William M Gallagher

Summary

Affiliation: University College Dublin
Country: Ireland

Publications

  1. pmc Elevated expression and altered processing of fibulin-1 protein in human breast cancer
    L M Greene
    Department of Pharmacology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland
    Br J Cancer 88:871-8. 2003
  2. pmc Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma
    G Gremel
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Br J Cancer 105:565-74. 2011
  3. doi request reprint Functional interrogation of breast cancer: from models to drugs
    Sharon F McGee
    UCD Conway Institute, UCD School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland
    Expert Opin Drug Discov 1:569-84. 2006
  4. pmc Prognostic ability of a panel of immunohistochemistry markers - retailoring of an 'old solution'
    Donal J Brennan
    Breast Cancer Res 10:102. 2008
  5. pmc The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation
    Sandra Sernbo
    Department of Immunotechnology, Lund University, Lund, Sweden
    BMC Cancer 11:405. 2011
  6. pmc Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer
    Donal J Brennan
    Dept of Obstetrics and Gynaecology, National Maternity Hospital, Holles Street, Dublin 2, Ireland
    BMC Cancer 10:125. 2010
  7. pmc The development and validation of the Virtual Tissue Matrix, a software application that facilitates the review of tissue microarrays on line
    Catherine M Conway
    Medical Informatics Group, School of Biotechnology, Dublin City University, Dublin, Ireland
    BMC Bioinformatics 7:256. 2006
  8. ncbi request reprint Molecular basis of cell-biomaterial interaction: insights gained from transcriptomic and proteomic studies
    William M Gallagher
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biomaterials 27:5871-82. 2006
  9. ncbi request reprint Human fibulin-4: analysis of its biosynthetic processing and mRNA expression in normal and tumour tissues
    W M Gallagher
    Conway Institute of Biomolecular and Biomedical Research, Department of Pharmacology, University College Dublin, Belfield, Ireland
    FEBS Lett 489:59-66. 2001
  10. ncbi request reprint Fibulins and cancer: friend or foe?
    William M Gallagher
    Department of Pharmacology, Centre for Molecular Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Trends Mol Med 11:336-40. 2005

Detail Information

Publications82

  1. pmc Elevated expression and altered processing of fibulin-1 protein in human breast cancer
    L M Greene
    Department of Pharmacology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland
    Br J Cancer 88:871-8. 2003
    ..003, n=36) and progesterone receptor (rs=0.43, P=0.008, n=36) expression in the tumour specimens. Taken together, these findings indicate that elevated expression and altered processing of fibulin-1 is associated with human breast cancer...
  2. pmc Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma
    G Gremel
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Br J Cancer 105:565-74. 2011
    ..The homeobox containing transcription factor MSX2 is a key regulator of embryonic development and has been implicated to have a role in breast and pancreatic cancer...
  3. doi request reprint Functional interrogation of breast cancer: from models to drugs
    Sharon F McGee
    UCD Conway Institute, UCD School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland
    Expert Opin Drug Discov 1:569-84. 2006
    ..The authors describe the applications of functional genomics in models of breast cancer and the integration of these disparate technologies, specifically in the context of the search for novel therapeutic targets...
  4. pmc Prognostic ability of a panel of immunohistochemistry markers - retailoring of an 'old solution'
    Donal J Brennan
    Breast Cancer Res 10:102. 2008
    ....
  5. pmc The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation
    Sandra Sernbo
    Department of Immunotechnology, Lund University, Lund, Sweden
    BMC Cancer 11:405. 2011
    ....
  6. pmc Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer
    Donal J Brennan
    Dept of Obstetrics and Gynaecology, National Maternity Hospital, Holles Street, Dublin 2, Ireland
    BMC Cancer 10:125. 2010
    ..In the present study, the prognostic value of HMG-CoAR expression was examined in tumours from a cohort of patients with primary epithelial ovarian cancer...
