- Up-regulation of ephrin-A1 during melanoma progressionD J Easty
St George s Hospital Medical School, London, UK
Int J Cancer 84:494-501. 1999..Both effects may be potentiated by inflammatory responses. Our data are consistent with earlier observations that an inflammatory infiltrate is associated with poor prognosis in thin primary melanomas...
- Protein tyrosine kinases in malignant melanomaD J Easty
Department of Pathology, University College Dublin, Ireland
Melanoma Res 10:401-11. 2000..In addition, PTKs expressed in significant amounts in both benign and malignant melanocytes, such as insulin-like growth factor-1 receptor (IGF1-R), FGF-R1, HER2/NEU and FAK, are likely to play a role in melanoma genesis and progression...
- Protein tyrosine phosphatases, new targets for cancer therapyDavid Easty
Department of Pathology, Conway Institute, University College Dublin, Dublin, Ireland
Curr Cancer Drug Targets 6:519-32. 2006..Finally, we address the role of PTPs in melanoma, an increasingly common tumour that may represent an appropriate target for therapeutic manipulation of PTP activity...
- Receptor tyrosine kinases and their activation in melanomaDavid J Easty
Department of Oncology, St James s Hospital, Dublin, Ireland Division of Biomedical Sciences, St George s, University of London, London, UK
Pigment Cell Melanoma Res 24:446-61. 2011..Kinases are considered druggable targets, so characterization of global RTK activity in melanoma should assist the rational development of tyrosine kinase inhibitors for clinical use...