Keith J Murphy

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. pmc NF-kappaB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations
    Graham K Sheridan
    Applied Neurotherapeutics Research Group, UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Learn Mem 14:525-32. 2007
  2. doi request reprint Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat
    Keith J Murphy
    Applied Neurotherapeutics Research Group, UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
    J Neurochem 113:601-14. 2010
  3. ncbi request reprint Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing
    Keith J Murphy
    Department of Pharmacology, Applied Neurotherapeutics Research Group, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Neuropsychopharmacology 31:90-100. 2006
  4. ncbi request reprint Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning
    Niamh C O'Sullivan
    Applied Neurotherapeutics Research Group, UCD Schools of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    J Neurochem 101:1085-98. 2007
  5. doi request reprint Hippocampal region-specific regulation of NF-kappaB may contribute to learning-associated synaptic reorganisation
    Niamh C O'Sullivan
    Applied Neurotherapeutics Research Group, UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Brain Res Bull 81:385-90. 2010
  6. doi request reprint Curcumin-induced degradation of PKC delta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats
    Lisa Conboy
    UCD Conway Institute, University College Dublin, Belfield, Ireland
    Biochem Pharmacol 77:1254-65. 2009
  7. ncbi request reprint Complex-environment rearing prevents prenatal hypoxia-induced deficits in hippocampal cellular mechanisms necessary for memory consolidation in the adult Wistar rat
    Andrew G Foley
    Department of Pharmacology, The Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    J Neurosci Res 82:245-54. 2005
  8. doi request reprint AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity
    Alex G McKee
    Applied Neurotherapeutics Research Group, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    J Neurochem 112:991-1004. 2010
  9. doi request reprint Learning-associated regulation of polysialylated neural cell adhesion molecule expression in the rat prefrontal cortex is region-, cell type- and paradigm-specific
    Judith P F ter Horst
    Applied Neurotherapeutics Research Group, UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Eur J Neurosci 28:419-27. 2008
  10. doi request reprint Reduced reelin protein synthesis in ventral hippocampus of isolation reared Wistar rats accompanies impaired avoidance conditioning
    Andrew W Cassidy
    The Applied Neurotherapeutics Research Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Behav Brain Res 213:130-4. 2010