  7. pmc The development and validation of the Virtual Tissue Matrix, a software application that facilitates the review of tissue microarrays on line
    Catherine M Conway
    Medical Informatics Group, School of Biotechnology, Dublin City University, Dublin, Ireland
    BMC Bioinformatics 7:256. 2006
    ....
  8. ncbi request reprint Molecular basis of cell-biomaterial interaction: insights gained from transcriptomic and proteomic studies
    William M Gallagher
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biomaterials 27:5871-82. 2006
    ....
  9. ncbi request reprint Human fibulin-4: analysis of its biosynthetic processing and mRNA expression in normal and tumour tissues
    W M Gallagher
    Conway Institute of Biomolecular and Biomedical Research, Department of Pharmacology, University College Dublin, Belfield, Ireland
    FEBS Lett 489:59-66. 2001
    ..Taken together, results reported here suggest that an intracellular form of fibulin-4 protein may exist and that dysregulated expression of the fibulin-4 gene is associated with human colon tumourigenesis...
  10. ncbi request reprint Fibulins and cancer: friend or foe?
    William M Gallagher
    Department of Pharmacology, Centre for Molecular Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Trends Mol Med 11:336-40. 2005
    ..Indeed, both tumour suppressive and oncogenic activities have been proposed for members of the fibulin family. Herein, we discuss the possible roles of fibulins in cancer, in addition to their diagnostic and therapeutic potential...
  11. ncbi request reprint Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies
    William M Gallagher
    Department of Pharmacology, University College Dublin, Ireland
    Carcinogenesis 26:1856-67. 2005
    ..Overall, our data support the hypothesis that multiple genes are targeted, either directly or indirectly, by DNA hypermethylation during melanoma progression...
  12. doi request reprint JAM-A expression positively correlates with poor prognosis in breast cancer patients
    Elaine A McSherry
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Ireland
    Int J Cancer 125:1343-51. 2009
    ..Our results are consistent with a previously unreported role for JAM-A overexpression as a possible mechanism contributing to progression in primary breast cancer; and a potential therapeutic target...
  13. ncbi request reprint Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer
    Fiona Lanigan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
    Int J Cancer 124:2088-97. 2009
    ..We conclude that high levels of claudin-4 protein are associated with adverse outcome in breast cancer patients, including the subgroup of patients treated with adjuvant tamoxifen...
  14. pmc Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer
    Elton Rexhepaj
    UCD Conway Institute, University College Dublin, Belfield, Ireland
    BMC Cancer 10:639. 2010
    ..Here, we validate survivin CNR in a separate and extended cohort. Furthermore, we present new data suggesting that a low CNR may predict outcome in tamoxifen-treated patients...
  15. ncbi request reprint CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer
    Sallyann L O'Brien
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Int J Cancer 120:1434-43. 2007
    ..036) and overall survival (p=0.040). In conclusion, we identified CENP-F as a biomarker associated with poor outcome in breast cancer and showed several novel associations of biological significance...
  16. doi request reprint miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro
    Laoighse Mulrane
    UCD Schools of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Ireland
    Clin Cancer Res 18:6702-13. 2012
    ..Here, we describe an integrated bioinformatics, functional analysis, and translational pathology approach to identify novel miRNAs involved in breast cancer progression...
  17. pmc Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer
    Elton Rexhepaj
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Ireland
    Breast Cancer Res 10:R89. 2008
    ..In the present article we describe the development of a novel approach for automatically quantifying oestrogen receptor (ER) and progesterone receptor (PR) protein expression assessed by IHC in primary breast cancer...
  18. doi request reprint Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science and UCD School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Clin Cancer Res 14:2681-9. 2008
    ..Quantitative determination of survivin expression using image analysis offers the opportunity to develop alternative scoring models for survivin immunohistochemistry. Here, we present such a model...
  19. ncbi request reprint Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis
    William J Faller
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Melanoma Res 20:392-400. 2010
    ..Overall, these studies suggest that MT1E is a potential tumour suppressor gene, whose loss may promote resistance to apoptosis-inducing therapies...
