C D Murphy

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. ncbi request reprint Biochemistry: biosynthesis of an organofluorine molecule
    David O'Hagan
    School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK
    Nature 416:279. 2002
  2. doi request reprint A convenient chemical-microbial method for developing fluorinated pharmaceuticals
    Tara V Bright
    UCD School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, University College Dublin, Ardmore House, Belfield, Dublin 4, Ireland
    Org Biomol Chem 11:1135-42. 2013
  3. doi request reprint The microbial cell factory
    Cormac D Murphy
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin, Dublin 4, Ireland
    Org Biomol Chem 10:1949-57. 2012
  4. ncbi request reprint The application of 19F nuclear magnetic resonance to investigate microbial biotransformations of organofluorine compounds
    Cormac D Murphy
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin, Ireland
    OMICS 11:314-24. 2007
  5. doi request reprint Metabolism of fluoroorganic compounds in microorganisms: impacts for the environment and the production of fine chemicals
    Cormac D Murphy
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin, Belfield, Dublin, 4, Ireland
    Appl Microbiol Biotechnol 84:617-29. 2009
  6. ncbi request reprint Fluorophenol oxidation by a fungal chloroperoxidase
    Cormac D Murphy
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin, Belfield, Dublin 4, Ireland
    Biotechnol Lett 29:45-9. 2007
  7. ncbi request reprint Recent developments in enzymatic chlorination
    Cormac D Murphy
    UCD School of Biomolecular and Biomedical Sciences, Centre for Synthesis and Chemical Biology, University College Dublin, Belfield, Ireland
    Nat Prod Rep 23:147-52. 2006
  8. doi request reprint Biodegradation and biotransformation of organofluorine compounds
    Cormac D Murphy
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin, Belfield, Dublin 4, Ireland
    Biotechnol Lett 32:351-9. 2010
  9. ncbi request reprint Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya
    Cormac D Murphy
    School of Chemistry, Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife KY16 9ST, UK
    Chemosphere 52:455-61. 2003
  10. ncbi request reprint New frontiers in biological halogenation
    C D Murphy
    Department of Industrial Microbiology, University College Dublin, Belfield, Ireland
    J Appl Microbiol 94:539-48. 2003

Collaborators

  • Graham Sandford
  • David O'Hagan
  • Benjamin R Clark
  • Barry Heffernan
  • Clár Donnelly
  • Tara V Bright
  • Jessica Amadio
  • Sarah J Higginbotham
  • Stephen Moran
  • Eoin Casey
  • Robin I Hutchinson
  • F G Hidde Boersma
  • Fay Dalton
  • Neil K O'Connor
  • Victoria L Elder
  • Deirdre Fox
  • Stephen O'Connor
  • Jacques Leroy
  • Eoin Syron
  • Dilip K Rai
  • Russell J Grant
  • Steven L Cobb
  • W Colin McRoberts

