Justin V McCarthy

Summary

Affiliation: University College Cork
Country: Ireland

Publications

  1. ncbi request reprint Apoptosis and development
    Justin V McCarthy
    Signal Transduction Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Essays Biochem 39:11-24. 2003
  2. ncbi request reprint Involvement of presenilins in cell-survival signalling pathways
    J V McCarthy
    Signal Transduction Laboratory, Biochemistry Department, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Soc Trans 33:568-72. 2005
  3. ncbi request reprint Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity
    J V McCarthy
    Signal Transduction Laboratory, Biochemistry Department, University College Cork, Cork, Ireland
    Cell Mol Life Sci 66:1534-55. 2009
  4. doi request reprint Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis
    Baukje M Elzinga
    Signal Transduction Laboratory, Biochemistry Department, University College Cork, Cork, Ireland
    J Biol Chem 284:1394-409. 2009
  5. doi request reprint Association between Presenilin-1 and TRAF6 modulates regulated intramembrane proteolysis of the p75NTR neurotrophin receptor
    James C Powell
    Signal Transduction Laboratory, Biochemistry Department, University College Cork, Cork, Ireland
    J Neurochem 108:216-30. 2009
  6. doi request reprint Presenilins are novel substrates for TRAF6-mediated ubiquitination
    Run Yan
    Signal Transduction Laboratory, Department of Biochemistry, Western Gate Building, Western Road, University College Cork, Cork, Ireland
    Cell Signal 25:1769-79. 2013
  7. ncbi request reprint Presenilin-1 is an unprimed glycogen synthase kinase-3beta substrate
    Ciara Twomey
    Signal Transduction Laboratory, Biochemistry Department, National University of Ireland, Cork, Ireland
    FEBS Lett 580:4015-20. 2006
  8. doi request reprint TRAF6 promotes ubiquitination and regulated intramembrane proteolysis of IL-1R1
    Ciara Twomey
    Signal Transduction Laboratory, Biochemistry Department, ABCRF, Cavanagh Pharmacy Building, University College Cork, Cork, Ireland
    Biochem Biophys Res Commun 381:418-23. 2009
  9. ncbi request reprint The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis
    Brian McElroy
    Signal Transduction Laboratory, Biochemistry Department, National University of Ireland, Cork, Ireland
    Biochem Biophys Res Commun 358:1136-41. 2007

Collaborators

  • Ciara Twomey
  • James C Powell
  • Run Yan
  • Baukje M Elzinga
  • Brian McElroy
  • Sean Farrelly
  • Raunak Jain
  • Frances Harte
  • Si Qian

Detail Information

Publications9

  1. ncbi request reprint Apoptosis and development
    Justin V McCarthy
    Signal Transduction Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Essays Biochem 39:11-24. 2003
    ....
  2. ncbi request reprint Involvement of presenilins in cell-survival signalling pathways
    J V McCarthy
    Signal Transduction Laboratory, Biochemistry Department, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Soc Trans 33:568-72. 2005
    ..In this paper, we review PS-regulated molecules, their role in cell signalling and possible involvement in neurodegeneration in patients suffering from AD...
  3. ncbi request reprint Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity
    J V McCarthy
    Signal Transduction Laboratory, Biochemistry Department, University College Cork, Cork, Ireland
    Cell Mol Life Sci 66:1534-55. 2009
    ..We also discuss regulation of the gamma-secretase complexes, with an emphasis on the functional role of presenilins in cell biology...
  4. doi request reprint Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis
    Baukje M Elzinga
    Signal Transduction Laboratory, Biochemistry Department, University College Cork, Cork, Ireland
    J Biol Chem 284:1394-409. 2009
    ..These findings also suggest that regulated intramembrane proteolysis may be a control mechanism for IL-1R1-mediated signaling...
  5. doi request reprint Association between Presenilin-1 and TRAF6 modulates regulated intramembrane proteolysis of the p75NTR neurotrophin receptor
    James C Powell
    Signal Transduction Laboratory, Biochemistry Department, University College Cork, Cork, Ireland
    J Neurochem 108:216-30. 2009
    ..In summary, our data suggest that an NGF-induced association between PS1 and TRAF6 influences regulated intramembrane proteolysis of p75(NTR)...
  6. doi request reprint Presenilins are novel substrates for TRAF6-mediated ubiquitination
    Run Yan
    Signal Transduction Laboratory, Department of Biochemistry, Western Gate Building, Western Road, University College Cork, Cork, Ireland
    Cell Signal 25:1769-79. 2013
    ....
  7. ncbi request reprint Presenilin-1 is an unprimed glycogen synthase kinase-3beta substrate
    Ciara Twomey
    Signal Transduction Laboratory, Biochemistry Department, National University of Ireland, Cork, Ireland
    FEBS Lett 580:4015-20. 2006
    ..These findings have important implications for regulation of PS1 function and the pathogenesis of Alzheimer's disease...
  8. doi request reprint TRAF6 promotes ubiquitination and regulated intramembrane proteolysis of IL-1R1
    Ciara Twomey
    Signal Transduction Laboratory, Biochemistry Department, ABCRF, Cavanagh Pharmacy Building, University College Cork, Cork, Ireland
    Biochem Biophys Res Commun 381:418-23. 2009
    ..Our results indicate that TRAF6-mediated ubiquitination of IL-1R1 has a decisive role in IL-1R1 signalling and propose a molecular mechanism whereby TRAF6 promotes ubiquitination and RIP of IL-1R1 through its ubiquitin ligase activity...
  9. ncbi request reprint The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis
    Brian McElroy
    Signal Transduction Laboratory, Biochemistry Department, National University of Ireland, Cork, Ireland
    Biochem Biophys Res Commun 358:1136-41. 2007
    ..This study suggests that the IGF-IR is a substrate for gamma-secretase and may mediate a function independent of its role as a receptor tyrosine kinase...