  20. doi request reprint Prioritization of candidate protein biomarkers from an in vitro model system of breast tumor progression toward clinical verification
    Thomas Y K Lau
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Ireland
    J Proteome Res 9:1450-9. 2010
    ..This approach provides a pragmatic approach to prioritizing candidates that may be most suitable for downstream assays such as multiple reaction monitoring...
  21. ncbi request reprint The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases
    Gillian O'Hurley
    OncoMark Ltd, Nova UCD, University College Dublin, Belfield, Dublin 4, Ireland Department of Pathology, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Prostate 74:306-13. 2014
    ..In this study, we aim to evaluate SRF protein expression in prostate cancer (PCa) metastases, which has not previously been reported...
  22. ncbi request reprint Surface-induced changes in protein adsorption and implications for cellular phenotypic responses to surface interaction
    Lorcan T Allen
    UCD School of Biomolecular and Biomedical Science, Centre for Molecular Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biomaterials 27:3096-108. 2006
    ....
  23. pmc Development of a pharmaceutical hepatotoxicity biomarker panel using a discovery to targeted proteomics approach
    Ben C Collins
    UCD School of Medicine and Medical Science, University College Dublin, Dublin, Ireland
    Mol Cell Proteomics 11:394-410. 2012
    ....
  24. doi request reprint The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate
    Stephen O'Connor
    School of Biomolecular and Biomedical Sciences and Centre for Synthesis and Chemical Biology, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Biomaterials 34:2710-8. 2013
    ..Combination studies showed that R10DP18L exhibited synergy with cisplatin, gemcitabine, and taxotere with IC(50) values in the nanomolar range...
  25. pmc Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro
    Fiona Lanigan
    University College Dublin School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 12:R59. 2010
    ..However, the clinical implications of Msx2 expression in breast cancer are unclear. The aims of this study were to investigate the potential clinical value of Msx2 as a breast cancer biomarker and to clarify its functional role in vitro...
  26. ncbi request reprint Novel method to prepare morphologically rich polymeric surfaces for biomedical applications via phase separation and arrest of microgel particles
    Iseult Lynch
    Irish Centre for Colloid Science and Biomaterials, Department of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland
    J Phys Chem B 110:14581-9. 2006
    ..This constitutes a sort of cell localization transition on a surface with identical chemical components, where only the morphology has been adjusted...
  27. doi request reprint Surface-induced cell signaling events control actin rearrangements and motility
    Ian S Miller
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Biomed Mater Res A 93:493-504. 2010
    ..These results highlight important signaling events which control actin rearrangements and the subsequent motility and its effectors...
  28. pmc Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Breast Cancer Res 13:R12. 2011
    ..Here, the predictive value of HMG-CoAR expression in relation to tamoxifen response was examined...
  29. pmc Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer
    Patrick C O Leary
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland
    BMC Cancer 13:175. 2013
    ....
  30. doi request reprint Mechanism of cell death mediated by a BF2-chelated tetraaryl-azadipyrromethene photodynamic therapeutic: dissection of the apoptotic pathway in vitro and in vivo
    Aisling E O'Connor
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Int J Cancer 130:705-15. 2012
    ..Taken together, this data clearly establishes ADPM06 as an exciting novel PDT agent with significant potential for further translational development...
  31. ncbi request reprint Contribution of DNA and tissue microarray technology to the identification and validation of biomarkers and personalised medicine in breast cancer
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, University College Dublin, Belfield, and Department of Pathology and Laboratory Medicine, St Vincent s University Hospital, Dublin 4, Ireland
    Cancer Genomics Proteomics 4:121-34. 2007
    ..Here, we review the role of DNA microarrays and tissue microarrays in the validation of biomarkers in breast cancer, with emphasis on their potential application to determine mode of personalised therapy in the future...
