
    Microb Cell Fact 10:S12. 2011
    ..Its variable abundance in human and animals may be linked to historical changes over time and geographical differences in dietary intake of complex carbohydrates...
  9. pmc The dissemination of C10 cysteine protease genes in Bacteroides fragilis by mobile genetic elements
    Roibeard F Thornton
    Department of Life Sciences, University of Limerick, Limerick, Ireland
    BMC Microbiol 10:122. 2010
    ..Bacteroides fragilis is a member of the dominant Bacteroidetes phylum of the human intestinal microbiota, and is a significant opportunistic pathogen...
  10. pmc Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen
    Paul W O'Toole
    Department of Microbiology, and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    BMC Genomics 11:164. 2010
    ..mustelae pathogenesis, and the ulcerogenic and carcinogenic potential of helicobacters in general, we sequenced the H. mustelae genome, and identified 425 expressed proteins in the envelope and cytosolic proteome...
  11. pmc Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts
    Brian M Forde
    Department Microbiology, University College Cork, Ireland
    Microb Cell Fact 10:S13. 2011
    ..salivarius clade available to date. Furthermore, there is no data to facilitate a functional genomic analysis of motility in the lactobacilli, a trait that is restricted to the L. salivarius clade...
  12. pmc Targeting the microbiota to address diet-induced obesity: a time dependent challenge
    Siobhan F Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    PLoS ONE 8:e65790. 2013
    ..The results highlight the resilience of the gut microbiota and suggest that interventions may need to be monitored and continually adjusted to ensure sustained modification of the gut microbiota...
  13. doi request reprint Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity
    Eileen F Murphy
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Gut 62:220-6. 2013
    ..This study explored two antimicrobial strategies for their impact on metabolic abnormalities in murine diet-induced obesity: oral vancomycin and a bacteriocin-producing probiotic (Lactobacillus salivarius UCC118 Bac(+))...
  14. pmc Posttranscriptional regulation of flagellin synthesis in Helicobacter pylori by the RpoN chaperone HP0958
    Francois P Douillard
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Ireland
    J Bacteriol 190:7975-84. 2008
    ..We conclude that HP0958 is a posttranscriptional regulator that modulates the amount of the flaA message available for translation in H. pylori...
  15. pmc Distribution of megaplasmids in Lactobacillus salivarius and other lactobacilli
    Yin Li
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    J Bacteriol 189:6128-39. 2007
    ..salivarius, and restricted carriage by other Lactobacillus species, provides an opportunity to study the contribution of large extrachromosomal replicons to the biology of Lactobacillus...
  16. ncbi request reprint Polyphasic analysis indicates that Lactobacillus salivarius subsp. salivarius and Lactobacillus salivarius subsp. salicinius do not merit separate subspecies status
    Yin Li
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Int J Syst Evol Microbiol 56:2397-403. 2006
    ..Based on the present study and literature data, an emended description of the species Lactobacillus salivarius is provided...
  17. pmc Characterization of pro-inflammatory flagellin proteins produced by Lactobacillus ruminis and related motile Lactobacilli
    B Anne Neville
    Department of Microbiology, University College Cork, Cork, Ireland
    PLoS ONE 7:e40592. 2012
    ..This study provides genetic, transcriptomic, phylogenetic and immunological insights into the trait of flagellum-mediated motility in the lactobacilli...
  18. pmc The HP0256 gene product is involved in motility and cell envelope architecture of Helicobacter pylori
    Francois P Douillard
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Ireland
    BMC Microbiol 10:106. 2010
    ..In Salmonella, FliJ is a chaperone escort protein for FlgN and FliT, two proteins that themselves display chaperone activity for components of the hook, the rod and the filament...
  19. pmc Microbiota diversity and stability of the preterm neonatal ileum and colon of two infants
    Eoin Barrett
    Food Biosciences, Teagasc Food Research Centre, Moorepark, Fermoy Co, Cork, Ireland
    Microbiologyopen 2:215-25. 2013
    ..These decreases were characterized by an increase in proportions of Streptococcus and Enterobacteriaceae. Clostridium was detected only in the colonic effluent, with large changes in the relative proportions over time...
