Lucy Golden-Mason

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. ncbi request reprint Adult human liver contains CD8pos T cells with naive phenotype, but is not a site for conventional alpha beta T cell development
    Lucy Golden-Mason
    Education and Research Center, St Vincent s University Hospital, Dublin, Ireland
    J Immunol 172:5980-5. 2004
  2. pmc Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development
    L Golden-Mason
    Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
    Clin Exp Immunol 138:94-101. 2004
  3. ncbi request reprint Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancer
    Malcolm Garland
    Education and Research Centre, St Vincent s University Hospital, Conway Institute, University College Dublin, Dublin 4, Ireland
    Anticancer Res 23:2531-5. 2003
  4. ncbi request reprint Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma: implications for hepatic anti-tumour immunity
    Anna M Kelly
    Education and Research Centre, St Vincent s University Hospital, Dublin 4, Ireland
    Cytokine 35:171-9. 2006
  5. ncbi request reprint Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver
    Tony Kenna
    Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
    Clin Immunol 113:56-63. 2004
  6. ncbi request reprint Interleukin 12 (IL-12) is increased in tumour bearing human liver and expands CD8(+) and CD56(+) T cells in vitro but not in vivo
    Anna M Kelly
    Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
    Cytokine 25:273-82. 2004
  7. ncbi request reprint NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells
    Tony Kenna
    Education and Research Center and Liver Unit, St Vincent s University Hospital, Dublin, Ireland
    J Immunol 171:1775-9. 2003
  8. doi request reprint Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility
    Emma McGrath
    Education and Research Centre, St Vincent s University Hospital Dublin, Dublin, Ireland
    Am J Reprod Immunol 61:265-76. 2009
  9. ncbi request reprint Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation
    Raghu Varadarajan
    Department of Surgery, Education and Research Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Transplantation 78:250-6. 2004
  10. ncbi request reprint Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection
    Tina Deignan
    Education and Research Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    J Hepatol 37:101-8. 2002

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Adult human liver contains CD8pos T cells with naive phenotype, but is not a site for conventional alpha beta T cell development
    Lucy Golden-Mason
    Education and Research Center, St Vincent s University Hospital, Dublin, Ireland
    J Immunol 172:5980-5. 2004
    ..The almost complete absence of TRECs suggests that normal AHL is not a site for the development of conventional alphabeta T cells...
  2. pmc Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development
    L Golden-Mason
    Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
    Clin Exp Immunol 138:94-101. 2004
    ..The significant increase observed in HCV-infected liver suggests a role for IL-15 in host antiviral responses in the liver...
  3. ncbi request reprint Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancer
    Malcolm Garland
    Education and Research Centre, St Vincent s University Hospital, Conway Institute, University College Dublin, Dublin 4, Ireland
    Anticancer Res 23:2531-5. 2003
    ....
  4. ncbi request reprint Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma: implications for hepatic anti-tumour immunity
    Anna M Kelly
    Education and Research Centre, St Vincent s University Hospital, Dublin 4, Ireland
    Cytokine 35:171-9. 2006
    ..Therapies aimed at antagonising IL-10-mediated immunosuppression may prove a useful strategy in the future treatment of metastatic disease...
  5. ncbi request reprint Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver
    Tony Kenna
    Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
    Clin Immunol 113:56-63. 2004
    ..001). Tumor-bearing livers had significant expansions and depletions of gamma delta T cell subsets but normal cytolytic activity. This study identifies novel populations of liver T cells that may play a role in immunity against tumors...
  6. ncbi request reprint Interleukin 12 (IL-12) is increased in tumour bearing human liver and expands CD8(+) and CD56(+) T cells in vitro but not in vivo
    Anna M Kelly
    Education and Research Centre, St Vincent s University Hospital, Dublin, Ireland
    Cytokine 25:273-82. 2004
    ..Alternatively, lack of IL-2 rather than a defect in IL-12, may be responsible for insufficient expansion/activation of tumour specific cytotoxic T lymphocytes...
  7. ncbi request reprint NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells
    Tony Kenna
    Education and Research Center and Liver Unit, St Vincent s University Hospital, Dublin, Ireland
    J Immunol 171:1775-9. 2003
    ..These data indicate that hepatic NKT cell repertoires are phenotypically and functionally distinct in humans and mice. Depletions of hepatic NKT cell subpopulations may underlie the susceptibility to metastatic liver disease...
  8. doi request reprint Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility
    Emma McGrath
    Education and Research Centre, St Vincent s University Hospital Dublin, Dublin, Ireland
    Am J Reprod Immunol 61:265-76. 2009
    ..Cycle-dependent fluctuations in natural killer (NK) cell populations in endometrium and circulation may differ, contributing to unexplained infertility...
  9. ncbi request reprint Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation
    Raghu Varadarajan
    Department of Surgery, Education and Research Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Transplantation 78:250-6. 2004
    ..In this study, we examined nitrate, nitrite, and nitrosothiols (NOx), NO synthases (endothelial [constitutive] nitric oxide synthase [eNOS] and inducible nitric oxide synthase [iNOS]), and nitrotyrosine in early IR injury after human LT...
  10. ncbi request reprint Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection
    Tina Deignan
    Education and Research Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    J Hepatol 37:101-8. 2002
    ..It is not known which of these populations contribute to immunity against HCV or immune pathology...