  32. pmc Generation of a new bioluminescent model for visualisation of mammary tumour development in transgenic mice
    Agnieszka M Zagozdzon
    Cancer Biology and Therapeutics Group, UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    BMC Cancer 12:209. 2012
    ..There is a crucial need for making these previously generated models suitable for modern methods of tumour visualisation and monitoring, e.g. by bioluminescence-based techniques. This approach was successfully used in the current study...
  33. doi request reprint Identification of transcription factors associated with castration-resistance: is the serum responsive factor a potential therapeutic target?
    Maria Prencipe
    UCD School of Medicine and Medical Science, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland
    Prostate 73:743-53. 2013
    ..We have previously shown that manipulating individual proteins has only minor alterations on the resistant phenotype so we hypothesize that targeting the central transcription factors (TFs) would represent a better therapeutic approach...
  34. doi request reprint Tumor profiling using protein biomarker panels in malignant melanoma: application of tissue microarrays and beyond
    Cormac W Joyce
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Expert Rev Proteomics 9:415-23. 2012
    ..We will show how tissue microarrays have become a vital step in the transition from molecular techniques to useful clinical assays and interventions and look at likely future developments for advances in this field...
  35. ncbi request reprint CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College, Dublin, and Department of Pathology and Laboratory Medicine, St Vincent s University Hospital, Ireland
    Clin Cancer Res 12:6421-31. 2006
    ..We examined the potential prognostic and predictive role of CA IX in premenopausal breast cancer patients...
  36. ncbi request reprint DNA microarray-based transcriptomic profiling of an isogenic cell culture model of breast tumour cell invasion
    Linda Hughes
    UCD School of Chemical and Bioprocess Engineering, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Anticancer Res 27:1353-9. 2007
    ..Our objective was to identify invasion-specific genes in a series of isogenic breast cancer cell lines of differing invasive potential using DNA microarray-based transcriptomic profiling...
  37. doi request reprint Identification of cell surface-specific markers to target human nucleus pulposus cells: expression of carbonic anhydrase XII varies with age and degeneration
    Karen A Power
    University College Dublin, Dublin, Ireland
    Arthritis Rheum 63:3876-86. 2011
    ..e., intervertebral disc anulus fibrosus (AF) cells and articular cartilage (AC) chondrocytes, in order to identify potential surface molecules for directed delivery of therapeutic agents...
  38. ncbi request reprint Heteroaryl substituted titanocenes as potential anti-cancer drugs
    Nigel Sweeney
    Conway Institute of Biomolecular and Biomedical Research, The UCD School of Chemistry and Chemical Biology, Centre for Synthesis and Chemical Biology CSCB, Belfield, Dublin 4, Ireland
    J Inorg Biochem 100:1479-86. 2006
    ..1x10(-4)M, respectively, were observed. These values represent improved cytotoxicity against LLC-PK, when compared to their corresponding ansa substituted analogues and also in comparison to unsubstituted titanocene dichloride...
  39. ncbi request reprint Application of DNA microarray technology in determining breast cancer prognosis and therapeutic response
    Donal J Brennan
    Conway Institute of Biomolecular and Biomedical Research, Department of Pharmacology, Centre for Molecular Medicine, University College Dublin, Dublin 4, Ireland
    Expert Opin Biol Ther 5:1069-83. 2005
    ..The most recent data supporting the integration of various publicly available data sets is also reviewed in detail...
  40. doi request reprint PKCzeta regulates cell polarisation and proliferation restriction during mammary acinus formation
    Jacqueline Whyte
    UCD Conway Institute and School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland
    J Cell Sci 123:3316-28. 2010
    ..Paralleling these contributions, we found that low levels of PKCζ mRNA expression are associated with more 'poorly differentiated' tumours and a poor outcome in a cohort of 295 breast cancer patients...
  41. doi request reprint Antibody-based proteomics: fast-tracking molecular diagnostics in oncology
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Nat Rev Cancer 10:605-17. 2010
    ..In this Review, we discuss the current status of antibody-based proteomics and its contribution to the development of new assays that are crucial for the realization of individualized cancer therapy...
