Affiliation: University College Dublin
- Adult human liver contains CD8pos T cells with naive phenotype, but is not a site for conventional alpha beta T cell developmentLucy Golden-Mason
Education and Research Center, St Vincent s University Hospital, Dublin, Ireland
J Immunol 172:5980-5. 2004..The almost complete absence of TRECs suggests that normal AHL is not a site for the development of conventional alphabeta T cells...
- Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and developmentL Golden-Mason
Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
Clin Exp Immunol 138:94-101. 2004..The significant increase observed in HCV-infected liver suggests a role for IL-15 in host antiviral responses in the liver...
- Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancerMalcolm Garland
Education and Research Centre, St Vincent s University Hospital, Conway Institute, University College Dublin, Dublin 4, Ireland
Anticancer Res 23:2531-5. 2003....
- Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma: implications for hepatic anti-tumour immunityAnna M Kelly
Education and Research Centre, St Vincent s University Hospital, Dublin 4, Ireland
Cytokine 35:171-9. 2006..Therapies aimed at antagonising IL-10-mediated immunosuppression may prove a useful strategy in the future treatment of metastatic disease...
- Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liverTony Kenna
Education and Research Centre, St. Vincent's University Hospital, Dublin, Ireland
Clin Immunol 113:56-63. 2004..001). Tumor-bearing livers had significant expansions and depletions of gamma delta T cell subsets but normal cytolytic activity. This study identifies novel populations of liver T cells that may play a role in immunity against tumors...
- Interleukin 12 (IL-12) is increased in tumour bearing human liver and expands CD8(+) and CD56(+) T cells in vitro but not in vivoAnna M Kelly
Education and Research Centre, St Vincent's University Hospital, Dublin, Ireland
Cytokine 25:273-82. 2004..Alternatively, lack of IL-2 rather than a defect in IL-12, may be responsible for insufficient expansion/activation of tumour specific cytotoxic T lymphocytes...
- NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cellsTony Kenna
Education and Research Center and. Liver Unit, St. Vincent's University Hospital, Dublin, Ireland
J Immunol 171:1775-9. 2003..These data indicate that hepatic NKT cell repertoires are phenotypically and functionally distinct in humans and mice. Depletions of hepatic NKT cell subpopulations may underlie the susceptibility to metastatic liver disease...
- Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertilityEmma McGrath
Education and Research Centre, St Vincent s University Hospital Dublin, Dublin, Ireland
Am J Reprod Immunol 61:265-76. 2009..Cycle-dependent fluctuations in natural killer (NK) cell populations in endometrium and circulation may differ, contributing to unexplained infertility...
- Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantationRaghu Varadarajan
Department of Surgery, Education and Research Centre, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland
Transplantation 78:250-6. 2004..CONCLUSIONS: iNOS protein may not contribute to early reperfusion injury during human LT. However, reduced NO bioavailability caused by reduced eNOS may contribute significantly to damage at this time point...
- Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infectionTina Deignan
Education and Research Centre, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland
J Hepatol 37:101-8. 2002..CONCLUSIONS: Failure to resolve HCV infection may be due to deficient innate and/or memory immune responses, while Th1 cells may mediate immune pathology...
- Cortisol does not mediate the suppressive effects of psychiatric morbidity on natural killer cell activity: a cross-sectional study of patients with early breast cancerMalcolm R Garland
Education and Research Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
Psychol Med 34:481-90. 2004..Secondary aims were to study the relationship between psychological, endocrine and immune variables and baseline tumour characteristics...
- Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasionDanijela Petrovic
Department of Clinical Medicine and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
Hepatology 53:1846-53. 2011....
- Trephine biopsies are enriched for activated T/NK cells and cytotoxic T cellsJonathan Dean
Education and Research Centre, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland
Immunol Lett 99:94-102. 2005....
- Having it all? Stem cells, haematopoiesis and lymphopoiesis in adult human liverLucy Golden-Mason
Education and Research Centre, St Vincent sUniversity Hospital and The Conway Institute, University College, Dublin, Ireland
Immunol Cell Biol 80:45-51. 2002..In particular, it is likely that the adult human liver is an important site of NK cell maturation. In this review, we explore the evidence for an active lymphopoietic role for the normal adult human liver...