  11. ncbi request reprint Cortisol does not mediate the suppressive effects of psychiatric morbidity on natural killer cell activity: a cross-sectional study of patients with early breast cancer
    Malcolm R Garland
    Education and Research Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Psychol Med 34:481-90. 2004
    ..Secondary aims were to study the relationship between psychological, endocrine and immune variables and baseline tumour characteristics...
  12. doi request reprint Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion
    Danijela Petrovic
    Department of Clinical Medicine and Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    Hepatology 53:1846-53. 2011
    ..HCV E2 further inhibited the secretion of other cytokines, including interferon-γ...
  13. ncbi request reprint Trephine biopsies are enriched for activated T/NK cells and cytotoxic T cells
    Jonathan Dean
    Education and Research Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Immunol Lett 99:94-102. 2005
    ....
  14. ncbi request reprint Having it all? Stem cells, haematopoiesis and lymphopoiesis in adult human liver
    Lucy Golden-Mason
    Education and Research Centre, St Vincent sUniversity Hospital and The Conway Institute, University College, Dublin, Ireland
    Immunol Cell Biol 80:45-51. 2002
    ..In particular, it is likely that the adult human liver is an important site of NK cell maturation. In this review, we explore the evidence for an active lymphopoietic role for the normal adult human liver...
  15. ncbi request reprint Detection and characterization of hemopoietic stem cells in the adult human small intestine
    Lydia Lynch
    Education and Research Centre, Department of Medicine, University College Dublin, Dublin, Ireland
    J Immunol 176:5199-204. 2006
    ..The phenotype of intestinal HSCs, which differs significantly from circulating or bone marrow HSCs, is consistent with a role in local lymphoid development...
  16. pmc Differential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease
    Ceara E Walsh
    Translation Rheumatology Research Group, Dublin Academic Medical Centre, St Vincent s University Hospital, Elm Park, Dublin, Ireland
    PLoS ONE 6:e27182. 2011
    ....
  17. ncbi request reprint Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence
    Lucy Golden-Mason
    Division of Gastroenterology and Hepatology, Hepatitis C Center, and Integrated Program in Immunology, University of Colorado Health Sciences Center and National Jewish Hospital, Denver, CO, USA
    Hepatology 44:1098-109. 2006
    ..These data provide a mechanistic basis for the observation that CTLs generated in early infection rapidly decline as chronicity is established; CD127 expression should be considered in the design of novel immunotherapeutic approaches...
  18. pmc Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction
    Lucy Golden-Mason
    Division of Gastroenterology Hepatology, Hepatitis C Center, University of Colorado Health Sciences Center and National Jewish Hospital, Denver, CO 80262, USA
    J Virol 81:9249-58. 2007
    ..Our data indicate that the PD-1/PD-L pathway is critical in persistent HCV infection in humans and represents a potential novel target for restoring function of exhausted HCV-specific CTLs...
  19. ncbi request reprint Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence
    Hugo R Rosen
    Division of Gastroenterology and Hepatology, Liver Transplantation Program Hepatitis C Research Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Liver Transpl 14:31-40. 2008
    ....
  20. ncbi request reprint Natural killer cells: primary target for hepatitis C virus immune evasion strategies?
    Lucy Golden-Mason
    University of Colorado Health Sciences Center, Denver, CO
    Liver Transpl 12:363-72. 2006
    ....
  21. ncbi request reprint Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver
    Michael P Curry
    The Liver Unit, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    J Hepatol 38:642-50. 2003
    ....
  22. ncbi request reprint Localization of T and B lymphocytes in histologically normal adult human donor liver
    Fiona Smith
    Department of Pathology, St Vincent s University Hospital, Dublin 4, Ireland
    Hepatogastroenterology 50:1311-5. 2003
    ..The aim was to identify donor livers, which were free of any evidence of damage, and to determine if, and where, leukocytes were present in these pristine livers...
  23. ncbi request reprint Cutting edge: programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: race-dependent differences
    Lucy Golden-Mason
    Division of Gastroenterology and Hepatology, Hepatitis C Center, University of Colorado Health Sciences Center and National Jewish Hospital, Aurora, CO 80045, USA
    J Immunol 180:3637-41. 2008
    ..Collectively, these data indicate that PD-1 is critical in persistent HCV and successful therapy results in global down-regulation of its expression...
  24. pmc Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help
    Susan Smyk-Pearson
    GI and Hepatology Division, B 158, Academic Office Building 1, 12631 East 17th Ave, Room 7614, P O Box 6511, Aurora, CO 80045, USA
    J Virol 82:1827-37. 2008
    ..These results have important implications for early prediction of the virologic outcome following acute HCV and for the development of novel immunotherapeutic approaches...
  25. pmc Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection
    Lucy Golden-Mason
    Division of Gastroenterology and Hepatology, Hepatitis C Center, University of Colorado at Denver Health Sciences Center, and National Jewish Hospital, Denver, Colorado, USA
    J Virol 81:9292-8. 2007
    ..These results indicate a previously unappreciated role for NT cells in acute HCV infection and identify a potential target for pharmacologic manipulation...
  26. ncbi request reprint The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration
    Yuri Volkov
    Dublin Molecular Medicine Centre and Department of Clinical Medicine, Trinity Centre College, Ireland
    Gastroenterology 130:482-92. 2006
    ..The aim of this study was to investigate the effect of the hepatitis C envelope protein E2 on LFA-1-stimulated T-cell migration and macrophage inflammatory protein (MIP-1alpha, MIP-1beta) secretion...