  42. ncbi request reprint Proteomic analysis of factors released from p21-overexpressing tumour cells
    Caroline A Currid
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Proteomics 6:3739-53. 2006
    ....
  43. doi request reprint Effect of surface wettability and topography on the adhesion of osteosarcoma cells on plasma-modified polystyrene
    Denis P Dowling
    Surface Engineering Research Group, UCD School of Electrical, Electronic and Mechanical Engineering, University College Dublin, Ireland
    J Biomater Appl 26:327-47. 2011
    ..This decrease in cell adhesion with an increase in hydrophobicity was also observed for the fluorinated PS surfaces with water contact angles in the range of 110-155°...
  44. pmc Interaction of soft condensed materials with living cells: phenotype/transcriptome correlations for the hydrophobic effect
    Lorcan T Allen
    Conway Institute of Biomolecular and Biomedical Research, Department of Pharmacology, University College Dublin, Belfield, Ireland
    Proc Natl Acad Sci U S A 100:6331-6. 2003
    ..This case study indicates that high-throughput analysis of gene expression not only can greatly refine our knowledge of cell-biomaterial interaction, but also can yield novel biomarkers for potential use in biocompatibility assessment...
  45. doi request reprint miRNA dysregulation in breast cancer
    Laoighse Mulrane
    Authors Affiliation UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Cancer Res 73:6554-62. 2013
    ..This review focuses on the area of miRNA dysregulation in breast cancer through both genetic and epigenetic mechanisms, and the impact of this dysregulation on breast cancer risk and resistance to therapies...
  46. doi request reprint Identification and functional validation of therapeutic targets for malignant melanoma
    Gabriela Gremel
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Crit Rev Oncol Hematol 72:194-214. 2009
    ..Here, we provide a summary of functional interrogation approaches in melanoma research, focusing on the application of these strategies to the development of new effective therapies...
  47. pmc Characterisation and manipulation of docetaxel resistant prostate cancer cell lines
    Amanda J O'Neill
    UCD School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    Mol Cancer 10:126. 2011
    ..Three Docetaxel resistant sub-lines were generated and confirmed to be resistant to the apoptotic and anti-proliferative effects of increasing concentrations of Docetaxel...
  48. ncbi request reprint Breast cancer proteomics: clinical perspectives
    Thomas Y K Lau
    UCD Conway Institute, UCD School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland
    Expert Opin Biol Ther 7:209-19. 2007
    ..It aims to analyse the complex circuitry of the breast cancer proteome. Here, the authors review how breast cancer proteomics has progressed so far, with emphasis on its potential application to clinically relevant scenarios...
  49. doi request reprint Differential proteomics incorporating iTRAQ labeling and multi-dimensional separations
    Ben C Collins
    UCD School of Biomolecular and Biomedical Science and Proteome Research Centre, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Methods Mol Biol 691:369-83. 2011
    ..Here, we describe a workflow for proteomic semi-quantitative expression profiling of liver from rats treated with a known hepatotoxicant using a multiplexed isobaric labeling strategy and multi-dimensional liquid chromatography...
  50. doi request reprint Absolute quantification of toxicological biomarkers by multiple reaction monitoring
    Thomas Y K Lau
    UCD School of Biomolecular and Biomedical Science and Proteome Research Centre, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Methods Mol Biol 691:417-27. 2011
    ..The speed of these experiments combined with their flexibility and ability to multiplex assays makes the technique a valuable strategy to validate biomarker discovery...
  51. ncbi request reprint TGF-beta1-induced thrombospondin-1 expression through the p38 MAPK pathway is abolished by fluvastatin in human coronary artery smooth muscle cells
    Fiona C McGillicuddy
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Vascul Pharmacol 44:469-75. 2006
    ..Targeted delivery of fluvastatin may therefore be a useful therapeutic objective for prevention of the intimal hyperplasia associated with in-stent restenosis...
