BRIAN O'NUALLAIN

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. doi Human plasma contains cross-reactive Abeta conformer-specific IgG antibodies
    BRIAN O'NUALLAIN
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Biochemistry 47:12254-6. 2008
  2. pmc Anti-amyloidogenic activity of IgGs contained in normal plasma
    BRIAN O'NUALLAIN
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA
    J Clin Immunol 30:S37-42. 2010
  3. pmc Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils
    BRIAN O'NUALLAIN
    Laboratory for Neurodegenerative Research, Conway Institute, University College Dublin, Belfield, Dublin 4, Republic of Ireland
    J Neurosci 30:14411-9. 2010
  4. ncbi Kinetics and thermodynamics of amyloid assembly using a high-performance liquid chromatography-based sedimentation assay
    BRIAN O'NUALLAIN
    University of Tennessee Medical Center, Graduate School of Medicine, Knoxville, TN, USA
    Methods Enzymol 413:34-74. 2006
  5. pmc Conformational Abs recognizing a generic amyloid fibril epitope
    BRIAN O'NUALLAIN
    Graduate School of Medicine, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920, USA
    Proc Natl Acad Sci U S A 99:1485-90. 2002
  6. pmc Phage display and peptide mapping of an immunoglobulin light chain fibril-related conformational epitope
    BRIAN O'NUALLAIN
    Human Immunology and Cancer Alzheimer s Disease and Amyloid Related Disorders Research Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Biochemistry 46:13049-58. 2007
  7. ncbi Amyloid-like features of polyglutamine aggregates and their assembly kinetics
    Songming Chen
    Graduate School of Medicine, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920, USA
    Biochemistry 41:7391-9. 2002
  8. ncbi Diagnostic and therapeutic potential of amyloid-reactive IgG antibodies contained in human sera
    BRIAN O'NUALLAIN
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Center for Health Science, College of Medicine, Knoxville, TN 37920, USA
    J Immunol 176:7071-8. 2006
  9. ncbi Thermodynamics of A beta(1-40) amyloid fibril elongation
    BRIAN O'NUALLAIN
    Graduate School of Medicine, University of Tennessee, 1924 Alcoa Highway, Knoxville, Tennessee 37920, USA
    Biochemistry 44:12709-18. 2005
  10. pmc Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide
    Alfred T Welzel
    The Conway Institute, University College Dublin, Belfield, Dublin, Republic of Ireland
    PLoS ONE 7:e50317. 2012

Collaborators

Detail Information

Publications13

  1. doi Human plasma contains cross-reactive Abeta conformer-specific IgG antibodies
    BRIAN O'NUALLAIN
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Biochemistry 47:12254-6. 2008
    ..Our studies provide further support for investigating the therapeutic use of IVIG in Alzheimer's disease...
  2. pmc Anti-amyloidogenic activity of IgGs contained in normal plasma
    BRIAN O'NUALLAIN
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA
    J Clin Immunol 30:S37-42. 2010
    ..These molecules cross-react with conformational epitopes on amyloidogenic assemblies, including amyloid beta (Abeta) protein fibrils that are a pathological hallmark of Alzheimer's disease...
  3. pmc Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils
    BRIAN O'NUALLAIN
    Laboratory for Neurodegenerative Research, Conway Institute, University College Dublin, Belfield, Dublin 4, Republic of Ireland
    J Neurosci 30:14411-9. 2010
    ....
  4. ncbi Kinetics and thermodynamics of amyloid assembly using a high-performance liquid chromatography-based sedimentation assay
    BRIAN O'NUALLAIN
    University of Tennessee Medical Center, Graduate School of Medicine, Knoxville, TN, USA
    Methods Enzymol 413:34-74. 2006
    ....
  5. pmc Conformational Abs recognizing a generic amyloid fibril epitope
    BRIAN O'NUALLAIN
    Graduate School of Medicine, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920, USA
    Proc Natl Acad Sci U S A 99:1485-90. 2002
    ..These Abs should contribute to the understanding of amyloid structure, assembly, and toxicity and also may benefit the development of diagnostic and therapeutic agents for amyloid diseases...
  6. pmc Phage display and peptide mapping of an immunoglobulin light chain fibril-related conformational epitope
    BRIAN O'NUALLAIN
    Human Immunology and Cancer Alzheimer s Disease and Amyloid Related Disorders Research Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Biochemistry 46:13049-58. 2007
    ..The identification of an 11-1F4-related mimotope should facilitate development of pan-light chain fibril-reactive antibodies that could be used in the diagnosis and treatment of patients with AL amyloidosis...
  7. ncbi Amyloid-like features of polyglutamine aggregates and their assembly kinetics
    Songming Chen
    Graduate School of Medicine, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920, USA
    Biochemistry 41:7391-9. 2002
    ..This ordered structure, or the assembly process leading to it, may be responsible for the cell-specific neuronal degeneration observed in Huntington's and other expanded CAG repeat diseases...
  8. ncbi Diagnostic and therapeutic potential of amyloid-reactive IgG antibodies contained in human sera
    BRIAN O'NUALLAIN
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Center for Health Science, College of Medicine, Knoxville, TN 37920, USA
    J Immunol 176:7071-8. 2006
    ..These promising experimental results suggest that fibril affinity-purified IGIV has potential as a diagnostic and therapeutic agent for patients with amyloid-associated disease...
  9. ncbi Thermodynamics of A beta(1-40) amyloid fibril elongation
    BRIAN O'NUALLAIN
    Graduate School of Medicine, University of Tennessee, 1924 Alcoa Highway, Knoxville, Tennessee 37920, USA
    Biochemistry 44:12709-18. 2005
    ..The ability to quantify and compare amyloid fibril thermodynamic stabilities makes it possible to include fibrils, and potentially other aggregates, in quantitative descriptions of protein folding landscapes...
  10. pmc Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide
    Alfred T Welzel
    The Conway Institute, University College Dublin, Belfield, Dublin, Republic of Ireland
    PLoS ONE 7:e50317. 2012
    ..These findings suggest that further investigations on the molecular basis and the therapeutic/diagnostic potential of anti-Aβ NAbs are warranted...
  11. ncbi Seeding specificity in amyloid growth induced by heterologous fibrils
    BRIAN O'NUALLAIN
    Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee 37920, USA
    J Biol Chem 279:17490-9. 2004
    ..Preliminary results also suggest that identical sequences can grow into different conformations of amyloid fibrils as detected by seeding efficiencies. The results have a number of implications for amyloid structure and biology...
  12. pmc A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ
    BRIAN O'NUALLAIN
    Laboratory for Neurodegenerative Research, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Neurochem 119:189-201. 2011
    ..These data prove the usefulness of covalent dimers and their assemblies as immunogens and recommend further investigation of the therapeutic and diagnostic utility of monoclonal antibodies raised to such assemblies...
  13. pmc Localization of a conformational epitope common to non-native and fibrillar immunoglobulin light chains
    BRIAN O'NUALLAIN
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Biochemistry 46:1240-7. 2007
    ..Our delineation of this LC fibril-associated epitope provides the rationale for the design of novel amyloid-reactive antibodies with diagnostic and therapeutic potential for patients with LC-associated and other forms of amyloidosis...