Detail Information

Publications23

  1. ncbi request reprint Biochemistry: biosynthesis of an organofluorine molecule
    David O'Hagan
    School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK
    Nature 416:279. 2002
    ..To our knowledge, this is the first fluorinase enzyme to be identified, a discovery that opens up a new biotechnological opportunity for the preparation of organofluorine compounds...
  2. doi request reprint A convenient chemical-microbial method for developing fluorinated pharmaceuticals
    Tara V Bright
    UCD School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, University College Dublin, Ardmore House, Belfield, Dublin 4, Ireland
    Org Biomol Chem 11:1135-42. 2013
    ....
  3. doi request reprint The microbial cell factory
    Cormac D Murphy
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin, Dublin 4, Ireland
    Org Biomol Chem 10:1949-57. 2012
    ....
  4. ncbi request reprint The application of 19F nuclear magnetic resonance to investigate microbial biotransformations of organofluorine compounds
    Cormac D Murphy
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin, Ireland
    OMICS 11:314-24. 2007
    ..In this review an account of the application of 19F NMR in the study of microbial metabolism of organofluorine compounds is presented...
  5. doi request reprint Metabolism of fluoroorganic compounds in microorganisms: impacts for the environment and the production of fine chemicals
    Cormac D Murphy
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin, Belfield, Dublin, 4, Ireland
    Appl Microbiol Biotechnol 84:617-29. 2009
    ..In this paper, we review the historical and recent developments of organofluorine biotransformation in microorganisms and highlight the possibility of using microbes as models of fluorinated drug metabolism in mammals...
  6. ncbi request reprint Fluorophenol oxidation by a fungal chloroperoxidase
    Cormac D Murphy
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin, Belfield, Dublin 4, Ireland
    Biotechnol Lett 29:45-9. 2007
    ..The degradation of fluorinated compounds is of significant environmental interest and this versatile enzyme may by employed to treat contaminated soil or water prior to discharge...
  7. ncbi request reprint Recent developments in enzymatic chlorination
    Cormac D Murphy
    UCD School of Biomolecular and Biomedical Sciences, Centre for Synthesis and Chemical Biology, University College Dublin, Belfield, Ireland
    Nat Prod Rep 23:147-52. 2006
    ..The discoveries of new classes of halogenases, described in this Highlight, have shed new light on the mechanisms of enzymatic chlorination of aromatic and aliphatic compounds...
  8. doi request reprint Biodegradation and biotransformation of organofluorine compounds
    Cormac D Murphy
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin, Belfield, Dublin 4, Ireland
    Biotechnol Lett 32:351-9. 2010
    ..Here our current understanding of organofluorine catabolism in microorganisms is summarised...
  9. ncbi request reprint Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya
    Cormac D Murphy
    School of Chemistry, Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife KY16 9ST, UK
    Chemosphere 52:455-61. 2003
    ..Studies with cell-free extracts of S. cattleya have identified two enzymes, an aldehyde dehydrogenase and a threonine transaldolase, that are involved in the biotransformation of fluoroacetaldehyde to fluoroacetate and 4-fluorothreonine...
  10. ncbi request reprint New frontiers in biological halogenation
    C D Murphy
    Department of Industrial Microbiology, University College Dublin, Belfield, Ireland
    J Appl Microbiol 94:539-48. 2003
  11. doi request reprint Degradation of fluorobiphenyl by Pseudomonas pseudoalcaligenes KF707
    Cormac D Murphy
    School of Biomolecular and Biomedical Science and Centre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin, Ireland
    FEMS Microbiol Lett 286:45-9. 2008
    ....
  12. pmc Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya
    C D Murphy
    School of Chemistry, University of St. Andrews, Fife KY16 9ST, United Kingdom
    Appl Environ Microbiol 67:4919-21. 2001
    ..Measurement of kinetic parameters shows that the enzyme has a high affinity for fluoroacetaldehyde and glycoaldehyde, but not acetaldehyde...
  13. doi request reprint Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum
    Benjamin R Clark
    School of Biomolecular and Biomedical Sciences, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin, Belfield, Dublin 4, Republic of Ireland
    Org Biomol Chem 7:111-6. 2009
    ..Label-dilution experiments with pyrrole-2-carboxylate confirmed it was a direct precursor in the biosynthesis of rumbrin. Both 3- and 4-chloropyrrolecarboxylates were also accepted as precursors in polyene production...
  14. doi request reprint Biotransformation of fluorobiphenyl by Cunninghamella elegans
    Jessica Amadio
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin, Dublin 4, Ireland
    Appl Microbiol Biotechnol 86:345-51. 2010
    ..Other fluorobiphenyls (2-fluoro-, 4,4'-difluoro- and 2,3,4,5,6-pentafluoro-biphenyl) were catabolised by C. elegans, yielding mono- and dihydroxylated products, but phase II metabolites were detected from 4,4'-difluorobiphenyl only...
  15. ncbi request reprint A 19F NMR study of fluorobenzoate biodegradation by Sphingomonas sp. HB-1
    F G Hidde Boersma
    Department of Industrial Microbiology, University College Dublin, Belfield, Dublin 4, Ireland
    FEMS Microbiol Lett 237:355-61. 2004
    ..The organism can also use 2- and 4-fluorobenzoates as growth substrates...
  16. ncbi request reprint Bacterial defluorination of 4-fluoroglutamic acid
    Clár Donnelly
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, University College Dublin, Dublin 4, Ireland
    Appl Microbiol Biotechnol 77:699-703. 2007
    ..The activity was located in the soluble fraction of cell extracts, thus is not related to the L-2-amino-4-chloro-4-pentenoic acid dehydrochlorinase previously identified in membrane fractions of P. mirabilis...
  17. ncbi request reprint Treatment of fluoroacetate by a Pseudomonas fluorescens bioflm grown in membrane aerated biofilm reactor
    Barry Heffernan
    School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4, Ireland
    Environ Sci Technol 43:6776-85. 2009
    ..The study demonstrated the potential of MABR for treating wastewater streams contaminated with organofluorine compounds...
  18. pmc Comparison of planktonic and biofilm cultures of Pseudomonas fluorescens DSM 8341 cells grown on fluoroacetate
    Barry Heffernan
    UCD School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4, Ireland
    Appl Environ Microbiol 75:2899-907. 2009
    ..Spatial stratification of oxygen within the biofilm was identified as a possible explanation for the overflow metabolism of glycolate and the decreased performance of the biofilm cells...
  19. doi request reprint Identification and characterisation of a Streptomyces sp. isolate exhibiting activity against methicillin-resistant Staphylococcus aureus
    Sarah J Higginbotham
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin, Belfield, Dublin 4, Ireland
    Microbiol Res 165:82-6. 2010
    ..lavendulae but not Streptomyces tenebrarius. Significantly, the partially purified antibiotic displayed activity towards clinical isolates of methicillin-resistant Staphylococcus aureus, representative of the major clonal complexes...
  20. doi request reprint Purification and properties of fluoroacetate dehalogenase from Pseudomonas fluorescens DSM 8341
    Clár Donnelly
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, University College Dublin, Dublin, 4, Ireland
    Biotechnol Lett 31:245-50. 2009
    ..The enzyme is specific for fluoroacetate, and the K(m) for this substrate (0.68 mM) is the lowest determined for enzymes of this type that have been investigated to date...
  21. doi request reprint Production of anticancer polyenes through precursor-directed biosynthesis
    Benjamin R Clark
    School of Biomolecular and Biomedical Sciences, Centre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin, Republic of Ireland
    Org Biomol Chem 9:6306-11. 2011
    ..The 3-chloro- and 3-bromo-isorumbrins had improved activity against HeLa cells compared with rumbrin; 3-bromoisorumbrin also showed dramatically improved activity towards a lung cancer cell line (A549)...
  22. ncbi request reprint Biosynthetic origin of [R-(Z)]-4-amino-3-chloro-2-pentenedioic acid in Streptomyces viridogenes
    Robin I Hutchinson
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Ardmore House, University College Dublin
    Biosci Biotechnol Biochem 70:3046-9. 2006
    ..Experiments with deuterated glutamate and proline imply that chlorination does not occur via a radical mechanism, but rather suggest that a FADH(2)-dependent halogenase is involved...
  23. doi request reprint Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp
    Stephen Moran
    School of Biomolecular and Biomedical Science, Ardmore House, University College Dublin, Dublin 4, Ireland
    Org Biomol Chem 7:644-6. 2009
    ..The fluorinated iturin might also be used as a probe for studying its interaction with biological membranes...