  52. ncbi request reprint Local drug delivery in restenosis injury: thermoresponsive co-polymers as potential drug delivery systems
    Caroline A Kavanagh
    Department of Pharmacology, Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Pharmacol Ther 102:1-15. 2004
    ....
  53. doi request reprint MetSizeR: selecting the optimal sample size for metabolomic studies using an analysis based approach
    Gift Nyamundanda
    School of Mathematical Sciences, University College Dublin, Dublin, Ireland
    BMC Bioinformatics 14:338. 2013
    ..Since pilot studies are rarely done in metabolomics, currently existing sample size estimation approaches which rely on pilot data can not be applied...
  54. doi request reprint Tissue microarrays and digital image analysis
    Denise Ryan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Methods Mol Biol 691:97-112. 2011
    ..We also describe the process of digital slide scanning of kidney and liver sections, in the context of creating an online resource of histopathological data...
  55. doi request reprint Use of SELDI MS to discover and identify potential biomarkers of toxicity in InnoMed PredTox: a multi-site, multi-compound study
    Ben C Collins
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
    Proteomics 10:1592-608. 2010
    ..In addition, we report on the intra- and inter-site variations observed based on measurements from a reference sample, and steps that can be taken to minimize this variation...
  56. ncbi request reprint Survivin: a promising tumor biomarker
    Michael J Duffy
    Department of Pathology and Laboratory Medicine, St Vincent s University Hospital, Dublin 4, Ireland
    Cancer Lett 249:49-60. 2007
    ..Furthermore, assays for the measurement of survivin should be simplified, standardized and evaluated in external quality assurance schemes...
  57. doi request reprint Identification of Apolipoprotein AI as a serum biomarker of chronic kidney disease in liver transplant recipients, using proteomic techniques
    Aisling O'Riordan
    Department of Nephrology and National Liver Transplant Unit, St Vincent s University Hospital, Elm Park, Dublin, Ireland University College Dublin School of Biomolecular and Biomedical Science, Conway Institute, Belfield, Dublin, Ireland
    Proteomics Clin Appl 2:1338-48. 2008
    ..057) and Western blot analysis (p = 0.003). Apolipoprotein AI is a novel, accurate marker of CKD post-OLT. It does require further validation in a large, more diverse patient population but could potentially improve detection of CKD...
  58. ncbi request reprint Cancer invasion and metastasis: changing views
    M J Duffy
    Department of Pathology and Laboratory Medicine, St Vincent s University Hospital, Dublin 4, Ireland
    J Pathol 214:283-93. 2008
    ..These recent advances in our understanding should lead to the development of new molecular markers for predicting the likely formation of metastasis as well as the identification of new targets for anti-metastatic therapies...
  59. doi request reprint Investigation of molecular alterations of AKT-3 in triple-negative breast cancer
    Gillian O'Hurley
    OncoMark Ltd, NovaUCD, Belfield Innovation Park, Belfield, Ireland
    Histopathology 64:660-70. 2014
    ..The aim of this study was to investigate molecular alterations of AKT-3 in TNBC, to perform associated survival analysis, and to compare these findings with the incidence of AKT-3 molecular alterations in ER-positive BC...
  60. doi request reprint microRNAs: a new class of breast cancer biomarkers
    Laoighse Mulrane
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Expert Rev Mol Diagn 14:347-63. 2014
    ..This review focuses on miRNAs that have prognostic, diagnostic or predictive potential in breast cancer as well as the possible challenges in the translation of such observations to the clinic. ..
  61. ncbi request reprint Real-time quantitative reverse transcriptase-polymerase chain reaction analysis of melanoma progression-associated genes
    Mairin Rafferty
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Ireland
    Anticancer Res 27:1301-7. 2007
    ..In an effort to provide insight into the molecular basis of melanoma progression, the expression of 94 genes in 20 metastatic melanomas using a high-throughput real-time quantitative RT-PCR assay was analysed...