  20. ncbi request reprint Diversity of the genus Lactobacillus revealed by comparative genomics of five species
    Carlos Canchaya
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Microbiology 152:3185-96. 2006
    ..salivarius-L. plantarum; L. sakei; E. faecalis; and L. acidophilus-L. johnsonii. The extreme divergence of the Lactobacillus genomes analysed supports the recognition of new subgeneric divisions...
  21. ncbi request reprint HP0958 is an essential motility gene in Helicobacter pylori
    Kieran A Ryan
    Department of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    FEMS Microbiol Lett 248:47-55. 2005
    ..We conclude that HP0958 is essential for normal motility and flagella production, and represents a novel flagellar component in the epsilon proteobacteria...
  22. pmc Influence of adhesion and bacteriocin production by Lactobacillus salivarius on the intestinal epithelial cell transcriptional response
    John O'Callaghan
    Department of Microbiology, University College Cork, Cork, Ireland
    Appl Environ Microbiol 78:5196-203. 2012
    ..Sortase-anchored cell surface proteins of L. salivarius UCC118 have a central role in promoting the interaction between the bacterium and epithelial cells...
  23. pmc Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine
    Marcus J Claesson
    Department of Microbiology, University College Cork, Cork, Ireland
    PLoS ONE 4:e6669. 2009
    ..Here we compare two such methods, pyrosequencing and a phylogenetic array, and evaluate classifications based on two variable 16S rRNA gene regions...
  24. pmc Effect of FliK mutation on the transcriptional activity of the {sigma}54 sigma factor RpoN in Helicobacter pylori
    Francois P Douillard
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Western Road, Cork, Ireland
    Microbiology 155:1901-11. 2009
    ..FliK thus appears to be involved in three processes: hook-length control, export substrate specificity and control of RpoN transcriptional activity...
  25. pmc Helicobacter pylori flagellar hook-filament transition is controlled by a FliK functional homolog encoded by the gene HP0906
    Kieran A Ryan
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    J Bacteriol 187:5742-50. 2005
    ..We conclude that the H. pylori HP0906 gene product is the hook length control protein FliK and that its function is required for turning off the sigma(54) regulon during progression of the flagellar gene expression cascade...
  26. doi request reprint Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production
    Eiji Miyauchi
    Department of Microbiology, University College Cork, National University of Ireland, Cork, Ireland
    Am J Physiol Gastrointest Liver Physiol 303:G1029-41. 2012
    ..Furthermore, bacteriocin production appears to have an attenuating influence on lactobacillus-mediated barrier protection...
  27. pmc Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig intestinal microbiota
    Eliette Riboulet-Bisson
    Department of Microbiology, University College Cork, Cork, Ireland
    PLoS ONE 7:e31113. 2012
    ..Thus L. salivarius UCC118 administration has a significant but subtle impact on mouse and pig microbiota, by a mechanism that seems at least partially bacteriocin-dependent...
  28. pmc Allelic variation of bile salt hydrolase genes in Lactobacillus salivarius does not determine bile resistance levels
    Fang Fang
    Department of Microbiology, University College Cork, Cork, Ireland
    J Bacteriol 191:5743-57. 2009
    ..salivarius, may have additional biological importance because of varying effects upon bile as a signaling molecule in the host...
  29. doi request reprint Fibrinogen-binding and platelet-aggregation activities of a Lactobacillus salivarius septicaemia isolate are mediated by a novel fibrinogen-binding protein
    James Collins
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Mol Microbiol 85:862-77. 2012
    ..salivarius strains, maintaining their potential to bind fibrinogen if expressed. We highlight the fact that without a full genetic analysis of strains for human consumption, potential pathogenicity traits may go undetected...
  30. doi request reprint Lactobacillus phylogenomics--towards a reclassification of the genus
    Marcus J Claesson
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Int J Syst Evol Microbiol 58:2945-54. 2008
    ..This will ideally be combined with phenotypic data using a polyphasic approach...
