Andrew E Firth
Affiliation: University College Cork
Firth A, Blitvich B, Wills N, Miller C, Atkins J. Evidence for ribosomal frameshifting and a novel overlapping gene in the genomes of insect-specific flaviviruses. Virology. 2010;399:153-166 pubmed publisher
Firth A, Atkins J. Bioinformatic analysis suggests that a conserved ORF in the waikaviruses encodes an overlapping gene. Arch Virol. 2008;153:1379-83 pubmed publisher
..The ORF overlaps the polyprotein ORF but is in the +1 reading frame. Here, we describe the bioinformatic analysis...
Firth A, Atkins J. A conserved predicted pseudoknot in the NS2A-encoding sequence of West Nile and Japanese encephalitis flaviviruses suggests NS1' may derive from ribosomal frameshifting. Virol J. 2009;6:14 pubmed publisher
..We hypothesize that this may explain the origin of the previously identified NS1 'extension' protein in JEV-group flaviviruses, known as NS1'. ..
Firth A. Bioinformatic analysis suggests that the Orbivirus VP6 cistron encodes an overlapping gene. Virol J. 2008;5:48 pubmed publisher
..These viruses have linear dsRNA genomes divided into ten segments, all of which have previously been assumed to be monocistronic...
Firth A, Atkins J. Bioinformatic analysis suggests that the Cypovirus 1 major core protein cistron harbours an overlapping gene. Virol J. 2008;5:62 pubmed publisher
..The ORFX amino acid sequences are hydrophilic and basic, with between 12 and 16 Arg/Lys residues in each though, at 7.5-10.2 kDa, the putative ORFX product is too small to appear on typical published protein gels...
Firth A, Chung B, Fleeton M, Atkins J. Discovery of frameshifting in Alphavirus 6K resolves a 20-year enigma. Virol J. 2008;5:108 pubmed publisher
..The results have implications for alphavirus biology, virion structure, viroporins, ribosomal frameshifting, and bioinformatic identification of novel frameshift-expressed genes, both in viruses and in cellular organisms...
Firth A, Atkins J. Analysis of the coding potential of the partially overlapping 3' ORF in segment 5 of the plant fijiviruses. Virol J. 2009;6:32 pubmed publisher
..Possible translation mechanisms for this unusually positioned ORF are discussed. ..
Firth A, Atkins J. Candidates in Astroviruses, Seadornaviruses, Cytorhabdoviruses and Coronaviruses for +1 frame overlapping genes accessed by leaky scanning. Virol J. 2010;7:17 pubmed publisher
..Overlapping gene predictions are presented for the astroviruses, seadornaviruses, cytorhabdoviruses and coronaviruses (families Astroviridae, Reoviridae, Rhabdoviridae and Coronaviridae, respectively). ..