  62. doi request reprint Automated image analysis in histopathology: a valuable tool in medical diagnostics
    Laoighse Mulrane
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Expert Rev Mol Diagn 8:707-25. 2008
    ..Reinforced by the phenomenal growth of the virtual pathology field, it is envisioned that the market for automated image analysis tools will greatly expand over the next 10 years...
  63. doi request reprint Bioluminescent imaging: a critical tool in pre-clinical oncology research
    Karen O'Neill
    UCD School of Medicine and Medical Science, Health Science Building, University College Dublin, Belfield, Dublin 4, Ireland
    J Pathol 220:317-27. 2010
    ..Such novel studies highlight the versatility and potential of bioluminescent imaging in future oncological research...
  64. doi request reprint An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia
    Susan F Fitzpatrick
    UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Immunol 186:1091-6. 2011
    ..These results implicate an essential role for NF-κB signaling in inflammatory gene expression in response to hypoxia both through the regulation of HIF-1 and through direct effects upon target gene expression...
  65. doi request reprint Examination of cell-host-biomaterial interactions via high-throughput technologies: A re-appraisal
    Karen A Power
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biomaterials 31:6667-74. 2010
    ..The technologies under focus include rapid cell-based screening, transcriptomics and proteomics...
  66. pmc High-throughput proteomics detection of novel splice isoforms in human platelets
    Karen A Power
    UCD Conway Institute and UCD School of Biomolecular and Biomedical Sciences, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    PLoS ONE 4:e5001. 2009
    ..Here we describe the application of this approach to human platelets, including the mRNA-based verification of novel splice isoforms of ITGA2, NPEPPS and FH. This methodology is applicable to all new or existing MS/MS datasets...
  67. doi request reprint Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy
    Aisling E O'Connor
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Photochem Photobiol 85:1053-74. 2009
    ..The aim of this review is to provide an insight into PDT photosensitizers clinically approved for application in oncology, as well as those which show significant potential in ongoing preclinical studies...
  68. doi request reprint Creation of a digital slide and tissue microarray resource from a multi-institutional predictive toxicology study in the rat: an initial report from the PredTox group
    Laoighse Mulrane
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Exp Toxicol Pathol 60:235-45. 2008
    ..The population of the PredTox database with these digitised images represents the creation of the first toxicological database integrating 'omics and preclinical data with histological images...
  69. doi request reprint Truncated HER2: implications for HER2-targeted therapeutics
    Radoslaw Zagozdzon
    Cancer Biology and Therapeutics Group, UCD Conway Institute, UCD School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland
    Drug Discov Today 16:810-6. 2011
    ..Recent development of several promising compounds brings hope that a generation of novel therapeutic modalities against HER2-positive cancers will be delivered in the future...
  70. ncbi request reprint Omic profiling for drug safety assessment: current trends and public-private partnerships
    William M Gallagher
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Drug Discov Today 14:337-42. 2009
    ..The focus of this article is on describing the current trends concerning the application of omic approaches in drug safety assessment, with specific emphasis on the role of public-private partnerships in advancing this emerging arena...
  71. doi request reprint Standardization of models and methods used to assess nanoparticles in cardiovascular applications
    Kathleen T Fitzgerald
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Small 7:705-17. 2011
    ..There is a need to standardize appropriate models and methods that will promote the development of novel nanomaterial-based cardiovascular therapies...
  72. ncbi request reprint Poly(N-isopropylacrylamide) co-polymer films as potential vehicles for delivery of an antimitotic agent to vascular smooth muscle cells
    Kevina B Doorty
    Department of Pharmacology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Cardiovasc Pathol 12:105-10. 2003
    ..This study sought to establish the principle that thermoresponsive poly(N-isopropylacrylamide) co-polymer films can be used to deliver, in a controlled manner, an antimitotic agent to vascular smooth muscle cells (VSMC)...