Collaborators

Detail Information

Publications26

  1. pmc NF-kappaB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations
    Graham K Sheridan
    Applied Neurotherapeutics Research Group, UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Learn Mem 14:525-32. 2007
    ..Further investigation into the cellular processes that occur during this molecular adaptation may increase our understanding of plasticity-related events common to both LTP and memory formation...
  2. doi request reprint Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat
    Keith J Murphy
    Applied Neurotherapeutics Research Group, UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
    J Neurochem 113:601-14. 2010
    ..These studies provide a molecular framework to understand the developmental emergence of the structural and behavioural characteristics that may in part define psychiatric illness...
  3. ncbi request reprint Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing
    Keith J Murphy
    Department of Pharmacology, Applied Neurotherapeutics Research Group, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Neuropsychopharmacology 31:90-100. 2006
    ..Moreover, the molecular and cellular events underpinning neuroplastic responses are identified as novel targets in the search for interventive drug strategies for the treatment of neurodegenerative and neuropsychiatric disorders...
  4. ncbi request reprint Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning
    Niamh C O'Sullivan
    Applied Neurotherapeutics Research Group, UCD Schools of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    J Neurochem 101:1085-98. 2007
    ..Thus, the memory-associated transcriptional cascade supports the cardinal periods of synaptic loosening, reorganisation and selection thought to underpin the process of long-term memory consolidation in the hippocampus...
  5. doi request reprint Hippocampal region-specific regulation of NF-kappaB may contribute to learning-associated synaptic reorganisation
    Niamh C O'Sullivan
    Applied Neurotherapeutics Research Group, UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Brain Res Bull 81:385-90. 2010
    ..These results suggest that NF-kappaB activity following hippocampal learning may contribute to consolidation-associated synaptic reorganisation...
  6. doi request reprint Curcumin-induced degradation of PKC delta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats
    Lisa Conboy
    UCD Conway Institute, University College Dublin, Belfield, Ireland
    Biochem Pharmacol 77:1254-65. 2009
    ..These results further confirm the role of PKCdelta in regulating PST and NCAM PSA expression and provide evidence that drug modulation of this system enhances the process of memory consolidation...
  7. ncbi request reprint Complex-environment rearing prevents prenatal hypoxia-induced deficits in hippocampal cellular mechanisms necessary for memory consolidation in the adult Wistar rat
    Andrew G Foley
    Department of Pharmacology, The Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    J Neurosci Res 82:245-54. 2005
    ..Rearing animals with prior prenatal hypoxia in a complex environment, however, eliminated the task acquisition and recall deficits and restored dentate polysialylated cell frequency and their transient posttraining increase...
  8. doi request reprint AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity
    Alex G McKee
    Applied Neurotherapeutics Research Group, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    J Neurochem 112:991-1004. 2010
    ..Together these studies provide the first evidence that excess SNAP-25 activity, restricted to the adult period, is sufficient to mediate significant deficits in the memory formation process...
  9. doi request reprint Learning-associated regulation of polysialylated neural cell adhesion molecule expression in the rat prefrontal cortex is region-, cell type- and paradigm-specific
    Judith P F ter Horst
    Applied Neurotherapeutics Research Group, UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Eur J Neurosci 28:419-27. 2008
    ..Thus, in contrast to other structures integrated functionally with the hippocampus, memory-associated plasticity mobilized in the PFC is region-, cell type- and task-specific...
  10. doi request reprint Reduced reelin protein synthesis in ventral hippocampus of isolation reared Wistar rats accompanies impaired avoidance conditioning
    Andrew W Cassidy
    The Applied Neurotherapeutics Research Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Behav Brain Res 213:130-4. 2010
    ..These findings suggest that environmental factors alone can impair forms of cognitive development with relevant region-specific dysfunctional plasticity...
  11. ncbi request reprint Notch signalling becomes transiently attenuated during long-term memory consolidation in adult Wistar rats
    Lisa Conboy
    School of Biomolecular and Biomedical Sciences, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Neurobiol Learn Mem 88:342-51. 2007
    ..As down-regulation of Notch signalling promotes differentiation and neurite outgrowth in post-mitotic neurons, it is proposed that this pathway regulates the integration of synapses transiently produced during memory consolidation...
  12. doi request reprint Mkl transcription cofactors regulate structural plasticity in hippocampal neurons
    Niamh C O'Sullivan
    Applied Neurotherapeutics Research Group, UCD Schools of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
    Cereb Cortex 20:1915-25. 2010
    ....
  13. ncbi request reprint Consolidation of memory for odour-reward association requires transient polysialylation of the neural cell adhesion molecule in the rat hippocampal dentate gyrus