  31. doi request reprint Lactobacillus salivarius modulates cytokine induction and virulence factor gene expression in Helicobacter pylori
    Kieran A Ryan
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    J Med Microbiol 58:996-1005. 2009
    ..These data identified a new mechanism whereby some probiotic bacteria have a positive effect on H. pylori-associated inflammation without clearing the infection...
  32. pmc Characterization of endogenous plasmids from Lactobacillus salivarius UCC118
    Fang Fang
    Department of Microbiology, University College Cork, Cork, Ireland
    Appl Environ Microbiol 74:3216-28. 2008
    ..salivarius promoter, demonstrated the utility of this vector for the expression of heterologous genes in Lactobacillus. This study thus expands the knowledge base and vector repertoire of probiotic lactobacilli...
  33. pmc Comparison of two next-generation sequencing technologies for resolving highly complex microbiota composition using tandem variable 16S rRNA gene regions
    Marcus J Claesson
    Department of Microbiology, University College Cork, Cork, Ireland
    Nucleic Acids Res 38:e200. 2010
    ..Nonetheless, with improved quality and longer reads, the far greater coverage of Illumina promises unparalleled insights into highly diverse and complex environments such as the human gut...
  34. pmc Diet-microbiota interactions and their implications for healthy living
    Ian B Jeffery
    Department of Microbiology, University College Cork, College Road, Cork, Ireland
    Nutrients 5:234-52. 2013
    ..In this review, we investigate the evidence that a balanced diet leads to a balanced, diverse microbiota with significant consequences for healthy ageing by focusing on conditions of interest...
  35. pmc Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome
    Eoin Barrett
    Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
    PLoS ONE 7:e48159. 2012
    ..Administration of B. breve DPC6330 to maternally separated rats significantly modified the palmitoleic acid, arachidonic acid and docosahexaenoic acid contents in tissues. The effect was not observed in non-separated animals...
  36. pmc The microbiota link to irritable bowel syndrome: an emerging story
    Ian B Jeffery
    Department of Microbiology, University College Cork, Cork, Ireland
    Gut Microbes 3:572-6. 2012
    ..This addendum contextualizes and summarizes the results of these studies, and defines the future challenges and opportunities in the field...
  37. doi request reprint Lactobacillus hordei sp. nov., a bacteriocinogenic strain isolated from malted barley
    Susan Rouse
    Department of Microbiology, National University of Ireland, Western Road, Cork, Ireland
    Int J Syst Evol Microbiol 58:2013-7. 2008
    ..The four bacteriocin-producing strains are therefore considered to represent a novel species of the genus Lactobacillus, for which the name Lactobacillus hordei sp. nov. is proposed. The type strain is UCC128T (=DSM 19519T=LMG 24241T)...
  38. doi request reprint Gut microbiota composition correlates with diet and health in the elderly
    Marcus J Claesson
    Department of Microbiology, University College Cork, Ireland
    Nature 488:178-84. 2012
    ..Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing...
  39. ncbi request reprint Analysis of bifidobacterial evolution using a multilocus approach
    Marco Ventura
    Alimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland, Western Road, Cork, Ireland
    Int J Syst Evol Microbiol 56:2783-92. 2006
    ..The results demonstrate that the concatenation of these seven gene sequences for phylogenetic purposes allows a significant increase in the discriminatory power between taxa...
  40. pmc Phenotypic variation of Helicobacter pylori isolates from geographically distinct regions detected by lectin typing
    Sean O Hynes
    Department of Microbiology, National University of Ireland, Galway, Ireland
    J Clin Microbiol 40:227-32. 2002
    ..In contrast, isolates with lectin reaction patterns MH1 and MH10, which had high lectin reactivities, were associated with ulcer disease (P = 0.046 and P = 0.0022, respectively)...
  41. pmc Pro-inflammatory flagellin proteins of prevalent motile commensal bacteria are variably abundant in the intestinal microbiome of elderly humans
    B Anne Neville
    Department of Microbiology, University College Cork, Cork, Ireland
    PLoS ONE 8:e68919. 2013
    ....