- Detection and characterization of hemopoietic stem cells in the adult human small intestineLydia Lynch
Education and Research Centre, Department of Medicine, University College Dublin, Dublin, Ireland
J Immunol 176:5199-204. 2006..The phenotype of intestinal HSCs, which differs significantly from circulating or bone marrow HSCs, is consistent with a role in local lymphoid development...
- Differential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active diseaseCeara E Walsh
Translation Rheumatology Research Group, Dublin Academic Medical Centre, St Vincent s University Hospital, Elm Park, Dublin, Ireland
PLoS ONE 6:e27182. 2011....
- Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistenceLucy Golden-Mason
Division of Gastroenterology and Hepatology, Hepatitis C Center, and Integrated Program in Immunology, University of Colorado Health Sciences Center and National Jewish Hospital, Denver, CO, USA
Hepatology 44:1098-109. 2006..These data provide a mechanistic basis for the observation that CTLs generated in early infection rapidly decline as chronicity is established; CD127 expression should be considered in the design of novel immunotherapeutic approaches...
- Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunctionLucy Golden-Mason
Division of Gastroenterology Hepatology, Hepatitis C Center, University of Colorado Health Sciences Center and National Jewish Hospital, Denver, CO 80262, USA
J Virol 81:9249-58. 2007..Our data indicate that the PD-1/PD-L pathway is critical in persistent HCV infection in humans and represents a potential novel target for restoring function of exhausted HCV-specific CTLs...
- Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrenceHugo R Rosen
Division of Gastroenterology and Hepatology, Liver Transplantation Program Hepatitis C Research Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Liver Transpl 14:31-40. 2008....
- Natural killer cells: primary target for hepatitis C virus immune evasion strategies?Lucy Golden-Mason
University of Colorado Health Sciences Center, Denver, CO
Liver Transpl 12:363-72. 2006....
- Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liverMichael P Curry
The Liver Unit, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland
J Hepatol 38:642-50. 2003....
- Localization of T and B lymphocytes in histologically normal adult human donor liverFiona Smith
Department of Pathology, St. Vincent's University Hospital, Dublin 4, Ireland
Hepatogastroenterology 50:1311-5. 2003..The demonstration of significant lymphocyte populations in pristine liver, particularly in the parenchyma, supports the hypothesis that the human liver harbors tissue-resident lymphocytes...
- Cutting edge: programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: race-dependent differencesLucy Golden-Mason
Division of Gastroenterology and Hepatology, Hepatitis C Center, University of Colorado Health Sciences Center and National Jewish Hospital, Aurora, CO 80045, USA
J Immunol 180:3637-41. 2008..Collectively, these data indicate that PD-1 is critical in persistent HCV and successful therapy results in global down-regulation of its expression...
- Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 helpSusan Smyk-Pearson
GI and Hepatology Division, B 158, Academic Office Building 1, 12631 East 17th Ave, Room 7614, P O Box 6511, Aurora, CO 80045, USA
J Virol 82:1827-37. 2008..These results have important implications for early prediction of the virologic outcome following acute HCV and for the development of novel immunotherapeutic approaches...
- Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infectionLucy Golden Mason
Division of Gastroenterology and Hepatology, Hepatitis C Center, University of Colorado at Denver Health Sciences Center, and National Jewish Hospital, Denver, Colorado, USA
J Virol 81:9292-8. 2007..These results indicate a previously unappreciated role for NT cells in acute HCV infection and identify a potential target for pharmacologic manipulation...
- The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migrationYuri Volkov
Dublin Molecular Medicine Centre and Department of Clinical Medicine, Trinity Centre College, Ireland
Gastroenterology 130:482-92. 2006..The aim of this study was to investigate the effect of the hepatitis C envelope protein E2 on LFA-1-stimulated T-cell migration and macrophage inflammatory protein (MIP-1alpha, MIP-1beta) secretion...