    Andrew G Foley
    Department of Pharmacology, Conway Institute, University College, Belfield, Dublin, Ireland
    J Neurosci Res 74:570-6. 2003
    ..The transient increase in NCAM PSA expression is suggested to facilitate dendritic elaboration in response to the acquisition of novel behavioural repertoires...
  14. doi request reprint Temporal proteomic profile of memory consolidation in the rat hippocampal dentate gyrus
    Marco P Monopoli
    Applied Neurotherapeutics Research Group, UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland
    Proteomics 11:4189-201. 2011
    ..Together these observations provide further insight into protein level regulations occurring in the hippocampus during spatial memory consolidation...
  15. ncbi request reprint The 5-HT(6) receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats
    Andrew G Foley
    Department of Pharmacology, Conway Institute, University College Dublin, Belfield, Ireland
    Neuropsychopharmacology 29:93-100. 2004
    ..This significant improvement of task recall suggests SB-271046, in addition to inducing symptomatic cognition-enhancing actions, also attenuates age-related decline in neural function...
  16. ncbi request reprint Pentyl-4-yn-valproic acid reverses age-associated memory impairment in the Wistar rat
    Andrew G Foley
    Department of Pharmacology, The Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Neurobiol Aging 25:539-46. 2004
    ..The action of pentyl-4-yn-VPA on platform latency, search strategy and task recall suggests that this agent may have great benefit in the treatment of age-dependent cognitive decline...
  17. doi request reprint Peripubertal viral-like challenge and social isolation mediate overlapping but distinct effects on behaviour and brain interferon regulatory factor 7 expression in the adult Wistar rat
    Bartlomiej Lukasz
    Neurotherapeutics Research Group, UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Brain Behav Immun 27:71-9. 2013
    ..Moreover, augmented interferon signalling in hippocampus may represent a common molecular imprint of environmental insults associated with neuropsychiatric illnesses like schizophrenia...
  18. ncbi request reprint Differential enantioselective effects of pentyl-4-yn-valproate on spatial learning in the rat, and neurite outgrowth and cyclin D3 expression in vitro
    Eamon D O'Loinsigh
    Department of Pharmacology, Conway Institute, University College, Dublin, Ireland
    J Neurochem 88:370-9. 2004
    ....
  19. ncbi request reprint Distribution of polysialylated neural cell adhesion molecule in rat septal nuclei and septohippocampal pathway: transient increase of polysialylated interneurons in the subtriangular septal zone during memory consolidation
    Andrew G Foley
    Department of Pharmacology, Centre of Integrative Biology, The Conway Institute, University College, Dublin, Ireland
    J Neurosci Res 74:807-17. 2003
    ..The unique location of these interneurons is proposed to provide a natural plexus by which bidirectional communication between the septum and hippocampus may be modified during memory consolidation...
  20. ncbi request reprint Amyloid precursor protein expression in the rat hippocampal dentate gyrus modulates during memory consolidation
    Lisa Conboy
    Applied Neurotherapeutics Research Group, Department of Pharmacology, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    J Neurochem 95:1677-88. 2005
    ....
  21. doi request reprint Discrimination of cell types in mixed cortical culture using calcium imaging: a comparison to immunocytochemical labeling
    Mark Pickering
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, Belfield, Dublin 4, Ireland
    J Neurosci Methods 173:27-33. 2008
    ..83% of the time. However, this technique cannot reliably distinguish between non-neuronal cell types...
  22. pmc Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation
    Gilyana G Borlikova
    Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Republic of Ireland
    Neurobiol Aging 34:1315-27. 2013
    ....
  23. pmc The development of myelin repair agents for treatment of multiple sclerosis: progress and challenges
    Robert P Murphy
    Neurotherapeutics Research Group, UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
    Bioengineered 4:140-6. 2013
    ..Finally, we aim to highlight the challenges in the identification and development of such therapeutics...
  24. pmc Neurobiological and endocrine correlates of individual differences in spatial learning ability
    Carmen Sandi
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria s n, 28040 Madrid, Spain
    Learn Mem 11:244-52. 2004
    ....
  25. ncbi request reprint Modulation of hippocampal NCAM polysialylation and spatial memory consolidation by fear conditioning
    Carmen Sandi
    Department of Psychobiology CS, JJM, MIC, NDK, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria, Madrid, Spain
    Biol Psychiatry 54:599-607. 2003
    ..At the infragranular zone of the dentate gyrus, neurons expressing the polysialylated form of the neural cell adhesion molecule (NCAM PSA) transiently increase their frequency 12 hours after training in different tasks...
  26. doi request reprint Olanzapine, but not haloperidol, enhances PSA-NCAM immunoreactivity in rat prefrontal cortex
    Angelisa Frasca
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Int J Neuropsychopharmacol 11:591-5. 2008
    ..Our findings reveal a possible role for PSA-NCAM in the mechanism of action of the SGA olanzapine adding complexity as well as specificity to the molecular changes set in motion by this drug...