  42. doi request reprint Lactobacillus: host-microbe relationships
    John O'Callaghan
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Curr Top Microbiol Immunol 358:119-54. 2013
    ..The rare cases of Lactobacillus septicaemia are explained in terms of the host impairment required for such an outcome. We discuss possibilities for exploitation of lactobacilli for therapeutic delivery and mucosal vaccination...
  43. ncbi request reprint HorB (HP0127) is a gastric epithelial cell adhesin
    William J Snelling
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Helicobacter 12:200-9. 2007
    ..Of the verified H. pylori porins, the HorB sequence is most similar to that of HopE, but the function of HorB is unknown. The aim of our study was to investigate the role of HorB in H. pylori gastric epithelial cell adhesion...
  44. pmc Composition, variability, and temporal stability of the intestinal microbiota of the elderly
    Marcus J Claesson
    Department of Microbiology, University College, Cork, Ireland
    Proc Natl Acad Sci U S A 108:4586-91. 2011
    ..We conclude that the fecal microbiota of the elderly shows temporal stability over limited time in the majority of subjects but is characterized by unusual phylum proportions and extreme variability...
  45. pmc Draft genome sequences of Helicobacter pylori strains 17874 and P79
    Ceara D Clancy
    Department of Microbiology, University College Cork, Cork, Ireland
    J Bacteriol 194:2402. 2012
    ..Here we announce the draft genomes of H. pylori strain 17874, commonly used for studying motility, and P79, a strain for which plasmid vectors have been developed...
  46. pmc Analysis, characterization, and loci of the tuf genes in lactobacillus and bifidobacterium species and their direct application for species identification
    Marco Ventura
    Nestle Research Center, 1000 Lausanne 26, Switzerland
    Appl Environ Microbiol 69:6908-22. 2003
    ..In contrast, bioinformatic and transcriptional analyses of the DNA region flanking the tuf gene in four Lactobacillus species indicated the same four-gene unit and suggested a novel tuf operon specific for the genus Lactobacillus...
  47. pmc Bifidobacterium lactis DSM 10140: identification of the atp (atpBEFHAGDC) operon and analysis of its genetic structure, characteristics, and phylogeny
    Marco Ventura
    Nestle Research Center, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    Appl Environ Microbiol 70:3110-21. 2004
    ..lactis DSM 10140. The rapid increase in the level of atp operon transcripts upon exposure to low pH suggested that the ATPase complex of B. lactis DSM 10140 was regulated at the level of transcription and not at the enzyme assembly step...
  48. pmc Characterization of the groEL and groES loci in Bifidobacterium breve UCC 2003: genetic, transcriptional, and phylogenetic analyses
    Marco Ventura
    Department of Microbiology, National University of Ireland, Western Road, Cork, Ireland
    Appl Environ Microbiol 70:6197-209. 2004
    ....
  49. pmc Prophage-like elements in bifidobacteria: insights from genomics, transcription, integration, distribution, and phylogenetic analysis
    Marco Ventura
    Alimentary Pharmabiotic Centre and Department of Microbiology, Biosciences Institute, National University of Ireland, Western Road, Cork, Ireland
    Appl Environ Microbiol 71:8692-705. 2005
    ..Interestingly, a gene predicted to encode an extracellular beta-glucosidase carried within the Bbr-1 prophage-like element was shown to be transcribed...
  50. doi request reprint An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
    Ian B Jeffery
    Department of Microbiology, University College Cork, Cork, Ireland
    Gut 61:997-1006. 2012
    ..The authors performed a detailed analysis of the faecal microbiota in IBS and control subjects and correlated the findings with key clinical and physiological parameters...
  51. doi request reprint Techniques used to characterize the gut microbiota: a guide for the clinician
    Marianne H Fraher
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Nat Rev Gastroenterol Hepatol 9:312-22. 2012
    ..This Review discusses the techniques that can used to characterize the gut microbiota, when they can be applied to human studies and their relative advantages and limitations...