  73. ncbi request reprint Use of proteomics for the discovery of early markers of drug toxicity
    Ben C Collins
    University College Dublin, UCD School of Biomolecular and Biomedical Science, Proteome Research Centre, UCD Conway Institute, Belfi eld, Dublin 4, Ireland
    Expert Opin Drug Metab Toxicol 3:689-704. 2007
    ..Here, the key proteomic approaches are reviewed, their applications in pharmaceutical toxicology are described and what shape future developments in this arena might take is considered...
  74. doi request reprint Topoisomerase I amplification in melanoma is associated with more advanced tumours and poor prognosis
    Denise Ryan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Pigment Cell Melanoma Res 23:542-53. 2010
    ..These observations open the possibility that TOP1-targeted therapeutics may be of benefit in a particular subgroup of advanced stage melanoma patients...
  75. ncbi request reprint Supramolecular photonic therapeutic agents
    Shane O McDonnell
    Centre for Synthesis and Chemical Biology, Conway Institute, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
    J Am Chem Soc 127:16360-1. 2005
    ..In vitro efficacy demonstrated that the SPTA derivatives can be activated within cells and one analogue is measured to have an EC50 value of 5.8 nM when assayed in the MRC5 cell line...
  76. ncbi request reprint Methoxy-phenyl substituted ansa-titanocenes as potential anti-cancer drugs derived from fulvenes and titanium dichloride
    Matthias Tacke
    Chemistry Department, Centre for Synthesis and Chemical Biology CSCB, University College Dublin, Belfield, Dublin 4, Ireland
    J Inorg Biochem 98:1987-94. 2004
    ..When titanocenes 2a-c were tested against pig kidney carcinoma cells (LLC-PK) inhibitory concentrations (IC50) of 2.8 x 10(-4), 3.6 x 10(-4) and 2.1 x 10(-4) M, respectively, were observed...
  77. ncbi request reprint Molecular links between mammary gland development and breast cancer
    F Lanigan
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Cell Mol Life Sci 64:3159-84. 2007
    ..Current in vivo and in vitro mammary gland models are also discussed. (Part of a Multi-author Review)...
  78. pmc Vascular-targeted photodynamic therapy with BF2-chelated Tetraaryl-Azadipyrromethene agents: a multi-modality molecular imaging approach to therapeutic assessment
    A T Byrne
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Br J Cancer 101:1565-73. 2009
    ..Herein, in vivo efficacy and mechanism of action studies have been completed for the lead agent, ADMP06...
  79. pmc Fibulins: physiological and disease perspectives
    W Scott Argraves
    Medical University of South Carolina, Department of Cell Biology, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
    EMBO Rep 4:1127-31. 2003
    ....
  80. pmc A microRNA DNA methylation signature for human cancer metastasis
    Amaia Lujambio
    Cancer Epigenetics Laboratory, Spanish National Cancer Research Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 105:13556-61. 2008
    ..Our findings indicate that DNA methylation-associated silencing of tumor suppressor miRNAs contributes to the development of human cancer metastasis...
  81. ncbi request reprint Low pH induces co-ordinate regulation of gene expression in oesophageal cells
    Shane P Duggan
    Department of Clinical Medicine, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    Carcinogenesis 27:319-27. 2006
    ..Further functional analysis of the genes and clusters identified in this low pH study is likely to lead to new insights into the pathogenesis and therapeutics of GORD and oesophageal cancer...
  82. pmc Combination of SELDI-TOF-MS and data mining provides early-stage response prediction for rectal tumors undergoing multimodal neoadjuvant therapy
    Fraser M Smith
    Department of Surgery and the Academic Unit of Clinical and Molecular Oncology, St James s Hospital and Trinity College Dublin, Ireland
    Ann Surg 245:259-66. 2007
    ..We investigated whether proteomic analysis of the low molecular weight region of the serum proteome could predict histologic response of locally advanced rectal cancer to neoadjuvant radiochemotherapy (RCT)...