Conor Horgan

Summary

Affiliation: University College Cork
Location: Cork, Ireland

Publications

  1. doi Rab GTPases and microtubule motors
    Conor P Horgan
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Soc Trans 39:1202-6. 2011
  2. doi Dynein LIC1 localizes to the mitotic spindle and midbody and LIC2 localizes to spindle poles during cell division
    Conor P Horgan
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Cell Biol Int 35:171-8. 2011
  3. doi The role of endosomal-recycling in long-term potentiation
    Eoin E Kelly
    Department of Biochemistry, Biosciences Institute, University College Cork, Ireland
    Cell Mol Life Sci 68:185-94. 2011
  4. doi Rab11-FIP3 binds dynein light intermediate chain 2 and its overexpression fragments the Golgi complex
    Conor P Horgan
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Biophys Res Commun 394:387-92. 2010
  5. doi Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment
    Conor P Horgan
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    J Cell Sci 123:181-91. 2010
  6. doi The dynamic Rab11-FIPs
    Conor P Horgan
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Soc Trans 37:1032-6. 2009
  7. doi Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase
    Eoin E Kelly
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Biol Cell 102:51-62. 2010
  8. doi Knockdown of beta2-microglobulin perturbs the subcellular distribution of HFE and hepcidin
    Lavinia Bhatt
    Department of Biochemistry, Molecular Cell Biology Laboratory, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Biophys Res Commun 378:727-31. 2009
  9. ncbi The hereditary hemochromatosis protein HFE and its chaperone beta2-microglobulin localise predominantly to the endosomal-recycling compartment
    Lavinia Bhatt
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Biophys Res Commun 359:277-84. 2007
  10. ncbi Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment
    Conor P Horgan
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Traffic 8:414-30. 2007

Collaborators

Detail Information

Publications14

  1. doi Rab GTPases and microtubule motors
    Conor P Horgan
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Soc Trans 39:1202-6. 2011
    ..In this mini-review, we highlight the expanding repertoire of Rab/microtubule motor protein interactions, and, in doing so, present an outline of the multiplicity of transport processes which result from such interactions...
  2. doi Dynein LIC1 localizes to the mitotic spindle and midbody and LIC2 localizes to spindle poles during cell division
    Conor P Horgan
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Cell Biol Int 35:171-8. 2011
    ..Conversely, LIC2 strongly localizes to the spindle poles from prophase through telophase. These data suggest distinct functions for LIC1 and LIC2-containing CD-1 complexes during cell division...
  3. doi The role of endosomal-recycling in long-term potentiation
    Eoin E Kelly
    Department of Biochemistry, Biosciences Institute, University College Cork, Ireland
    Cell Mol Life Sci 68:185-94. 2011
    ..In this review, we discuss the importance of endosomal-recycling and the role of key proteins which control these processes in the context of LTP...
  4. doi Rab11-FIP3 binds dynein light intermediate chain 2 and its overexpression fragments the Golgi complex
    Conor P Horgan
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Biophys Res Commun 394:387-92. 2010
    ..In conclusion, we have identified FIP3 as the first membrane-associated interacting-partner for DLIC-2 and propose that this interaction serves to control endosomal trafficking from sorting endosomes to the ERC...
  5. doi Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment
    Conor P Horgan
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    J Cell Sci 123:181-91. 2010
    ..On the basis of these and other data, we propose that FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport of material from peripheral sorting endosomes to the centrally located ERC...
  6. doi The dynamic Rab11-FIPs
    Conor P Horgan
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Soc Trans 37:1032-6. 2009
    ..In this mini-review, we summarize the Rab11-FIP field and discuss, at molecular and cellular levels, the recent findings on FIP function...
  7. doi Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase
    Eoin E Kelly
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Biol Cell 102:51-62. 2010
    ..This protein family has been sub-classified into two groups - class I FIPs [FIP2, RCP (Rab coupling protein) and Rip11 (Rab11-interacting protein)] and class II FIPs (FIP3 and FIP4)...
  8. doi Knockdown of beta2-microglobulin perturbs the subcellular distribution of HFE and hepcidin
    Lavinia Bhatt
    Department of Biochemistry, Molecular Cell Biology Laboratory, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Biophys Res Commun 378:727-31. 2009
    ..In summary, our data suggest that beta2M is essential for the correct subcellular distribution of both HFE and hepcidin, two proteins, which are critical for iron homeostasis...
  9. ncbi The hereditary hemochromatosis protein HFE and its chaperone beta2-microglobulin localise predominantly to the endosomal-recycling compartment
    Lavinia Bhatt
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Biophys Res Commun 359:277-84. 2007
    ..In summary, our study sheds light on the localisation and functional effects of the HFE and its chaperone protein beta2M...
  10. ncbi Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment
    Conor P Horgan
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Traffic 8:414-30. 2007
    ..Together, these data indicate that Rab11-FIP3 is necessary for the structural integrity of the pericentrosomal ERC...
  11. ncbi Purification and functional properties of Rab11-FIP3
    Conor P Horgan
    Methods Enzymol 403:499-512. 2005
    ..Here we describe the purification of Rab11-FIP3 and report its biological properties in eukaryotic cells as visualized by immunofluorescence microscopy...
  12. ncbi Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis
    Conor P Horgan
    Molecular Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Biophys Res Commun 319:83-94. 2004
    ..It is likely that Rab11-FIP3 is involved in trafficking events other than Tfn trafficking; these may include the transport of endosomally derived membrane to the cleavage furrow during cytokinesis...
  13. doi GRAB is a binding partner for the Rab11a and Rab11b GTPases
    Conor P Horgan
    Molecular Cell Biology Laboratory, School of Biochemistry and Cell Biology, Biosciences Institute, University College Cork, Cork, Ireland Electronic address
    Biochem Biophys Res Commun 441:214-9. 2013
    ..These data identify GRAB as a dual Rab-binding protein that could potentially link Rab3 and Rab11 and/or Rab8 and Rab11-mediated intracellular trafficking processes...