  52. doi request reprint The 2.2-Å structure of the HP0958 protein from Helicobacter pylori reveals a kinked anti-parallel coiled-coil hairpin domain and a highly conserved ZN-ribbon domain
    Delphine L Caly
    Department of Microbiology, University College Cork, Cork, Ireland
    J Mol Biol 403:405-19. 2010
    ..The data thus suggest the arrangement of HP0958 into distinct structural and functional domains...
  53. ncbi request reprint Genetic tools for investigating the biology of commensal lactobacilli
    Fang Fang
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Front Biosci (Landmark Ed) 14:3111-27. 2009
    ..The current state of the art with respect to the available complement of genetic tools including genomic resources, and more traditional approaches to investigate the biology of commensal lactobacilli, will now be reviewed...
  54. ncbi request reprint How high G+C Gram-positive bacteria and in particular bifidobacteria cope with heat stress: protein players and regulators
    Marco Ventura
    Alimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland, Cork, Ireland
    FEMS Microbiol Rev 30:734-59. 2006
    ..Temporal expression of heat-shock genes based on functional genomics in members of the Actinobacteridae group is also discussed, as well as the emerging molecular mechanisms controlling the heat-stress response...
  55. doi request reprint Molecular dialogue between the human gut microbiota and the host: a Lactobacillus and Bifidobacterium perspective
    Francesca Turroni
    Alimentary Pharmabiotic Centre, Department of Microbiology Biosciences Institute, University College Cork, National University of Ireland, Western Road, Cork, Ireland
    Cell Mol Life Sci 71:183-203. 2014
    ....
  56. pmc The gut microbiota and its relationship to diet and obesity: new insights
    Siobhan F Clarke
    Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland
    Gut Microbes 3:186-202. 2012
    ....
  57. pmc Comparative and functional analysis of sortase-dependent proteins in the predicted secretome of Lactobacillus salivarius UCC118
    Jan Peter van Pijkeren
    Department of Microbiology, University College Cork, Cork, Ireland
    Appl Environ Microbiol 72:4143-53. 2006
    ..The genome-wide investigation of surface proteins can thus help our understanding of their roles in host interaction...
  58. pmc Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor
    Mary O'Connell Motherway
    Alimentary Pharmabiotic Centre, National University of Ireland, Cork, Ireland
    Proc Natl Acad Sci U S A 108:11217-22. 2011
    ..Conservation of the Tad pilus-encoding locus among other B. breve strains and among sequenced Bifidobacterium genomes supports the notion of a ubiquitous pili-mediated host colonization and persistence mechanism for bifidobacteria...
  59. pmc Comparative analyses of prophage-like elements present in two Lactococcus lactis strains
    Marco Ventura
    Alimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland, Western Road, Cork, Ireland
    Appl Environ Microbiol 73:7771-80. 2007
    ..cremoris strains MG1363 and SK11, respectively. Phylogenetic investigation as well bioinformatic analyses indicates that all 11 prophages belong to subdivisions of the lactococcal P335 group of temperate bacteriophages...
  60. doi request reprint Challenges and implications for biomedical research and intervention studies in older populations: insights from the ELDERMET study
    Siobhan Cusack
    Department of Microbiology, University College Cork, Cork, Ireland
    Gerontology 59:114-21. 2013
    ..The increased benefit brought by the generalisation and application of research and intervention outcomes to older populations is discussed...
  61. pmc Probiotic bacteria influence the composition and function of the intestinal microbiota
    Paul W O'Toole
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Interdiscip Perspect Infect Dis 2008:175285. 2008
    ..Rigorous characterization of interactions between the diet, microbiota, and probiotic bacteria will provide new opportunities for modulating the microbiota towards improving human health...
  62. ncbi request reprint Sequence and comparative genomic analysis of lactococcal bacteriophages jj50, 712 and P008: evolutionary insights into the 936 phage species
    Jennifer Mahony
    Department of Microbiology, University College Cork, Ireland
    FEMS Microbiol Lett 261:253-61. 2006
    ..These genetic differences may be responsible for the observed differential sensitivity to the lactococcal DNA injection blocking protein, Sie(2009), and the abortive infection system, AbiA...